Real-world pharmacovigilance of ofatumumab in multiple sclerosis: a comprehensive FAERS data analysis by Hui Chen

“…Additionally, novel off-label adverse events, including brain fog, muscle spasms, and mood alterations, were identified, marking the first real-world evidence of these potential risks. Temporal analysis revealed that most adverse events occurred within the first month of treatment, indicating an early risk phase. …”
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The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome by Blazej Misiak, Marta Krolik, Anna Kukowka, Anna Lewera, Przemyslaw Leszczynski, Joanna Stankiewicz-Olczyk, Ryszard Slezak

“…Background. Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). …”
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Antifibrotic Activity of Acylated and Unacylated Ghrelin by Elia Angelino, Simone Reano, Michele Ferrara, Emanuela Agosti, Andrea Graziani, Nicoletta Filigheddu

“…The aim of this review is to summarize the available evidence regarding the effects of acylated and unacylated ghrelin on different pathologies and experimental models in which fibrosis is a predominant characteristic.…”
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Observations of the Ultraviolet-bright Star III-60 in the Globular Cluster NGC 6723 by William V. Dixon

“…The star exhibits strong P Cygni profiles in both components of the N  v λ 1240 doublet, but the resonance lines of other species show no evidence of a stellar wind. The star's effective temperature and luminosity place it on the evolutionary tracks of stars evolving from the blue horizontal branch, but its high mass (∼1.2 M _⊙ ) indicates that it is the product of a stellar merger. …”
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Canadian Association of Gastroenterology Policy on the Application for, and Implementation of, Clinical Practice Guidelines by Harminder Singh, Grigorios I Leontiadis, Lawrence Hookey, Robert Enns, Lana Bistritz, Louis-Charles Rioux, Louise Hope, Paul Sinclair

“…The benefits of timely, high-quality and evidenced-based recommendations include: Enhancing the professional development of clinical members through education and dissemination of synthesized clinical research;Improving patient care provided by members by providing focus on quality and evidence;Creating legislative environments that favour effective clinical practice;Enhancing the clinical care provided to patients with digestive disease by nongastroenterologists; andIdentifying areas that require further information or research to improve clinical care.The present document provides the foundation required to ensure that clinical practice guidelines produced by the CAG are necessary, appropriate, credible and applicable. …”
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Exploring Grammatical Structure: A Corpus Analysis on the Use of “To Be” in Vocational Students’ WhatsApp Group Conversations using AntConc by Muhammad Arba’in, Itsna Millatul Himmayati, Dwi Hastuti, Desi Nosita, Triyoko Triyoko

“…The research aims to identify sentence variations and common errors among the students. The source of evidence is the corpus of unstructured written conversations among the students on the WhatsApp group platform. …”
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Canadian Junior Public Markets Health Check: Surprising Resilience Thus Far, Some Concerns Looking Forward by L. Daniel Wilson

“…This paper conducts a health check on the Canadian junior public markets. Surprisingly, the evidence demonstrates that the junior markets have proved resilient in the face of headwinds and the total number of listed operating companies on the junior stock exchanges in Canada has not followed the declining trendline of the senior markets. …”
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Adult-Onset Idiopathic Cervical Dystonia by Shameer Rafee, Mahmood Al-Hinai, Michael Hutchinson

“…Botulinum toxin injections alone, no matter how expertly given, will not provide optimal therapy and improved health-related quality of life without an holistic approach to patient management. Increasing evidence indicates that AOICD is a neurophysiological network disorder of GABAergic inhibition, causing a syndrome of dystonia, mood disturbance, and social cognitive dysfunction, with the superior colliculus playing a central role.…”
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Competencies of nurses to participate in safe medication management practices for biologics: A scoping review. by Wansheng Li, Li Li, Linbo Li, Cardenas Xiaodong, Mudiao Chen, Hongye Liu, Peirao Li

“…<h4>Aim</h4>To review the existing literature relating to nurse competence in safe medication management practices for biologics, identify evidence, and develop a competency framework to clarify the role of nurses in these practices.…”
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Importance of Android/Gynoid Fat Ratio in Predicting Metabolic and Cardiovascular Disease Risk in Normal Weight as well as Overweight and Obese Children by Lennie Samsell, Michael Regier, Cheryl Walton, Lesley Cottrell

