Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…Additionally, innate immune activation following IRI links PGD to adaptive alloimmunity, highlighting the impact of early events on LTx outcomes. Immune checkpoints (ICPs) such as PD-1/PD-L1, CD40/CD40LG, and OX40/OX40L, regulate post-LTx T cell responses, and dysregulation of microRNAs (miRNAs) has been implicated in altering ICP expression, influencing the amplification of immune responses.In this preliminary study, we used the taqMan low-density array (TLDA) cards to investigate miRNA dysregulation's prognostic potential as a PGD marker in pre-transplant back-table lung biopsies. …”
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Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation by Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida

“…Indeed, alterations of the MEK5/ERK5 pathway are present in many types of cancer, including melanoma. One of the key events in MAPK signalling is MAPK nuclear translocation and its subsequent regulation of gene expression. …”
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Research on the directional fracturing mechanism of multiborehole rock mass plasma blasting by Xue LI, Chuanbing WANG, Yanbing WANG, Hongjia MEI, Yanqing LI, Zhaoyang WANG, Diancai XIAO

“…When the precut slot spacing is small, the shock waves from the electro-explosive events are closer together, overlapping to form a combined shock wave. …”
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Developmental Proteomics Reveals the Dynamic Expression Profile of Global Proteins of <i>Haemaphysalis longicornis</i> (Parthenogenesis) by Min-Xuan Liu, Xiao-Pei Xu, Fan-Ming Meng, Bing Zhang, Wei-Gang Li, Yuan-Yuan Zhang, Qiao-Ying Zen, Wen-Ge Liu

“…In this study, we identified changes in the proteome throughout the <i>H. longicornis</i> development, and functional analysis highlighted the important roles of many key proteins in developmental events (ovarian development, the molting process, the development of midgut, the development and degeneration of salivary glands, etc.). …”
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Cerebral vascular shunting and oxygen metabolism in sickle cell disease by Alexander K. Song, Wesley T. Richerson, Megan A. Aumann, Spencer L. Waddle, R. Sky Jones, Samantha Davis, Lauren Milner, Chelsea Custer, L. Taylor Davis, Sumit Pruthi, Dann Martin, Lori C. Jordan, Manus J. Donahue

“…Abstract: Patients with sickle cell disease (SCD) are at elevated risk of silent cerebral infarcts and strokes; however, they frequently lack established stroke risk factors (eg, macrovascular arterial steno-occlusion) and the mechanisms underlying such events are incompletely characterized. This study evaluated cerebral hemometabolism with respect to imaging markers of vascular shunting in 143 participants with SCD, including 73 pediatric (aged 6-17 years) and 70 adult (aged 18-40 years) participants using 3-Tesla brain magnetic resonance imaging (MRI). …”
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Use and Outcomes of Dexamethasone in the Management of Malignant Small Bowel Obstruction by Frank F. Yang, MD, Elina Serrano, MD, Kyle S. Bilodeau, MD, Michael Weykamp, MD, Caitlin J. Silvestri, MD, Ashleigh C. M. Bull, MD, Brenda Lin, MD, Sara L. Schaefer, MD, Colette Galet, PhD, Luis J. Garcia, MD, FACS, Baraka Gitonga, BS, David T. Kolodziej, BS, Samantha Esposito, BS, Molly Parker-Brigham, BS, Rohan Luhar, BS, Avinash Mamgain, MS, Kendrick C. Brown, BS, Summer Dewdney, MD, Thea P. Price, MD, FACS, Nicole Siparsky, MD, FACS, Sarah Knerr, PhD, Pauline K. Park, MD, FACS, Sabrina Sanchez, MD, FACS, Dionne A. Skeete, MD, FACS, Katherine N. Fischkoff, MD, FACS, David R. Flum, MD, FACS

“…Among dexamethasone recipients, 13% (95% CI = 9%–20%) subsequently required nonelective surgery during the same admission and 4 dexamethasone-related safety-events were reported. Amongst 421 eligible admissions where dexamethasone was not used, 17% (95% CI = 14%–21%) required nonelective surgery. …”
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The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study by Ruotong Wang, Shaodi Wen, Xiaoyue Du, Jingwei Xia, Bowen Hu, Yihan Zhang, Guoren Zhou, Feng Jiang, Xiaomin Lu, Miaolin Zhu, Xinyu Xu, Bo Shen

“…The ICT group demonstrated a superior pathological response rate (PRR) (47.2% vs. 29.4%, p = 0.034) with comparable adverse events and postoperative complications. The ICT group also showed a median disease‐free survival (DFS) of 39.8 months, unattained by the CT group. …”
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Impact of family socio-economic status on the prognosis of heart transplantation in children by Shun Liu, Han Mo, Yiqi Zhao, Xiao Chen, Weiteng Wang, Yijing Li, Ningning Zhang, Mengni Bao, Zeyu Cui, Qian Zhao, Jun Yan, Xiumeng Hua, Jiangping Song

