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12641
DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model
Published 2025-03-01“…Trained on comprehensive SELEX data, DeepAptamer outperformed existing models in accuracy as substantiated by experimental evidence. More importantly, DeepAptamer effectively identified key nucleotides for target binding. …”
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12642
Evaluating the role of environmental advertising on the use of eye movements towards the brand
Published 2025-02-01“…By using the eye tracking technique, behavioral evidence can be obtained (Guitart et al, 2018). Eye tracking is very sensitive to the processes of attention and alertness, and this technique can be used to improve teaching and learning (Javora et al, 2021) and the effectiveness of advertisements, video and graphic images (Niehorster et al, 2017). …”
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12643
Discovery and Spectroscopic Confirmation of Aquarius III: A Low-mass Milky Way Satellite Galaxy
Published 2025-01-01“…We interpret this metallicity spread as strong evidence that the system is a dwarf galaxy as opposed to a star cluster. …”
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Pressure Methods for Primary Hemorrhage Control: A Randomized Crossover Trial
Published 2019-02-01“…However, the scientific evidence regarding the best methods and mechanisms of applying direct manual pressure to stop hemorrhage is lacking to inform first aid education skill development. …”
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Designing a security-oriented leadership model of Mazandaran University of Medical Sciences
Published 2024-11-01“…In this context, the transformation and innovation package in medical science education has been implemented by the Ministry of Health, Treatment and Medical Education, one of the packages discusses the movement towards leadership systems and the role of management in influencing employees, which oversees three general policies of institutionalization of the management approach in the health system, being present in regional and global educational arenas, and producing and localizing valid scientific evidence for the promotion of higher health education (Obeydi et al, 2023). …”
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Quais et ouvrages portuaires romains de Rouen/Rotomagus (Seine-Maritime)
Published 2020-12-01“…The very short distance separating these spaces from the domus may suggest that its wealthy owner was linked to important trade exchanges, although there is no direct evidence to prove this. In the southern part of the Place de la Haute-Vieille-Tour, a little closer to the Seine River than the previous excavation, two discoveries were made, one in 1902 and then again in 1956. …”
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Ground-based Reconnaissance Observations of 21 Exoplanet Atmospheres with the Exoplanet Transmission Spectroscopy Imager
Published 2025-01-01“…We find that none of the eight comparisons of exoplanet atmospheres measured with ETSI and other observatories (including the Hubble Space Telescope) provide evidence that the spectra are statistically dissimilar. …”
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Cohort profile: the BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) cohort study
Published 2025-01-01“…There is, however, limited evidence about multidimensional determinants of NCDs in this population. …”
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COVID-19 – if the cure is worse than the disease. The Italian chaos
Published 2020-03-01“…Why the death rate is not showing significant evidence of a slow down despite Lombardy has been put in lockdown for a very prolonged amount of time now? …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials
Published 2023-03-01“…These subjects would not produce valuable data in service to the study’s endpoints or knowledge generalizable to broader patient populations. Requiring evidence of simultaneous allograft listing fulfills the ethical requirement that subjects who withdraw consent are not worse off than if they had not pursued research enrollment.…”
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Addressing Shortcomings in Contingency Standards of Care
Published 2022-09-01“…Given the empirical evidence demonstrating ER treatment and admission disparities that disadvantage Black and Hispanic patients, such a measure would only exacerbate these disparities by further limiting access to needed care.[20] Second, altered staffing ratios, which stretch a limited number of providers to meet patient needs during a staffing shortage, are another concerning yet common contingency measure. …”
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Study of Long-term Spectral Evolution and X-Ray and γ-Ray Correlation of Blazars Seen by HAWC
Published 2025-01-01“…For Mrk 501, we found evidence of a long-term correlation. Additionally, we identified a period in the light curve where the flux was very low for more than 2 yr. …”
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Hybrid versus vaccine immunity of mRNA-1273 among people living with HIV in East and Southern Africa: a prospective cohort analysis from the multicentre CoVPN 3008 (Ubuntu) studyRe...
Published 2025-02-01“…Methods: Previously unvaccinated adults with HIV and/or other comorbidities associated with severe COVID-19 received either one (hybrid immunity) or two (vaccine immunity) 100-mcg doses of ancestral strain mRNA-1273 in the first month, depending on baseline evidence of prior SARS-CoV-2 infection. In a prospective cohort study design, we used covariate-adjusted Cox regression and counterfactual cumulative incidence methods to determine the hazard ratio and relative risk of COVID-19 and severe COVID-19 with hybrid versus vaccine immunity within six months. …”
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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo...
Published 2025-02-01“…Overall, 222 participants (21.1%) were treated for a minimum period of 24 months, among them the 5-year survival rates were: 31.7%, 72.7%, 78.6%, 84.2% for patients who discontinued treatment due to progressive disease, toxicity, treatment completion, and other reasons, respectively.Conclusion This study provides valuable real-world evidence that confirms the long-term efficacy of pembrolizumab outside of clinical trials. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials?
Published 2022-07-01“…The condition includes cases where PCT is believed to be necessary to demonstrate efficacy, such as in trials of psychoactive drugs where evidence is inconsistent due to disease heterogeneity and demonstrating equivalence to an established treatment is insufficient. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study
Published 2025-01-01“…Feedback from the interviews and questionnaire were collated, and Study Management Group members with a background in urology then considered this in conjunction with available evidence/guidelines to inform the development of the draft management recommendations. …”
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ZARûRİYYÂT DÜZEYİNDEKİ GÂÎ DEĞERLERİN MAHİYETİ VE EVRENSEL NİTELİĞİ ÜZERİNE
Published 2008-03-01“…If Islamic rules are necessarily studied in view of source and method, it is possibly said that the source means evidences (dalil) which are the bases of the rules and the method means the procedure of deducting these rules from the evidences. …”
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Impact of Educational Technology on Teaching and Learning of Biology in Secondary Schools of Kabale Municipality.
Published 2025“…In recent years, this growth has been evident in innovations such as laptops, smartphones, mobile applications, websites, text messaging, and social networking platforms. …”
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12660
Historic Sites during the World War II in South Konawe, Southeast Sulawesi as a Source of Historiography
Published 2022-06-01“…The massive military activities that took place in Indonesian territory during the World War II definitely left a lot of and varied material evidences. However, in fact, many of the material evidences from the World War II have been forgotten due to its dilapidated condition. …”
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