The risk of repeated self-harm and suicide after emergency department presentation with self-harm in mental health presenters: a retrospective cohort study with data linkage in Que... by Richard A.F. Pellatt, David R. Painter, Jesse T. Young, Kairi Kõlves, Gerben Keijzers, Stuart A. Kinner, Ed Heffernan, Julia Crilly, Marc Broadbent, Amy Johnston, Melinda Martin-Khan, Paul Scuffham, Marianne Wallis, Ping Zhang

“…Suicide was particularly associated with older males. Implementing evidence-based interventions to support people presenting to ED with self-harm should be a public health priority. …”
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Determinants of tobacco use transitions in smoker nursing students in Catalonia: A prospective longitudinal study by Kenza Laroussy, Esteve Fernández, Yolanda Castellano, Marcela Fu, Antoni Baena, Ariadna Feliu, Armando Peruga, Mercè Margalef, Olena Tigova, Jordi Galimany, Montserrat Puig, Carmen Moreno, Albert Bueno, Antonio López, Judith Roca, Judith Saura, Cristina Martínez

“…Conclusions Nursing students who smoked experienced diverse transitions in tobacco use patterns over time. Evidence-based tobacco use preventive and cessation interventions are needed to tackle tobacco use among future nurses.…”
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Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration by Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Sylvia Bolz, Andjela Sekulic, Marius Ueffing, Marius Ueffing, Simon J. Clark, Simon J. Clark, Simon J. Clark, Nadine Reichhart, Sergio Crespo-Garcia, Nicola Wilck, Nicola Wilck, Nicola Wilck, Nicola Wilck, Olaf Strauß

“…Furthermore, flow cytometry and gene expression analysis were used on ocular and splenic tissues of Cx3cr1GFP/GFP and C57BL/6J mice at 8 and 12 months of age to characterize the dynamics of local and systemic T cell populations.ResultsWe show the presence of memory T cells such as CD45RO+ cells in the choroid and retina of patients with AMD with a peak of abundance in early stages of AMD. As further evidence for the contribution of the adaptive immune system to GA we identified an increased frequency of CD44+ CD69+ KLRG1+ T cells and para-inflammation of the retina in a mouse model that mimics features of GA. …”
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Association between traffic-related air pollution and risk of outpatient visits for dry eye disease in a megacity along the subtropical coast in South China by Fan Cao, Yue Chen, Yan-Chao Gui, Zi-Yue Fu, Zheng Lyu, Kou Liu, Li-Ming Tao, Zhi-Fan Chen, Hai-Feng Pan, Zheng-Xuan Jiang, Qian-Li Meng

“…Conclusions Our study revealed that short-term exposure to PM2.5, NO2 and SO2 were positively associated with risk of DED outpatient visits, especially for the youngers, females and during warm seasons, providing evidence for making public health policy to improve life quality in developed megacity.…”
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease typically characterized by chronic airway inflammation, with emerging evidence highlighting the driving role of cellular senescence-related lung aging. …”
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Les premiers outils : où, quand et qui ? by Emmanuelle Pouydebat

“…Le lien entre capacités de manipulation et arboricolie n’était-il pas mis en évidence ? La capacité des bonobos et des chimpanzés à fabriquer des outils complexes, parfois en pierre, malgré un pouce court n’était-elle pas connue ? …”
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Gastrointestinal complications of hepatic glycogen storage disease: a national survey questionnaire study in China by Xiaoyan Zhang, Zexiong Su, Jiaxing Wu, Hanshi Zeng, Xun Jiang, Ying Wang, Huiqing Shen, Xiaoli Xie, Yuan Xiao, Qing Tang, Xiaoping Luo, Xuemei Zhong, Huan Chen, Jiaoli Lan, Yongxin Chen, Xiaolu Zeng, Huiqiong Zhang, Zhiling Li, Yuxin Zhang, Min Yang

“…This study aimed to describe the gastrointestinal symptoms and endoscopic features of hepatic GSD, including types Ia, Ib, III, VI, and IX, to provide evidence for etiology and treatment. Methods A national cohort survey questionnaire was distributed to patients diagnosed with GSD type Ia, Ib, III, VI, and IX through genetic testing or their parents in mainland China in May 2022. …”
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Azithromycin to prevent acute lower respiratory infections among Australian and New Zealand First Nations and Timorese children (PETAL trial): study protocol for a multicentre, int... by Anne B Chang, Keith Grimwood, Yuejen Zhao, Gabrielle B McCallum, Catherine A Byrnes, Heidi Smith-Vaughan, Peter S Morris, Christine Connors, Adrian Trenholme, Shirley Lawrence, Joshua Francis, Kobi L Schutz, Mark D Chatfield, Nevio Sarmento, Robyn L. Marsh, Emily R Bowden, Nicholas Fancourt, Adriano Vieira, Kim M Hare, Dennis Bonney, Felicity Marwick, Bronwyn Karvonen, Carolyn Maclennan, Milena Santos Lay, Endang Soares da Silva

