Playful brains: a possible neurobiological pathway to cognitive health in aging by Yulia Golland, Yulia Golland, Boaz M. Ben-David, Boaz M. Ben-David, Boaz M. Ben-David, Mara Mather, Mara Mather, Mara Mather, Shoshi Keisari, Shoshi Keisari, Shoshi Keisari

“…Social playfulness, characterized by spontaneity and mutual enjoyment, allows individuals to step away from routine roles and engage in novel and surprising exchanges. Emerging evidence suggests that social playfulness is a promising approach for supporting cognitive functions in aging in a joyful and engaging way. …”
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Beta-hydroxy-beta-methyl butyrate supplementation in critically ill patients: a systematic review and meta-analysis of randomized controlled trials by Yu Ren, Ya-Bei Gao, Da-Xing Yu, Hui-Bin Huang

“…BackgroundBeta-hydroxy-beta-methylbutyrate (HMB) is beneficial for restoring muscle mass. However, the evidence supporting its use in critically ill patients remains unclear. …”
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Electroacupuncture for mild-to-moderate dry eye: study protocol for a multicentre, randomised, single-blind, sham-controlled trial by Yue Zhao, Guang Yang, Yun-Qiong Lu, Mei-Yan Li, Jue Hong, Yan-Ting Yang, Xue-Jun Wang, Xie-He Kong, Zhao Ma, Xin-Yun Huang, Yue-Lan Zou, Xing-Tao Zhou, Xiao-Peng Ma

“…We aim to provide solid clinical evidence for the EA treatment of DE.Methods and analysis This is a multicentre, randomised, sham-controlled trial. …”
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Impact of English proficiency on use of Glasgow Coma Scale in geriatric patients with traumatic brain injury by Veronica Layrisse-Landaeta, Gabriela R Dincheva, Shahenda Khedr, Andrew Geng, Michele Schombs, Kazi Maisha, Steven Y Chao, Chun-Cheng Chen

“…Moreover, GCS remained effective for predicting ICH in LEP individuals, highlighting its value with suitable translation resources.Level of evidence This is a Level III evidence restrospective comparative study.…”
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The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases by Rojin Sarallah, Shima Jahani, Alireza Soltani Khaboushan, Amir Kian Moaveni, Maryam Amiri, Masoumeh Majidi Zolbin

“…This review explores the role of this axis in the pathogenesis of CI across these neurodegenerative diseases, synthesizing current evidence and its implications for targeted therapies. …”
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Comparative efficacy of acupuncture therapies in premature ovarian failure: A systematic review and network meta-analysis by Yonghang Yi, Fengjun Ma, Yang Jiao, Rongqi Zhang, Yunhao Yi, Yuxia Ma

“…However, severe methodological constraints, such as insufficient randomization and a lack of blinding, may reduce trust in these results. To offer robust evidence, high-quality RCTs must overcome these limitations. …”
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Effect of Low-Load Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction: A Systematic Review by Baris B. Koc, Alexander Truyens, Marion J.L.F. Heymans, Edwin J.P. Jansen, Martijn G.M. Schotanus

“…However, more randomized controlled trials with standardized intervention protocols and outcome measurements are needed to add evidence on the clinical value of LL-BFR training. # Level of evidence 2a…”
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Heterogeneous Acupuncture Effects of Taixi (KI3) on Functional Connectivity in Healthy Youth and Elder: A Functional MRI Study Using Regional Homogeneity and Large-Scale Functional... by Linlu He, Guangxiang Chen, Ruwen Zheng, Yan Hu, Xiu Chen, Jianghai Ruan

“…Our study led to converging evidence supporting the acupuncture effect segregation of different condition subjects and supporting evidence for prevention and treatment with acupuncture in the future.…”
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Modular-based psychotherapy (MoBa) versus cognitive–behavioural therapy (CBT) for patients with depression, comorbidities and a history of childhood maltreatment: study protocol fo... by Elisabeth Schramm, Martin Hautzinger, Carolin Jenkner, Moritz Elsaesser, Sabine Herpertz, Hannah Piosczyk

“…According to a specific questionnaire-based treatment algorithm, elements from cognitive behavioural analysis system of psychotherapy, mentalisation-based psychotherapy and/or mindfulness-based cognitive therapy are integrated for a personalised modular procedure.As a proof of concept, this trial will provide evidence for the feasibility and efficacy (post-treatment and 6-month follow-up) of a modular add-on approach for patients with depression, comorbidities and a history of childhood maltreatment. …”
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The Impact of Chronic Pelvic Pain and Bowel Morbidity on Quality of Life in Cervical Cancer Patients Treated With Radio (Chemo) Therapy. A Systematic Literature Review by Natuhwera G, Ellis P

