La nécropole de Vannes/Darioritum : données inédites sur les pratiques funéraires armoricaines dans un secteur occupé du ier au ive s. apr. J.-C. by Annaïg Le Martret, Marie Grall, Vanessa Brunet

“…The necropolis of Vannes/Darioritum (Morbihan, France) has been known since the 19th century, but it was only really explored in 2015, during a preventive excavation. As is usually the case, it is located beside a road and close to an entrance to the town. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…The primary objective of this study is to explore the potential significant role of immune response products in influencing the proliferation and biofilm formation of gut microbiota, which may subsequently lead to changes in fecal characteristics. …”
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mHealth-Based Diabetes Prevention Program for Chinese Mothers With Abdominal Obesity: Randomized Controlled Trial by Qinyuan Huang, Qinyi Zhong, Yanjing Zeng, Yimeng Li, James Wiley, Man Ping Wang, Jyu-Lin Chen, Jia Guo

“…Future research could further explore the efficacy improvement on dietary behaviors to better serve the health care needs of this population. …”
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Two Novel Compounds Isolated from the Marine Fungal Symbiont of Aspergillus unguis Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells: In vitro Study by Bashari MH, Agung MUK, Ariyanto EF, Al Muqarrabun LMR, Salsabila S, Chahyadi A, Rosandy AR, Afifah E, Afni M, Atmaja HE, Putri T, Utami F, Subhan B, Syafrizayanti, Andriani Y, Elfahmi

“…The objective of this study was to explore the anticancer activities of compounds from the fungal symbiont of Aaptos suberitoides on breast cancer cells.Methods: In the present research, Aspergillus unguis, an endophytic fungal strain derived from the marine sponge A. suberitoides was successfully isolated and characterized. …”
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Active ingredients and mechanisms of peony seed blended oil in diabetes treatment using Kunming mice: Insights from GC–MS, network pharmacology, and experimental verification by Yuning Gu, Fengliang Zhong, Tiantian Sun, Zirui Chang

“…This study aimed to evaluate the combined hypoglycemic potential of these oils through in vitro and in vivo experiments, supported by network pharmacology and molecular docking analyses to explore the underlying mechanisms. The research provides valuable insights into the potential therapeutic use of this blended oil in diabetes management, offering a natural alternative for hypoglycemic treatments. …”
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Incidence of unintended pregnancies and pregnancy experience among adolescents living with perinatally-acquired HIV in West Africa: a mixed-method study by Désiré Lucien Dahourou, Clément Tisseron, Caroline Yonaba, Joël Djaha, Marie-Sylvie N’Gbeche, Corinne Moh, Kouakou Kouadio, Patricia Nindjin, François Eboua, Belinda Bouah, Karen Malateste, Jean-Claude Azani, Eulalie Kangah, Elisabeth Thio, Philippe Msellati, Julie Jesson, Valériane Leroy, for the IeDEA West-African Collaboration

“…We studied the 18-month pregnancy incidence, and explored experiences of pregnancy among female ALHIV enrolled in the OPTIMISE-AO cohort, nested in the prospective paediatric IeDEA cohort in Côte d’Ivoire and Burkina Faso. …”
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Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

“…<b>Introduction/Objectives:</b> Since the biological activities and toxicities of ‘foreign’ and/or excess levels of metal ions are predominantly determined by their precise molecular nature, here we have employed high-resolution ¹H NMR analysis to explore the ‘speciation’ of paramagnetic Ni(II) ions in human saliva, a potentially rich source of biomolecular Ni(II)-complexants/chelators. …”
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Comparative analysis of retinal vascular structural parameters in populations with different glucose metabolism status based on color fundus photography and artificial intelligence by Naimei Chen, Naimei Chen, Zhentao Zhu, Di Gong, Xinrong Xu, Xinya Hu, Weihua Yang

“…ObjectiveMeasure and analyze retinal vascular parameters in individuals with varying glucose metabolism, explore preclinical retinal microstructure changes related to diabetic retinopathy (DR), and assess glucose metabolism’s impact on retinal structure.MethodsThe study employed a cross-sectional design encompassing a 4-year period from 2020 to 2024. …”
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Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis by Bo Pan, Yiming Pan, Yu-Song Huang, Meng Yi, Yuwei Hu, Xiaoyu Lian, Hui-Zhong Shi, Mingwei Wang, Guifen Xiang, Wen-Yi Yang, Zhong Liu, Fangfang Xia

“…Comprehensive subgroup analyses were undertaken to explore factors influencing MTT’s efficacy in treating depression. …”
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Psychosocial factors are associated with community mobility and participation in persons with dizziness by Pamela M. Dunlap, Jeffrey P. Staab, Patrick J. Sparto, Patrick J. Sparto, Joseph M. Furman, Susan L. Whitney, Susan L. Whitney

