Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia by David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó

“…However, several lines of evidence from animal models have indicated the efficiency of mGluR2/3 PAMs. …”
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Do global health networks facilitate innovation, learning and sharing? A qualitative analysis of the Quality-of-Care Network in Bangladesh, Ethiopia, Malawi, and Uganda. by Kondwani Mwandira, Seblewengel Lemma, Albert Dube, Kohenour Akter, Asebe Amenu Tufa, Agnes Kyamulabi, Gloria Seruwagi, Catherine Nakidde, Kasonde Mwaba, Nehla Djellouli, Charles Makwenda, Tim Colbourn, Yusra Ribhi Shawar

“…Nevertheless, there was evidence that QCN improved their functionality. We provide evidence of how learning, sharing, and innovation among and within countries can be fostered for improving maternal and child health; and limitations. …”
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A realist evaluation to explain and understand the role of paramedics in primary care by Georgette Eaton, Geoff Wong, Stephanie Tierney, Veronika Williams, Kamal R. Mahtani

“…Conclusions Our realist evaluation used a mixed-method approach to present empirical evidence of the role of paramedics in primary care. …”
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Decoding CKD-induced muscle atrophy through the critical role of lncRNA GAS5 and pyroptosis by Rong Huang, Xinying Tang, Shuang Liu, Lijing Sun

“…Our findings provide new evidence for GAS5’s role in regulating cellular pyroptosis in CKD-induced skeletal muscle atrophy.…”
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Fate and long-lasting therapeutic effects of mesenchymal stromal/stem-like cells: mechanistic insights by Akram Hoseinzadeh, Seyed-Alireza Esmaeili, Reza Sahebi, Anahita Madani Melak, Mahmoud Mahmoudi, Maliheh Hasannia, Rasoul Baharlou

“…Abstract A large body of evidence suggests that mesenchymal stromal cells (MSCs) are able to respond rapidly to the cytokine milieu following systemic infusion. …”
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Missing The Forest For The Trees: A Lack Of Upper Extremity Physical Performance Testing In Sports Physical Therapy by Matthew L Gauthier, Casey A Unverzagt, Luciana De Michelis Mendonça, Amee L Seitz

“…These outcomes may be driven by the absence of evidence-informed testing to determine an athlete's readiness for sport…”
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Upstream interventions to promote oral health and reduce socioeconomic oral health inequalities: a scoping review protocol by Richard G Watt, Eleanor R Dawson, Michelle Stennett, Blánaid Daly, Lorna M D Macpherson, Paul Cannon

“…Furthermore, there is little evidence on the effectiveness, impact and sustainability of upstream interventions that have focused on oral health and wider public health measures that impact on oral health. …”
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Multisectoral actions in primary health care: A realist synthesis of scoping review. by Resham B Khatri, Daniel Erku, Aklilu Endalamaw, Eskinder Wolka, Frehiwot Nigatu, Anteneh Zewdie, Yibeltal Assefa

“…<h4>Methods</h4>We reviewed published evidence that reported the MSAs, PHC and UHC. The keywords used in the search strategy were built on these three key concepts. …”
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First identification of a Neanderthal bone spear point through an interdisciplinary analysis at Abric Romaní (NE Iberian Peninsula) by Paula Mateo-Lomba, Andreu Ollé, Juan Luis Fernández-Marchena, Palmira Saladié, Juan Marín, M. Gema Chacón, Josep Vallverdú, Isabel Cáceres

“…Through an interdisciplinary, multi-technique, and multi-scale approach combining technology, taphonomy, and functional analysis, compelling evidence for manufacture, use, and hafting was uncovered. …”
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Taking stock of vaccine hesitancy among migrants: a scoping review protocol by Charles S Wiysonge, Sten H Vermund, Akhenaten Siankam Tankwanchi, Anelisa Jaca, Heidi J Larson

