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24521
A Multifunctional MIL-101-NH2(Fe) Nanoplatform for Synergistic Melanoma Therapy
Published 2025-01-01“…Cellular studies using B16F10 cells assessed cytotoxicity, cellular uptake, migration inhibition, and colony formation suppression. In vivo experiments in melanoma-bearing mice evaluated antitumor efficacy and systemic safety through tumor growth inhibition, histological analyses, and toxicity assessments.Results: MIL@DOX@ICG exhibited a uniform octahedral structure with a particle size of approximately 139 nm and high drug loading efficiencies for DOX (33.70%) and ICG (30.59%). …”
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24522
Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics
Published 2025-01-01“…The integrated transcriptomic and proteomic analysis suggests that HO-1 and Lnc286.2 are potentially significant in iron overload-induced liver injury in rats. In vitro experiments utilizing ferric ammonium citrate (FAC) were conducted to establish an iron overload model in rat liver-derived BRL-3A cells. …”
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24523
Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease
Published 2025-02-01“…This subpopulation simultaneously expressed characteristic markers of peripheral blood monocytes, suggesting that these cells may originate from peripheral blood monocytes, thereby triggering neuroinflammation through the ferroptosis pathway. Cell experiments confirmed that SLC11A1 was significantly upregulated in inflammatory microglia induced by ferroptosis.Conclusion: This study reveals the key role of SLC11A1 in AD, particularly in the context of ferroptosis and immune inflammation. …”
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24524
Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Published 2025-01-01“…The functionality of CFR T cells was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production analysis, and assessment of tumor xenograft destruction specificity in mouse models using different monoclonal antibodies (MoAbs). …”
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24525
THE ROLE OF N. I. VAVILOV AND VIR’S SCIENTISTS IN DESERT RECLAMATION
Published 2018-06-01“…They were the first in the world to suggest using phytomelioration by psammophytes of moving sands, conducted successful experiments in the introduction of black saxaul, calligonum and sandy acacia into cultivation and discovered the wet condensation subsurface horizon creating reserves of moisture in the sand dunes. …”
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24526
Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer
Published 2024-01-01“…Through bioinformatics analysis and in vitro experiments, the biological function and possibly associated signal pathways of SAE1 in BC were further analyzed. …”
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24527
MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism
Published 2025-02-01“…The optimal drug concentration for inducing CPO was subsequently determined, and in vitro experiments revealed that HUVEC activity was significantly decreased in the CPO group under hypoxic culture, accompanied by increased DLAT oligomerization, decreased SDHB expression, increased HSP70 expression. …”
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24528
Les paysages mémoriels de la Grande Guerre (1914-1918) : un changement de paradigme dans la recherche sur le tourisme de mémoire
Published 2015-11-01“…L’inclusion dans l’enquête de questions ouvertes portant sur les valeurs, expériences ou souvenirs de plus de 2.400 répondants provenant de 61 pays ont permis d’établir une vaste base de données, d’où se dégagent des variables pertinentes dans le processus actuel de mise en tourisme d’anciens paysages mémoriels. …”
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24529
Relationship between chlorophyll-a, sea surface temperature, and sea surface salinity
Published 2023-07-01“…It was carried out in the Northern Bay of Bengal, which experiences extreme monsoons, in the southwest monsoon and northeast monsoon from June to September and November to February, respectively. …”
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24530
Masculinization of Nile tilapia (Oreochromis niloticus) by administration of bull testes meal
Published 2011-01-01“…Experimental design was utilized two factors experiments in completely randomized design. Fry kept in 40-L glass aquaria at a density of 40 fry/aquarium. …”
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24531
Reduced Circulating Levels of miR-491-5p and miR-485-3p Are Associated with the Occurrence of Vertebral Fractures in Postmenopausal Women with Osteoporosis
Published 2022-01-01“…Postmenopausal women experiences osteoporotic structural damage and bone fragility resulting from reduced bone formation and increased bone resorption. …”
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24532
Prediksi Produksi Biofarmaka Menggunakan Model Fuzzy Time Series dengan Pendekatan Percentage Change dan Frequency Based Partition
Published 2023-02-01“…Thus, competent parties can use the outcomes of this experiment to help determine future strategic policies. …”
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24533
Chemical composition and insecticidal potential of botanical fractionation extracts for the management of Sitophilus zeamais Motschulsky, 1855 (Coleoptera: Curculionidae) in stored...
