Cellular Plasticity in Prostate Cancer Bone Metastasis by Dima Y. Jadaan, Mutaz M. Jadaan, John P. McCabe

“…The aim of this review was to appraise the clinical evidence for the role of cellular plasticity in prostate cancer (PC) bone metastasis. …”
Get full text

Reduzir a desigualdade, mas até que ponto? Breves comentários a partir da "Vida Boa" de Aristóteles by Robson Antonio Grassi

“…However, some more developed countries are already at a greater level of progress in terms of these indicators, and even so, in recent decades, there is strong evidence of an increase in inequality and a reduction in important indicators of the well-being of their population. …”
Get full text

Exercise Interventions in Children with Cancer: A Review by Tseng-Tien Huang, Kirsten K. Ness

“…Generally, interventions tested were either in-hospital supervised exercise training or home based programs designed to promote physical activity. Early evidence from small studies indicates that the effects of exercise include increased cardiopulmonary fitness, improved muscle strength and flexibility, reduced fatigue and improved physical function. …”
Get full text

Patent Foramen Ovale Closure for Treating Migraine: A Meta-Analysis by Yu Zhang, Haijiao Wang, Ling Liu

“…This study evaluated the efficacy and safety of PFO closure in patients with migraine using evidence-based medicine. Methods. The Pubmed (MEDLINE), Embase, and Cochrane Library databases were searched for randomized controlled trials (RCTs), cohort studies, and retrospective case series from January 1, 2001, to February 30, 2021. …”
Get full text

Promoting Pancasila values through dialectical project-based learning for Indonesian youth by Endang Prihatin, Encep Syarief Nurdin, Yadi Ruyadi, Tri Suhartati, An Nisaa Atila Thabrani

“…The results provide substantial evidence that a dialectical approach can be an efficacious strategy in fortifying the values of Pancasila among the younger generation, as well as promoting constructive discourse on national identity in the contemporary global context.…”
Get full text

Role of Hypothalamus in Acupuncture’s Effects by Ryan Bae, Hyung Kyu Kim, Baoji Lu, Jing Ma, Juping Xing, Hee Young Kim

“…Among the brain regions, the hypothalamus, a small yet critical region in the brain, plays a pivotal role in maintaining homeostasis by regulating a wide array of physiological processes, including stress responses, energy balance, and pain modulation. Emerging evidence suggests that acupuncture may exert its therapeutic effects by modulating the activity of the hypothalamus and its associated neural circuits, particularly in relation to pain, stress, and metabolic regulation. …”
Get full text

Investigating the Feasibility and Impact of Perinatal Depression Screening and Treatment in Rural Nsambe, Malawi by Waste Kayira, Mark Chalamanda, Kingsley Kanzoole, Kondwani Mpinga, Moses Banda Aron, Ksakred Kelly, Sarah Singer, Enoch Ndarama, Stephanie Smith, Giuseppe Raviola, Basimenye Nhlema, Emilia Connolly, Todd Ruderman

“…However, due to low resources and little evidence on the impact of screening and treatment, few interventions are offered. …”
Get full text

Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease by Longbiao Yao, Oana Herlea-Pana, Janet Heuser-Baker, Yitong Chen, Jana Barlic-Dicen

“…In this review, we focus on and discuss members of the chemokine system for which there is clear evidence of participation in the development of obesity and obesity-induced pathologies.…”
Get full text

Unruptured Cerebral Aneurysms: Evaluation and Management by Norman Ajiboye, Nohra Chalouhi, Robert M. Starke, Mario Zanaty, Rodney Bell

“…This review provides a comprehensive overview of the epidemiology, pathophysiology, natural history, clinical presentation, diagnosis, and management options for unruptured intracranial aneurysms based on the current evidence in the literature. Furthermore, the authors discuss the genetic abnormalities associated with intracranial aneurysm and current guidelines for screening in patients with a family history of intracranial aneurysms. …”
Get full text

From Abnormal Hippocampal Synaptic Plasticity in Down Syndrome Mouse Models to Cognitive Disability in Down Syndrome by Nathan Cramer, Zygmunt Galdzicki

“…At the core of cognitive processes is the phenomenon of synaptic plasticity, a functional change in the strength at points of communication between neurons. A wide variety of evidence from studies on DS individuals and mouse models of DS indicates that synaptic plasticity is adversely affected in human trisomy 21 and mouse segmental trisomy 16, respectively, an outcome that almost certainly extensively contributes to the cognitive impairments associated with DS. …”
Get full text