“…Findings will be reported through summary narratives, tables, flowcharts and evidence maps.Ethics and dissemination This review is exempted from ethical approval and will be published in a peer-reviewed open-access journal to ensure wide dissemination.…”
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The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones by Marcello Maggio, Francesca De Vita, Alberto Fisichella, Fulvio Lauretani, Andrea Ticinesi, Graziano Ceresini, Anne Cappola, Luigi Ferrucci, Gian Paolo Ceda

“…Although RCTs have shown beneficial effects, stronger for testosterone and the GH-IGF-1 axis and less evident for thyroid hormones, in improving different hematological parameters, there is no clear evidence for the usefulness of hormonal treatment in improving anemia in older subjects. …”
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Immunosuppression for adult steroid-dependent or frequently relapsing nephrotic syndrome: A systematic review and meta-analysis. by Zhi Yong Wong, Chiu Yee Teo, Yan Qi Fiona Wong, Ka Ting Ng, Soo Kun Lim

“…<h4>Objective</h4>There is limited evidence on which immunosuppressive agents produce the best outcomes for adult patients with steroid-dependent or frequently relapsing nephrotic syndrome (SDNS/FRNS). …”
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Iron deficiency and fatigue in inflammatory bowel disease: A systematic review. by Stephanie Sartain, Maryam Al-Ezairej, Martin McDonnell, Catherine Westoby, Vasiliki Katarachia, Stephen A Wootton, J R Fraser Cummings

“…This systematic review examined the evidence of whether iron deficiency, with or without anaemia, was associated with fatigue in IBD. …”
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Atypical Femoral Fracture in Hypophosphatasia: A Systematic Review by Nipith Charoenngam, Jerapas Thongpiya, Pitchaporn Yingchoncharoen, Ben Ponvilawan, Mehmet S. Marangoz, Jirat Chenbhanich, Patompong Ungprasert

“…Based on the limited evidence, AFF occurred in up to 10% of patients with HPP. …”
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Spinal Instrumentation in the Setting of Nontuberculous Spondylodiscitis: A Prospective Analysis by Himanshu Prasad, P. V. Satyanarayana Murthy, Vamsi K Varma, A. V. Gurava Reddy

“…Microbiological details of each patient were noted. Radiological evidence of healing was reported at the final 1-year follow-up. …”
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Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management by Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou, Nikolaos Sofikitis, Michael Chrisofos

“…This narrative review integrates current evidence from in vitro studies, animal models, and clinical research to clarify the roles of PDEs in effecting the male reproductive tract, with an emphasis on the mechanistic pathways underlying cyclic nucleotide signaling, the cellular specificity of PDE isoform expression, and the effects of PDE5 inhibitors on Leydig and Sertoli cell functions. …”
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Nutritional care for children with feeding difficulties and disabilities: A scoping review. by Alyssa Klein, Malia Uyehara, Andrew Cunningham, Madina Olomi, Kristen Cashin, Catherine M Kirk

“…The review found insufficient policies, programs, and evidence to support children with feeding difficulties and disabilities and their families. …”
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Sensory substitution and augmentation techniques in cerebral visual impairment: a discussion of lived experiences by Stephanie L. Duesing, Katie Lane-Karnas, Sebastian James Adam Duesing, Mae Lane-Karnas, Nai Y, Arvind Chandna, Arvind Chandna

“…Pediatric vision loss due to cerebral visual impairment (CVI) is an urgent public health issue, demanding evidence-based (re)habilitation and educational strategies. …”
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Moments that matter: childhood pain treatment shapes pain for life—we can do better every time in every child by Rebeccah Slater, Suellen Walker, Christopher Eccleston, Carlo Bellieni, Tanvi Hirekodi, Ricardo Carbajal, Lucinda Smart, William Laughey, Maria M. Cobo, Stefan Friedrichsdorf

“…Every child has the right to expect pain relief, and we have evidence-based tools to reduce needle procedure-related pain. …”
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Health inequalities for older people from minority ethnic groups receiving palliative care and end of life care: A scoping review protocol. by Narin Aker, Rachael Frost, Kate Walters, Emily West, Nathan Davies

“…The results of this review will be shared with stakeholders and will provide evidence-based recommendations for inclusive palliative and end of life care.…”
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