Evaluation of fluorinated phospholipid analogs: A study on ADMET profiles, molecular docking and dynamics simulation in anticancer therapy by Saqib Ishaq, Obaid Habib, Abdul Aziz, Raheel Tahir, Hira Mushtaq, Said Hassan, Sarah Sarwar, Mohammad S. Mubarak, Ajaz Ahmad, Amin Ullah

“…Functional annotation and phylogenetic investigation affirmed the evolutionary conservation and pivotal biological function of heat shock protein (HSP70KDa1A). …”
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Dose-dependent role of AMH and AMHR2 signaling in male differentiation and regulation of sex determination in Spotted knifejaw (Oplegnathus punctatus) with X1X1X2X2/X1X2Y chromosom... by Haixia Zhao, Jun Li, Zhizhong Xiao, Yongshuang Xiao

“…Abstract Sex determination mechanisms vary significantly across different chromosomal systems and evolutionary contexts. Nonetheless, the regulatory framework governing the multi-sex chromosome system (X1X1X2X2/X1X2Y) remains enigmatic. …”
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Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures by Clairet, Colin, Lapalu, Nicolas, Simon, Adeline, Soyer, Jessica L., Viaud, Muriel, Zehraoui, Enric, Dalmais, Berengère, Fudal, Isabelle, Ponts, Nadia

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Hepatovirus infections in juvenile seals from the North Sea by Monica Mirolo, Bianca Kühl, Melvin Daniel Roji, Ana Rubio-García, Valéria Andrade Lima, Christina Puff, Byron Martina, Andreas Beineke, Peter Wohlsein, Wolfgang Baumgärtner, Martin Ludlow, Albert Osterhaus

“…Abstract The discovery of several novel hepatovirus species in marine and terrestrial mammals has expanded the recognised members of the genus Hepatovirus and has provided better understanding on the evolutionary origins of human hepatovirus A (HAV). Using high throughput sequencing we detected a seal hepatovirus (SealHAV_NL/PV/21), in liver tissue of a deceased harbor seal (Phoca vitulina) originating from the Dutch North Sea coast. …”
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Genome- and Transcriptome-Wide Characterization and Expression Analyses of bHLH Transcription Factor Family Reveal Their Relevance to Salt Stress Response in Tomato by Jianling Zhang, Xiaoying Liu, Zuozhen Yin, Tiantian Zhao, Dan Du, Jing Li, Mingku Zhu, Yueying Sun, Yu Pan

“…The collinearity between SlbHLHs and interrelated orthologs from 10 plants further revealed evolutionary insights into <i>SlbHLHs</i>. Cis-element investigations of <i>SlbHLHs</i> promotors further suggested the potential roles of <i>SlbHLHs</i> in tomato development and stress responses. …”
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Intraspecific Morphometric Variation in a New Species of <i>Ceratomyxa</i> Thélohan 1892 (Cnidaria) from the South Atlantic Ocean: An Ecomorphological Study Using Geometric Morphom... by Delfina M. P. Cantatore, Martina Lisnerová, Paula S. Marcotegui, María A. Rossin, Astrid S. Holzer

“…The work highlights the utility of GM in advancing the understanding of myxozoan morphology and its evolutionary implications and emphasizes the need for further research on myxospore shape evolution and its ecological and adaptive significance in natural populations.…”
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New View on the Genesis of the Bashuihe Pluton, Laoshan Granites, China: Indications from Fluid Inclusions and H–O Isotopes by Huimin Liu, Zhaojun Song, Hongbo Yan, Wenyu Wang, Xinru Wang, Yifang Sun, Haonan Li

“…This study conducted microthermometry and stable isotope analysis of quartz inclusions from oval caves and host rocks from the Bashuihe pluton to reconstruct the diagenetic evolutionary history of the Laoshan area. The temperature measurement results indicated a homogenisation temperature range from 162.5 to 261.6°C (mean 203.9°C), a salinity range of 2.1–8.3 wt% (mean 5.07 wt%), and a density range of 0.8–0.98 g/cm3 (mean 0.90 g/cm3), indicating a low-temperature, low-salinity, and low-density fluid. …”
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Dynamic damage characteristics of coal and rock mass under shock wave pulsating load by Xiankai BAO, Bin JIANG, Wu ZHANG, Xiangyu SONG, Jinchang ZHAO, Chaoyun YU, Tong ZHANG

“…Based on CT scans and the ABAQUS numerical simulation software,damage variables for coal rock mass with different hydraulic and electrical parameters were calculate and then evaluate the dynamic damage and crack initiation and propagation morphologies and evolutionary properties of coal rock mass. The results show that the peak pressure of the impulsive water shock increases rapidly with the amplification voltage and the water pressure, and the loading rate increases with the discharge voltage and decreases with the water pressure. …”
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Effects of physical activity on brain function: Mechanisms, adaptations and clinical implications by Dariusz Fabian, Klaudia Maria Kufel, Mateusz Teofilak, Natalia Maria Smyl, Olga Śpiołek, Jan Siwiec, Aleksandra Słowikowska, Julia Szatkowska, Marcelina Paula Sztyler-Krąkowska, Agnieszka Alicja Wąsowicz, Franciszek Kędziora

“…This paper explores these relationships, starting with the evolutionary aspects of brain development in the context of physical activity. …”
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Antenatal Steroids and the IUGR Fetus: Are Exposure and Physiological Effects on the Lung and Cardiovascular System the Same as in Normally Grown Fetuses? by Janna L. Morrison, Kimberley J. Botting, Poh Seng Soo, Erin V. McGillick, Jennifer Hiscock, Song Zhang, I. Caroline McMillen, Sandra Orgeig

