Effects of a periodic intermittent theta burst stimulation in Alzheimer’s disease by Yue Wu, Lu Wang, Kai Wang, Shanshan Zhou, Pan Wu, Yibing Yan, Ling Wei, Bensheng Qiu, Yanghua Tian, Zhi Geng, Xingqi Wu, Panpan Hu, Guixian Xiao, Gongjun Ji, Hesheng Liu

“…However, the long-term effects of iTBS on cognitive decline and brain structure in patients with AD are unknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised, assessor-blinded, controlled trial, iTBS was administered to the left dorsolateral prefrontal cortex (DLPFC) of 42 patients with AD for 14 days every 13 weeks. …”
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Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy by Francesco Bruno, Francesco Bruno, Patrizia Spadafora, Ida Veltri, Mario L. Cuconati, Francesca Condino, Annamaria Cerantonio, Selene De Benedittis, Beatrice M. Greco, Beatrice M. Greco, Gemma Di Palma, Olivier Gallo, Luigi Citrigno, Antonio Qualtieri, Maurizio Cundari, Maurizio Cundari, Maurizio Cundari, Francesca Cavalcanti

“…However, the combined effects of APOE genotype and sex on cognitive performance and depression in temporal lobe epilepsy have not been previously investigated.ObjectiveThis study aims to (i) identify impaired cognitive performance and clinically relevant depression; (ii) explore the interaction between sex and APOE ε4 genotype on cognitive performance and depression in individuals with temporal lobe epilepsy.MethodsWe used a comprehensive battery of neuropsychological tests to assess domains such as learning and memory, attention, executive functions, language, and visuo-spatial constructional skills and the Hamilton Depression Rating Scale. …”
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Prevalence of Diabetic Retinopathy in Patients with Cerebrovascular Accident: A Cross-sectional Study by (Col.) OK Radhakrishnan, Rutu K Rao, Varsha Manade, Swaranjali Gore, Shreya Gandhi, Khushboo Goyal, Tushar Agrawal

“…Aim: To assess the prevalence of DR among individuals who have experienced CVAs and to explore the relationship between DR and CVAs within the Indian population. …”
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PIK3CA mutational status in tissue and plasma as a prognostic biomarker in HR+/HER2− breast cancer by Eduardo Terán, Rebeca Lozano, César A. Rodríguez, Mar Abad, Luis Figuero, José Antonio Muñoz, Belén Cigarral, Aline Rodrígues, Magdalena Sancho, M. Asunción Gómez, Daniel Morchón, Juan Carlos Montero, José María Sayagués, M. Dolores Ludeña, Emilio Fonseca

“…The overall agreement within plasma and tissue methods has not been well explored. Our aim was to correlate tissue and plasma approaches and to analyze the prognostic impact of PIK3CA mutations (PIK3CAm) in HR+/HER2− BC. …”
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The walnut tree as a source of progesterone for reproductive control in goats by P. Chemineau, A.L. Lainé, D. Gennetay, C. Porte, D. Chesneau, C. Laclie, G. Goudet, M. Meunier, M. Delmas, M.L. Greil, P. Liere, A. Pianos, A. Bernard, E. Dirlewanger, J.A. Delgadillo, M. Keller

“…Intravaginal sponges impregnated with the progesterone (P4) analogue fluorogestone acetate (FGA) induce synchronous oestrous behaviour and normal ovulatory cycle in goats. To explore alternatives using natural P4 from plants, we developed a method of ethanolic extraction and a specific enzyme immunoassay (EIA) to measure P4 in the different parts of the walnut tree Juglans regia. …”
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Chinese herbal formula Tongxie Yaofang granules for diarrhoea-predominant irritable bowel syndrome: a randomised, double-blind, placebo-controlled, phase II trial by Nicola Robinson, Mei Han, Ling Yan, Vincent Chi Ho Chung, Jian-Ping Liu, Hui-Juan Cao, Shi-Bing Liang, Hong-Jie Cheng, Qiao-Yan Zhang, Yu-Fei Li, Ze-Yu Yu, Ling-Yao Kong, Yan-Mei Cai, Li-Bao An, Bao-Tuan Zhao, Shan-Shan Xu, Nai-Wei Zhang, Bo-Yi Jia, Wei-Fang Liu, Fang Niu, Ba-Teer Wu, Jin-Ming Song, Shu-Xin Jia, Meng-Meng Shi, Xiao-Na Zhang

