Contribution of flood early warning response measures in reducing flood effects in Kilosa District, Tanzania by Japhet Ringo, Shadrack Sabai, Anesi Mahenge

“…The responders to these warnings are the people in flood-prone areas at the individual and community (collective) levels, who then have to take voluntary or mandatory measures before and during flood events (onset time). Such measures include running, climbing on roofs or trees, informing others and moving to uplands (safe areas). …”
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The Simcup Morocco: Exploration of the concept, innovative pedagogical relevance, and perspectives by Mohamed El Mouhajir, Yahaya Maijimaa Tourey, Majdouline Obtel, Mohammed Mouhaoui

“…Introduction: The Simcup is a leading national event in the medical field, with clinical competition in terms of simulation. …”
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Circulating Soluble ST2 Predicts All-Cause Mortality in Severe Heart Failure Patients with an Implantable Cardioverter Defibrillator by Zhi-wei Hou, Hai-bo Yu, Yan-chun Liang, Yang Gao, Guo-qing Xu, Min Wu, Zhu Mei, Zu-lu Wang, Zhi-guo Li, Yu-ying Li, Hai-xu Song, Jia-yin Li, Ya-ling Han

“…Heart failure (HF) is the terminal stage of all cardiovascular events. Although implantable cardioverter defibrillator (ICD) therapies have reduced mortality among the high-risk HF population, it is necessary to determine whether certain factors can predict mortality even after cardiac device implantation. …”
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The first experience with brolucizumab for neovascular age-related macular degeneration by A.N. Kulikov, D.S. Maltsev, A.Yu. Malafeeva, S.M. Perminova, V.R. Zhalimova, A.S. Vasiliev, A.A. Kazak

“…BCVA, central macular thickness (CMT), macular volume (MV), sub/intraretinal fluid, and adverse events were evaluated.</i> </p> <p> <i><b>Results</b>: in group 1, a significant increase in BCVA from 34.9±6.6 letters to 44.1±4.2 letters (p=0.02) was reported. …”
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Prospective Single-Arm Study of Remifentanil-Propofol Anesthesia with Manual Right Hypochondrial Compression for Painless Gastroscopy in Obese Patients by Wang M, Tang J, Pan Z, Jiang H, Hu D, Zhu B, Liang Z, Zhao X, Li Y

“…Second outcomes included severe hypoxemia, the lowest SpO2 (L-SpO2), duration of hypoxemia, and other events.Results: The 98 obese patients under LAPO, the median body mass index (BMI) was 39.2 kg/m2 and the incidence of hypoxemia was 27.5%, while the conventional anesthetic protocol for obesity (CAPO) in the reference was 40.4% with BMI 31.4 kg/m2. …”
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A Model for Bank Management Performance Appraisal with the Advanced Technologies Approach (Meta-Synthesis Method) by Ehsan Kiani Ghalehno, Habibollah Salarzehi, Bahareh Naseri, Abdolali Keshtegar

“…This is vastly accepted by a large number of banks, such as industrial companies, manufacturing companies, the health sector, the financial sector, and the educational system in their daily operations. The dynamics of events in the current competent financial world make financial banks dependent on this technology (Andry , 2017). …”
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Feasibility, Usability, and Pilot Efficacy Study of a Software-Enabled, Virtual Pulmonary Rehabilitation with Remote Therapeutic Monitoring by Flynn S, Mosher CL, Cornelison S, Rao E, Metzler KA, Pu W, Davies J, Paladenech C, Doyle D, MacIntyre N, Ohar J

“…In both groups, 6MWT distance improved significantly, as did scores on the CAT and SGRQ. No adverse events were reported in either group.Conclusion: A software-enabled virtual PR program with remote therapeutic monitoring is feasible, usable, and effective. …”
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Comprehensive Evaluation of GPM-IMERG, CMORPH, and TMPA Precipitation Products with Gauged Rainfall over Mainland China by Guanghua Wei, Haishen Lü, Wade T. Crow, Yonghua Zhu, Jianqun Wang, Jianbin Su

