Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation by V. B. Chandana Kumari, Ramith Ramu, Sujay S. Huligere, Shashank M. Patil, Shivasharanappa Nayakvadi, Sharath Bijoor, Uma Venkateswaran Manjappara, Mohammad Z. Ahmed, Ling Shing Wong

“…This study is a novel approach that explores the antihyperglycemic and antihyperlipidemic effects of Levilactobacillus brevis RAMULAB54 (LB13243), isolated from fermented sugarcane juice. …”
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Co-creating a person-centered creative engagement intervention for Parkinson's care by Blanca T. M. Spee, Blanca T. M. Spee, Blanca T. M. Spee, Thieme B. Stap, Thieme B. Stap, Marjoke Plijnaer, Gert Pasman, Sara Zeggio, Annelien Duits, Annelien Duits, Julia S. Crone, Suzanne Haeyen, Suzanne Haeyen, Matthew Pelowski, Matthew Pelowski, Bastiaan R. Bloem, Jan-Jurjen Koksma

“…Future research will focus on rigorously evaluating its effectiveness and exploring its scalability in diverse settings.…”
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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD) by Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini, Giulia Lopatriello, Luca Bertoli, Hugo De Jonge, Luisa Iamele, Annalisa Altimari, Elisa Gruppioni, Andrea Ardizzoni, Marzia Rossato, Francesco Gelsomino, Pier-Luigi Lollini, Arianna Palladini

“…In vitro investigations, including the evaluation of cell sensitivity to interferon-gamma (IFN-γ) and cell response to PD-L1 modulation, were conducted to explore the influence of these factors on cell plasticity regulation. …”
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Association of socioeconomic status with diabetic microvascular complications: a UK Biobank prospective cohort study by Yikeng Huang, Zhi Zheng, Haibing Chen, Chufeng Gu

“…Abstract Background Prior studies on the link between socioeconomic status (SES) and diabetic microvascular complications have been inconclusive. This study aimed to explore whether SES is associated with the risk of diabetic retinopathy (DR), nephropathy (DN) and diabetic peripheral neuropathy (DPN) using large prospective cohort. …”
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Association analysis of suicide risk assessed with Mini International Neuropsychiatric Interviews’ Suicidality Module in adolescents with non suicidal self injury disorder by Shuo Geng, Shuo Geng, Wen Zhang, Xiang Gao, Lele Qu, Xueping Zheng, Jian Sun, Mingdong Xu, Hua Lin, Xueyu Jia, Xu Zhang

“…This study observes the association between depressive and anxiety symptoms and suicide risk among adolescents with non suicidal self injury disorder, and explores the mechanism underlying the high risk of suicide in this population.MethodAdolescents with non suicidal self injury disorder and their parents from a psychiatric outpatient clinic were selected to conduct paper questionnaires to measure their sociodemographic conditions. …”
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Ice-proximal sea ice reconstruction in the Powell Basin, Antarctica, since the Last Interglacial by W. W. Khoo, J. Müller, J. Müller, J. Müller, O. Esper, W. Xiao, C. Stepanek, P. Gierz, G. Lohmann, G. Lohmann, G. Lohmann, W. Geibert, J. Hefter, G. Mollenhauer, G. Mollenhauer, G. Mollenhauer

“…In this study, we apply a multiproxy approach, in combination with numerical climate modeling, to explore glacial–interglacial environmental variability. …”
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Investigating a caregiver-assisted social skills group programme for primary and early high school-aged children with acquired brain injury or cerebral palsy: protocol for a pilot... by Koa Whittingham, Roslyn N Boyd, Rose Gilmore, Leanne Sakzewski, Nicola Hilton, Afroz Keramat, Bianca Thompson, Jacqui Barfoot, Christine T Moody

