The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling by Wang C, Lu Z, She G, Chen K, Zhou H, Zhan X, Yu H, Pi L, Zuo L, Che D

“…Chenlu Wang,1,* Zhaojin Lu,1,* Guangpeng She,2 Kaining Chen,1 Huazhong Zhou,1 Xueli Zhan,3 Hongyan Yu,1 Lei Pi,1 Liandong Zuo,4 Di Che1 1Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510620, People’s Republic of China; 2Department of Laboratory Medicine, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, People’s Republic of China; 3Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510620, People’s Republic of China; 4Department of Andrology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510620, People’s Republic of China*These authors contributed equally to this workCorrespondence: Di Che, Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, No. 9 Jinsui Road, Guangzhou, Guangdong, 510620, People’s Republic of China, Email chedi@gwcmc.org Liandong Zuo, Department of Andrology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, Guangdong, 510620, People’s Republic of China, Email zuold@163.comPurpose: Recurrent abortion(RA) is a prevalent adverse pregnancy event. Exosomes, secreted by various body fluids, are known to play a role in disease diagnosis and serve as biomarkers through intercellular communication. …”
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Regional climatic changes and their impact on the level of avalanche hazard in East Kazakhstan by Olga Petrova, Natalya Denissova, Gulzhan Daumova, Yelena Ivashchenko, Evgeny Sergazinov

“…At the same time, the situation is complicated by not always predictable weather events, the frequency of which is increasing every year. …”
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Evaluation of pulmonary tuberculosis disease burden in Shenyang, China, 2023 by Huijie Chen, Haiyan Bi, Peng Li, Zhixing Yang, Lihai Wen, Baijun Sun, Wei Sun

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Krebs von den Lungen-6 surveillance in immune checkpoint inhibitor-induced pneumonitis by Isamu Okamoto, Kazuya Tsubouchi, Ryosuke Matsukane, Shoji Nakamura, Haruna Minami, Yasuto Yoneshima, Kojiro Hata, Sai Yasukochi, Kimitaka Suetsugu, Takeshi Hirota

“…Background The immune-related adverse event (irAE), pneumonitis, is a potentially fatal complication of immune checkpoint inhibitors (ICIs). …”
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Exploring the benefits and prescribing informations of combining East Asian herbal medicine with conventional medicine in the treatment of rheumatoid arthritis: A systematic review... by Hee-Geun Jo, Jihye Seo, Eunhye Baek, Donghun Lee

“…The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using the American College of Rheumatology (ACR) 20/50/70 Response Criteria and the incidence of adverse events (AEI) as primary outcomes. This meta-analysis was performed using a random-effects model. …”
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Predictors of Unfavorable Outcomes in Patients with Atrial Fibrillation and Concomitant Heart Failure with Different Ejection Fractions: RIF-CHF Register One-Year Follow-Up by Igor Zhirov, Natalia Safronova, Yulia Osmolovskaya, Alina Alshevskaya, Andrey Moskalev, Sergey Tereshchenko

“…The endpoints included hospitalization due to HF worsening, mortality, thromboembolic events, and hemorrhage. Predictors of unfavorable outcomes were analyzed separately for patients with HF and preserved ejection fraction (AF + HFpEF), midrange ejection fraction (AF + HFmrEF), and reduced ejection fraction (AF + HFrEF). …”
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Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study by Sumeet Rai, Dale M. Needham, Rhonda Brown, Teresa Neeman, Krishnaswamy Sundararajan, Arvind Rajamani, Rakshit Panwar, Mary Nourse, Frank M. P. van Haren, Imogen Mitchell, for the PRICE study investigators

“…Adult family members of ICU survivors and family-survivor dyads had follow-up assessments (3 and 12 months after ICU discharge), using Impact of Event Scale-Revised; Depression, Anxiety Stress Scales-21; EQ-5D-5L. …”
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Smartphone-Based Telemonitoring for Better Oral Health With Toothbrushes: 6-Month Randomized Controlled Trial by Jaeyeon Kim, Yiseul Choi, Yoolbin Song, Wonse Park