“…However, all four products are unreliable over XJ at both an annual and seasonal scale. (4) Across all products, TRMM 3B42 best reproduces the probability density function (PDF) of daily precipitation intensity. (5) According to the categorical verification technique in this study, both IMERG products yield better results for the detection of precipitation events on the basis of probability of detection (POD) and critical success index (CSI) categorical evaluations compared to TRMM 3B42 and CMORPH-CRT over China and across most of the subregions. …”
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Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

“…Because ICIs block immune checkpoint pathways that include cytotoxic T lymphocyte antigen 4 (CTLA4), we hypothesized that biomarkers of immune dysregulationpreviously defined in patients with congenital CTLA4 deficiency, including elevated soluble interleukin-2 receptor alpha (sIL-2R) and flow cytometric cell-based markers of B and T cell dysregulation in peripheral blood may aid the diagnosis of ICI-nephritis.Methods A retrospective cohort of patients diagnosed with ICI-nephritis was compared with three prospectively enrolled control cohorts: ICI-treated controls without immune-related adverse events, patients not on ICIs with hemodynamic acute kidney injury (hemodynamic AKI), and patients not on ICIs with biopsy proven acute interstitial nephritis from other causes (non-ICI-nephritis). sIL-2R level and flow cytometric parameters were compared between groups using Wilcoxon rank sum test or Kruskal-Wallis test. …”
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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…There were no adverse events of any grade attributable to the cellular gene therapy intervention or host conditioning throughout the follow‐up interval of 5 years. …”
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Association of accelerated phenotypic aging, genetic risk, and lifestyle with progression of type 2 diabetes: a prospective study using multi-state model by Lulu Pan, Yahang Liu, Chen Huang, Yifang Huang, Ruilang Lin, Kecheng Wei, Ye Yao, Guoyou Qin, Yongfu Yu

“…Methods We conducted a prospective cohort study that included 376,083 adults free of T2D and diabetes-related events at baseline in UK Biobank. PhenoAgeAccel > 0 and ≤ 0 were defined as biologically older and younger than chronological age. …”
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Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis by Alisha Puri, Anita M. Lloyd, Aminu K. Bello, Marcello Tonelli, Sandra M. Campbell, Karthik Tennankore, Sara N. Davison, Stephanie Thompson

“…By conducting this systematic review and meta-analysis, we found that frailty status, as measured by the Fried Frailty Phenotype and the Clinical Frailty Scale provided important prognostic information beyond age and clinical factors on the risk of mortality and hospitalization, with an approximate doubling in the hazard for these events among people with kidney failure. We also found that in both the kidney failure and non-dialysis CKD populations, the agreement between clinicians’ subjective impression of frailty and the FFP was low. …”
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Epidemiology, Controversies, and Dilemmas of Perioperative Nutritional Risk/Malnutrition: A Narrative Literature Review by He M, Long Y, Peng R, He P, Luo Y, Zhang Y, Wang W, Yu X, Deng L, Zhu Z

“…Nutrition-related perioperative adverse events included mainly infection, wound healing disorders, reoperation and unplanned readmission, prolonged hospital stay, mortality, perioperative neurocognitive dysfunction, and venous thrombosis. …”
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ADMINISTRATIVE PREREQUISITES FOR FINANCIAL MANAGEMENT AND MARKETING OF SMALL BUSINESSES AT THE REGIONAL LEVEL by Natalia Koval, Oksana Kubai, Natalia Germaniuk

“…If the enterprise employs 15 persons, it is classified as a micro-enterprise. In the event that the number of employees in a commercial organisation exceeds 101, said organisation is classified as a medium-sized business. …”
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Editorial by Jörg Tremmel, Marisa dos Reis, Joseph Burke, Raphaelle Schwarzberg (†)

