Alternative splicing expands the antiviral IFITM repertoire in Chinese rufous horseshoe bats. by Nelly S C Mak, Jingyan Liu, Dan Zhang, Jordan Taylor, Xiaomeng Li, Kazi Rahman, Feiyu Chen, Siddhartha A K Datta, Kin Kui Lai, Zhengli Shi, Nigel Temperton, Aaron T Irving, Alex A Compton, Richard D Sloan

“…These findings demonstrate that alternative splicing is a key strategy for evolutionary diversification in the IFITM family. Our study also highlights an example of convergent evolution where species-specific selection pressures led to expansion of the IFITM family through multiple means, underscoring the importance of IFITM diversity as a component of innate immunity.…”
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University proceedings. Volga region. Social sciences by Legislation on the rights of indigenous small-numbered peoples of the Russian Federation: current situation and some development trends

“…The objective of this study is to examine the situation and discern the evolutionary trajectory of legal frameworks designed to safeguard the rights of these communities. …”

Unraveling the Psyche: A Critical Analysis of Historical and Contemporary Theories in Light of Neuroscientific Advances by Mir Mahmoud Seyyedvalilou, Marziye Alivandi Vafa, Seyed Mahmoud Tabatabaei

“…This creative inner reflection symbolizes the highest transcendent process, with the mind's diverse aspects emerging from the interplay of the brain, body, and existence throughout an evolutionary trajectory.…”
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Optimization of Time-Varying Temperature Profiles for Enhanced Beer Fermentation by Evolutive Algorithms by Pablo Ruarte, Nadia Pantano, Marianela Noriega, Cecilia Fernández, Emanuel Serrano, Gustavo Scaglia

“…This method integrates Fourier series and orthogonal polynomials for control action parameterization, in combination with evolutionary algorithms for parameter optimization. A key advantage of this methodology lies in its ability to handle a reduced parameter set efficiently, resulting in temperature profiles that are continuous and differentiable. …”
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Prognostic Factors for in-hospital Complications of Acute ST-segment Elevation Myocardial Infarction by Geovedy Martínez García, Miguel Ángel Serra Valdés

“…Epidemiological variables, clinical, evolutionary and treatment variables were analyzed. Descriptive statistics were used. …”
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Cooperative evolution with reward-based heterogeneous tax in spatial public goods games by Li Yue, Huizhen Zhang, Yueyu Sun, Tianbo An, Jingrui Wang

“…Summary: In recent years, incorporating tax mechanisms into evolutionary game theory has become a popular research focus. …”
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Evolutionarily Developed Alternatively Spliced Exons Containing Translation Initiation Sites by Jun-ichi Takeda, Takaaki Okamoto, Akio Masuda

“…Interestingly, MATR3 represses its own translation by skipping a 5UC-ASE in <i>MATR3</i> to autoregulate its expression level. 5UC-ASEs are larger than other types of alternative exons. Furthermore, evolutionary analysis revealed that 5UC-ASEs have already appeared in cartilaginous fishes, have increased in amphibians, and are concentrated in the genes involved in transcription in mammals. …”
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Research review of network defense decision-making methods based on attack and defense game by Xiaohu LIU, Hengwei ZHANG, Junqiang MA, Yuchen ZHANG, Jinglei TAN

“…Game theory studies the optimal decision-making problem under the condition of conflict confrontation.It is one of the basic theories of cyberspace security, and can provide a theoretical basis for solving the problem of network defense decision-making.The six game characteristics of network attack and defense were defined, such as goal opposition, strategy dependence, non-cooperative relationship, incomplete information, dynamic evolution and interest drive.Based on the hypothesis of rational player and limited resources, a 5-tuple network attack and defense game model was formally defined by using player, attack and defense strategy set, attack and defense action set, attack and defense information set and attack and defense income.The existing conditions of game equilibrium were analyzed, and the general process of network defense decision-making based on attack and defense game model was summarized.The applicable scenarios of network defense decision-making methods based on eight different types of game models were analyzed, such as complete information static game, complete information dynamic game, incomplete information static game, incomplete information dynamic game, evolutionary game, differential game, time game and random game, and summarizes their research ideas.The advantages and disadvantages of network defense decision-making methods based on different types of game models were given.The development process of network defense decision-making method based on attack defense game was summarized, and the advantages and characteristics of defense decision-making method was explained.It were pointed out that there were three problems in the research process, such as the relationship between the number of factors considered in game modeling and the complexity of the model, the dependence of game reasoning on information and data, and the generalization and migration of game model.It also looked forward to the next research direction from the description mechanism of normative strategy, the calculation method of optimizing revenue and the integration with other network security technologies.And the problems that should be solved were explained.…”
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Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS by Chaoyi Yin, Kede Chi, Zhiqing Chen, Shabin Zhuang, Yongsheng Ye, Binshan Zhang, Cailiang Cai

