Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…Results Modeling TTC with high doses of epinephrine (Epi) treatment in hiPSC-CMs shows suppression of depolarization velocity (Vmax), prolongation of action potential duration (APD), and induction of arrhythmic events. Exo derived from HCMECs treated with Epi (Epi-exo) mimicked or enhanced the effects of Epi. …”
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Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study by Yanning Qu, Rui Tang, Zhuyan Duan, Mengyi Sheng, Hui Wang, Shuang Liu, Jiao Li, Linlin Guo, Linying Guo, Si Zheng, Si Zheng

“…The majority exposure events occurred at home (89.3%) and in urban settings (78.4%). …”
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Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover tr... by Xiexiong Zhao, Tao Liu, Qiong Yang, Guoping Yang, Xingli Li, Xiaohong Tang, Jingle Li, Zhongshu Liang, Anying Li, Lixiong Zeng, Juan Wen, Xiaoyan Wang, Liping Peng, Wenjuan Wang, Jingjing Cai, Ye Chen, Miao Huang, Ruixuan Li, Ru Fu, Lin Zhao, Xiaogang Li, Weihong Jiang

“…Apart from significant increases of fasting blood glucose (P = 0.029) and blood uric acid (P < 0.001) in the half-dose quadruple group, no other adverse events or changes in laboratory values differed significantly between the two treatments. …”
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A phase Ia study of a novel anti-HER2 antibody–drug conjugate GQ1001 in patients with previously treated HER2 positive advanced solid tumors by Chenfei Zhou, Bin Wang, Christina Teng, Hui Yang, Sarina A. Piha-Paul, Gary Richardson, Ashanya Malalasekera, Yajun Sun, Wei Wang, Jieqiong Liu, Yan Shi, Xianbao Zhan, Charlotte Lemech

“…Grade ≥ 3 treatment-related adverse events rate was 28.1% (9/32) and platelet count decreased (4/32, 12.5%) was the most common one. …”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb in acute and subacute Stroke (RHOMBUS II): results of a feasibility randomised controlle... by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Elmar Kal, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…The control group (n=8) received usual care only.Outcomes Safety was assessed through adverse events (AEs), pain, spasticity and fatigue. Feasibility was assessed through training and support requirements and intervention fidelity. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…We examined the effect of sociodemographic and clinical covariates on the incidence of dementia using a cause-specific hazard (CSH) model, with all-cause mortality as a competing risk event.Results Among 5121 eligible PLWH, 108 (2%) developed dementia. …”
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Safety and efficacy of telaprevir in treatment of a chronic hepatitis C in patients of the Russian population included in early access program study by D. T. Abrurakhmanov, V. G. Morozov, I. G. Nikitin, P. O. Bogomolov, N. I. Geyvandova, Ye. N. Bessonova, I. G. Bakulin, V. A. Isakov, K. V. Zhdanov, M. V. Mayevskaya, Ye. A. Nurmukhametova, E. Z. Burnevich, Ye. V. Chesnokov, V. D. Pasechnikov, A. Hill, I. Lonjon-Domanec, S. N. Kizhlo

“…Most frequent adverse events of the 2-4 degrees, related to telaprevir, were anemia (63 patients, 41%), thrombocytopenia (15 patients, 10%) and skin rash (7 patients, 5%). …”
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Pharmacokinetic Analysis of an Isoniazid Suspension Among Spanish Children Under 6 Years of Age by Antoni Noguera-Julian, Emma Wilhelmi, Maria Cussó, Rob Aarnoutse, Angela Colbers, Loreto Martorell, Maria Goretti López-Ramos, Joan Vinent, Rosa Farré, Dolors Soy, Sílvia Simó-Nebot, Clàudia Fortuny

“…Treatment was well tolerated, and no severe adverse events were observed; three patients developed asymptomatic mildly elevated alanine aminotransferase levels. …”
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Soviet Researchers on the Middle East: Ahead of Their Time by I. D. Zvyagelskaya

“…The article attempts to consider some breakthrough ideas and assessments of historical events in the Middle East put forward by the Soviet experts. …”
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O perspectivă inedită asupra romanului latin by Carmen-Nicola Jumara

“…Drawing a distinction between the story and the intrigue, we underline that the first one is a narration of some events, especially based upon curiosity, while the intrigue is also a narration, but it implies also intelligence and good memory, the stress being focused on causality. …”
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Usability and Usefulness of a Symptom Management Coaching System for Patients With Cancer Treated With Immune Checkpoint Inhibitors: Comparative Mixed Methods Study by Savannah Lucia Caterina Glaser, Itske Fraterman, Noah van Brummelen, Valentina Tibollo, Laura Maria Del Campo, Henk Mallo, Sofie Wilgenhof, Szymon Wilk, Vitali Gisko, Vadzim Khadakou, Ronald Cornet, Manuel Ottaviano, Stephanie Medlock

