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24701
RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study
Published 2023-05-01“…The latter showed that five core targets of the PI3K/AKT signaling pathway could bind to quercetin, among which EGFR, IL-6, and MYC showed strong docking, and the diosgenin ligand could bind to VEGFA. Cell experiments showed that asparagus, through the PI3K/AKT/NF-κB pathway, inhibited the proliferation and migration of MM cells, and caused retardation and apoptosis of MM cells in the G0/G1 phase.Discussion: In this study, the anti-cancer activity of asparagus against MM was demonstrated using network pharmacology, and potential pharmacological mechanisms were inferred using in vitro experimental data.…”
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24702
Micro-nano aerated subsurface drip irrigation and biochar promote photosynthesis, dry matter accumulation and yield of cucumbers in greenhouse
Published 2025-03-01“…Compared to CK, in the two-season experiment, the average soil aeration porosity (SAP) increased by 0.53–44.00 %, the soil oxygen content (SO) increased by 0.47–31.80 %, the net photosynthetic rate (Pn) increased by 1.91–50.78 %, the dry matter accumulation increased by 10.53–69.19 %, the yield increased by 1.72–44.23 %, and the water use efficiency (WUE) improved by 0.42–76.57 %. …”
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24703
Effects of nitrogen fertilizer basal-to-top-dressing ratios on maize straw decomposition, soil carbon and nitrogen, and bacterial community structure in different soil textures on...
Published 2025-02-01“…In a wheat–maize rotation system, field experiments were conducted over 2 years in loam and clay loam soils with five fertilizer (N) application treatments (i.e., no N fertilizer (N0) and N fertilizer basal-to-top-dressing ratios of 3:7 (N3:7), 4:6 (N4:6), 5:5 (N5:5), and 6:4 (N6:4)) to investigate the dynamics of maize straw decomposition, changes in soil organic carbon (SOC) and total nitrogen (TN) concentrations, soil bacterial diversity and abundance, and their interactions. …”
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24704
Flood susceptibility mapping based on watershed geomorphometric characteristics and land use/land cover on a small island
Published 2024-01-01“…Lombok, a small tropical island, experiences severe flooding almost yearly. Flood susceptibility mapping is important to determine the priority watershed in implementing flood mitigation action, including improving the spatial planning in watershed management. …”
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24705
Production of giant gourami Osphronemus goramy Lac. juvenile with different rate of water exchange
Published 2015-03-01“…The results of this experiment showed that 125% daily water exchange improved the production performance of giant gourami juvenile cultured at a density of 20 fish/L. …”
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24706
Utilization of fish bone charcoal in feed on growth and physiological responses of catfish fry Clarias gariepinus
Published 2025-01-01“… This study aimed to assess the impact of charcoal inclusion in feed on the physiological responses and growth of catfish. The experiment employed a completely randomized design (CRD) with five treatments and four replicates. …”
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24707
Blending of Slow-Release N Fertilizer and Urea Improve Rainfed Maize Yield and Nitrogen Use Efficiency While Reducing Apparent N Losses
Published 2024-12-01“…The purpose of this study was to improve N use efficiency (NUE) and minimize N loss by optimizing the rate and type of N fertilizer application while maintaining a high yield of maize. A two-year field experiment with U (urea), S (slow-release N fertilizer), and SU (blending of S and U) under four N application levels (N1: 90 kg ha<sup>−1</sup>, N2: 120 kg ha<sup>−1</sup>, N3: 180 kg ha<sup>−1</sup>, N4: 240 kg ha<sup>−1</sup>) was conducted to investigate their effects on ammonia (NH<sub>3</sub>) volatilization, residual soil nitrate N (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mi mathvariant="normal">N</mi><mi mathvariant="normal">O</mi></mrow><mrow><mn>3</mn></mrow><mrow><mo>−</mo></mrow></msubsup><mo>-</mo><mi mathvariant="normal">N</mi></mrow></semantics></math></inline-formula>), yield, NUE, apparent N losses of rainfed maize. …”
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24708
Hurricane Effects on a Shallow Lake Ecosystem and Its Response to a Controlled Manipulation of Water Level
Published 2001-01-01“…We treated this operation as a whole ecosystem experiment, and assessed ecological responses using data from an existing network of water quality and submerged plant monitoring sites. …”
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24709
进口大豆储存期间品质变化研究 Quality changes of imported soybeans during storage
Published 2025-01-01“…The American soybeans with moisture content of 10.85%, crude fat acidity of 0.80 mgKOH/g, and percent of heat-damaged kernel of 0.27% had a crude fat acidity of 2.25 mgKOH/g after being stored for 77 d in an accelerated simulated experiment at 40 ℃, and even at 45 ℃, the crude fat acidity was only 3.05 mgKOH/g, which still met the suitable storage requirements for high oil soybeans. …”
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24710
PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis
