Targeted intra-tumoral hyperthermia using uniquely biocompatible gold nanorods induces strong immunogenic cell death in two immunogenically ‘cold’ tumor models by Barry E. Kennedy, Erin B. Noftall, Cheryl Dean, Alexander Roth, Kate N. Clark, Darren Rowles, Kulbir Singh, Len Pagliaro, Carman A. Giacomantonio, Carman A. Giacomantonio, Carman A. Giacomantonio

“…THT induces controlled tumor heating, promoting immunogenic cell death (ICD) and modulating the tumor microenvironment (TME) to enhance immune engagement. This study explores the synergistic potential of GNR-mediated THT with immunotherapies in immunogenically ‘cold’ tumors to achieve durable anti-tumor immunity.MethodsGNRs from Sona Nanotech Inc.™ were intratumorally injected and activated using NIR light to induce mild hyperthermia (42–48°C) for 5 minutes. …”
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Analysis of Prognostis Factors and Effect of Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease by Yiming XU, Honghua SHEN, Jingbo DU, Lei REN

“…Objective:To evaluate the rehabilitation effect of different intensity aerobic exercise on patients with chronic obstructive pulmonary disease (COPD), and explore an appropriate pulmonary rehabilitation strategy for COPD patients with different degrees of pulmonary function in alleviating period.Methods:A total of 529 COPD patients were from the respiratory department of Shanghai Fourth Rehabilitation Hospital. …”
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Effect and Mechanism of Running on Mouse Emphysema Model Induced by Cigarette Extract by LI Yongrong, XIE Haibin, LI hong, SUN Jie

“…ObjectiveTo observe the effect of running on mouse emphysema model induced by cigarette extract, and to explore its mechanism based on signal transducer and activator of transcription 3 (STAT3).MethodsA total of 40 male C57BL/6 mice were randomly divided into control group, exercise group, emphysema group and emphysema + exercise group, with 10 mice in each group. …”
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Genome-Wide Profiling of Human Papillomavirus DNA Integration into Human Genome and Its Influence on PD-L1 Expression in Chinese Uygur Cervical Cancer Women by Feng Yang-chun, Wang Sen-yu, Zhang Yuan, Huang Yan-chun

“…We aimed to investigate the integration situation of 20 subtypes of HPV gene into host cell genome in Chinese Uygur cervical cancer patients; meanwhile, we explored the influence of gene integration on PD-L1 expression. …”
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Simultaneous estimation of multiple soil properties from vis-NIR spectra using a multi-gate mixture-of-experts with data augmentation by Xiaoqing Wang, Mei-Wei Zhang, Ya-Nan Zhou, Lingli Wang, Ling-Tao Zeng, Yu-Pei Cui, Xiao-Lin Sun

“…Furthermore, performance of feature-spectrum selected by competitive adaptive reweighted sampling (CARS) on the accuracy of the MMoE was also explored, as well as a data augmentation method of stacking raw spectra with five preprocessed spectra data. …”
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Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series by Giacomo Savini, Alice Galzignato, Catarina P. Coutinho, Jinhai Huang, Yue Wu, Piero Barboni, João Mendanha Dias, Filomena J. Ribeiro, Domenico Schiano-Lomoriello

“…Abstract Background To investigate the functional results of the AcrySof IQ Vivity (Alcon, Fort Worth, TX) extended depth-of-focus intraocular lens (EDoF-IOL) and explore correlations between the preoperative biometric parameters and the postoperative functional outcomes. …”
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Time-series analysis on relationship between short-term exposure to atmospheric ozone and the risk of non-accidental deaths in Hefei during 2017−2020 by Linling YU, Yu ZHU, Changchun XIAO

“…Ambient O3 pollution has become one of the big issues in Hefei.ObjectiveTo explore the health risks of non-accidental deaths (NAD) in local residents associated with ambient O3 in Hefei City, and propose effective measures.MethodsThe data of daily NAD, mortality due to circulatory system diseases, mortality due to respiratory system diseases, atmospheric pollution, and meteorological factors were collected in Hefei from 2017 to 2020. …”
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Effects of open-skill exercise on executive functions in children and adolescents: a systematic review and meta-analysis by Shunding Hu, Peng Shi, Ziyun Zhang, Xiaosu Feng, Kai Zhang, Kai Zhang, Kai Zhang, Teng Jin

