Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention by Nawal Alsubaie, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Tarek Khamis, Tarek Khamis, Mohamed M. M. Metwally, Mohamed M. M. Metwally, Nawal Helmi, Afnan M. Alnajeebi, Badriyah S. Alotaibi, Amirah Albaqami, Wedad Mawkili, Mai A. Samak, Mai A. Samak, Samar A. Eissa

“…Besides, a significant reduction in IgG, not IgM, but increased C3 serum levels was evident in the FTN-exposed rats. Moreover, their splenic tissues displayed a substantial increase in the ROS, MDA, IL-6, and IL-1β content, altered splenic histology, and reduced GPX, GSH, and GSH/GSSG. …”
Get full text

Pattern of Disinfection of Root Canal Dentin by Alternated Acid-Base Irrigating Regimen by Janir Alves Soares, Maria Auxiliadora Roque de Carvalho, Suelleng Maria Cunha Santos Soares, Rodrigo Dantas Pereira, Manoel Brito-Júnior, Paula Prazeres Magalhães, Isabel Alessandra Miranda Nunes, Rudys Rodolpho de Jesus Tavarez, Claudia de Castro Rizzi, Rafaela Nogueira Moreira, Luiz de Macêdo Farias, Etevaldo Matos Maia Filho

“…Root canals (RC) were contaminated with E. faecalis (ATCC 19433) for 3 weeks and evident biofilms were obtained. After initial sampling (S1), the CMP was aided by irrigants: saline solution (control; n=12), a conventional regimen (CR) (group 1; n=12) using 5.25% NaOCl and a final rinse with 17% EDTA, and an alternating regimen (AR) of intercalated use of NaOCl and EDTA (group 2, n=12), followed by a second sampling (S2). …”
Get full text

PROTON RADIATION THERAPY: CLINICAL APPLICATION OPPORTUNITIES AND RESEARCH PROSPECTS by M. V. Zabelin, V. A. Klimanov, J. J. Galyautdinova, A. S. Samoilov, A. O. Lebedev, E. V. Shelyhina

“…Advantages of proton therapy on the level of local control and depression of frequency of development of the radio induced cataract are refl ected in the provided data. In evident material the technology of preparation and carrying out radiation of an eye is shortly covered with a fascicle of protons. …”
Get full text

Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…Additionally, molecular docking studies of 6d within the activesites of hAChE, hMAO-B, and Aβ1−42 elucidated the inhibition mechanism.Discussion and conclusionBased on these findings, it is evident that 6d, 8c, and 8d hold potential as promising multi-functional drugs for AD treatment.…”
Get full text

Design and Experimental Research on a Chisel-Type Variable Hierarchical Deep Fertilization Device Suitable for Saline–Alkali Soil by Nan Xu, Zhenbo Xin, Jin Yuan, Zenghui Gao, Yu Tian, Chao Xia, Xuemei Liu, Dongwei Wang

“…Under this condition, the average deviation in the fertilization amount was merely 2.76%, and the average coefficients of variation in the fertilizer amount uniformity in each soil layer were 7.62, 6.32, 6.06, and 5.65%, respectively. Evidently, the experimental results not only successfully met the pre-set objectives, but also fully satisfied the design requirements. …”
Get full text

Characterization of polyethylene and polyurethane microplastics and their adsorption behavior on Cu2+ and Fe3+ in environmental matrices by Ilaria Zanoni, Lucia Briccolani, Lara Faccani, Magda Blosi, Simona Ortelli, Matteo Crosera, Giovanna Marussi, Stefania Albonetti, Anna Luisa Costa

“…Both samples showed a spherical morphology and an evident surface micro-roughness. The elemental and thermal analysis did not show the presence of any significant metal impurities. …”
Get full text

Efficacy and Safety of a Stimulator Using Low-Intensity Pulsed Ultrasound Combined with Transcutaneous Electrical Nerve Stimulation in Patients with Painful Knee Osteoarthritis by Eu-Deum Kim, Yu Hui Won, Sung-Hee Park, Jeon-Hwan Seo, Da-Sol Kim, Myoung-Hwan Ko, Gi-Wook Kim

“…Cartilage regeneration, which was expected as an additional benefit of LIPUS, was also not significantly evident. Therefore, further investigation is warranted to determine whether the combination therapy is beneficial. …”
Get full text

Quantification of Myocardial Biomarkers in Sudden Cardiac Deaths Using a Rapid Immunofluorescence Method for Simultaneous Biomarker Analysis by Matteo Antonio Sacco, Valerio Riccardo Aquila, Saverio Gualtieri, Roberto Raffaele, Maria Cristina Verrina, Lucia Tarda, Santo Gratteri, Isabella Aquila

“…Background/Objectives: Differential diagnosis of sudden cardiac death (SCD) remains challenging, particularly in cases lacking evident structural abnormalities. Cardiac markers have been proposed as useful tools for this differentiation in forensic contexts. …”
Get full text

ASSOCIATION BETWEEN POLYMORPHISMS IN GENES ENCODING 2′-5′-OLIGOADENYLATE SYNTHETASES AND THE HUMORAL IMMUNE RESPONSE UPON VACCINATION AGAINST TICK-BORNE ENCEPHALITIS by N. S. Yudin, A. V. Igoshin, S. L. Lutova, Ya. Gon, M. I. Voevoda, V. A. Belyavskaya

“…Thus, the data obtained indicate that SNP rs1732778 in the regulatory region of the OAS2 gene correlates with the formation of antiviral IgG antibodies and changes in IL-4 levels upon vaccination. Evidently, the genetic polymorphism in OAS2 gene should be considered when performing individualized TBE vaccinations.…”
Get full text

