Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature by Cristina Dumitrescu, Dominique Lossignol

“…After five doses of IT trastuzumab, at escalading doses, once weekly, the patient's neurological status stabilised, and that result was maintained for two months. There is evidence in the literature that breast cancer receptor status may change over time, and when it occurs, it may modify the therapeutical approach. …”
Get full text

Treatment Dilemmas in a Young Man Presenting with Narcolepsy and Psychotic Symptoms by Victoria Fernandez, Sharon Davies, Nicola Walters

“…Our report illustrates the relevance of a thorough differential diagnosis as well as the need to explore treatment avenues based on the evidence available for both narcolepsy and psychosis symptoms to try and maximise the therapeutic impact.…”
Get full text

Mystery flu-like outbreak raises another alarm in Congo: The next disease X? by Pawan Kumar, Shubham Kumar, Rachana Mehta, Ranjana Sah

Get full text

The Non-Existent May Cycle: Methods, Colonial Texts and Epigraphy by Péter Bíró

“…Current ideas based on such a model should therefore be re-examined in light of these findings and other evidence should be used in order to prove their plausibility.…”
Get full text

Measuring Quality in Emergency Medical Services: A Review of Clinical Performance Indicators by Mazen J. El Sayed

“…The different types of performance indicators, the advantages and limitations of each type, and the evidence-based prehospital clinical bundles are discussed. …”
Get full text

Ribosomal Alteration-Derived Signals for Cytokine Induction in Mucosal and Systemic Inflammation: Noncanonical Pathways by Ribosomal Inactivation by Yuseok Moon

“…In the present study, ribosomal inactivation-related modulation of cytokine production was reviewed in leukocyte and epithelial pathogenesis models to characterize mechanistic evidence of ribosome-derived cytokine induction and its implications for potent therapeutic targets of mucosal and systemic inflammatory illness, particularly those triggered by organellar dysfunctions.…”
Get full text

Cerebellar Involvement in Clumsiness and Other Developmental Disorders by Richard B. Ivry

“…Cerebellar abnormalities have been linked to a number of developmental disorders. Much evidence is based on the analysis of highresolution MRI scans. …”
Get full text

Ethics and Institutions of Scientific Policy Advice by Überblick

“…In addition, progress in empirical economics has strengthened the demand for “evidence-based policy advice”. What incentives do scientists have to participate in the policy discourse and what scientific ethos should they follow? …”
Get full text

Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin by Michela Guglielmotto, Elena Tamagno, Oliviero Danni

“…Here we review the role of the release of reactive oxygen species (ROS) by the mitochondrial electron chain in response to hypoxia, providing evidence that hypoxia fosters the amyloidogenic APP processing through a biphasic mechanism that up-regulates β-secretase activity, which involves an early release of ROS and an activation of HIF-1α.…”
Get full text

Les trames vertes pour les citadins : une appropriation contrastée à Marseille, Paris, Strasbourg by Sandrine Glatron, Étienne Grésillon, Nathalie Blanc

“…The debates between the participants allowed us to evidence that what they imagine is part of an environmental esthetic and reveals a relationship with nature which are different from one town to another. …”
Get full text

Outposts. Design inventories for a possible future between biology and the artefact by Vincenzo Moschetti

“…The essay makes use of the examples offered by Giorgini’s Casa Esagono in Baratti and Perugini’s Casa Albero in Fregene, together with the more recent Horizontal Skyscraper by Herzog & de Meuron, to manifest a preferable advance, parallel to that of forests which, according to the evidence available, will continue to expand in the future and within which it is desirable, if not necessary, to ‘work’ using the figure of the outpost.…”
Get full text

New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary Disease by Jordan A Guenette

“…Despite this viewpoint, there is emerging clinical and physiological evidence of peripheral airway dysfunction, diminished quality of life and reduced physical activity levels, and increased mortality, hospitalizations, dyspnea and exercise intolerance in patients with mild COPD compared with healthy controls. …”
Get full text

Implementing Learner Experience Design in University Teaching by Christian Rogers

“…It shares observations collected from workshop participants that indicate not only evidence of intended innovative curricular enhancements, but an unanticipated increase in student-teacher connection and motivation. …”
Get full text

Integrative systematics with structural monophyly and ancestral signatures: Chionoloma (Bryophyta) by Richard Zander

“…The methods include second-order morphological Markov chains, Shannon–Turing sequential Bayes statistical support, and multi-node molecular evidence of ancestry. This study is based on data and revisionary results from the original studies by other authors and from the study of herbarium specimens of authentic material. …”
Get full text

Effective Attentional Focus Strategies after Anterior Cruciate Ligament Reconstruction: A Commentary by Harjiv Singh, Alli Gokeler, Anne Benjaminse

“…The purpose of this commentary is to provide a clinical framework for the application of attentional focus strategies and guide clinicians towards effectively utilizing an external focus of attention in rehabilitation after ACLR. # Level of Evidence 5…”
Get full text

The acquisition of rhotics in onset clusters in L2 Spanish by Carolina González, Christine Weissglass

“…The comparison of rhotic manner, duration, and svarabhakti vowel occurrence shows partial evidence of English transfer in the L2 group, since fricative, retroflex approximant and coarticulated variants, common in English, account for almost 40% of realizations. …”
Get full text

The Role of Gut Microbiota in Hypertension Management - A Review by Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej

“…Animal studies using fecal microbiota transplantation (FMT) have provided strong evidence for a causal role of gut microbiota in blood pressure regulation. …”
Get full text

Estimated baseline density of a spotted hyaena population in a post-war landscape by Willem D. Briers-Louw, Tamar A. Kendon, Matthew S. Rogan, Alison J. Leslie, Drew Bantlin, Emma Evers, David Gaynor, Peter Lindsey, João Almeida, Vincent N. Naude

“…The spotted hyaena Crocuta crocuta is relatively understudied across its range despite evidence of widespread declines. It is therefore essential that robust baseline population density assessments are conducted to inform current management and future conservation policy. …”
Get full text

Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study by Wang YP, Wei HX, Hu YY, Zhang C, Niu YM

“…Yu-Pei Wang,1,* Hui-Xia Wei,2,* Yuan-Yuan Hu,3 Chao Zhang,4 Yu-Ming Niu3– 5 1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 2Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 3Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China; 4Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 5Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yu-Ming Niu, Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China, Tel +86 13581370999, Email niuyuming@yeah.net Chao Zhang, Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China, Email zhangchao0803@126.comObjective: Patients with obstructive sleep apnea (OSA) frequently suffer from migraine, however the causal relationship between OSA and migraine is unknown. …”
Get full text

ASA Class Is a Stronger Predictor of Early Revision Risk Following Primary Total Knee Arthroplasty than BMI by Christopher J. Wall, MBBS, BMedSc, FRACS, FAOrthA, Richard N. de Steiger, MBBS, PhD, DipBiomech, FRACS, FAOrthA, Christopher J. Vertullo, MBBS, PhD, FRACS, FAOrthA, Dylan Harries, BSc(Hons), MBiostat, PhD, Srinivas Kondalsamy-Chennakesavan, MBBS, MPH, FRSPH

“…Patients with poorly controlled comorbidities should be referred for medical optimization prior to TKA. Level of Evidence:. Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.…”
Get full text