“…Following completion of the PEERS Plus programme, semistructured focus group interviews will be conducted separately with caregivers and children to explore the lived experience of PEERS. Interpretive description will be used to identify patterns and themes related to participants’ experiences. …”
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Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness by Nan Wang, Nan Wang, Nan Wang, Yifang He, Sipeng Zhu, Dongsheng Liu, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Jianghong He, Jingqi Li, Juanning Si, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

“…Functional near-infrared spectroscopy (fNIRS), with its real-time, portable, and noninvasive imaging capabilities, has emerged as a promising tool for evaluating functional brain activity and nonrecovery potential in DoC patients. This review explores the current applications of fNIRS in DoC research, identifies its limitations, and proposes future directions to optimize its clinical utility.AimThis review examines the clinical application of fNIRS in monitoring DoC. …”
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Insights into simulation-based learning: student and faculty experiences in a PharmD program in Saudi Arabia by Reem Binsuwaidan, Najla A. Altwaijry, Alnada A. Ibrahim, Rawan A. Alghamdi, Razan Bin Humaid, Alaa A. AlSharif, Alaa A. AlHubaishi, Elshaymaa I. Elmongy, Lina I. Alnajjar, Ghadah H. Alshehri

“…The study aimed to evaluate student satisfaction and perceived learning outcome acquisition and to explore faculty perceptions of simulation-based learning. …”
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Unveiling the role of ASPP1 in cancer progression: pan-cancer bioinformatics and experimental validation in colorectal cancer by Keyuan Xiao, Xiang Li, Ihsan Ullah, Wenqing Hu, Kaiqiang Wang, Fan Yang, Chengyu Yang, Chunqi Feng, Liang Zong, Xinghua Li

“…ASPP1’s function in colorectal cancer was further explored through in vitro assays, including qRT-PCR, Western blotting, colony formation, Transwell, and wound healing.ResultsASPP1 expression exhibited significant variability across different cancer types, with marked associations with patient outcomes, particularly overall survival (OS) and disease-specific survival (DSS) across several cancer types. …”
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Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

“…The regulation of tumor cell proliferation and apoptosis by the active ingredients of probiotics may be one of the mechanisms of their prevention of CRC. In this study, we explored the effects of L. salivarius LZZAY01 on autophagy and apoptosis of colon cancer cells in vitro and in vivo and proposed a possible mechanism for the prevention of CRC by probiotics.…”
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Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer by Xiang Pan, Kailai Chen, Wei Gao, Meiqi Xu, Fanlong Meng, Mengyuan Wu, Zi Qi Wang, Yun Qi Li, Wanhai Xu, Manjie Zhang, Yakun Luo

“…The interactions between circBNC2, miR-4298, and ACSL6 were explored via luciferase reporter assays, RNA immunoprecipitation, and western blotting analysis. …”
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Cognitive impairment in a primary healthcare population: a cross-sectional study on the island of Crete, Greece by Panagiotis Simos, Simeon Panagiotakis, Joanna Moschandreas, Dimitrios Boumpas, Antonios Konstantinos Bertsias, Ioanna Tsiligianni, Sophia Papadakis, Ioannis Zaganas, George Duijker, Emmanouil K Symvoulakis, Polyvios Papadokostakis, Kornilia Makri, Eliza Iatraki, Chariklia Tziraki, Maria Basta, Alexandros Vgontzas, Christos Lionis

“…The objective of this study is to assess the extent of cognitive impairment among elders visiting primary healthcare (PHC) practice settings, to explore associated risk factors and discuss current care challenges for PHC providers.Design A cross-sectional study was conducted between March 2013 and May 2014.Setting Fourteen PHC units located in rural and urban areas of the Heraklion district in Crete, Greece.Participants Consecutive visitors aged at least 60 years attending selected PHC practices.Primary and secondary outcome measures The Mini-Mental State Examination (MMSE) was used to indicate cognitive status. …”
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Biotechnological Phytocomplex of <i>Zanthoxylum piperitum</i> (L.) DC. Enhances Collagen Biosynthesis In Vitro and Improves Skin Elasticity In Vivo by Giovanna Rigillo, Giovanna Pressi, Oriana Bertaiola, Chiara Guarnerio, Matilde Merlin, Roberto Zambonin, Stefano Pandolfo, Angela Golosio, Francesca Masin, Fabio Tascedda, Marco Biagi, Giulia Baini

