Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study. by Lin Geng, Lilith K Whittles, Borame L Dickens, Martin T W Chio, Yihao Chen, Rayner Kay Jin Tan, Azra Ghani, Jue Tao Lim

“…<h4>Background</h4>Gonorrhea is the second most common sexually transmitted disease notified in Singapore in 2023. Evidence suggests that the 4CMenB vaccine designed to protect against Neisseria meningitidis infection may offer partial cross-protection against gonorrhea. …”
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Effectiveness of shared decision-making for glycaemic control among type 2 diabetes mellitus adult patients: A systematic review and meta-analysis. by Edosa Tesfaye Geta, Dufera Rikitu Terefa, Wase Benti Hailu, Wolkite Olani, Emiru Merdassa, Markos Dessalegn, Miesa Gelchu, Dereje Chala Diriba

“…Despite widespread calls for SDM to be embedded in health care, there is little evidence to support SDM in the management and care of diabetes. …”
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Les réseaux d’alimentation en eau des pentes de la Croix-Rousse et de la presqu’île de Lyon by Jules Ramona

“…Moreover, the absence of evidence of forced water pipes in the southern part of the Peninsula could be attributable to a technical geographical limit on the distribution of water under pressure. …”
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Beyond the current state of just-in-time adaptive interventions in mental health: a qualitative systematic review by Claire R. van Genugten, Claire R. van Genugten, Melissa S. Y. Thong, Melissa S. Y. Thong, Melissa S. Y. Thong, Wouter van Ballegooijen, Wouter van Ballegooijen, Wouter van Ballegooijen, Annet M. Kleiboer, Annet M. Kleiboer, Donna Spruijt-Metz, Arnout C. Smit, Mirjam A. G. Sprangers, Mirjam A. G. Sprangers, Yannik Terhorst, Yannik Terhorst, Heleen Riper, Heleen Riper, Heleen Riper

“…., adaptivity and receptivity) within the core components were missing and the core components were only partly substantiated by empirical evidence (e.g., interventions were supported, but the decision rules and points were not). …”
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Supporting and hindering environments for participation of adolescents diagnosed with autism spectrum disorder: A scoping review. by Beate Krieger, Barbara Piškur, Christina Schulze, Uta Jakobs, Anna Beurskens, Albine Moser

“…Sources of scientific evidence were searched for in four databases. Inclusion criteria were the perspectives of adolescents between 12 and 21, families, peers, or significant others; ecologic validity; and a clear connection between environment and participation. …”
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Iterative delivery of an implementation support package to increase and sustain the routine provision of antenatal care addressing alcohol consumption during pregnancy: study proto... by John Attia, Luke Wolfenden, Nicole Nathan, Melanie Kingsland, Olivia Wynne, Penny Reeves, Alix Hall, John Wiggers, Elizabeth J Elliott, Tameka McFadyen, Tracey W Tsang, Emma Doherty, Belinda Tully, Adrian John Dunlop, Ian Symonds

“…The package will consist of evidence-based strategies to support increases in care provision (remind clinicians; facilitation; conduct educational meetings) and sustainment (develop a formal implementation blueprint; purposely re-examine the implementation; conduct ongoing training). …”
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From fear to food: predation risk shapes deer behaviour, their resources and forest vegetation by Martin, Jean-Louis, Chamaillé-Jammes, Simon, Salomon, Anne, Gomez Pourroy, Devana Veronica, Schlaeflin, Mathilde, Le Saout, Soizic, Lucas, Annick, Bentaleb, Ilham, Chollet, Simon, Pattison, Jake, Martin-Blangy, Soline, Gaston, Anthony James

“…We interpreted our results as evidence that risk is key in shaping, and potentially selecting for, lasting behavioural contrasts between deer populations, contrasts intimately connected to deer effects on plant cover and diversity, ecological networks, and ecosystem complexity.…”
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Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

“…Smartphone-based mobile health (mHealth) technologies offer national TB programmes an appealing platform to improve patient care and management; however, clinical trial evidence to support their use is lacking. This trial will test the hypothesis that an mHealth intervention can improve treatment success among patients with MDR-TB and is cost-effective compared with standard practice.Methods and analysis A community-based, open-label, parallel-group randomised controlled trial will be conducted among patients treated for MDR-TB in seven provinces of Vietnam. …”
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Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy by Coraline Radermecker, Pascale Hubert, Patrick Roncarati, Stephanie Demoulin, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Margot Meunier, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs

“…We also reported that a significant fraction of HMGB1 encountered within cancer microenvironment (interstitial fluids) is oxidized and, in opposite to its reduced isoform, oxidized HMGB1 acts as a tolerogenic signal in a receptor for advanced glycation endproducts-dependent manner.Conclusion Collectively, we present evidence that extracellular HMGB1 blockade may complement first-generation cancer immunotherapies by remobilizing antitumor immune response.…”
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Treating drug-resistant tuberculosis in an era of shorter regimens: Insights from rural South Africa by J-D K Lotz, J Porter, H Conradie, T Boyles, B Gaunt, S Dimanda, D Cort

“…Amidst these, a shorter regimen was introduced in 2017 with weak evidence, and has shown mixed results. Outcomes still fall short of national targets, and the coronavirus disease 2019 pandemic has undermined progress to date. …”
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Refined Mapping of Subsurface Water Ice on Mars to Support Future Missions by G. A. Morgan, N. E. Putzig, D. M. H. Baker, A. Pathare, C. M. Dundas, M. B. Russell, M. R. Perry, M. Chojnacki, H. G. Sizemore, A. M. Bramson, E. I. Petersen, S. Nerozzi, R. H. Hoover, Z. Bain

