Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis by Piotr Wojdasiewicz, Pawel Turczyn, Barbara Dobies-Krzesniak, Justyna Frasunska, Beata Tarnacka

“…The present study, based on world literature review, sums and describes convincing evidences of a significant role of the CX3CL1/CX3CR1 axis in processes leading to bone mineral density (BMD) reduction. …”
Get full text

Social network analysis of key stakeholders in Brucellosis prevention in Western Iran by Meysam Behzadifar, Mohammad Yarahmadi, Ahad Bakhtiari, Sahar Kargar, Saeed Shahabi, Samad Azari, Mariano Martini, Masoud Behzadifar

“…Fragmented coordination was particularly evident in rural areas, where traditional livestock practices, inadequate veterinary services, and the consumption of unpasteurized dairy products perpetuate disease transmission. …”
Get full text

Phytochemical and toxicological evaluation of aqueous leaf extract of Premna integrifolia L. in male balb/c mice by Suman, Pratibha Gaurav, Rajesh Saini, Kavindra Nath Tiwari, Gautam Geeta Jiwatram

“…Conclusion: Based on the findings from both the acute and subacute toxicity studies, it is evident that the ALEPI does not actuate adverse effects of toxicological significance at the tested doses and hence can be used at appropriate concentrations in therapeutic application.…”
Get full text

Serum 25-hydroxyvitamin D level in relation to weight change and the risk of weight gain in adults of normal weight at baseline: the Norwegian HUNT cohort study by Yi-Qian Sun, Yue Chen, Xiao-Mei Mai, Adaline Heitz

“…A statistically significant trend was evident for the risk of clinical weight gain when 25(OH)D levels were treated as a categorical variable (p=0.006).Conclusions The findings suggested an inverse association of serum 25(OH)D level with the risk of clinical weight gain in adults who had normal weight at baseline over 11 years’ follow-up.…”
Get full text

INTRA-REGIONAL DIFFERENTIATION OF ENTREPRENEURSHIP OF MUNICIPALITIES OF THE ŚWIĘTOKRZYSKIE VOIVODESHIP IN TERMS OF SUSTAINABLE DEVELOPMENT IN 2010 AND 2020 by Paweł Dziekański, Łukasz Popławski, Fabio Fragomeni

“…The diversity of the municipalities is attributable to a range of factors, including demographic, natural and socio-economic development processes. It is evident that additional support is required to facilitate the growth and development of entrepreneurship in the Świętokrzyskie province. …”
Get full text

Experience of Aging in the Ngäbe-Buglé Community in Coto Brus, Costa Rica: A Qualitative Study by Melissa Rallo, Nicholas Leahy, Alexis Vetack, Hima Konduru, Shania Bailey, Lillianna Pedersen, Christine Wan, Wendel Mora, Virginia Rowthorn, Shailvi Gupta, Carlos Faerron Guzmán

“…Insufficient social support was evident through heavy reliance on family, limited community aid, and an absence of engaging activities. …”
Get full text

Validating the reproductive tract score (RTS) technique in pre-service buffalo heifers by Freddys Escalona-Ramírez, Jessenia Mercado-Carrillo, Balbino A. Jaimes-Vazques, Antonio Landaeta-Hernández

“…Using rectal palpation, the RTS (scale 1-5) assign the following scores: 1=flabby uterus and ovaries both <10 mm of diameter with no detectable follicles; 2=flabby uterus and ovaries both 10-15mm of diameter with <8 mm follicles; 3=soft tone uterus and ovaries both <15-20 mm of diameter with 8-10 mm follicles; 4=good tone uterus with 20-25 mm of diameter, ovaries >20mm with >10 mm follicles; 5= good tone uterus >25 mm of diameter, ovaries >20mm with evident luteal tissue. Therefore, the objective of this study was to validate the technique of RTS in pre-service buffalo heifers as a management strategy to improve the pregnancy rate. …”
Get full text

Constraints of S–Pb–Sr Isotope Compositions and Rb–Sr Isotopic Age on the Origin of the Laoyingqing Noncarbonate-Hosted Pb–Zn Deposit in the Kunyang Group, SW China by Hongsheng Gong, Runsheng Han, Peng Wu, Gang Chen, Lingjie Li

“…Third, sulfur isotopic composition of sphalerite from the Laoyingqing deposits shows δ34SCDT values that range mainly from -2.62‰ to 1.42‰, which is evidently lower than the δ34SCDT values of sulfides (8–20‰) from other Pb–Zn deposits in the SYGT. …”
Get full text

Riesgo de contagio por COVID-19 en un entorno urbano (Málaga, noviembre del 2020) by Ángel Miramontes Carballada, Rubén Lois González, María Jesús Perles Roselló, Jesús Miranda Páez

“…Never have the relationships between the local and the global been so evident, and the importance of the geographic focus so necessary. …”
Get full text

Association between adolescent obesity and early adulthood healthcare utilization—a two-cohort prospective study by Emilia Hagman, Vidar Halsteinli, Resthie R. Putri, Christina Hansen Edwards, Gudrun Waaler Bjørnelv, Claude Marcus, Rønnaug A. Ødegård

“…A distinct sex difference was evident, with females incurring higher costs compared to males.…”
Get full text

Effects of Seasonal Variations in Physical Parameters on Quality of Gravity Flow Water in Kyanamira Sub-County, Kabale District, Uganda by Hannington, Ngabirano, Denis, Byamugisha, Emmanuel, Ntambi

“…Basing on these findings above, it was evident to justify discouraging the use of gravity flow water at these study sites for domestic purposes without proper treatment.…”
Get full text

