A protocol for mobilising novel finance models for collaborative health promotion and disease prevention initiatives: taking a smart capacitating investment approach in the Invest4... by Joanna Lane, Joanna Lane, Rhiannon T. Edwards, Balázs Babarczy, Holly Whiteley, Vidya Oruganti, Vidya Oruganti, Maureen Rutten-van Mölken, Caroline Costongs, Anant R. Jani, Sarah Wordsworth, Alison Maassen, Apostolos Tsiachristas, Jacob Davies, Bengt Stavenow, Jolanda van Vliet, Steve Wright, Steve Wright, Lina Papartyte, Jennifer Catherine Camaradou, Rositsa Koleva-Kolarova

“…The lack of fiscal space post-COVID-19 means shifting from models of care built around treatment to those with greater emphasis on prevention will require innovative, evidence-based investment within and between sectors. …”
Get full text

Study protocol of a pilot randomised controlled trial assessing the feasibility and acceptability of RecoverEsupport: a digital health intervention to enhance recovery in women und... by Christopher Oldmeadow, Mitch J Duncan, Penny Reeves, Priscilla Viana da Silva, Rebecca Wyse, Helen Moore, Alison Zucca, Sancha Robinson, Stephen Ridley Smith, Emma Sansalone, Owen Morris, Rebecca Chenery, Lara Riley, Anna Palazzi-Parsons

“…The DHI incorporates the following evidence-based behaviour change strategies: education, self-monitoring and feedback and prompts and cues. …”
Get full text

THE PUBLIC DEBT OF UKRAINE: A NEW DIMENSION OF DYNAMICS AND ARCHITECTURE OF THE MODEL FRAMEWORK OF THE MANAGEMENT SYSTEM by Serhii Petrukha, Nina Petrukha, Roman Miakota

“…The principal risk factors identified in the study are as follows: low rates of economic growth, a high level of dependence on foreign aid, demographic challenges and high costs for meeting the needs of the security and defence forces. Empirical evidence has demonstrated that the exchange rate and the real interest rate are the predominant factors influencing debt dynamics, thereby exacerbating the debt burden. …”
Get full text

Cyanoacrylate glue in breast surgery: the GLUBREAST Trial by Emanuela Esposito, Claudio Siani, Ivana Donzelli, Anna Crispo, Sergio Coluccia, Piergiacomo Di Gennaro, Assunta Luongo, Franca Avino, Alfredo Fucito, Ugo Marone, Maria Teresa Melucci, Ruggero Saponara, Raimondo di Giacomo

“…An advantage for the Experimental Arm was observed from third and fourth to fifth outpatient visits without reaching a statistical significance (p=0.069 and p=0.072, respectively); so far, 5% of patients in the Experimental Group had clinical benefit from the glue.ConclusionsThe vast majority of data in the literature come from case series, and surgeons need a higher level of evidence to drive surgical decision-making and choose proper devices to increase patient quality of life. …”
Get full text

Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer... by Dong-Dong Wang, Ming-Qian Jia, He-Li Xu, Yu Li, Jia-Xin Liu, Jia-Cheng Liu, Jia-Nan Sun, Fan Cao, Lang Wu, Fang-Hua Liu, Yi-Zi Li, Yi-Fan Wei, Xiao-Ying Li, Qian Xiao, Song Gao, Dong-Hui Huang, Tao Zhang, Ting-Ting Gong, Qi-Jun Wu

“…Abstract Background The evidence on the relationship of dietary antioxidant nutrients with the survival of ovarian cancer (OC) remains scarce. …”
Get full text

Comparing Campylobacter jejuni to three other enteric pathogens in OligoMM12 mice reveals pathogen-specific host and microbiota responses by Mathias K.-M. Herzog, Audrey Peters, Nizar Shayya, Monica Cazzaniga, Kardokh Kaka Bra, Trisha Arora, Manja Barthel, Ersin Gül, Luca Maurer, Patrick Kiefer, Philipp Christen, Katharina Endhardt, Julia A. Vorholt, Gad Frankel, Markus M. Heimesaat, Stefan Bereswill, Cormac G. M. Gahan, Marcus J. Claesson, Xavier Domingo-Almenara, Wolf-Dietrich Hardt