“…As such, our issue includes summaries of the presentations made during this event. Unfortunately, we cannot capture all the energy and progressive suggestions that occurred but hopefully the conference material contained here will provide readers with a sense of the occasion and inspire a commitment to future collaboration and research in this area. …”
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Outcomes with bridging radiation therapy prior to chimeric antigen receptor T-cell therapy in patients with aggressive large B-cell lymphomas by Gohar S. Manzar, Chelsea C. Pinnix, Stephanie O. Dudzinski, Kathryn E. Marqueen, Elaine E. Cha, Lewis F. Nasr, Alison K. Yoder, Michael K. Rooney, Paolo Strati, Sairah Ahmed, Chijioke Nze, Ranjit Nair, Luis E. Fayad, Michael Wang, Loretta J. Nastoupil, Jason R. Westin, Christopher R. Flowers, Sattva S. Neelapu, Jillian R. Gunther, Bouthaina S. Dabaja, Susan Y. Wu, Penny Q. Fang

“…Survival was modeled using Kaplan-Meier or Cox regression models for events distributed over time, or binary logistic regression for disease response. …”
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Evaluation of long‐acting cabotegravir safety and pharmacokinetics in pregnant women in eastern and southern Africa: a secondary analysis of HPTN 084 by Sinead Delany‐Moretlwe, Brett Hanscom, Xu Guo, Clemensia Nkabiito, Patricia Mandima, Patricia Ntege Nahirya, Juliet Mpendo, Muchaneta Bhondai‐Mhuri, Nyaradzo Mgodi, Rebecca Berhanu, Jennifer Farrior, Estelle Piwowar‐Manning, Susan L. Ford, Craig W. Hendrix, Alex R. Rinehart, James F. Rooney, Adeola Adeyeye, Raphael J. Landovitz, Myron S. Cohen, Mina C. Hosseinipour, Mark A. Marzinke, the HPTN 084 Study Team

“…Pregnancy incidence, maternal adverse event (AE) incidence, pregnancy outcomes (including composite outcome of spontaneous abortion <20 weeks, intrauterine foetal death or stillbirth ≥20 weeks, premature birth <37 weeks, or small for gestational age) were assessed. …”
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BRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center’s experience by S. S. McThenia, S. S. McThenia, S. S. McThenia, K. M. Reddy, K. M. Reddy, E. Damaraju, E. Castellino, Z. He, R. Beer, F. Chien, F. Chien, F. Chien, R. C. Castellino, R. C. Castellino, R. C. Castellino, A. E. Goldman-Yassen, A. E. Goldman-Yassen, J. R. Fangusaro, J. R. Fangusaro, J. R. Fangusaro, T. MacDonald, T. MacDonald, T. MacDonald

“…All toxicities possibly associated with BRAF inhibition therapy were evaluated and described according to Common Terminology Criteria for Adverse Events version 5 (CTCAEv5). MRI brain imaging data at baseline and best response was evaluated to identify patterns that may predict response to BRAF inhibition monotherapy.ResultsFifteen patients diagnosed with BRAFV600E mutated pLGG, treated with monotherapy BRAF inhibition, were identified. …”
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Initial clinical experience with [177Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer: dosimetry, safety, and efficacy from the lead-in cohort o... by Aaron R. Hansen, Stephan Probst, Jean-Mathieu Beauregard, Benjamin L. Viglianti, Jeff M. Michalski, Scott T. Tagawa, Oliver Sartor, Ronald F. Tutrone, Orhan K. Oz, Kevin D. Courtney, Ebrahim S. Delpassand, Luke T. Nordquist, Medhat M. Osman, Kim N. Chi, Richard Sparks, Noble George, Sara M. Hawley, Wenting Wu, Jessica D. Jensen, Neil E. Fleshner

“…Mean (median, range) tumor specific absorbed dose was 4.3 (2.1, 0.3-33.4) Gy/GBq (approximately 29 Gy/cycle) based on planar + SPECT/CT of 21 lesions in seven participants. [177Lu]Lu-PNT2002 was associated with no treatment-related deaths, few treatment-related grade ≥3 treatment-emergent adverse events (TEAEs), and no discontinuations for unacceptable toxicity. …”
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Standardised packaging, minimum excise tax, and RYO focussed tax rise implications for UK tobacco pricing. by Rosemary Hiscock, Nicole H Augustin, J Robert Branston, Anna B Gilmore

“…Second, the tax and standardised packaging events were sometimes too close in time to separate their consequences statistically. …”
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