Monte Carlo simulation methods-based models for analyzing the kinetics of drug delivery from controlled release systems by Saúl Jiménez-Jiménez, Salomón Cordero-Sánchez, José-Gerardo Mejía-Hernández, David Quintanar-Guerrero, Luz-María Melgoza-Contreras, Rafael Villalobos-García

“…In this review, we discuss key findings related to the use of this probabilistic method for analyzing the drug-controlled release process in different pharmaceutical devices. Based on this evidence, we propose their potential application in the characterization of new drug-controlled release systems, synergy with other computational methods, and their capability to be adapted for in vivo or in vitro kinetic analysis.…”
Get full text

Solid Pseudopapillary Neoplasms Are Rare, Indolent Pancreatic Tumors in Young Women by Amin Dalili, Mohsen Aliakbarian, Mehdi Karimi-Shahri, Alireza Samadi, Sara Raji

“…Histopathological examination and immunohistochemistry confirmed SPN without evidence of malignancy. Discussion. SPN is known as a tumor with a favorable prognosis and a long survival rate after complete resection. …”
Get full text

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases by Maria H. Madeira, Raquel Boia, Paulo F. Santos, António F. Ambrósio, Ana R. Santiago

“…One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. …”
Get full text

Probiotics to Prevent the Need for, and Augment the Use of, Antibiotics by Gregor Reid

“…The timing of resurgent interest in this ancient field coincides with the need to augment or replace antibiotics whose side effects are unwelcome and whose efficacy is diminishing due to drug resistance. Evidence that probiotic strains can act as adjuncts to antibiotic therapy by reducing adverse effects, improving antibiotic function and enhancing mucosal immunity is mounting. …”
Get full text

The Association Between Functional Movement Screen Scores and Knee Valgus Moments During Unplanned Sidestep Cutting in Netball by Desmond Boey, Marcus Lee

“…This suggests that the FMS™ has limited utility in screening for non-contact ACL injury risks during USC. # Level of Evidence 3…”
Get full text

Sirtuin 1: A Dilemma in Transplantation by Sara Assadiasl, Nuala Mooney, Bahareh Mohebbi, Yousef Fatahi, Narjes Soleimanifar

“…Moreover, despite the findings of sirtuin 1 implication in thymic tolerance induction and T regulatory (Treg) cells survival, there is also evidence for its involvement in Treg suppression and in T helper 17 cells differentiation. …”
Get full text

Teenagers and new media technologies: Gratifications obtained as a factor for adoption by Theodora Dame Adjin-Tettey

“…With the aid of the stratified sampling technique, 300 students of two senior high schools in the Greater Accra region of Ghana, representing 10% of the total population, were recruited to take part in a study to explore whether there would be substantial empirical evidence to support the stance that gratifications obtained could potentially account for teenagers’ adoption of new media technologies. …”
Get full text

Shared decision making embedded in the undergraduate medical curriculum: A scoping review. by Marie-Anne Durand, Peter R DiMilia, Julia Song, Renata W Yen, Paul J Barr

“…<h4>Objective</h4>Shared decision making (SDM) training is shown to be effective and is increasingly embedded in continuing medical education. There is little evidence, however, about undergraduate medical education for SDM. …”
Get full text

Morphology and multigene phylogeny revealed four new species of Geastrum (Geastrales, Basidiomycota) from China by Xin Yang, Yonggao Zhu, Songjing Duan, Xingxing Wu, Changlin Zhao

“…In the present study, four new species, Geastrum artocarpicola, G. fibulatum, G. sinense and G. trachelium collected from China, are proposed based on a combination of morphological characteristics and molecular evidence. Geastrum artocarpicola is characterized by shallowly saccate to deep saccate exoperidium, bubble-shaped to flask shaped basidia, spherical basidiospores. …”
Get full text

2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks by Jinah Park, Sunmi Lee, Sanghyuk Lee, Sang Won Kang

“…These enzymes distribute throughout the cellular compartments and, therefore, are thought to be broad-range antioxidant defenders. However, recent evidence demonstrates that typical 2-Cys peroxiredoxins play key signal regulatory roles in the various signaling networks by interacting with or residing near a specific redox-sensitive molecule. …”
Get full text