“…In this study, we applied the standardized gnotobiotic OligoMM12 microbiota mouse model and compared the infections in the same facility. We provide evidence of robust colonization and significant pathological changes in OligoMM12 mice following infection with these pathogens. …”
Get full text

Survival feature and trend of female breast cancer: A comprehensive review of survival analysis from cancer registration data by Dan-Dan Tang, Zhuo-Jun Ye, Wan-Wan Liu, Jing Wu, Jing-Yu Tan, Yan Zhang, Qun Xu, Yong-Bing Xiang

“…Differences in age, stage at diagnosis, and molecular subtype may explain some of the disparities, providing evidence for targeted management strategies.…”
Get full text

Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders by Yang Zhang, Yang Zhang, Yihui He, Yihui He, Yuan Fang, Yuan Fang, Miaotian Cai, Guangqiang Sun, Guangqiang Sun, Rui Wang, Rui Wang, Jiaxin Zhen, Jiaxin Zhen, Yulin Zhang, Zhen Li, Zhen Li, Yundong Ma, Yundong Ma, Tong Zhang, Tong Zhang

“…These imaging results were significantly correlated with peripheral blood indicators and clinical variables.ConclusionThis rs-fMRI study provides considerable evidence for abnormal intrinsic brain activity in people with HADD. …”
Get full text

Probiotic Supplementation Alleviates Corticosterone-Induced Fatty Liver Disease by Regulating Hepatic Lipogenesis and Increasing Gut Microbiota Diversity in Broilers by Yuyan Feng, Wenqing Mei, Qu Chen, Xiaojing Chen, Yingdong Ni, Mingming Lei, Jie Liu

“…Emerging evidence indicates a close relationship between gut microbiota and fatty liver disease. …”
Get full text

Prevalence and determinants of overweight/obesity, elevated blood pressure, and their comorbidities among primary and secondary school students in Guizhou province: a cross-section... by Zhuan WANG, Xiangdong DU, Xin LI, Xiaoqin ZHANG, Xiujuan LU, Xiying PENG

“…ObjectiveTo analyze the prevalence and determinants of overweight/obesity and elevated blood pressure among primary and secondary school students aged 7 – 18 years in Guizhou province to provide evidence for the development of effective interventions. …”
Get full text

Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis by Bo Pan, Yiming Pan, Yu-Song Huang, Meng Yi, Yuwei Hu, Xiaoyu Lian, Hui-Zhong Shi, Mingwei Wang, Guifen Xiang, Wen-Yi Yang, Zhong Liu, Fangfang Xia

“…Subgroup analyses by geography showed that effectiveness was demonstrated in Asia (SMD −0.46, 95% CI [−0.56, −0.36], I 2  = 36%), while no evidence of effectiveness was found in Europe (SMD −0.07, 95% CI [−0.19, 0.05], I 2  = 55%), America (SMD −0.33, 95% CI [−0.67, 0.02], I 2  = 60%), and Oceania (SMD 0.00, 95% CI [−0.18, 0.18], I 2  = 0%). …”
Get full text

The state of the science of interprofessional collaborative practice: A scoping review of the patient health-related outcomes based literature published between 2010 and 2018. by May Nawal Lutfiyya, Linda Feng Chang, Cynthia McGrath, Clark Dana, Martin S Lipsky

“…The research question for this review was: What does the evidence from the past decade reveal about the impact of Interprofessional collaborative practice on patient-related outcomes in the US healthcare system?…”
Get full text

Triglycerides mediate the relationships of per- and poly-fluoroalkyl substance (PFAS) exposure with nonalcoholic fatty liver disease (NAFLD) risk in US participants by Wenying Qiao, Jiashuo Li, Lijia Luo, Wenjuan Peng, Xi Wang, Ronghua Jin, Junnan Li

“…This result could provide more comprehensive epidemiological evidence and guide clinical applications.…”
Get full text

Antimicrobial Resistance Surveillance of Skin and Soft Tissue Infections: Hospital-Wide Bacterial Species and Antibiograms to Inform Management at a Zonal Tertiary Hospital in Mwan... by Justine BN, Mushi MF, Silago V, Igembe Z, Muyombe J, Kishengena PP, Michael Jnr NS, Maganga MG, Massenga A, Tegete F, Massaga FA, Seni J