“…The number of brushing events decreased significantly in the ORT group (P=.02), while brushing duration increased in the MT group (P=.01). …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Pegmolesatide showed significant PK-PD dual prolongation effects and was well tolerated. Adverse events were mild and manageable, with no reports of severe anaphylaxis. …”
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Artificial intelligence-assisted clinical decision support for childhood asthma management: A randomized clinical trial. by Hee Yun Seol, Pragya Shrestha, Joy Fladager Muth, Chung-Il Wi, Sunghwan Sohn, Euijung Ryu, Miguel Park, Kathy Ihrke, Sungrim Moon, Katherine King, Philip Wheeler, Bijan Borah, James Moriarty, Jordan Rosedahl, Hongfang Liu, Deborah B McWilliams, Young J Juhn

“…<h4>Conclusions</h4>While A-GPS-based intervention showed similar reduction in AE events to usual care, it might reduce clinicians' burden for EHRs review resulting in efficient asthma management. …”
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Regular versus as-needed treatments for mild asthma in children, adolescents, and adults: a systematic review and network meta-analysis by Prapaporn Pornsuriyasak, Sunatee Sa-nguansai, Kunlawat Thadanipon, Pawin Numthavaj, Gareth J. McKay, John Attia, Ammarin Thakkinstian

“…., formoterol or SABA) or long-acting β2-agonists (LABA), LTRA, tiotropium, and SABA alone, for the following outcomes: exacerbations, asthma symptoms, forced expiratory volume in 1 s (FEV1), asthma-specific quality-of-life (QoL), or severe adverse events (SAEs). The two-stage network meta-analysis (NMA) was used to pool risk ratios (RR) or mean differences for treatment outcomes. …”
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Impact of Bone-Modifying Agents on Post-Bone Metastasis Survival Across Cancer Types by Hironari Tamiya, Kazumi Nishino, Yuji Kato, Reina Nakahashi-Kato, Yurika Kosuga-Tsujimoto, Shota Kinoshita, Rie Suzuki, Makiyo Watanabe, Toru Wakamatsu, Shigeki Kakunaga, Satoshi Takenaka

“…Bone-modifying agents (BMA) are commonly used for the prevention or treatment of skeletal-related events (SRE) in patients with bone metastasis; however, whether or not treatment with BMA improves survival remains unclear. …”
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Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape: A systematic scoping review of clinical trials and observational studies to assess the feasibility of esta... by Sauman Singh-Phulgenda, Rishikesh Kumar, Prabin Dahal, Abdalla Munir, Sumayyah Rashan, Rutuja Chhajed, Caitlin Naylor, Brittany J Maguire, Niyamat Ali Siddiqui, Eli Harriss, Manju Rahi, Fabiana Alves, Shyam Sundar, Kasia Stepniewska, Ahmed Musa, Philippe J Guerin, Krishna Pandey

“…Extracted data includes variables on patient characteristics, treatment regimens, diagnostic methods, geographical locations, efficacy endpoints, adverse events and statistical methodology.<h4>Results</h4>A total of 3,418 records were screened, of which 56 unique studies (n = 2,486 patients) were included in this review. …”
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Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study. by Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J Gordijn, Kimberley Kavanagh, Paul Murray, Laura A Magee, Henk Groen, Peter von Dadelszen

“…In the 2 weeks window, the number of daily outcome events decreased from over 200 to around 10. For both PIERS-ML and fullPIERS models, we observed consistently higher mean risk in the adverse outcome (versus uncomplicated course) group. …”
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Effect of Buyang Huanwu Decoction Foot Bath on Pulmonary Rehabilitation of Patients with Chronic Obstructive Pulmonary Disease at Stable Phase by HUANG Huirong, HAN Xueqi, LIU Qinyu, XUE Jialu, YU Zhenling, CHEN Bin, MIAO Shaofang, CHEN Shuifeng

