Radiotherapy for Melanoma: More than DNA Damage by Susanne J. Rogers, Emsad Puric, Brigitte Eberle, Niloy R. Datta, Stephan B. Bodis

“…Despite its reputation as a radioresistant tumour, there is evidence to support a role for radiotherapy in patients with melanoma and we summarise current clinical practice. …”
Get full text

ENDOSCOPIC SURGERY FOR TREATING SPINAL STENOSIS: AN INTEGRATIVE REVIEW OF RANDOMIZED CLINICAL TRIALS by Rafael Augusto da Silva Aparício, Rodrigo Freitas Maringoni de Oliveira, Felipe de Almeida Pinto, Carlos Gorios, Lorran Azevedo Zanon, Alessandra Masi

“…Conclusion: The reviewed studies showed that endoscopic surgery to correct spinal stenosis could offer adequate decompression of neural elements, resulting in shorter hospital stays, faster recovery and favorable operative results. Level of Evidence IV, evidence from descriptive (non-experimental) or qualitative studies.…”
Get full text

From fangs to antidotes: A scoping review on snakebite burden, species, and antivenoms in the Eastern Mediterranean Region. by Ali Alshalah, David J Williams, Alessandra Ferrario

“…<h4>Background</h4>Snake bites cause considerable morbidity and mortality worldwide, yet evidence from low- and middle-income countries remains fragmented. …”
Get full text

Venüs Heykelciklerinden İdollere Kadın Temsilleri by Tülin CENGİZ

“…When we trace back to the past on the issue of women, the earliest evidence that archaeology encountered are the Venus figurines from the Upper Paleolithic Period. …”
Get full text

Tumor-Associated Mast Cells in Thyroid Cancer by Carla Visciano, Nella Prevete, Federica Liotti, Gianni Marone

“…There is compelling evidence that the tumor microenvironment plays a major role in mediating aggressive features of cancer cells, including invasive capacity and resistance to conventional and novel therapies. …”
Get full text

Coronary Microvascular Dysfunction: Insights on Prognosis and Future Perspectives by Filippo Luca Gurgoglione, Giorgio Benatti, Andrea Denegri, Davide Donelli, Marco Covani, Mattia De Gregorio, Gabriella Dallaglio, Rebecca Navacchi, Giampaolo Niccoli

“…This review aims to elucidate briefly the pathogenesis and diagnostic modalities of CMD and to shed light on contemporary evidence on the prognostic impact of CMD. Finally, we will provide an overview of novel emerging therapeutic strategies for CMD.…”
Get full text

A Comparative Systematic Review of the Optimal CD4 Cell Count Threshold for HIV Treatment Initiation by Babatunde Olubajo, Kathryn Mitchell-Fearon, Oluseye Ogunmoroti

“…This systematic review provides an evidence-based comparison of starting treatment at >500 cells/μL with starting treatment at the range between 350 cells/μL and 500 cells/μL. …”
Get full text

Efficacy and Safety of Iguratimod for the Treatment of Rheumatoid Arthritis by Jiangtao Li, Hejuan Mao, Yan Liang, Yanrong Lu, Shuo Chen, Nanping Yang, Guixiu Shi

“…The Review Manager software was used for meta-analysis to assess risk bias of the studies included, and GRADE profiler software was used for the evidence quality of the studies included. Four RCTs involving 1407 patients with RA were included. …”
Get full text

Periodontal Disease: A Covert Source of Inflammation in Chronic Kidney Disease Patients by Gener Ismail, Horia Traian Dumitriu, Anca Silvia Dumitriu, Fidan Bahtiar Ismail

“…In general population, also, evidence shows that moderate to severe periodontitis can contribute to inflammatory burden by increasing serum CRP levels and may increase the prevalence of atherosclerotic events. …”
Get full text

Orden dentro del desorden: circulación de libros de derecho en Nueva España, 1585–1640 by Idalia García

“… Law books circulated widely in New Spain; we find evidence of them both in the private libraries of Crown officials and in the institutional libraries of religious orders. …”
Get full text

Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis by Ka Yin Chu, King Hei King Cheng

“…Optimal treatment protocol remains inconclusive due to heterogeneity among studies. More robust evidence is required to determine whether the combined approach can serve as an effective intervention in clinical practice. …”
Get full text

Unsupervised data imputation with multiple importance sampling variational autoencoders by Shenfen Kuang, Yewen Huang, Jie Song

“…The statistical model and variational distributions are iteratively updated by maximizing the Multiple Importance Sampling Evidence Lower Bound (MISELBO) on the joint log-likelihood. …”
Get full text

Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies by Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke

“…Based on a large body of mostly in vitro evidence, ammonia-induced cellular and molecular disturbances include astrocyte swelling and oxidative stress. …”
Get full text

A Systematic Review of the Effectiveness of Core Stability Exercises in Patients with Non-Specific Low Back Pain by Zachary Smrcina, Sarah Woelfel, Christopher Burcal

“…. # Level of Evidence 1b…”
Get full text

Transfer Across Episodes of Analogical Reasoning: The Role of Visuo-Spatial Schemas by Jairo A. Navarrete-Ulloa, Maximo Trench

“…Across three experiments, we obtained evidence suggesting that the carry-over of visuo-spatial schemas can also be involved in meta-analogical transfer. …”
Get full text

Effects of Resveratrol on Liver Function Tests in Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials by P. Ebrahimpour, M. Karamian, A. Sharifi

“…This study aimed to provide up-to-date evidence regarding the effect of resveratrol on the liver enzymes (ALT &amp; AST) in NAFLD patients. …”
Get full text

Unlocking the Potential of German Smart Cities: Strategy Analysis through Online Content Examination by Matthias SCHMUCK

“…Furthermore, this study contributes to the academic discourse on smart cities by providing empirical evidence on the implementation of strategies in a German context. …”
Get full text

Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders by Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang

“…In this paper, we discuss three major psychiatric disorders, depression, schizophrenia, and drug addiction, in light of preclinical evidence used in establishing the neurobiological significance of adult neurogenesis. …”
Get full text

Intussusception in the Setting of an Ulcerative Colitis Flare by Varag Abed, Alexis Faber, Cristina Jageka, Ryan Goleniak, Raef Fadel

“…Acute care surgery was consulted and suggested obtaining a CT enterography for further evaluation which showed spontaneous resolution of intussusception with no evidence of pneumatosis, portal venous gas, or intraperitoneal free air. …”
Get full text

Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome by P. Stiefel, A. J. Vallejo-Vaz, S. García Morillo, J. Villar

“…In this respect, recent evidence involves aldosterone in the pathogenesis of metabolic syndrome. …”
Get full text