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Dynamics of the evolution of the strategic management concept: From the planning school to the neostrategic approach by Tomasz Kafel, Bernard Ziębicki

“…They indicate different factors that allow for success in strategic management such as: setting long-term goals, selection of programs and their execution plans (planning school); connection of the enterprise with the environment (evolutionary school); focusing attention on competitive advantage and achieved performance (position-based school); focus on one’s own resources and competences (resource school); use of opportunities and creating innovation (simple rules school); selection of the best option and orientation in business management (real options school); or eclectic perspectives, integrating the listed approaches. …”
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A comparative analysis of sequence composition in different lots of a phage display peptide library during amplification by Anders Wilgaard Sinkjaer, Ane Beth Sloth, Amanda Oester Andersen, Malte Jensen, Babak Bakhshinejad, Andreas Kjaer

“…Our findings can be instrumental for phage display researchers by bringing fundamental insights into the vast extent of non-uniformity between phage display libraries and by providing a clear picture of how these discrepancies can lead to different evolutionary fates for the peptide composition of phage pools, which can have profound impacts on the outcome of phage display selections through biopanning.…”
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GlucoGenes^®, a database of genes and proteins associated with glucose metabolism disorders, its description and applications in bioinformatics research by V. V. Klimontov, K. S. Shishin, R. A. Ivanov, M. P. Ponomarenko, K. A. Zolotareva, S. A. Lashin

“…With GlucoGenes®, an evolutionary analysis of genes associated with glucose metabolism disorders was performed. …”
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Genetic differentiation and historical dynamics of the endemic species Rheum pumilum on the Qinghai-Tibetan Plateau inferred from phylogeography implications by Shuliang Liu, Jianxin Gao, Bo Xiao, Wenjie Guo, Qiushi Yu, Ailan Wang, Weiwei Li

“…This study employs chloroplast DNA fragments (trnL-F, trnS-G, and matK) to delve into how Rh. pumilum adapted to the extreme environmental changes on the QTP, during its evolutionary process through phylogenetic geographical analysis, revealing its population differentiation and historical dynamics. …”
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A 7,000 years trajectory of socio-ecosystems in the montane belt of the northern French Alps by Andréa Julien, Andréa Julien, Erwan Messager, Elise Doyen, David Etienne, Laurent Marquer, Charline Giguet-Covex

“…However, the vegetation composition trajectory of the Glières reveals three regimes: two are characterized by an evolutionary trend of the system, and between them, the a third regime is characterized by a “dynamic steady state” of the system. …”
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Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity by Yue Fang, Lingjie Meng, Jun Xia, Yasuhiro Gotoh, Tetsuya Hayashi, Keizo Nagasaki, Hisashi Endo, Yusuke Okazaki, Hiroyuki Ogata

“…ABSTRACT Giant viruses are crucial for marine ecosystem dynamics because they regulate microeukaryotic community structure, accelerate carbon and nutrient cycles, and drive the evolution of their hosts through co-evolutionary processes. Previously reported long-term observations revealed that these viruses display seasonal fluctuations in abundance. …”
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The Aquatic Metatron: A large‐scale experimental facility to study the combined effects of habitat fragmentation and climate change on aquatic meta‐ecosystems by Murielle Richard, Alexandre Garreau, Elvire Bestion, Julien Cucherousset, Jose M. Montoya, Simon Blanchet

“…Here, we present the Aquatic Metatron, a unique mesocosm facility providing a large‐scale experimental resource to study the combined effects of global change components, in particular climate change and habitat fragmentation, on the ecological and evolutionary dynamics of aquatic ecosystems. The Aquatic Metatron consists of 144 mesocosms of 2 m3 each that can be connected to each other with aquatic corridors, and—for a subset of them—with aerial corridors. …”
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Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins by A. Catania, G. Colombo, C. Rossi, A. Carlin, A. Sordi, C. Lonati, F. Turcatti, P. Leonardi, P. Grieco, S. Gatti

“…The natural antimicrobial peptides are ancient host defense effector molecules, present in organisms across the evolutionary spectrum. Several properties of α-melanocyte stimulating hormone (α-MSH) suggested that it could be a natural antimicrobial peptide. α-MSH is a primordial peptide that appeared during the Paleozoic era, long before adaptive immunity developed and, like natural antimicrobial molecules, is produced by barrier epithelia, immunocytes, and within the central nervous system. α-MSH was discovered to have antimicrobial activity against two representative pathogens, Staphylococcus aureus and Candida albicans. …”
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Hook, line, and social media: crowd-sourced images reveal size and species patterns of ocean sunfishes (Tetraodontiformes, Molidae) from California to Alaska by Tor Mowatt-Larssen, Tierney M. Thys, Jackie Hildering, Eric J. Caldera, Ellen E. Biesack, Jan R. McDowell, Marianne Nyegaard, Marianne Nyegaard

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Complete Genome Sequence and Comparative Genome Analysis of Variovorax sp. Strains PAMC28711, PAMC26660, and PAMC28562 and Trehalose Metabolic Pathways in Antarctica Isolates by Prasansah Shrestha, Jayram Karmacharya, So-Ra Han, Jun Hyuck Lee, Hyun Park, Tae-Jin Oh

“…Likewise, MEGA X was used for evolutionary and conserved genes. The complete genomes of Variovorax strains PAMC28711, PAMC26660, and PAMC28562 are circular chromosomes of length (4,320,000, 7,390,000, and 4,690,000) bp, respectively, with GC content of (66.00, 66.00, and 63.70)%, respectively. …”
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