“…Therefore, this study systematically explores the aforementioned issues and examines the potential moderating factors in the effects of open-skill exercise intervention on executive functions.MethodsComputer searches of the CNKI, WOS, PubMed, ScienceDirect and SPORTDiscus databases were conducted. …”
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Le mouvement étudiant et la question des langues en Algérie (1962-1965) : à propos d’un épisode méconnu de l’histoire de l’UGEMA-UNEA by Yassine Temlali

“…In reconstructing this obscure episode in the light of many sources, including the accounts of participants, this article explores the attitude of the student movement, in the immediate post-independence period (1962–1965), to the question of Berber languages, which were spoken by a fifth of the population but which at the time enjoyed no explicit juridical status. …”
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Sexual Practices and HIV Prevention Strategies Used by Female Sex Workers in Lagos, Nigeria: An Assessment of the Willingness to Use a Microbicide by Ekama SO, Sheth AN, Ilomuanya MO, Okwuzu JO, Musa AZ, Idigbe I, Ezeobi PM, Oladele DA, Ezechi OC, Salako BL

“…This research aimed to evaluate the sexual practices, existing HIV prevention methods, and willingness to use a microbicide for HIV prevention among female sex workers in Nigeria. We also explored factors that might influence their willingness to use a new microbicide product.Methods: A cross-sectional study was conducted among female sex workers recruited from brothels within Lagos-Nigeria, in which participants were selected via purposive sampling over a period of five-months. …”
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Socio-economic assessment of drought impacts in Lesotho: implications for early action by Relebohile Agnes Mojaki, Makoala Vitalis Marake, Evan Easton-Calabria, Joalane Rethabile Marunye, Erin Coughlan de Perez

“…While drought-related research has explored the association between rainfall and crop production, there is a gap in understanding people’s experiences of drought impacts and their opinion about what actions could be taken to avoid such impacts in the future. …”
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A comparative study of hospitalization costs of TKA inpatients before and after National Volume-based Procurement in Guangdong, China: an interrupted time-series analysis by Anqi Li, Gongduan Li, Dong Han, Manru Fu, Jinghui Chang, Jinghui Chang

“…BackgroundThis study aims to explore the impact of the National Volume-based Procurement Policy in Guangdong Province on hospitalization costs for total knee arthroplasty inpatients.MethodsInterrupted time-series analysis were used to examine the expenses associated with total knee arthroplasty for inpatients at a hospital in Guangzhou between May 10, 2021, and December 26, 2023. …”
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The role of Anti-PAD4, Anti-CarP, and Anti-RA33 antibodies combined with RF and ACPA in predicting abatacept response in rheumatoid arthritis by Alberto Floris, Maria Maddalena Angioni, Mattia Fadda, Micaela Rita Naitza, Mattia Congia, Elisabetta Chessa, Matteo Piga, Alberto Cauli

“…Abstract Objectives To explore the role of newly emerging autoantibodies (AAbs) - peptidyl-arginine deiminase 4 (aPAD4), carbamylated proteins (aCarP), and anti-RA33 (aRA33) - alongside the traditionally assessed rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), in predicting the response to abatacept (ABT) and its retention rate in rheumatoid arthritis (RA) patients. …”
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Adaptive Just-in-Time Intervention to Reduce Everyday Stress Responses: Protocol for a Randomized Controlled Trial by Jillian A Johnson, Matthew J Zawadzki, Martin J Sliwinski, David M Almeida, Orfeu M Buxton, David E Conroy, David Marcusson-Clavertz, Jinhyuk Kim, Robert S Stawski, Stacey B Scott, Christopher N Sciamanna, Paige A Green, Emily M Repka, Meynard John L Toledo, Nicole L Sturges, Joshua M Smyth