“…Participants treated with immunotherapy, specifically with previous experience in immune-related adverse events, encountered critical problems with symptom reporting that would not have been identified if these participants were not included. …”
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The cardioprotective effects of HTK solution and conventional blood cardioplegia in patients with atrial fibrillation undergoing valvular replacement and Cox maze III procedure by BingMei Qiu, Lei Zhang, Dan Wu, Qian Li, Lei Sun, AnLi Wang, Zhilong Xi, HaiWei Wu, ChangTian Wang, ShanWu Feng

“…Results No substantive disparities were observed concerning mortality rates, arrhythmias, neurological events, or renal complications. The duration of cardiopulmonary bypass and the aortic cross-clamp time did not demonstrate any marked variations between both groups, with p-values of 0.71 and 0.05, respectively. …”
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A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in He... by Lee HW, Kang WY, Park JS, Lee JH, Park JJ, Gwon MR, Yoon YR, Seong SJ

“…Both treatments were well tolerated, with no serious adverse events reported.Conclusion: Through extended systemic exposure of esomeprazole, YYD601 produces gastric acid suppression that is comparable to that of the conventional esomeprazole formulation, with a greater tendency to suppress acid at night. …”
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ANALISIS SENTIMEN DATA TWITTER TERKAIT CHATGPT MENGGUNAKAN ORANGE DATA MINING by Tri Yuli Pahtoni, Handaru Jati

“…This study aims to analyze the sentiment of public postings on Twitter to provide insight into people's attitudes and perceptions of an event that has occurred. This research illustrates Twitter's role in accommodating Twitter user posts regarding chatGPT. …”
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Effect analysis of radiofrequency catheter ablation in the treatment of 7 children with atrial tachycardia-induced cardiomyopathy by Min Zhang, Xiaoxiao Cao, Suqiong Ji, Mohammadreza Kosari, Yong Zhang

“…Abstract Background Tachycardia-induced cardiomyopathy refers to changes in cardiac structure and function that result from rapid arrhythmia and can manifest as a continuous or recurrent event. Cardiomyopathy induced by atrial tachycardia is typically reversible if the arrhythmia is effectively controlled. …”
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Risk Management in Sustainable Construction Projects: A Systematic Review and Bibliometric Analysis by Kasra Hosseini, Youness Javid

“…ObjectiveIn recent years, with the expansion of the concept of sustainable development in the life cycle of construction projects and the dynamic and eventful nature of these projects, the issue of sustainable risk management has garnered increasing attention from researchers. …”
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Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial by Ruihao Huang, Xiaoqi Wang, Hongju Yan, Xu Tan, Yingying Ma, Maihong Wang, Xiao Han, Jia Liu, Li Gao, Lei Gao, Guangjun Jing, Cheng Zhang, Qin Wen, Xi Zhang

“…No grade 3–4 adverse events were observed, except bone marrow suppression, which was relieved within one month. …”
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TiMON: a real-time integrated monitor for improving the placement and wear of emergency tourniquets by John Quan Nguyen, Avery Goss, Helen Keshishian, Francis Berchard, Jonathan Parks, Conor Evans

“…These indicators are not always accurate and are difficult to assess during chaotic events where fast and effective tourniquet application by both trained and untrained personnel can contribute significantly to saving lives. …”
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Chronic Rhinosinusitis with Nasal Polyps and Biologics: A Call for Better Data Standardisation and Presentation in Clinical Studies by Kariyawasam HH, Langan D, Rimmer J

“…For binary outcomes, the number of individuals experiencing the event should be reported alongside the number of observations that the summary is based on.Effect estimates and inferential statistics presented in a journal article are less ideal for meta-analysis. …”
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ANALISIS ZONA RAWAN GEMPA BUMI DI KABUPATEN BENGKULU SELATAN BERDASARKAN PERCEPATAN TANAH PUNCAK MENGGUNAKAN FORMULA KANAI by Giltro Kencoro, M Farid, Arif Ismul Hadi, Darmawan Ikhlas Fadli, Agung Sedayu

“…PGA values were obtained from a 100-year earthquake event and calculated using the Kanai equation. The results show that PGA values range from 0.18 g to 0.78 g. …”
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