“…Future large-scale, rigorously designed trials with longer treatment and follow-up periods are essential to evaluate the therapeutic effects and safety of TXYF, and to explore the psychological factors.Trial registration number ISRCTN12453166.…”
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Disparities in dolutegravir utilisation in children, adolescents and young adults (0–24 years) living with HIV. An analysis of the IeDEA Pediatric West African cohort by Valériane Leroy, Anandi Sheth, Julie Jesson, Jean Jacques Koffi, Antoine Jaquet, François Dabis, Didier Koumavi Ekouevi, Karen Malateste, Olivia Keiser, Lehila Bagnan, Simon Boni, Madeleine Amorissani Folquet, Mariam Sylla, Olivier Marcy, Raoul Moh, Gildas Boris Hedible, Sophie Desmonde, Joycelyn Dame, Agatha David, Madeleine Amorissani-Folquet, Sylvie N'Gbeche, Elom Takassi, François Tanoh Eboua, Kouadio Kouakou, Lehila Bagnan Tossa, Caroline Yonaba, Jocelyn Dame, Sylvie Marie N’Gbeche, Fatoumata Dicko Traore, Oliver Ezchechi, Rosemary Audu, Charlotte Bernard, Caroline Couturier, Marie Kerbie Plaisy, Elodie Rabourdin, Thierry Tiendrebeogo, Désiré Dahourou, Emile Sodinyessi, Jean-Claude Azani, Kadidja Diarra, Maika Bengali, Abdoulaye Cissé, Guy Gnepa, Eric Komena, Séverin Lenaud, Eulalie Kangah, Igho Ofotokun, Cecile Delille Lahiri, Noëlle Benzekri, Geoffrey Gottlieb

“…We computed the cumulative incidence function for DTG initiation; associated factors were explored in a shared frailty model, accounting for clinic heterogeneity.Results Since 2019, 3350 patients were included; 47.2% were female; 78.9% had been on ART ≥12 months. …”
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Pilot study of a ketogenic diet in bipolar disorder: a process evaluation by Benjamin P. Rigby, Nicole Needham, Helen Grossi, Ivana Kamenska, Iain H. Campbell, Ben Meadowcroft, Frances Creasy, Cheryl Fisher, Pankaj Bahuguna, John Norrie, Gerard Thompson, Melissa C. Gibbs, Maja Mitchell-Grigorjeva, Ailsa McLellan, Tessa Moses, Karl Burgess, Rachel Brown, Michael J. Thrippleton, Harry Campbell, Daniel J. Smith, Sharon A. Simpson

“…This research aimed to explore the feasibility and acceptability of a ketogenic diet intervention for bipolar disorder, fidelity to its behavioural components and the experiences of the participants and research clinicians involved. …”
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Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa by Katrien F.M. Bracké, Laura Monteiro Rente Dias, Marisha N. Meijer, Cathelijne P.M. Steegers, Laurinde F. den Heijer, Tess van der Harst, Marjolein H.G. Dremmen, Meike W. Vernooij, Gwen C. Dieleman, Tonya White

“…Therefore, this study aimed to identify aberrant brain networks related to the core clinical symptoms of AN and to explore the longitudinal association with clinical outcome in a large population of adolescents experiencing their first episode of AN. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…Additionally, a dual-luciferase reporter assay confirmed that GATA2 binds to the promoter of SERPINE1 (PAI-1), thereby initiating its transcription.ConclusionThe IL-6/GATA2/SERPINE1 pathway mediates cellular senescence after acute kidney injury, and inhibiting IL-6 can alleviate AKI-induced cellular senescence, providing an important basis for exploring new therapeutic strategies.…”
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Re-evaluating large for gestational age: differential effects on perinatal outcomes in term and premature births by Chun-Heng Kuo, Chun-Heng Kuo, Chun-Heng Kuo, Yi-Ling Wu, Chi-Nien Chen, Chi-Nien Chen, Yu-Ru Lo, I-Weng Yen, Kang-Chih Fan, Yi-Yun Tai, Ming-Wei Lin, Chih-Cheng Hsu, Chih-Cheng Hsu, Chih-Cheng Hsu, Chih-Cheng Hsu, Hung-Yuan Li

“…While existing research primarily focuses on term neonates, less is known about preterm neonates. This study aims to explore the risks of adverse maternal and neonatal perinatal outcomes associated with LGA in term neonates and neonates with different degrees of prematurity, compared to appropriate-for-gestational-age (AGA) neonates.MethodsUsing the Birth Reporting Databases (2007–2018) linked to Taiwan's National Health Insurance Research Database, we conducted a retrospective nationwide cohort study of singleton neonates delivered between 24 and 42 weeks of gestation. …”
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Awareness, knowledge, and attitudes of the Belgian general population towards paternal perinatal depression: a descriptive cross-sectional study by Ayse Akalin, Ayse Akalin, Florence D’haenens, Sandra Tricas-Sauras, Sandra Tricas-Sauras, Joeri Vermeulen, Joeri Vermeulen, Joeri Vermeulen, Dennis Demedts, Dennis Demedts, Ronald Buyl, Maaike Fobelets, Maaike Fobelets