“…Despite the high burden and long-term consequences of severe ALRIs, clinical, evidence-based and feasible interventions (other than vaccine programmes) that reduce ALRI hospitalisations in children are limited. …”
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Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study by Shihan Zhen, Na Li, Yan Li, Qian Li, Lu Zheng, Zhouxin Yin, Yan Dou, Shuqi Wu, Yilin Liu, Xiaoyan Zhang, Xinyue Yang, Ye Wang, Wenxiu Ge, Xiaoyu Gao, Jing Yang, Fengchao Liang, Jiajin Hu, Ying Zhao

“…Although epidemiological evidence has linked maternal exposure to air pollution with adverse birth outcomes, the association between exposure to fine particulate matter (PM2.5) and the risk of total birth defects in highly polluted developing regions remains limited. …”
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Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation studyResearch in context by Shruti Agrawal, Claudia Smith, Stefan Y. Bogli, Michal M. Placek, Manuel Cabeleira, Deborah White, Esther Daubney, Adam Young, Erta Beqiri, Riaz Kayani, Diarmuid O'Donnell, Nazima Pathan, Suzanna Watson, Anna Maw, Matthew Ganrett, Hari Krishan Kanthimathianathan, Harish Bangalore, Santosh Sundararajan, Gayathri Subramanian, Dusan Raffaj, Avishay Sarfatti, Simona Lampareillo, Anton Mayer, Oliver Ross, Marek Czosnyka, Peter J. Hutchinson, Peter Smielewski, Carly Tooke, Caroline Payne, Holly Belfield, Amisha Mistry, Collette Spencer, Claire Jennings, Lara Bunni, Laura Anderson, Emily Morgan, Melanie James, Rebecca Beckley, Tahnima Khatun, Hafiza Khatun, Olivia Nugent, Richard Aldridge, Ruth Morgan, Julie Morcombe, Martin Quinton, Catherine Postlethwaite, Jenny Pond, Jessica Cutler, Caitlin Oxford

“…This provides additional evidence for the potential use of PRx for individualizing prognosis and treatment and pave way for further research in pTBI with the created database. …”
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IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3 by Huiyue Dong, Huiyue Dong, Ling Zhu, Ling Zhu, Jingjing Sun, Jingjing Sun, Qiuyan Chen, Qiuyan Chen, Pengyang Liu, Pengyang Liu, Wei Zhang, Huajing Zeng, Rong Lin, Rong Lin, Zongyang Yu, Zongyang Yu, Jun Lu, Jun Lu, Jun Lu, Jun Lu

“…Meanwhile, compared to the groups treated with either IFNβ or RSL3 alone, the combination treatment of IFNβ and RSL3 significantly inhibited the growth of HT1080 three-dimensional (3D) spheroids and tumor in a mouse xenograft model.ConclusionsOur work reveals a role for IFNβ in promoting ferroptosis and provides evidence that IFNβ could be used with RSL3 to increase cytotoxic effects in tumor cells.…”
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Comparison of autism domains across thirty rare variant genotypesResearch in context by Nabila M.H. Ali, Samuel J.R.A. Chawner, Leila Kushan-Wells, Carrie E. Bearden, Jennifer Gladys Mulle, Rebecca M. Pollak, Raquel E. Gur, Wendy K. Chung, Michael J. Owen, Marianne B.M. van den Bree, Harriet Housby, Irene Lee, David Skuse, Jeanne Wolstencroft, William Mandy, Spiros Denaxas, Kate Baker, Lucy Raymond, Marianne van den Bree, Samuel Chawner, Jeremy Hall, Peter Holmans, Josh Hope-Bell, Danielle Le Roux, Sally Morrin, Michael Owen, Shreeya Sivakumar

“…Despite subdomain-specific patterns, there was no strong evidence for specific genotype-phenotype associations. …”
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The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats by Xiaoyun Fan, Qing Zhang, Weiling Guo, Qi Wu, Jinpeng Hu, Wenjian Cheng, Xucong Lü, Pingfan Rao, Li Ni, Youting Chen, Lijiao Chen

“…In conclusion, our findings provide the evidence that L. brevis FZU0713 has the potential to improve disturbance of lipid metabolism by regulating intestinal microflora and liver metabonomic profile. …”
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Study protocol for an observational cohort study of heat stress impacts in pregnancy in The Gambia, West Africa [version 2; peer review: 1 approved, 2 approved with reservations] by Jane E Hirst, Ana Bonell, Abdul Sesay, Leonidas G. Ioannou, Bubacarr Bah, Kris A. Murray, Andy Haines, Sophie E. Moore, David Jeffries, Neil S Maxwell, Ana Vicero-Cabrera, Apolline Saucy, Cally Tan, Emmanuel Okoh, Dorothy Watters, Bakary Sonko, Williams Oluwatosin Adefila, Yahaya Idris, Mam Leigh-Nabou, Jarra Manneh, Andreas Flouris, Sainabou Bojang, Amanda N Sferruzzi-Perri, Andrew Prentice