“…After 2 weeks of treatment, the FEV1%pred, FEV1/FVC value, and 6MWD of the treatment group were all higher than those of the control group (<italic>P</italic>&lt;0.05); the mMRC score, CAT score, and AIR score of the treatment group were all lower than those of the control group (<italic>P</italic>&lt;0.05). 3) Safety results showed that no adverse events occurred during the clinical treatment, suggesting that the Buyang Huanwu decoction foot bath was safe and reliable.ConclusionThe Buyang Huanwu decoction foot bath could improve pulmonary function, athletic ability, dyspnea, anxiety level, and quality of life of COPD patients at stable phase. …”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…Oral selexipag is effective, but may be discontinued due to factors like side effects, emergency conditions, or inability to take oral medication, potentially leading to severe adverse events, such as rebound pulmonary hypertension and right heart failure. …”
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Assessment of the southern polar and subpolar warming in the PMIP4 last interglacial simulations using paleoclimate data syntheses by Q. Gao, Q. Gao, Q. Gao, E. Capron, L. C. Sime, R. H. Rhodes, R. Sivankutty, X. Zhang, B. L. Otto-Bliesner, M. Werner

“…We run a 3000-year 128 ka simulation using HadCM3 with a 0.25 Sv North Atlantic freshwater hosing, which approximates the PMIP4 127 ka Tier 2 H11 (Heinrich event 11) simulation. The hosed 128 ka HadCM3 simulation captures much of the warming and sea ice loss shown in the four data syntheses at 127 ka relative to preindustrial: south of 40° S, modeled annual sea surface temperature (SST) rises by 1.3 <span class="inline-formula">±</span> 0.6 °C, while reconstructed average anomalies range from 2.2 to 2.7 °C; modeled summer SST increases by 1.1 <span class="inline-formula">±</span> 0.7 °C, close to the 1.2–2.2 °C reconstructed average anomalies; September sea ice area (SIA) is reduced by 40 <span class="inline-formula"><i>%</i></span>, similar to the reconstructed 40 <span class="inline-formula">%</span> reduction of sea ice concentration (SIC); over the Antarctic Ice Sheet, modeled annual surface air temperature (SAT) increases by 2.6 <span class="inline-formula">±</span> 0.4 °C, even larger than reconstructed average anomalies of 2.2 °C. …”
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Characteristics and real-world medication persistence of people living with HIV treated with DTG/3TC or BIC/FTC/TAF: a hospital claims database study in Japan by Rie Kanamori, Nozomi Aoki, Akio Kanazawa, Mayumi Yuda, Nao Makino, Emi Ohata, Nobuyuki Fukui, Hirotake Mori, Hirohide Yokokawa, Toshio Naito

“…Due to the limitations of the database, further research to assess viral loads, emergence of resistance and adverse events will be encouraged.…”
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A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response i... by Ian J Neeland, Luiz H de Gregório, Roberto Zagury, Bo Ahrén, Joel Neutel, Christian Darimont, John Corthesy, Yohan Grzywinski, Emilie Perrin, Maximilian von Eynatten, Odd Erik Johansen

“…Postprandial plasma BCAA patterns were characterized by a rapid increase and larger iAUC_0–2h (all <i>p</i> < 0.001) after WPM. No adverse events were ascribed to consuming WPM. <b>Conclusions</b>: A 125 mL pre-meal drink containing just 10 g WPM before a mixed meal reduced PPG and increased insulin, GLP-1, and BCAAs. …”
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Comparison of search and rescue operations involving emergency physicians in devastating earthquakes in Turkey: a 24-year experience study by Mustafa Ferudun Celikmen, Gülbin Aydoğdu Umaç, Melih Imamoglu, Mümin Murat Yazici, Elif Çiğdem Keleş, Sarper Yilmaz

“…Disseminating this knowledge is crucial not only for managing earthquakes but also for preparing for other catastrophic events that could cause widespread destruction. Harnessing this accumulated experience can significantly enhance knowledge-sharing and the development of more effective preparedness strategies.…”
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