Published 2025-02-01“…Fractionated extracts were obtained by macerating and soaking E. globulus leaves, whole T. minuta plants and A. squmosa seeds using hexane, chloroform, and methanol as extraction solvents. Experiment tests were carried out at different doses (5, 10, and 15 g/kg) on adult S. zeamais to investigate adult mortality rate, progeny inhibition rate, repellent effect, fumigation effects, and effects on grain weight loss. …”
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24534
Association between sperm motility in thawed semen and pregnancy rate in Mediterranean buffaloes
Published 2023-11-01“…To contribute to knowledge in buffalo reproduction, an experiment was carried out where four sperm motility descriptors (VCL: curvilinear velocity, VSL: straight-line velocity, VAP: average path velocity, and LIN: linearity) were evaluated using a Computerized Semen Analysis System (Sperm Class Analyzer®, CASA System, Barcelona, Spain) in samples obtained from 8 frozen-thawed straws of 8 Mediterranean buffaloes. …”
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24535
Nisin A-producing Lactococcus cremoris formulations for pre- and post-milking teat disinfection modulate the bovine milk microbiota
Published 2025-01-01“…This study aimed to evaluate the effect of the use of pre- and post-dipping formulations containing the fermented broth of Nisin A-producing Lactococcus cremoris FT27 strain (treated group, TR) on the abundance and biodiversity of milk microbiota as compared to iodine-based commercial disinfectants (control group, CTR) during a three-month trial. The experiment was conducted on 20 dairy cows, divided into two groups (CTR and TR) of 10 lactating cows each. …”
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24536
Survival and growth responses of snakehead fish Channa striata Bloch. juvenile in aerated and unaerated acid sulfate water
Published 2017-07-01“… ABSTRACT The aim of the research was to analyze survival rate, specific growth rate, albumin, and feed efficiency and physiological (blood glucose, cortisol, dan haemoglobin) responses of snake head fish juvenil that reared at aerated and unaerated of tidal land water have been conducted in the laboratory. Experiments using completely randomized design with aerated and unaerated as a treatment, and each treatment has twelve replications. …”
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24537
Bases cérébrales de la motivation chez le singe rhésus : études pharmacologiques et neurophysiologiques
Published 2015-03-01“…Par ailleurs, nous montrons que le cortex préfrontal ventro-médian joue un rôle spécifique dans les processus d’évaluation en fonction de paramètres internes. Nos expériences futures viseront à comprendre les interactions fonctionnelles entre ces différentes structures cérébrales, et ainsi à mieux comprendre le comportement des primates.…”
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24538
Assessing Heat Resistance and Selecting Heat-Resistant Individuals of Largemouth Bass (<i>Micropterus salmoides</i>) with Tiered Thermal Exposure
Published 2025-01-01“…The CTmax values of the experimental fish (average body weight 9.87 ± 3.14 g) ranged from 39 to 40 °C but were too close together to differentiate the individual heat resistance. Static exposure experiments with varying temperatures and fish groups also did not provide a clear method for determining the heat resistance. …”
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24539
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24540
The role of health literacy in intervention studies targeting children living with overweight or obesity and their parents—a systematic mixed methods review
Published 2025-01-01“…Thus, there is a need to summarize the effects of and experiences with interventions that include health literacy components to guide the development of effective, future weight-related interventions.AimThis review aims to identify how health literacy is integrated into studies of interventions targeting children with excess weight or obesity and/or their parents and to appraise the identified literature.MethodsWe conducted a systematic mixed methods review, with searches in Medline, CINAHL, Cochrane, EMBASE, ERIC, PsycINFO, and Web of Science. …”
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