“…Revisiting SSTIs treatment guidelines at BMC and inclusion of SSTIs in the on-going AMR surveillance in Tanzania are recommended.Plain Language Summary: Tanzania National Action Plan on combating resistant bugs is exclusively focused on urinary tract infections and blood stream infections despite enormous impact conferred by skin and soft tissue infections.Bugs which are resistant to commonly used antibiotics were found more among patients admitted in the hospital in contrast to those attending outpatient clinics.This study highlights a pressing need to develop treatment guidelines based on generated local research-evidence to foster favorable patients’ outcomes.Keywords: skin and soft tissue infections, antimicrobial resistance, surveillance, Tanzania…”
Get full text

The incidence of incomplete abortion and the prevalence of abortion-related morbidity in South African public hospitals, 2018 by D N Conco, J Levin, B Komane, K Blanchard, T Bessenaar, N G Nkosi, S Fonn

“…South Africa (SA) is internationally recognised for its progressive reproductive rights framework, supported by its Constitution and laws. However, evidence suggests that women encounter barriers to accessing safe abortions, including stigma, resistance from healthcare providers, a shortage of trained professionals and a lack of awareness of their rights. …”
Get full text

Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Abstract Background Clonal myeloproliferation and fibrotic transformation of the bone marrow (BM) are the pathogenetic events most commonly occurring in myelofibrosis (MF). There is great evidence indicating that tumor microenvironment is characterized by high lactate levels, acting not only as an energetic source, but also as a signaling molecule. …”
Get full text

Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF by Shuhei Yamamoto, Saeko Yamasaki, Satoko Higuchi, Kentaro Kamiya, Hiroshi Saito, Kazuya Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Kentaro Jujo, Hiroshi Wada, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Naoki Aizawa, Akihiro Makino, Kazuhiro Oka, Shin‐ichi Momomura, Nobuyuki Kagiyama, Yuya Matsue

“…Abstract Aims Although evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated with prognosis, the impact of concurrent physical frailty and cognitive impairment, that is, cognitive frailty, on prognosis has yet to be fully investigated. …”
Get full text

Investigating the Efficacy of the Web-Based Common Elements Toolbox (COMET) Single-Session Interventions in Improving UK University Student Well-Being: Randomized Controlled Trial by Jeffrey Lambert, Maria Loades, Noah Marshall, Nina Higson-Sweeney, Stella Chan, Arif Mahmud, Victoria Pile, Ananya Maity, Helena Adam, Beatrice Sung, Melanie Luximon, Keren MacLennan, Clio Berry, Paul Chadwick

“…Single-session interventions (SSIs) are designed to be scalable and accessible, delivering core evidence-based intervention components within a one-off encounter. …”
Get full text

Comprehensive health risk assessment of urban ambient air pollution (PM2.5, NO2 and O3) in Ghana by Boansi Adu Ababio, Gerheart Winfred Ashong, Thomas Peprah Agyekum, Blessed Adjei Yeboah, Marian Asantewah Nkansah, Jonathan Nartey Hogarh, Michael Kweku Commeh, Edward Ebow Kwaansa-Ansah, Kwabena Dabie, Felix Adulley, Eldad Boansi, Lorenda Sarbeng, Birago Adu Ababio, Maame Serwaa Boapea, Nana Kwabena Oduro Darko, Meshach Kojo Appiah

“…It emphasizes the significance of robust real-time monitoring of air pollutants and the investigation of seasonal dust storm effects, to fill data gaps in Ghana and West Africa, facilitating evidence-based interventions that improve urban air quality and public health outcomes.…”
Get full text

Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies by Xiaoming Zhang, Yibing Guo, Kun Fang, Xiangqian Huang, Duo Lan, Mengqi Wang, Lina Jia, Xunming Ji, Ran Meng, Da Zhou

“…Conclusions: MSC-Exos reveal significant therapeutic potential for IS, with evidence supporting their efficacy in reducing infarct size and enhancing functional recovery in preclinical rodent models. …”
Get full text