Published 2025-03-01“…Methods: The effects of HBV replicative capacity, ER stress signaling, inflammation, cell death, and tumorigenesis resulting from PreS1 deletions were investigated through in vitro and in vivo experiments. Inhibitors of the IRE1-JNK pathway and IL6 blockade were used to examine HCC tumor load induced by preS1 deletions. …”
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24711
Effects of taurine on growth performance, body composition and physiological responses of western white shrimp, Litopenaeus vannamei broodstock
Published 2024-06-01“…To evaluate the effects of Tau on growth, body composition, digestive enzymes, and haemolymph biochemical parameters, sampling was taken at the end of the experiment. Results and discussion: The results showed that final weight, specific growth rate, weight gain, condition factor, and survival of shrimp fed with the supplemented diets with Tau had no significant differences than the control group (p>0.05). …”
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24712
Width evolution of channel belts as a random walk
Published 2025-01-01“…Model predictions compare well to data of sediment age distributions measured at field sites and the temporal evolution of channel belts observed in flume experiments. Both comparisons indicate that a random walk approach adequately describes the lateral migration of channels and the formation of channel belts. …”
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24713
Investigating the Effect of Chicken Manure and Potassium Sulfate on the Physiological Properties of Fenugreek )Trigonella foenum-graecum L.( Medicinal Plant
Published 2025-12-01“…The investigated traits of this experiment included morphological and physiological traits, which were sampled after the plants were fruited and the pods turned yellow by removing the marginal effect.Results and Discussion The results showed that the highest level of secondary and main stem height, leaf dry weight and other growth traits were obtained with the highest level of chicken manure (2000 kg/ha), which of course was not significantly different from the level of 1000 kg/ha of chicken manure. …”
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24714
Combined Effects of Humic Acid-Modified Magnetic Biochar and AMF on the Properties of Saline-Alkali Soil and Photosynthetic Parameters of Muskmelon
Published 2024-12-01“…Moreover, by conducting pot experiments, the influence of individual fungi, individual biochar, and combined biochar-fungi (AMF+10%B, AMF+20%B) on the physicochemical properties, and enzyme activities of saline soil and alkaline soil, and the photosynthetic parameters of muskmelon were studied. …”
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24715
Effects of <i>Enterococcus faecalis</i> Supplementation on Growth Performance, Hepatic Lipid Metabolism, and mRNA Expression of Lipid Metabolism Genes and Intestinal Flora in Geese
Published 2025-01-01“…Each group was divided into six replicates, with five geese per replicate. During the 45-day experiment, the control group received a basal diet, while the experimental group was provided with the same basal diet supplemented with <i>E. faecalis</i> in drinking water at a concentration of 1.0 × 10<sup>8</sup> CFU/mL. …”
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24716
Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment
Published 2025-01-01“…Molecular docking identified Dig and AA as high-affinity binders of NANOS1. Animal experiments showed Dig and PD-1 inhibitor combination enhanced immunotherapy efficacy for TNBC.DiscussionThe findings from this study suggest that TOE may offer a novel therapeutic approach for TNBC by targeting NANOS1, a protein whose down-regulation is associated with improved patient outcomes. …”
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24717
Annexin A8 deficiency delays atherosclerosis progression
Published 2025-01-01“…Oxidized low‐density lipoprotein (ox‐LDL) increased AnxA8 expression in murine aortic endothelial cells (MAECs). In vitro experiments revealed that AnxA8 deficiency in MAECs suppressed P/E‐selectin and CD31 expression and secretion induced by ox‐LDL with a concomitant reduction in platelet and leukocyte adhesion. …”
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24718
Wild grasses as the reservoirs of infection of rust species for winter soft wheat in the Northern CaucasusWild grasses as the reservoirs of infection of rust species for winter sof...
Published 2021-10-01“…Monopustular Puccinia spp. isolates were used for virulence genetics analysis. In experiments to study the specialization of rust species from wild-growing cereals on common wheat, 12 winter cultivars were used (Grom, Tanya, Yuka, Tabor, Bezostaya 100, Yubileynaya 100, Vekha, Vassa, Alekseich, Stan, Gurt, Bagrat). …”
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24719
Evaluation of Some Cumin Ecotypes Based on Selection Index of Ideal Genotype
Published 2024-11-01“…Methods: To evaluate cumin ecotypes using the SIIG, an experiment was conducted on 12 cumin ecotypes based on a randomized complete block design with three replications in the 2022-2023 cropping season. …”
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24720
Conflict-related and sexual trauma in treatment-seeking Arabic-speaking men: a cross-sectional studyResearch in context
Published 2025-01-01“…Interpretation: The results of this exploratory study reveal that a substantial proportion of Arabic-speaking treatment seeking men from different countries in the MENA region reported experiences of sexual and conflict-related trauma, which were associated with high psychological symptom scores. …”
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