“…Numerous studies have shown that android or truncal obesity is associated with a risk for metabolic and cardiovascular disease, yet there is evidence that gynoid fat distribution may be protective. …”
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Long-Term Trends in Marriage Timing and the Impact of Migration, the Netherlands (1650-1899) by Charlotte Störmer, Corry Gellatly, Anita Boele, Tine De Moor

“…However, there is a lack of empirical evidence on the demographics of marriage prior to the nineteenth century. …”
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Effect of Oral PUVAsol on the Quality of Life in Indian Patients Having Chronic Plaque Psoriasis by Pratik Gahalaut, Nitin Mishra, Puneet S. Soodan, Madhur K. Rastogi

“…This study will add upon the growing evidence of efficacy of PUVAsol.…”
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Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide by Kumju Youn, Chi-Tang Ho, Mira Jun

“…ABSTRACT: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by cognitive decline and memory impairment. Many lines of evidence indicate that excessive β-amyloid peptide (Aβ) generation and aggregation play pivotal roles in the initiation of AD, leading to various biochemical alteration including oxidative damage, mitochondrial dysfunction, neuroinflammation, signaling pathway and finally resulting in neuronal death. …”
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Use of Adjuvant Sorafenib in Liver Transplant Recipients with High-Risk Hepatocellular Carcinoma by Kirti Shetty, Chiranjeev Dash, Jacqueline Laurin

“…We prospectively enrolled patients transplanted for HCC into a treatment protocol utilizing sorafenib if their explant examination showed evidence of viable tumor exceeding Milan criteria. …”
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Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy by Shereen Elazzazy, Taghrid Abu Hassan, Ashraf El Seid, Cicy Mary Jacob

“…This paper presents evidence that TEN may be induced by concurrent use of radiation with both phenytoin and levetiracetam. …”
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MicroRNAs as Haematopoiesis Regulators by Ram Babu Undi, Ravinder Kandi, Ravi Kumar Gutti

“…Haematopoiesis is a complex process regulated by several mechanisms including microRNAs (miRNAs). miRNAs are small RNAs which regulate the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells. Evidence shows that miRNAs play an important role in haematopoiesis; for example, myeloid and erythroid differentiation is blocked by the overexpression of miR-15a. miR-221, miR-222, and miR-24 inhibit the erythropoiesis, whereas miR-150 plays a role in B and T cell differentiation. miR-146 and miR-10a are downregulated in megakaryopoiesis. …”
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Augmentation of Tonic GABAA Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABAA Receptors by Adam C. Errington, David W. Cope, Vincenzo Crunelli

“…In particular, increased activation of extrasynaptic GABAA receptors (eGABAAR) and augmented “tonic” GABAA inhibition in thalamocortical neurons have been demonstrated across a range of genetic and pharmacological models of absence epilepsy. Moreover, evidence from monogenic mouse models (stargazer/lethargic) and the polygenic Genetic Absence Epilepsy Rats from Strasbourg (GAERS) indicate that the mechanism underlying eGABAAR gain of function is nonneuronal in nature and results from a deficiency in astrocytic GABA uptake through the GAT-1 transporter. …”
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Metabolic Dysfunction in the Regulation of the NLRP3 Inflammasome Activation: A Potential Target for Diabetic Nephropathy by Wenli Zhao, Le Zhou, Petr Novák, Xian Shi, Chuang Biao Lin, Xiao Zhu, Kai Yin

“…The pyrin domain-containing protein 3 (NLRP3) inflammasome, a member of the nod-like receptor family, is considered a crucial inflammatory regulator and plays important roles in the progress of DN. A growing body of evidence suggests that high glucose, high fat, or other metabolite disorders can abnormally activate the NLRP3 inflammasome. …”
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Validity and reliability of the executive function scale in Cuban university student by Diego D. Díaz-Guerra, Marena De La C. Hernández-Lugo, Carlos Ramos-Galarza, Yunier Broche-Pérez

“…The scale demonstrated good internal consistency and overall reliability (α = 0.91, ω = 0.91).ConclusionThe study provided evidence that the UEF-1 is a reliable and valid tool for assessing executive functions in Cuban university students. …”
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Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies by Natascia Brondino, Simona Re, Annalisa Boldrini, Antonella Cuccomarino, Niccolò Lanati, Francesco Barale, Pierluigi Politi

“…To date there is insufficient evidence to suggest the use of curcumin in dementia patients. …”
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