Efficacy and safety of anti-thrombotic therapy after surgical mitral valve repair: a scoping review by Jian Ye, Jenny Chen, Hazal Ece Babadagli, Ricky Turgeon, Erica HZ Wang

“…We proposed a study design for a pragmatic RCT that addresses prior study limitations and that could provide definitive evidence to guide anti-thrombotic management in MVr patients.…”
Get full text

Metformin for neurocognitive dysfunction in schizophrenia: a systematic review by Zhen-Juan Qin, Zhan-Ming Shi, Li-Juan Li, Xin Wei, Hui-Lin Hu, Wei Wei, Zhi-Yuan Xie, Hang-Xi Ji, Yu-Hua Wei, Wei Zheng, Wei Zheng

“…Other adverse events and discontinuation rates were comparable between groups.ConclusionPreliminary evidence suggests that metformin may improve neurocognitive function in schizophrenia. …”
Get full text

What can qualitative research do for randomised controlled trials? A systematic mapping review by J Hewison, A O'Cathain, A Rudolph, K J THOMAS, S J Drabble

“…Researchers can increase the impact of this work on trials by undertaking more of it at the pretrial stage and being explicit within their articles about the learning for trials and evidence-based practice.…”
Get full text

Overview of styles, content, learning effects and attitudes of students towards digitally enhanced physiotherapy education – a scoping review by Larissa Pagels, Oskar Schindler, Kerstin Luedtke

“…Outcome measures included knowledge, performance, perception, satisfaction, and attitudes. Most sources of evidence reported positive impacts of digitally enhanced education, particularly in knowledge transfer and skill performance. …”
Get full text

Effectiveness of Scapular Stabilization Versus Non-Stabilization Stretching on Shoulder Range of Motion, a Randomized Clinical Trial by Alan J Howell, Andrew Burchett, Nicholas Heebner, Cody Walker, Alec Baunach, Asia Seidt, Tim L Uhl

“…Stretching interventions improved range of motion but had limited effect on shoulder pain. # Level of Evidence 2…”
Get full text

Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database by Go Anan, Daisuke Kikuchi, Kenji Omae, Takuo Hirose, Kouji Okada, Takefumi Mori

“…Guidelines for the proper use of SGLT2 inhibitors recommend caution regarding urinary tract infections (UTIs). However, little evidence has been reported on the relationship between SGLT2 inhibitors and UTIs in large epidemiological studies. …”
Get full text

Ferroptosis triggers mitochondrial fragmentation via Drp1 activation by Lohans Pedrera, Laura Prieto Clemente, Alina Dahlhaus, Sara Lotfipour Nasudivar, Sofya Tishina, Daniel Olmo González, Jenny Stroh, Fatma Isil Yapici, Randhwaj Pratap Singh, Nils Grotehans, Thomas Langer, Ana J. García-Sáez, Silvia von Karstedt

“…Yet, how this is regulated and whether it is involved in ferroptotic cell death has remained unexplored. Here, we provide evidence that Drp1 is activated upon experimental induction of ferroptosis and promotes cell death execution and mitochondrial fragmentation. …”
Get full text

மலரும் சருகும் நாவலில் நாடார் மக்களின் இனவரைவியல் / Ethnography of Nadar People in the Novel Malarum Sarugum... by ஜோ. கிளம்மி ஜெனி பிரியா / J. Clemy Jeni Priya

“…Sangam literature is evidence of the cultural, historical, political, linguistic and ethnographic truth of Tamil society. …”
Get full text

The Efficacy of the Mulligan Concept to Treat Meniscal Pathology: A Systematic Review by Nathan C. Reep, Sydney N. Leverett, Rebecca M. Heywood, Russell T. Baker, Darren L. Barnes, Scott W. Cheatham

“…# Background Meniscal pathologies are common knee injuries and arthroscopic surgery is the current accepted gold standard for treatment. However, there is evidence to support the use of the Mulligan Concept (MC) Mobilization with Movement (MWM) for meniscal pathologies including the 'Squeeze' technique, tibial internal rotation (IR), and tibial external rotation (ER)…”
Get full text

Characteristics of knowledge translation platforms and methods for evaluating them: a scoping review protocol by Taryn Young, Bey-Marrié Schmidt, Sara Cooper, Nasreen S Jessani

“…Introduction Knowledge translation platforms (KTPs) are intermediary organisations, initiatives or networks whose intent is to bridge the evidence into action divide. Strategies and tools include collaborative knowledge production, capacity building, information exchange and dialogue to facilitate relevant and timely engagement between researchers and decision-makers and other relevant stakeholders. …”
Get full text