Life history, reproductive, and demographic parameters for bottlenose dolphins (Tursiops truncatus) in Sarasota Bay, Florida by Randall S. Wells, Aleta A. Hohn, Michael D. Scott, Jay C. Sweeney, Forrest I. Townsend, Jason B. Allen, Aaron A. Barleycorn, Katherine A. McHugh, Kim Bassos-Hull, Gretchen N. Lovewell, Deborah A. Duffield, Cynthia R. Smith, A. Blair Irvine

“…Seasonal reproduction was evident, with 81% of births occurring during May-July. …”
Get full text

Highly Aggressive CD4-Positive Mast Cell Leukaemia (Leukaemic Variant) Associated with Isolated Trisomy 19 and Hemophagocytosis by Neoplastic Mast Cells: A Case Report with Challen... by Dina Sameh Soliman, Ahmad Al-Sabbagh, Feryal Ibrahim, Amna Gameil, Mohamed Yassin, Halima El-Omri

“…Bone marrow (BM) aspirate showed extensive infiltration with immature mast cells of blast-like morphology with trilineage dysplasia and evident hemophagocytic activity exhibited by histiocytes and neoplastic mast cells. …”
Get full text

Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metast... by Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski

“…In an MSS mCRC participant with PR as best response, increased infiltration of T cells, dendritic cells, and to a lesser extent NK cells, were evident 5 weeks post-treatment.Conclusions Pixatimod is well tolerated at 25 mg in combination with nivolumab. …”
Get full text

Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence by Ji‐Hua Shi, Wen‐Zhi Guo, Yang Jin, Hua-Peng Zhang, Chun Pang, Jie Li, Pål‐Dag Line, Shui‐Jun Zhang

“…Abstract Background The ERBB2 oncogene hypothesis is challenged in hepatocellular carcinoma (HCC) with the conflicting evidences of human epidermal growth factor receptor 2 (HER2) overexpression. …”
Get full text

Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the pro... by Zeyu Li, Guoying Wang, Joseph M. Braun, Xiumei Hong, Giehae Choi, Shawn P. O’Leary, Chang Ho Yu, Colleen Pearson, William G. Adams, Zhihua (Tina) Fan, Jessie P. Buckley, Xiaobin Wang

“…Synergistic effects of PFAS exposures and maternal pre-pregnancy OWO became evident in adolescence.…”
Get full text

Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury by Achi Haider, Susan Bengs, Angela Portmann, Sandro Fröhlich, Dominik Etter, Monika Maredziak, Geoffrey I. Warnock, Alexander Akhmedov, Sebastian Kozerke, Claudia Keller, Fabrizio Montecucco, Bruno Weber, Linjing Mu, Ronny R. Buechel, Vera Regitz-Zagrosek, Philipp A. Kaufmann, Giovanni G. Camici, Simon M. Ametamey, Catherine Gebhard

“…These sex differences were no longer evident in gonadectomized animals (p = NS vs. females). …”
Get full text

The Petrogenesis of the Permian Podong Ultramafic Intrusion in the Tarim Craton, Western China: Constraints from C-He-Ne-Ar Isotopes by Mingjie Zhang, Pengyu Feng, Tong Li, Liwu Li, Juerong Fu, Peng Wang, Yuekun Wang, Zhongping Li, Xiaodong Wang

“…The type and addition mechanism of the confirmed crustal contaminations and possible mantle plume involved in the intrusion formation require evidences from carbon and noble gas isotopic compositions. …”
Get full text

Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study by Sonia López-Monzoni, Gloria Hernando Benito, Sofía Romero-Peralta, Laura Silgado-Martínez, Maria Esther Viejo-Ayuso, Leticia Álvarez-Balado, Enrique Rodríguez Matarranz, Carles Forné Izquierdo, Manuel Sánchez-de-la-Torre, Juan Fernando Masa, Ferrán Barbé, Francisco García-Río, Antonio Martínez-Nicolás, Belén García-Mediano, Esther Solano-Pérez, Olga Mediano

“…The limitations of pharmacological treatments for chronic pain have become increasingly evident: dependency, side effects, resistance, and diminishing efficacy. …”
Get full text

<i>Phytophthora</i> Species and Their Associations with Chaparral and Oak Woodland Vegetation in Southern California by Sebastian N. Fajardo, Tyler B. Bourret, Susan J. Frankel, David M. Rizzo

“…Evidence of unintended introductions of <i>Phytophthora</i> species into native habitats has become increasingly prevalent in California. …”
Get full text

Progress on HIV and other sexually transmitted infections elimination among youth and adults across BRICS-plus countries: Results from the Global Burden of Disease Study 2021 by Rizhen Wang, Yinuo Sun, Huan Wang, Xiaoran Yu, JiYan Ma, Zuokun Liu, Jing Li, Zhiyong Zou, Yangmu Huang

“…Individuals aged 15–24 years (-32·9 %) had a decline for HIV new cases, while individuals aged ≥ 25 years plateaued. There were evident period risks of morbidity for HIV in Russia and Iran since 2012 and for syphilis and gonorrhea in Brazil since 2012. …”
Get full text

Safety and efficacy of switching from adalimumab to sarilumab in patients with rheumatoid arthritis in the ongoing MONARCH open-label extension by Gerd R Burmester, Mark C Genovese, Vibeke Strand, Gregory St John, Andrea Rubbert-Roth, Howard Amital, Tatiana Raskina, Antonio Gómez-Centeno, Claudia Pena-Rossi, Leon Gervitz, Karthinathan Thangavelu, Susan Boklage

“…Among switch patients, improvement in disease activity was evident at OLE week 12: 47.1%/34.8% had changes ≥1.2 in Disease Activity Score (28 joints) (DAS28)-erythrocyte sedimentation rate/DAS28-C-reactive protein. …”
Get full text