“…It is also crucial for caregivers, as they play a vital role in identifying symptoms, encouraging help-seeking, and reducing stigma. This study aimed to explore the awareness, knowledge, and attitudes of the general population in Belgium towards paternal perinatal depression, using the validated DDads (Depression in Dads) questionnaire.MethodsThis descriptive, cross-sectional study was conducted between March and May 2020-2022 using convenience sampling. …”
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Effectiveness of different solvent-modulated Traditional Chinese Medicine applied to Shenque(RN8) in the treatment of constipation (不同溶剂调制药物贴敷神阙穴治疗便秘的效果观察)... by ZHANG Li (张莉), SHEN Juan (沈娟), PAN Lei (潘磊), ZHANG Yuanyuan (张园园), LI Yuye (李玉叶), DI Yanhui (邸延辉), ZHOU Xiaoyan (周晓艳)

“…Objective The aim of this study is to explore the clinical effect of applying Traditional Chinese Medicine prepared with different solvents to Shenque(RN8) acupoint for the treatment of constipation. …”
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Predicting the effectiveness of omalizumab in patients with refractory chronic rhinosinusitis with nasal polyps comorbid with asthma based on inflammatory biomarkers by Yutong Sima, MD, Ming Zheng, MD, Yan Zhao, PhD, Siqi Ge, PhD, Chengyao Liu, MD, Ping Wang, BS, Xiangdong Wang, MD, PhD, Luo Zhang, MD, PhD

“…Nevertheless, ideal quantitative or qualitative biomarkers for predicting a different response to biologics urgently need to be explored. We aim to identify potential biomarkers for predicting a good or poor response in patients with refractory CRSwNP. …”
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Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD by Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Sun, Lu Qian, Julia TCW, Helena C. Chui, Dante Dikeman, Isaac Asante, Stan G. Louie, David A. Bennett, Zoe Arvanitakis, Alan T. Remaley, Bilal E. Kerman, Hussein N. Yassine

“…Additionally, we used APOE4-TR mice and induced pluripotent stem cell (iPSC) models to explore cholesterol-ABCA1-senescence pathways. Results Transcriptomic profiling of the human dorsolateral prefrontal cortex from the Religious Order Study/Memory Aging Project (ROSMAP) cohort revealed the upregulation of cellular senescence transcriptome signatures in AD, which correlated with ABCA1 expression and oxysterol levels. …”
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Impacts of alfalfa nutrient concentrate on pellet physical attributes, growth performance, metabolism and nutritional quality of rainbow trout, Oncorhynchus mykiss by Hu Chen, Patrick C. Blaufuss, Dong-Fang Deng, Fabio Casu, Emma K. Kraco, Brian Shepherd, Wendy M. Sealey, Aaron M. Watson, Matthew F. Digman, Deborah A. Samac

“…This study addressed the escalating demand for aquatic feed by exploring the potential of alfalfa nutrient concentrate (ANC) as feed ingredient for rainbow trout. …”
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Validation study of synthetic models for esophageal atresia with tracheoesophageal fistula (EA/TEF): A simulation-based training in pediatric surgery by Zahradníková Petra, Hnilicová Silvia, Lindák Martin, Pechanová Rebeka, Števková Dominika, Vitovič Pavol, Laurovičová Miroslava, Horn František, Tvrdoň Tomáš, Babala Jozef

“…The purpose of this study was to explore MIS perceptions, training experiences, and preferences regarding laparoscopic simulation training. …”
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Recycling waste biosolids to forest propagation of Pinus leiophylla Schltdl. & Cham by Pedro Sinai Rivera-Torres, Jorge Flores-Velázquez, Miguel Ángel López-López, Abdul Khalil-Gardezi, Carlos Ramírez-Ayala, Erickson Basave-Villalobos

“… • In the critical transplant phase, the contribution of biosolids to the soil is explored as a material with buffer characteristics in the soil, to promote the survival of the pine in adverse conditions of drought and extreme heat…”
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Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Lipoprotein(a) by Frederick Berro Rivera, MD, Sung Whoy Cha, MD, Cruz Linnaeus Louisse, MD, Genquen Philip Carado, MD, John Vincent Magalong, MD, Vincent Anthony Tang, MD, Mary Grace Enriquez, MD, Martha Gulati, MD, MS, Byambaa Enkhmaa, MD, PhD, Neha Pagidipati, MD, MPH, Nishant P. Shah, MD

“…Subgroup analyses were done to explore potential treatment effect differences. Results: PCSK9i reduced Lp(a) levels on average of −27% (95% CI: −29.8% to −24.1%, P < 0.001). …”
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Brain iron deposition and cognitive decline in patients with cerebral small vessel disease : a quantitative susceptibility mapping study by Yian Gao, Changhu Liang, Qihao Zhang, Hangwei Zhuang, Chaofan Sui, Nan Zhang, Mengmeng Feng, Haotian Xin, Lingfei Guo, Yi Wang

“…Purpose Our study compares brain iron deposition in gray matter (GM) nuclei between cerebral small vessel disease (CSVD) patients and healthy controls (HCs), exploring factors that affect iron deposition and cognitive function. …”
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