“…ObjectiveThis study aims to (1) use an experimental medicine approach to evaluate the impact of a smartphone-delivered JIT stress management intervention on the frequency and intensity of person-specific stress responses (ie, stress reactivity, nonrecovery, and pileup); (2) evaluate the impact of the JIT intervention on the enactment of health behaviors in everyday life (physical activity and sleep); and (3) explore whether changes in stress responses mediate the interventions’ effects on health behaviors. …”
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Assessing the Future ODYSEA Satellite Mission for the Estimation of Ocean Surface Currents, Wind Stress, Energy Fluxes, and the Mechanical Coupling Between the Ocean and the Atmosp... by Marco Larrañaga, Lionel Renault, Alexander Wineteer, Marcela Contreras, Brian K. Arbic, Mark A. Bourassa, Ernesto Rodriguez

“…Since measurement noise in surface currents strongly depends on the square root of the transmit power of the Doppler scatterometer antenna, noise levels can be reduced by increasing the antenna length. However, exploring other alternatives, such as the use of neural networks, could also be a promising approach. …”
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Health and Experiences During the COVID-19 Pandemic Among Children and Young People: Analysis of Free-Text Responses From the Children and Young People With Long COVID Study by Natalia K Rojas, Sam Martin, Mario Cortina-Borja, Roz Shafran, Lana Fox-Smith, Terence Stephenson, Brian C F Ching, Anaïs d'Oelsnitz, Tom Norris, Yue Xu, Kelsey McOwat, Emma Dalrymple, Isobel Heyman, Tamsin Ford, Trudie Chalder, Ruth Simmons, Snehal M Pinto Pereira

“…Some quantitative studies report increased emotional problems and depression; others report improved mental health and well-being. Qualitative explorations reveal heterogeneity, with themes ranging from feelings of loss to growth and development. …”
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Effects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis by Qi Jin, Ge Xu, Yuchen Ying, Lumin Liu, Huimin Zheng, Shifen Xu, Ping Yin, Yuelai Chen

“…Furthermore, subgroup analysis and network meta-regression analysis were conducted to explore potential sources of heterogeneity. Results The review included 21 studies with 1,196 participants, with meta-analysis focusing on 17 studies involving 1,013 participants. …”
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Meta-analysis of Therapeutic Effect of Warm Acupuncture and Moxibustion on Knee Osteoarthritis of Yang Deficiency and Cold Coagulation and Research on Regularity of Acupoint Select... by Zeling HUANG, Shanni SHI, Junjun HE, Hongjian GAO, Haiya GE, Zhenqiang HONG

“…Excel software was used to analyze the acupoint selection prescriptions of warm acupuncture and moxibustion, and to explore the acupoint selection regularity of warm acupuncture and moxibustion in the treatment of KOA of Yang deficiency and cold coagulation.Results:A total of 18 RCTs and 1 209 patients were included. …”
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Transcriptome analysis reveals that PRV XJ delgE/gI/TK protects against intestinal damage in nose-dropping-infected mice by regulating ECM-ITGA/ITGB-P-FAK by Tong Xu, Yang Zhang, Qian Tao, Lei Xu, Si-Yuan Lai, Yan-Ru Ai, Jian-Bo Huang, Ben-Lu Yang, Ling Zhu, Zhi-Wen Xu

“…This study addresses a critical gap in understanding the impact of PRV infection on the gut, which has been less explored compared to its neurological effects. By developing a drip-nose PRV-infection mouse model, the research indicated that PRV might promote self-infection through activation of the ECM-ITGA/ITGB-p-FAK signaling pathway, and PRV XJ delgE/gI/TK immunization effectively prevents intestinal damage by significantly reducing the expression of genes in the ECM-ITGA/ITGB-p-FAK signaling pathway. …”
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Probiotics Can Boost the Antitumor Immunity of CD8+T Cells in BALB/c Mice and Patients with Colorectal Carcinoma by Jie Mao, Shu-Ze Zhang, Peng Du, Zhi-Bin Cheng, Huan Hu, Shi-Yao Wang

“…The aim of the study is to verify antitumor immune response of probiotics in patients with colorectal carcinoma and to explore its mechanism. Methods. To detect the tumor samples of 122 patients with colorectal carcinoma after surgery, analyze the effect of probiotics on enhancing tumor-infiltrating CD8+T cells to inhibit colorectal carcinoma, and further verify the mechanism of probiotics on enhancing the antitumor immune response of CD8+T cells through animal experiments. …”
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