“…To assess the impact of socio-economic status, we followed up with the discharged children until September 30, 2023, monitoring for all-cause mortality and unplanned readmission events. To evaluate the relationship between socio-economic status and prognosis, we assigned a composite score based on an assessment of household income, parental education level, and occupation. …”
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Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM by Krzysztof Kalwak, Laura M. Moser, Ulrike Pötschger, Peter Bader, Katharina Kleinschmidt, Roland Meisel, Jean-Hugues Dalle, Akif Yesilipek, Adriana Balduzzi, Gergely Krivan, Evgenios Goussetis, Raquel Staciuk, Petr Sedlacek, Herbert Pichler, Peter Svec, Melissa Gabriel, Tayfun Güngör, Ernest Bilic, Jochen Buechner, Marleen Renard, Kim Vettenranta, Marianne Ifversen, Cristina Diaz-de-Heredia, Jerry Stein, Jacek Toporski, Marc Bierings, Christina Peters, Marc Ansari, Franco Locatelli

“…Data were analyzed as of February 2023, with a median follow-up of 4.2 years (range, 0.3-9.1). 3-year overall survival was 0.71 (BU, 95% confidence interval [0.64-0.77]) and 0.72 (TREO, [0.63-0.79]) and 3-year event-free survival was 0.60 (BU, [0.53-0.67]) and 0.55 (TREO, [0.46-0.63]). …”
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Neoadjuvant chemotherapy combined with antiangiogenic therapy and immune checkpoint inhibitors for the treatment of locally advanced gastric cancer: a real - world retrospective co... by Zhouwei Zhan, Bijuan Chen, Shaohua Xu, Ruyu Lin, Haiting Chen, Xiaohuan Ma, Xuanping Lin, Wanting Huang, Changhua Zhuo, Yu Chen, Zengqing Guo

“…The neoadjuvant therapy regimen was generally well-tolerated, with no grade 5 treatment-related adverse events (TRAEs) reported. Only one patient experienced a grade 4 TRAE (immune-related hepatitis), while the most common grade 3 TRAEs included thrombocytopenia, elevated aminotransferase levels, and neutropenia.ConclusionsThe combination of neoadjuvant chemotherapy, anti-angiogenic therapy, and ICIs has proven effective in treating LAGC patients, achieving high pCR rates and favorable survival outcomes while maintaining an acceptable safety profile.…”
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Gender differences in early posttraumatic stress disorder symptoms: a network analysis by Line Rønning, Rachel L. Zelkowitz, Marilyn L. Piccirillo, Jianlin Liu, Jordan L. Thomas, Jessy Guler, J. Joana Kyei, Chris M. Hoeboer, Jeanet F. Karchoud, Miranda Olff, Anke B. Witteveen, Mirjam van Zuiden

“…Background: Despite known gender/sex differences in the prevalence of posttraumatic stress disorder (PTSD), potential differences in the associations among PTSD symptoms between men and women in the early post-trauma period are not well-characterized.Objective: This study utilized network analysis to assess potential differences in the associations among PTSD symptom clusters between men and women during the early post-trauma period.Method: We included n = 475 participants (57.5% self-identified women) who recently (≤2 months) experienced an interpersonal or motor vehicle potential traumatic event in the Netherlands. Past month PTSD symptoms were measured with the PTSD Checklist for DSM-5 (PCL-5) and composited according to the five-node PTSD symptom cluster dysphoric arousal model. …”
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Prognostic Value of Postpercutaneous Coronary Intervention Murray-Law-Based Quantitative Flow Ratio by Daixin Ding, PhD, Jinlong Zhang, MD, PhD, Peng Wu, PhD, Zhiqing Wang, MD, PhD, Huiping Shi, MSc, Wei Yu, PhD, Xinyang Hu, MD, PhD, Jeehoon Kang, MD, Joo-Yong Hahn, MD, Chang-Wook Nam, MD, Joon-Hyung Doh, MD, Bong-Ki Lee, MD, Weon Kim, MD, Jinyu Huang, MD, Fan Jiang, MD, Hao Zhou, MD, Peng Chen, MD, Lijiang Tang, MD, Wenbing Jiang, MD, Xiaomin Chen, MD, Wenming He, MD, Sung Gyun Ahn, MD, Myeong-Ho Yoon, MD, Ung Kim, MD, You-Jeong Ki, MD, Eun-Seok Shin, MD, Seung-Jea Tahk, MD, Jun Pu, MD, William Wijns, MD, PhD, Jian’an Wang, MD, PhD, Bon-Kwon Koo, MD, PhD, Shengxian Tu, PhD