“…Nevertheless, both direct and indirect evidence indicates extensive buried ice across the midlatitudes, including locations where it is presently unstable. …”
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Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by Campylobacter jejuni by Brandon Ruddell, Alan Hassall, Orhan Sahin, Paul J. Plummer, Qijing Zhang, Amanda J. Kreuder

“…As a growing body of evidence suggests that maintenance of L-met homeostasis appears to be critical for C. jejuni colonization, interventions targeting the AMC could provide a critical control point for therapeutic drug options to combat this zoonotic pathogen. …”
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Single-qubit anisotropy induced by micromagnet in Si-MOS quantum dot by Ning Chu, Xin Zhang, Rong-Long Ma, Zhen-Zhen Kong, Wei-Zhu Liao, Sheng-Kai Zhu, Chu Wang, Ao-Ran Li, Gui-Lei Wang, Gang Cao, Hai-Ou Li, Guo-Ping Guo

“…Here, we investigate the anisotropic properties of single spin qubit in silicon metal-oxide-semiconductor (Si-MOS) quantum dot and provide experimental evidence for the control of SSOC. Additionally, we experimentally demonstrate that tuning the operating point away from the conventional configuration can enhance the quality factor of the spin qubit. …”
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Sparse seagrass meadows are critical dugong habitat: A novel rapid assessment of habitat-wildlife associations using paired drone and in-water surveys by Nicole E. Said, Christophe Cleguer, Paul Lavery, Amanda J. Hodgson, Connor Gorham, Julian A. Tyne, Ankje Frouws, Simone Strydom, Johnny Lo, Holly C. Raudino, Kelly Waples, Kathryn McMahon

“…This study provided evidence of critical seagrass habitat, which is important knowledge for the protection and conservation of dugongs and their foraging habitat. …”
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The role of artificial intelligence and machine learning in predicting and combating antimicrobial resistance by Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Muhammad Shafiq, Wenjie Fang, Rahat Ullah Khan, Mujeeb Ur Rahman, Xiaohui Li, Qiao-Li Lv, Bin Xu

“…Although AI/ML are relatively new fields, numerous case studies offer substantial evidence of their successful application in predicting AMR outbreaks with greater accuracy. …”
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Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus by Dian-dian Zhao, Pei-lin Jiao, Jing-jia Yu, Xiao-jing Wang, Lin Zhao, Yan Xuan, Li-hao Sun, Bei Tao, Wei-qing Wang, Guang Ning, Jian-min Liu, Hong-yan Zhao

“…Accumulating evidence suggests that oxidative stress is associated with osteoporosis. …”
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Real life outcome analysis of breast cancer brain metastases treated with Trastuzumab Deruxtecan by Alessandra Fabi, Alessandro Rossi, Roberta Caputo, Simona Pisegna, Simone Scagnoli, Francesco Pantano, Giuliana D’Auria, Palma Fedele, Agnese Fabbri, Claudio Vernieri, Michela Palleschi, Luisa Carbognin, Gianluigi Ferretti, Elena Di Monte, Ida Paris, Francesco Pavese, Ornella Garrone, Antonio Franco, Michelino De Laurentiis, Gianluca Franceschini, Giovanni Scambia, Diana Giannarelli, Riccardo Masetti, Andrea Botticelli

“…However, a real-world evidence is lacking in literature. We conducted a multicenter, observational, retrospective real-world analysis on 39 cases collected at 12 Italian Oncological Units. …”
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Traditional herbal medicine legislative and regulatory framework: a cross-sectional quantitative study and archival review perspectives by Sileshi Dubale, Rashed Edris Usure, Yesuneh Tefera Mekasha, Gemmechu Hasen, Firdos Hafiz, Dereje Kebebe, Sultan Suleman

“…For future roadmaps, collaboration among traditional healers, regulatory bodies, and scientific communities, along with supporting evidence-based research, could further enhance THM regulation in Ethiopia. …”
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Mapping the Λ_sCDM Scenario to <i>f</i>(<i>T</i>) Modified Gravity: Effects on Structure Growth Rate by Mateus S. Souza, Ana M. Barcelos, Rafael C. Nunes, Özgür Akarsu, Suresh Kumar

“…Our findings indicate that the new corrections expected at the linear perturbative level, as revealed through RSD samples, can provide significant evidence in favor of this new scenario. Additionally, this model may be an excellent candidate for resolving the current <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>S</mi><mn>8</mn></msub></semantics></math></inline-formula> tension.…”
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Pharmacogenomic profiling of variants affecting efficacy and toxicity of anti-infective medicines in a south Asian population from Sri Lanka by Priyanga Ranasinghe, Hajanthy Jeyapragasam, Nirmala Sirisena, D. P. Bhagya Hendalage, Vajira H. W. Dissanayake

“…Methods Pharmacogenomic data on anti-infective medicines were obtained from the PharmGKB database, selecting variants with evidence levels 1 A, 1B, 2 A, and 2B. Sri Lankan genetic data were sourced from an anonymized database of 670 Sri Lankans maintained by the Centre for Genetics and Genomics, Faculty of Medicine, University of Colombo. …”
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