“…Climate change has resulted in an increase in heat exposure globally. There is strong evidence that this increased heat stress is associated with poor maternal and fetal outcomes, especially in vulnerable populations. …”
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Genomic insights into population dynamics and adaptive strategies of the endangered dipterocarp, Hopea chinensis by Wei-Min Xiang, Yu-Ting Jiang, Jie Zou, Yan Deng, Kai Jiang, Kai-Jian Zhang, Xin-Yu Zhou, Kai-Xi Quan, Zi-Wen Han, Wei-Chao Liu, Liang Tang, Yuan-Yuan Li, Simon T. Segar, Yuan-Ye Zhang, Xing-Hua Hu, Rong Wang, Xiao-Yong Chen

“…Despite high levels of inbreeding, we detected only 441 derived deleterious and 337 derived major-effect mutations, which were not significantly enriched in any KEGG pathway, providing evidence of low genetic loads. Furthermore, selective sweep analysis showed 12 genes associated with cold and drought tolerance and plant defense and immunity. …”
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Anti-Inflammatory Potential and Synergic Activities of <i>Eclipta prostrata</i> (L.) L. Leaf-Derived Ointment Formulation in Combination with the Non-Steroidal Anti-Inflammatory Dr... by Muhammad M. Poyil, Mohammed H. Karrar Alsharif, Mahmoud H. El-Bidawy, Salman Bin Dayel, Mohammed Sarosh Khan, Zainab Mohammed M. Omar, Alaaeldin Ahmed Mohamed, Reda M. Fayyad, Tarig Gasim Mohamed Alarabi, Hesham A. Khairy, Nasraddin Othman Bahakim, Mohamed A. Samhan, Abd El-Lateef Saeed Abd El-Lateef

“…Thus, based on this evidence, the authors suggest that <i>E. prostrata</i> extract should be studied further for its anti-inflammatory and antibacterial activities and topical application in the treatment of atopic dermatitis.…”
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Defining neonatal status epilepticus: A scoping review from the ILAE neonatal task force by Magda L. Nunes, Elissa G. Yozawitz, Courtney J. Wusthoff, Renée A. Shellhaas, Efraín Olivas‐Peña, Jo M. Wilmshurst, Ronit M. Pressler, Chahnez C. Triki, Hans Hartmann, Terrie Inder, Geraldine B. Boylan, Kette Valente, Solomon L. Moshe, Eli M. Mizrahi, Nicholas S. Abend

“…The most common definitions were based around a 30‐min seizure duration criterion, but evidence was insufficient to support that 30 min was a cutoff defining prolonged seizures or that seizures exceeding this burden were more likely to be pharmacoresistant or associated with worse outcomes. …”
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Effect of exposure to environmental phenols and parabens on folate concentrations among 3–19 years old children and adolescents: A cross-sectional study in NHANES 2005–2016 by Meng Ni, Zhenying Lin, Ze Chen, Ziwen Xu, Qianqian Zhang, Jiuru Zhao, Wei Li, Yanan Tang, Zelin Cao, Baihe Li, Dongting Yao, Chunyu Cheng, Yi Hu, Xiaorui Liu, Jiji Chen, Zhiwei Liu

“…This study provides evidence of an inverse relationship between exposure to phenols and parabens and folate concentrations in children and adolescents, which would be of significance in providing guidance for clinical interventions and calling for remediation actions to be prioritized during childhood.…”
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Long-term exposure to PM2.5 and its constituents and visual impairment in schoolchildren: A population-based survey in Guangdong province, China by Jia-Hui Li, Hui-Xian Zeng, Jing Wei, Qi-Zhen Wu, Shuang-Jian Qin, Qing-Guo Zeng, Bin Zhao, Guang-Hui Dong, Ji-Chuan Shen, Xiao-Wen Zeng

“…Background: Exposure to fine particulate matter (PM2.5) has been linked to visual impairment. Nevertheless, evidence associating PM2.5 constituents with visual impairment in schoolchildren is sparse. …”
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Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor... by Cody-Aaron L. Gathers, Nadir Yehya, Anireddy Reddy, Paula M. Magee, Vanessa C. Denny, Michelle R. Mayeda, Amanda O’Halloran, Sanjiv D. Mehta, Stephanie Wanamaker, Jessica C. Fowler, Garrett Keim

“…Interpretation: We found evidence of racial and ethnic disparities in mortality for children diagnosed with community-acquired pneumonia. …”
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