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31241
Preparation of oat galactolipid and anti-liver cancer effects of oat galactolipid–modified curcumin-loaded liver targeting vesicle
Published 2025-01-01“…The present work endeavors to explore the influences of plant galactolipids as natural galactosyl ligands for LTDDSs.MethodsPlant galactolipids were extracted from oat bran, and their characteristics were tested. …”
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31242
Involvement of Cholesterol Metabolic Pathways in Recovery from Noise-Induced Hearing Loss
Published 2020-01-01“…The objective of this study was to explore the molecular mechanisms of acute noise-induced hearing loss and recovery of steady-state noise-induced hearing loss using miniature pigs. …”
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31243
Short-term variability of Alzheimer’s disease plasma biomarkers in a mixed memory clinic cohort
Published 2025-01-01“…We measured intra- and inter-individual variability and explored if the variability could be affected by confounding factors. …”
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31244
Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer
Published 2025-01-01“…Our current research explored the prognostic value, biological function and targeting strategy of KIF11 in EC through approaches including bioinformatics, machine learning and experimental studies. …”
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31245
Application of metagenomic next-generation sequencing in the diagnosis of post-stroke infections: a case series study using multiple sample types
Published 2025-01-01“…Despite its extensively employed in the pathogen diagnosis for various infectious diseases, its application in diagnosing stroke-related infection, and its potential impact on clinical decision-making, anti-infection treatment, clinical intervention, and patient prognosis remain insufficiently explored. Additionally, while mNGS offers promising potential, it facts limitations related to sensitivity, specificity, cost, and standardization, which could influence its integration into routine clinical practice.MethodsWe retrospectively analyzed 18 stroke patients admitted to the First Affiliated Hospital of Medical College of Shantou University from January to February 2023, comparing culture-based methods with mNGS detection, and assessing its significance in etiological diagnosis. …”
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31246
Emotion recognition deficits in children and adolescents with autism spectrum disorder: a comprehensive meta-analysis of accuracy and response time
Published 2025-01-01“…Future research should prioritize standardized methodologies and explore cultural and contextual factors influencing emotion recognition abilities.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
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31247
Modelling the health, financial protection and equity impacts of upscaling the ACT NOW early intervention breast cancer pilot program in the Philippines: an extended cost-effective...
Published 2025-02-01“…Probabilistic, one-way sensitivity and scenario analyses explored uncertainty.Results Over 5 years, the ACT NOW intervention is cost-effective with an ICER of PHP60 711 (USD1098) (average incremental cost PHP743 [95% UI 424–960] and DALYs saved 0.01 [95% UI 0.01–0.02], below Philippines 2022 gross domestic product per capita PHP178 751). …”
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31248
Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis
Published 2025-01-01“…Additionally, for the variables identified in multivariable model, we explored the associations with longitudinal cognitive decline. …”
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31249
Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context
Published 2025-01-01“…Logistic regression models were used to explore risk factors for PNSP carriage compared to susceptible strains. …”
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31250
Job burnout and resilience among palliative care professionals in china: a qualitative study
Published 2025-01-01“…Objective We aimed to explore the factors influencing job burnout and resilience among palliative care professionals. …”
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31251
Metabolic profiling of Perilla leaves of different colors: insights into metabolite variation and bioactive compound distribution
Published 2025-01-01“…Furthermore, they offer valuable data for a comprehensive use of Perilla leaves and exploring gene-metabolites interactions in Perilla leaves.…”
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31252
Construction of "One Syndrome and One Product" Traditional Chinese Medicine nursing service in the specialized spine department (脊柱专科“一证一品”中医特色护理服务品牌建设思路)...
Published 2021-07-01“…This paper explored the the method, path and content of "One Syndrome and One Product" Traditional Chinese Medicine (TCM) nursing service in the specialized spine department, and summarized the construction and practice of "One Syndrome and One Product" nursing plan. …”
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31253
LcProt: Proteomics‐based identification of plasma biomarkers for lung cancer multievent, a multicentre study
Published 2025-01-01“…The performance of NaY‐based plasma proteomics as a preclinical diagnostic tool was validated through both internal and external cohort. Furthermore, we explored the different patterns of plasma protein changes during the progression of lung cancer and used the explanations method to elucidate the roles of proteins in the multitask predictive model.…”
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31254
STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren’s Syndrome: Association with Disease Susceptibility and Clinical Aspects
Published 2019-01-01“…A predisposing genetic background is likely, and, to date, several polymorphisms in non-HLA genes have been explored with interesting results. We investigated the association between the STAT4, TRAF3IP2, HCP5, and IL10 polymorphisms and SS susceptibility and their possible role in the modulation of clinical and laboratory features. 195 consecutive patients with SS were enrolled and clinical and laboratory data were collected. 248 age- and sex-matched healthy subjects were used as controls. …”
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31255
Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells
Published 2021-01-01“…Here, we performed an investigation on the pathogenesis of hypoxia-induced senescence through proteomic analyses and aimed to explore the mechanisms of stem cell senescence. Methods. …”
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31256
Correlation between Hyperalgesia and Upregulation of TNF-α and IL-1β in Aqueous Humor and Blood in Second Eye Phacoemulsification: Clinical and Experimental Investigation
Published 2021-01-01“…The aim of this study was to explore the correlation between intraoperative hyperalgesia of the second eye and the dynamic changes of tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels in aqueous humor (AH) of the second eye and whole blood after the first eye cataract surgery. …”
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31257
Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner
Published 2025-01-01“…The molecular mechanism was explored through RNA sequencing, immunofluorescence staining, co-immunoprecipitation assay, and protein-protein docking. …”
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31258
Molecular Mechanisms of Synergistic Effect of PRIMA‐1met and Oxaliplatin in Colorectal Cancer With Different p53 Status
Published 2025-01-01“…PRIMA‐1met has progressed to the Phase III clinical trial. Our study explores the combination therapy of PRIMA‐1met and L‐OHP for CRC with different p53 status. …”
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31259
Ultrasonic assisted stir squeeze casting of AA5456/Al2O3–SiC-Gr-MoS2 hybrid nanocomposites: Microstructure and strengthening analysis
Published 2025-01-01“…This study explores the development of aluminum metal matrix hybrid nanocomposites (AMMHNCs) using AA5456 alloy reinforced with 2 wt % of SiC, Al2O3, graphite (Gr), and MoS2 nanoparticles (NPs) through ultrasonic-assisted bottom pouring stir-squeeze casting. …”
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31260
Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study
Published 2025-01-01“…The value of including FVC in risk score models to improve their precision in predicting the onset of cardiometabolic diseases should be explored.…”
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