“…BackgroundOsteosarcoma (OS) exhibits significant epigenetic heterogeneity, yet its systematic characterization and clinical implications remain largely unexplored.MethodsWe analyzed single-cell transcriptomes of five primary OS samples, identifying cell type-specific epigenetic features and their evolutionary trajectories. An epigenetics-based Random Survival Forest (RSF) model was constructed using 801 curated epigenetic factors and validated in multiple independent cohorts.ResultsOur analysis revealed distinct epigenetic states in the OS microenvironment, with particular activity in OS cells and osteoclasts. …”
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A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis by Chiara Spinsante, Federica Carducci, Elisa Carotti, Adriana Canapa, Davide Bizzaro, Maria Assunta Biscotti, Marco Barucca

“…Moreover, to get a holistic view of the evolutionary history of this gene superfamily, we extended our investigation to all 15 genes belonging to the LDLR superfamily analyzing through a phylogenetic analysis a total of 161 sequences belonging to 11 genera of vertebrates. …”
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Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021-2024. by Andrew D Marques, Matthew Hogenauer, Natalie Bauer, Michelle Gibison, Beatrice DeMarco, Scott Sherrill-Mix, Carter Merenstein, Ronald G Collman, Roderick B Gagne, Frederic D Bushman

“…Multiple examples of recurrent mutations were identified associated with transmissions, suggesting WTD-specific evolutionary pressures. These data document ongoing infections in white-tailed deer, probable onward transmission in deer, and a remarkable rate of new spillovers from humans.…”
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Image Evolution Using 2D Power Spectra by Michael Gircys, Brian J. Ross

“…Procedurally generated images and textures have been widely explored in evolutionary art. One active research direction in the field is the discovery of suitable heuristics for measuring perceived characteristics of evolved images. …”
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Ecolinguistic dynamics of English loanwords in Chinese: a case study on terms for cement by Ruifeng Mo, Hao-Zhang Xiao

“…This study examines five cement-related English loanwords in Chinese to uncover the evolutionary mechanisms governing the adaptation of these loanwords by analyzing their ecological dynamics. …”
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A peripheral subepithelial network for chemotactile processing in the predatory sea slug Pleurobranchaea californica. by Tigran Norekian, Yichen Liu, Ekaterina D Gribkova, Jilai Cui, Rhanor Gillette

“…These observations may facilitate future analyses of the PNS in odor discrimination and memory, and also suggest such SeNs as potential evolutionary precursors of CNS place-coding circuitry in the segmented, skeletonized protostomes and deuterostomes.…”
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Mitogenome Phylogenetics of Spiruromorpha Porpoise Parasite: Insights Into Phylogeny of <i>Crassicauda magna</i> by Lei Han, Yuling Yang, Maolin Lu, Hongyan Yu, Yaxian Lu, Mengchao Zhou, Tianlu Liu, Ruisi Zhang, Bingyao Chen, Zhijun Hou

“…Mitochondria have an important function in revealing taxonomic and evolutionary history. (2) Methods: In this study, we sequenced the mitochondrial genome of <i>C. magna</i> and conducted a phylogenetic analysis with the mitochondrial sequences of species belonging to the Habronematoidea family. (3) Results: The complete mitochondrial genome was 13,604 bp and it has an AT-rich sequence and one non-coding region (NCR). …”
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Comparative analysis of organizationalculture transformation models by I. V. Groshev, Menin He

“…Four main sources of change have been determined, three of which are relatively independent of management actions, and the fourth is directly related to management actions: survival, evolutionary, revolutionary processes, and managed changes. …”
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Analysis of Spatial Distribution Pattern and Driving Factors of Nature Reserves in Xinjiang by Yue Yang, Zhaoping Yang, Fang Han

“…In this study, we focused on the nature reserves in Xinjiang and used kernel density and standard deviation ellipse analysis methods to examine data from 1980, 1990, 2000, 2010, and 2020 in order to reveal the dynamics of spatial distribution, clustering characteristics, and evolutionary patterns, providing a scientific basis for optimizing the spatial layout of nature reserves in Xinjiang. …”
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Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease by Vincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

“…For other antivirals where resistance has been a challenge, we have demonstrated that the likelihood of resistance can be minimized by designing inhibitors that leverage the evolutionary constraints of the target. Here, we characterize a series of 3C inhibitors against EV68-3C protease through enzyme inhibition, protein crystallography, and structural analysis. …”
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Securing Urban Landscape: Cybersecurity Mechanisms for Resilient Smart Cities by Qiang Lyu, Sujuan Liu, Zhouyuan Shang

“…By combining deep learning with evolutionary algorithms, the CNN-GA framework offers a dynamic and adaptive solution to address the complex and evolving nature of cyber threats. …”
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NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts by Selim Terhzaz, David Kerrigan, Floriane Almire, Agnieszka M. Szemiel, Joseph Hughes, Jean-Philippe Parvy, Massimo Palmarini, Alain Kohl, Xiaohong Shi, Emilie Pondeville

“…Overall, we unveiled a key evolutionary process that allows the transmission of vector-borne bunyaviruses between arthropod and vertebrate hosts.…”
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