“…The secondary aim of this study was to explore the constructs measured using patient-reported outcomes associated with psychosocial factors in this population.Materials and methodsWe conducted a prospective cohort study with an in-person baseline assessment and a follow-up assessment completed at 3-months via computerized questionnaires. …”
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The association between metabolomic profiles of lifestyle and the latent phase of incident chronic kidney disease in the UK Population by Tingting Jin, Yunqi Wu, Siyi Zhang, Ya Peng, Yao Lin, Saijun Zhou, Hongyan Liu, Pei Yu

“…Therefore, we utilized the latest metabolomics data from the UK Biobank to explore the relationship between plasma metabolites and lifestyle factors, as well as to investigate the associations between various factors, including lifestyle-related metabolites, and the latent phase of CKD onset. …”
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Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction by Weicheng Ni, Ruihao Jiang, Di Xu, Jianhan Zhu, Jing Chen, Yuanzhen Lin, Hao Zhou

“…However, the ability of different IR indices to predict outcome in HFpEF patients has not been extensively explored. Methods Patients having HFpEF were recruited from January 2012 and December 2023. …”
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Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro by Yuanyuan Sun, Dadong Guo, Bin Liu, Xuewei Yin, Huixia Wei, Kai Tang, Hongsheng Bi

“…Further, the inflammatory manifestation of the anterior segment and pathological examination of the eye were explored in experimental autoimmune uveitis (EAU) rats. …”
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Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…This study provided a potential treatment for influenza from BB, and network pharmacology provided a strategy to explore active components and mechanism of TCMs against influenza virus infection. …”
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Temperature Sensitivity Response of Soil Enzyme Activity to Simulated Climate Change at Growth Stages of Winter Wheat by Yaokun Jiang, Bingbing Lu, Meng Liang, Yang Wu, Yuanze Li, Ziwen Zhao, Guobin Liu, Sha Xue

“…This study is of great significance in exploring the effects of global warming on food production and the mechanism of soil ecosystem functional stability under future climate change.…”
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Preoperative ultrasound risk factors for peripartum hysterectomy among PAS suspected pregnancies by Lulu Wang, Tianjiao Liu, Yang Yang, Yalan Li, Li Xiao, Xin Li, Sumei Wei

“…Multivariate logistic regression analysis was performed on the characteristics with statistical significance to explore risk factors for peripartum hysterectomy. …”
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Green Tea Extract (<i>Theaceae</i>; <i>Camellia sinensis</i> L.): A Promising Antimicrobial, Anti-Quorum Sensing and Antibiofilm Candidate Against Multidrug-Resistant <i>Campylobac... by Mona S. Emara, Ahmed M. Ammar, Ashraf M.O. Abdelwahab, Attia A. Elgdawy, Adel Abdelkhalek, Elena Pet, Gabi Dumitrescu, Mirela Ahmadi, Norhan K. Abd El-Aziz

“…Many studies have been carried out to explore innovative and alternative strategies to control antibiotic-resistant campylobacters in animal reservoirs and human hosts; however, limited studies have been performed to develop efficient control schemes against <i>Campylobacter</i> biofilms. …”
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Status and annual change of vulnerability among middle-aged and elderly people with cardiometabolic multimorbidity in a division of Xinjiang Production and Construction Corps, 2017... by Ziqi WANG, Jieting CHEN, Mei ZHANG, Mingxia JING

“…The contribution rate of each vulnerability dimension was calculated to explore the vulnerability level and its hierarchical changes in different comorbidity combinations. …”
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Coronary Heart Disease Risk Prediction Model Based on Machine Learning by YUE Haitao, HE Chanchan, CHENG Yuyou, ZHANG Sencheng, WU You, MA Jing

“…Factors influencing the incidence of CHD were explored through univariate analysis and stepwise logistic regression to select pertinent variables for inclusion in the predictive model. …”
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Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…., Nanjing, 210018, People’s Republic of China; 6Department of Pulmonary and Critical Care Medicine, Zhoushan Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Zhoushan, 316000, People’s Republic of China; 7Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jie Fang, Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin 2nd Road, Shanghai, 200025, People’s Republic of China, Email fj40517@rjh.com.cn Min Zhou, Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin 2nd Road, Shanghai, 200025, People’s Republic of China, Email doctor_zhou_99@163.comBackground: Targeted next-generation sequencing (tNGS) is a high-throughput and cost-effective diagnostic alternative for pneumonia, with the ability to simultaneously detect pathogens, antimicrobial resistance genes, and virulence genes. We aimed to explore the applicability of tNGS in the co-detection of the responsible pathogens, antimicrobial resistance (AMR) genes, and virulence genes in patients with pneumonia.Methods: A prospective study was conducted among patients with suspected pneumonia at Ruijin Hospital from March 1 to May 31, 2023. …”
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