“…While further studies are needed to explore its full efficacy, especially for aging and environmentally stressed skin, these findings highlight ZPP’s potential as a new ingredient for cosmetic formulations aimed at skin care and the treatment of alterations caused by aging or environmental conditions.…”
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Prognostic nutritional index as a predictor of cardiovascular and all-cause mortality in American adults with hypertension: results from the NHANES database by Jing Tang, Jing Tang, Long Yang, Guan-Ying Yang, Yan-Hong Li, You-Sen Zhu, Hui Li, Xiao-Ming Gao, Xiao-Ming Gao, Xiao-Ming Gao

“…We used the Cox proportional hazard regression model to explore the predictive role of PNI on ACM and CVM in American adults with hypertension. …”
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CT45A1‐mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell‐in‐cell structure, potentiating the progression of microsatellite... by Hao‐Wei Teng, Hsiang‐Yueh Huang, Chun‐Chi Lin, Yuh‐Ching Twu, Wen‐Hao Yang, Wen‐Chun Lin, Hsin‐Yi Lan, Yen‐Yu Lin, Wei‐Lun Hwang

“…Clinicopathological characterization of formalin‐fixed paraffin‐embedded (FFPE) MSI‐H CRC specimens was performed to explore the underlying mechanisms involved. We showed that cancer/testis antigen family 45 member A1 (CT45A1) expression was upregulated in MSI‐H CRC patients with poor survival outcomes. …”
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Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank by Ting Li, Jing Chen, Yan Zheng, Klodian Dhana, Geng Zong, Yuan Ma, Trudy Voortman, Wei Gan, Yaying Cao, Yonghua Hu, Changzheng Yuan, Jie Shen, Gaohong Zhu, Chengwu Feng

“…Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure, while the role of genetics and incident cardiovascular disease (CVD) remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample, and to explore the role of genetics and CVD onset.Methods A prospective study among 354 654 participants free of CVD and dementia (2006–2010, mean age 56.4 years) was conducted within the UK Biobank, with brain magnetic resonance imaging (MRI) measurement available for 15 104 participants since 2014. …”
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Efficacy and Safety of Pramipexole Sustained Release versus Immediate Release Formulation for Nocturnal Symptoms in Chinese Patients with Advanced Parkinson’s Disease: A Pilot Stud... by Haiyan Zhou, Shuhua Li, Hongmei Yu, Shenggang Sun, Xinhua Wan, Xiaodong Zhu, Chun-Feng Liu, Ling Chen, Wei Xiang, Yaqing Sun, Haibo Chen, Shengdi Chen

“…Objective. To explore the efficacy and safety of pramipexole sustained release (SR) versus pramipexole immediate release (IR) in treating nocturnal symptoms in levodopa-treated Chinese patients with advanced Parkinson’s disease (PD) and sleep disturbances. …”
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A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults by Zi-yue Liu, Sha Liu, Xue Yao, Chun-yang Wang, Yunhao Song, Yan-ming Bi, Jin-Xiu Wang, Yang Li, Ta-la Shi, Wei Mi, Caiyun Chen, Zhi-Yong Hu

“…The relationship between demographic characteristics and the incidence of hyperlipidemia among the study participants was explored.ResultsA total of 1,210 participants were included in this study, with 43.80% being male. …”
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Optimal dietary vitamin E level facilitates ovarian development of female largemouth bass (Micropterus salmoides) broodstock by Qiuyu Gao, Qiao Feng, Dong Zhou, Zhili Ding, Changle Qi, Youqin Kong, Qiyou Xu

“…The current study was designed to explore the effects of dietary vitamin E on the ovarian development and health of female largemouth bass (Micropterus salmoides). …”
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