Shared perceptions of flavored cigarette pack design among young adults who smoke in Mexico and the Philippines by Graziele Grilo⁺, Jennifer L. Brown⁺, Joanna E. Cohen, Katherine Clegg Smith

“…Therefore, jurisdictions might use evidence from other jurisdictions to support the implementation of evidence-based tobacco control policies. …”
Get full text

Implementing psychosocial interventions for teachers' mental health: Protocol for integrating scoping review with teachers lived experiences in LMICs. by Kanika Malik, Sadananda Reddy, Yasmine A Shilla, Aditi Khanna, Ranya R Kaurr, Abbey Boban

“…Despite the availability of various psychosocial interventions, comprehensive evidence of their effectiveness and implementation is limited for this occupational group, especially in low- and middle-income countries (LMICs). …”
Get full text

Fever and infections in surgical intensive care: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document by Deborah M Stein, Hee Soo Jung, Lisa M Kodadek, Bryce Robinson, Aussama Khalaf Nassar, Joseph Cuschieri, Michael Steven Farrell, Abhijit Pathak, Samuel Mandell, Jasmeet Paul, Rachel D Appelbaum, Eden Nohra, Thomas Carver, Jordan Michael Kirsch

“…Fever can be infectious or non-infectious; it is important to distinguish between the two entities wherever possible. The evidence is growing for shortening the duration of antibiotic treatment of common infections. …”
Get full text

DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…Chemotherapy remains the primary treatment option, yet TNBC frequently develops resistance, leading to relapse and metastasis. Emerging evidence highlights the potential of combining DNA methylation inhibitors with immune checkpoint inhibitors (ICIs). …”
Get full text

The contribution of leaders' and managers' attributes, values, principles, and behaviours to the sustainable implementation of Lean in healthcare: A realist review protocol [versio... by Seán Paul Teeling, Anne Marie Keown, Martin McNamara

“…Following the RAMESES guidelines, a five-stage structured methodology will be used: defining the scope of the review and developing initial theories, developing the search strategy, reviewing primary studies and extracting data, synthesising evidence and developing conclusions, refining theory iteratively, and disseminating findings. …”
Get full text

The Rise of Transradial Artery Access for Percutaneous Coronary Intervention in Patients with Acute Coronary Syndromes in Australia by Ryan James Ocsan, Ata Doost, Paul Marley, Ahmad Farshid

“…Over the last decade, evidence for the benefit of TRA for PCI has grown, leading to a steady uptake of TRA around the world. …”
Get full text

Risks to human and animal health from the presence of bromide in food and feed by EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Villa, Holger Zorn, Vasileios Bampidis, Jacqueline Castenmiller, Marie‐Christine Chagnon, Bruce Cottrill, Keyvin Darney, Jürgen Gropp, Secundino Lopez Puente, Martin Rose, Marco Vinceti, Maria Bastaki, Petra Gergelová, Luna Greco, Matteo Lorenzo Innocenti, Judit Janossy, Anna Lanzoni, Andrea Terron, Diane Benford

“…The TDI and ARfD are considered as conservative with 90% certainty. Insufficient evidence related to the toxicological effects of bromide was available for animals, with the exception of dogs. …”
Get full text

What are the problems and suggestions related to cancer health education in Sichuan, China? A qualitative study of community health workers (CHWs) by Zhonghua Yang, Qingqing Wang, Fang Yi, Linglin Zhang, Yuting Li, Lilou Rong, Shaoping Wan

“…Abstract Background Health education conducted by community health workers (CHWs) is an evidence-based strategy for promoting cancer prevention, cancer screening, and adherence to medical guidance from doctors. …”
Get full text

Protocol for a meta-review of interventions to prevent and manage ICU delirium by Andrew Booth, Maria Pufulete, Ben Gibbison, Burak Kundakci, Katherine Louise Jones

“…They will also form part of an evidence map and logic model for the prevention and management of ICU delirium.PROSPERO registration number CRD42023473260…”
Get full text

The Effect of Occupational Engagement on Lifestyle in Adults Living with Chronic Pain: A Systematic Review and Meta-analysis by Svetlana Solgaard Nielsen, Søren T. Skou, Anette Enemark Larsen, Alessio Bricca, Jens Søndergaard, Jeanette Reffstrup Christensen

“…The overall certainty of the evidence was deemed low. Conclusion. Including occupational engagement in chronic pain interventions may increase short-term physical activity and long-term sleep quality. …”
Get full text