“…However, the treatments often result in adverse events, mainly chronic pelvic pain and bowel morbidity, which can negatively impact quality of life.Aim: To systematically appraise peer reviewed evidence regarding chronic pelvic pain and bowel morbidity and their impact on quality-of-life of cervical cancer patients treated with radiotherapy with or without chemoradiation therapy.Design: A systematic review of original peer-reviewed research evidence.Data Collection Methods and Tools: A systematic search conducted between April and May 2021, and updated in September 2024, using PubMed, Hinari, CINAHL and Google Scholar, for peer reviewed papers published between 2008 and 2019. …”
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Exploring manual therapy in the management of irritable bowel syndrome in adults: A scoping review by Natalia Płóciennik-Korycka, Sara Maria Pani, Bogumiła Bruc, Paolo Contu, Magdalena Wrzesińska

“…However, no comprehensive review has assessed the evidence for MT in treating IBS. Objective: The objective of this review is to identify and map the available evidence on the effects of various manual therapy (MT) techniques on the biopsychosocial functioning, well-being, and QoL of individuals with irritable bowel syndrome (IBS). …”
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The Genetic Expression Difference of A2058 Cells Treated by Plasma Direct Exposure and Plasma-Treated Medium and the Appropriate Treatment Strategy by Chao-Yu Chen, Chung-Hsien Chou, Yun-Chien Cheng

“…To achieve better therapeutic effects and selectivity, more evidence is necessary to find optional plasma treatments.…”
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The clinical efficacy of scalp acupuncture for tinnitus: A systematic review and meta-analysis by Jiadi Chen, Ruizhi Jing

“…However, the current evidence is limited due to potential biases and heterogeneity across studies.Future studies should standardize protocols, ensure higher methodological rigor, and explore long-term effects to validate the findings further.The review was registered with PROSPERO (CRD42024537806):Jiadi Chen, Ruizhi Jing.Analysis of clinical effect of scalp acupuncture on tinnitus. …”
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Implications of cytokine genes polymorphisms in Jordanian patients with obsessive compulsive disorder by Ahmad M. Khalil, Manal W. Khrais, Khaled M. Al-Qaoud, Mohamad Y. Al Ta’any

“…There is substantial evidence that immune system and genetic changes are involved in OCD pathogenesis. …”
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Don’t assume, ask! A focus group study on end-of-life care planning with people with intellectual disabilities from minoritised ethnic groups by Andrea Bruun, Leon Jordan, Jo Giles, Rhidian Hughes, Rebecca Anderson-Kittow, Irene Tuffrey-Wijne

“…Abstract Background People with intellectual disabilities are less likely to have access to palliative care, and the evidence shows that their deaths are often unanticipated, unplanned for, and poorly managed. …”
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Understanding the implementation strategy of a secondary care tobacco addiction treatment pathway (the CURE project) in England: a strategic behavioural analysis by Matthew Evison, Anna Haste, Catherine Haighton, Freya Howle, Angela M Rodrigues, Angela Wearn, Verity Mallion

“…Objectives The Conversation, Understand, Replace, Experts and evidence-based treatment (CURE) project implemented an evidence-based intervention that offers a combination of pharmacotherapy and behavioural support to tobacco-dependent inpatients. …”
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Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them by Philip Smith, Stuart Bloom, Christian Selinger, Ailsa Hart, Christopher Lamb, Anjan Dhar, Helen Steed, Matthew Brookes, Jonathan Macdonald, Ian Arnott, Shellie Radford, Gordon W Moran, Susan Ritchie, Victoria Fletcher, Jonathan Segal, N Sharma, Shahida Din, Daniel Gaya, J Butterworth, S Andrews, P Adams, Deborah Morris, Pearl Avery, Philip Oppong, Mario Guslandi, Maro Kyriacou, Rachel Linger, Madhoor Ramdeen, John Appleton, John Anneh, B Kussel

“…Currently, there is limited research and evidence-based guidance, resulting in many patients living with the symptomatic burden of disease and reduced quality of life. …”
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Impact of “Enhanced Recovery After Surgery” (ERAS) protocols vs. traditional perioperative care on patient outcomes after colorectal surgery: a systematic review by Vaishnavi Kannan, Najeeb Ullah, Sunitha Geddada, Amir Ibrahiam, Zahraa Munaf Shakir Al-Qassab, Osman Ahmed, Iana Malasevskaia

“…This systematic review was designed to investigate the evidence-based literature pertinent to comparing patient outcomes after ERAS versus conventional perioperative care. …”
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Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis by Ritin Fernandez, Heidi Green, Arti Muley, Prasad Muley

“…Multicentre well-designed RCT with higher doses of thiamine and a follow-up period of 1–2 years will provide better evidence.PROSPERO registration number CRD42020170520.…”
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810-nm Photobiomodulation Evokes Glutamate Release in Normal and Rotenone-Dysfunctional Cortical Nerve Terminals by Modulating Mitochondrial Energy Metabolism by Silvia Ravera, Elisa Farsetti, Guido Maura, Manuela Marcoli, Matteo Bozzo, Chiara Cervetto, Andrea Amaroli

“…The dysfunction of mitochondria, the primary source of cellular energy and producer of reactive oxygen species (ROS), is associated with brain aging and neurodegenerative diseases. Scientific evidence indicates that light in the visible and near-infrared spectrum can modulate mitochondrial activity, a phenomenon known in medicine as photobiomodulation therapy (PBM-t). …”
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