Soil preferential flow dynamics in the southern drylands of India—a watershed based approach by Pushpanjali, K. S. Reddy, Ashish S. Dhimate, K. Karthikeyan, Josily Samuel, A. G. K. Reddy, N. Ravi Kumar, K. V. Rao, Prabhat Kumar Pankaj, Jagriti Rohit, Manoranjan Kumar, V. K. Singh

“…The presence of preferential flow was clearly evident across all three different land uses and elevations within the watershed. …”
Get full text

Critical care services in Bagmati province of Nepal: A cross sectional survey [version 4; peer review: 4 approved, 2 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Conclusions Disparities in critical care resources were evident across districts in Bagmati Province, highlighting the need for a balanced and decentralized approach to ensure equitable access to care. …”
Get full text

How resistant is anammox biofilm against antibiotics: A special insight into anammox response towards fluoroquinolones by Faysal-Al Mamun, Rohit Kumar, Kelvin Ugochukwu Anwuta, Sovik Das, Madis Jaagura, Koit Herodes, Tetyana Kyrpel, Agnieszka Fiszka Borzyszkowska, Anna Zielińska-Jurek, Zane Vincevica-Gaile, Juris Burlakovs, Andrey E. Krauklis, Mohamad Nor Azra, Md Salauddin, Jiexi Zhong, Taavo Tenno, Kai Bester, Ivar Zekker

“…During batch operations that lasted for up to 6 h, the total nitrogen removal efficiency (TNRE) and total nitrogen conversion rate (TNCR) reached a maximum of 93 ± 5 % and 6.97 ± 1.30 mg N g−1 TSS d−1, respectively. Evidently, at higher PhAC levels, the anammox process was active, and up to 75 % PhAC removal efficiency was obtained within 6 h of the batch cycle. …”
Get full text

Pattern of Disinfection of Root Canal Dentin by Alternated Acid-Base Irrigating Regimen by Janir Alves Soares, Maria Auxiliadora Roque de Carvalho, Suelleng Maria Cunha Santos Soares, Rodrigo Dantas Pereira, Manoel Brito-Júnior, Paula Prazeres Magalhães, Isabel Alessandra Miranda Nunes, Rudys Rodolpho de Jesus Tavarez, Claudia de Castro Rizzi, Rafaela Nogueira Moreira, Luiz de Macêdo Farias, Etevaldo Matos Maia Filho

“…Root canals (RC) were contaminated with E. faecalis (ATCC 19433) for 3 weeks and evident biofilms were obtained. After initial sampling (S1), the CMP was aided by irrigants: saline solution (control; n=12), a conventional regimen (CR) (group 1; n=12) using 5.25% NaOCl and a final rinse with 17% EDTA, and an alternating regimen (AR) of intercalated use of NaOCl and EDTA (group 2, n=12), followed by a second sampling (S2). …”
Get full text

The therapeutic potential of PX-478 in a murine model of pelvic organ prolapse by Wei-Min Fan, Yu-Qi Yang, Li-Wen Zhang, Xiao-Hui Mei, Ke Sun, Duan-Qing Wu, Ying Yang, Chun-Fang Duan, Jun Ye, Ru-Jun Chen

“…Its immunomodulation is evident through reduced M1 and M2 macrophages and suppressed IL-18 secretion.…”
Get full text

PROTON RADIATION THERAPY: CLINICAL APPLICATION OPPORTUNITIES AND RESEARCH PROSPECTS by M. V. Zabelin, V. A. Klimanov, J. J. Galyautdinova, A. S. Samoilov, A. O. Lebedev, E. V. Shelyhina

“…Advantages of proton therapy on the level of local control and depression of frequency of development of the radio induced cataract are refl ected in the provided data. In evident material the technology of preparation and carrying out radiation of an eye is shortly covered with a fascicle of protons. …”
Get full text

Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation by Chrissa Petersen, Adhini Kuppuswamy Satheesh Babu, Ceres Mattos Della Lucia, Henry A. Paz, Lisard Iglesias-Carres, Ying Zhong, Thunder Jalili, J David Symons, Kartik Shankar, Andrew P. Neilson, Umesh D. Wankhade, Pon Velayutham Anandh Babu

“…Evidence suggests that a healthy gut microbiome is essential for metabolizing dietary phytochemicals. …”
Get full text

Extracellular vesicles, RNA sequencing, and bioinformatic analyses: Challenges, solutions, and recommendations by Rebecca T. Miceli, Tzu‐Yi Chen, Yohei Nose, Swapnil Tichkule, Briana Brown, John F. Fullard, Marilyn D. Saulsbury, Simon O. Heyliger, Sacha Gnjatic, Natasha Kyprianou, Carlos Cordon‐Cardo, Susmita Sahoo, Emanuela Taioli, Panos Roussos, Gustavo Stolovitzky, Edgar Gonzalez‐Kozlova, Navneet Dogra

“…Circulating EVs carry functional small RNAs and other molecular footprints from their cell of origin, and thus have evident applications in liquid biopsy, therapeutics, and intercellular communication. …”
Get full text

Pharmacological activities and phytochemical evaluation of coconut crude oil and upon exposure to ozone by Mohammed S. Almuhayawi, Mohammed H. Alruhaili, Muyassar K. Tarabulsi, Soad K. Al Jaouni, Abdulmajeed A. Alqurashi, Faisal A. Alraddadi, Duaa A. Bukhari, Hibah M. Albasri, Moayad S. Waznah, Samy Selim

“…A notable elevation of anti-Alzheimer impact was evident upon exposing coconut oil to ozone. Besides, the cytotoxic impact towards A-431 cells was slightly increased after exposing the oil to ozone. …”
Get full text