“…Conclusions: In patients with intermediate lesions who underwent PCI with contemporary imaging or physiology guidance, lower post-PCI μQFR values predict subsequent adverse events. (Fractional FLow Reserve And IVUS for Clinical OUtcomes in Patients With InteRmediate Stenosis [FLAVOUR]; NCT02673424)…”
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Carbon sequestration in different urban vegetation types in Southern Finland by L. Thölix, L. Backman, M. Havu, M. Havu, E. Karvinen, J. Soininen, J. Trémeau, O. Nevalainen, J. Ahongshangbam, L. Järvi, L. Järvi, L. Kulmala

“…Our analysis revealed that these models effectively simulated seasonal and annual variations, as well as the impacts of weather events on carbon fluxes and related factors. However, the validation of the absolute level of modelled fluxes proved difficult due to differences in the scale of the observations and models, particularly for mature trees, and due to the fact that net ecosystem exchange measurements in urban areas include some anthropogenic emissions. …”
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Methods to Adjust for Confounding in Test-Negative Design COVID-19 Effectiveness Studies: Simulation Study by Elizabeth AK Rowley, Patrick K Mitchell, Duck-Hye Yang, Ned Lewis, Brian E Dixon, Gabriela Vazquez-Benitez, William F Fadel, Inih J Essien, Allison L Naleway, Edward Stenehjem, Toan C Ong, Manjusha Gaglani, Karthik Natarajan, Peter Embi, Ryan E Wiegand, Ruth Link-Gelles, Mark W Tenforde, Bruce Fireman

“…These studies require methods that adjust for the confounding that arises when morbidities and demographics are associated with vaccination and the risk of outcome events. Methods based on propensity scores (PS) are well-suited to this when the exposure is dichotomous, but present challenges when the exposure is multinomial. …”
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Monozygotic twins with myocarditis and a novel likely pathogenic desmoplakin gene variant by Antheia Kissopoulou, Eva Fernlund, Christina Holmgren, Eira Isaksson, Jan‐Erik Karlsson, Henrik Green, Jon Jonasson, Rada Ellegård, Hanna Klang Årstrand, Anneli Svensson, Cecilia Gunnarsson

“…The extensive inflammation of the LV that was apparent in the CMR may or may not be the primary event of ARVC. Nevertheless, our data suggest that irrespective of a possible link here to ARVC, genetic testing for arrhythmogenic cardiomyopathy might be advisable for patients with recurrent myocarditis associated with a family history of myocarditis.…”
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Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES by Junqi Liao, Jingyi Chen, Huimin Wu, Qing Zhu, Xiaogang Tang, Li Li, Aimei Zhang, Peiyi Mo, Yan Liu, Xinyi Yang, Yang Han, Zhaoyao Chen, Wenlei Li, Yuan Zhu, Minghua Wu

“…Results We identified 133 all-cause deaths [major adverse cardiovascular events (MACE), 34; non-MACE, 79] with a median follow-up of 5.8 years (interquartile, 2.8–8.9 years). …”
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A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model by Mitsuru Sugimoto, Tadayuki Takagi, Tomohiro Suzuki, Hiroshi Shimizu, Goro Shibukawa, Yuki Nakajima, Yutaro Takeda, Yuki Noguchi, Reiko Kobayashi, Hidemichi Imamura, Hiroyuki Asama, Naoki Konno, Yuichi Waragai, Hidenobu Akatsuka, Rei Suzuki, Takuto Hikichi, Hiromasa Ohira

“…Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. …”
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Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation by Sören J. Backhaus, Alexander Schulz, Torben Lange, Simon F. Rösel, Lennart S. Schmidt-Schweda, Shelby Kutty, Johannes T. Kowallick, Julia Treiber, Andreas Rolf, Samuel Sossalla, Gerd Hasenuß, Andreas Schuster

“…Repeat rest and exercise-stress CMR was performed in median 2.94 years after recruitment during which timeframe some HFpEF patients had undergone interatrial shunt device (IASD) implantation. Cardiovascular events were assessed after 4 years.Serial CMR scans were available for NCD n = 10, HFpEF n = 10 and HFpEF with IASD implantation following baseline diagnosis n = 6. …”
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From across the globe – traumatic injuries are an international concern at the US-Mexico border wall by Allison E Berndtson, Jay Doucet, Todd W Costantini, Laura Haines, Sarah Lagan, Laura Adams, Jarrett Santorelli, Gabriella Waters

“…Introduction Socio-economic and political events of recent years have caused a significant increase in immigrants attempting to illegally cross the United States (US)-Mexico border. …”
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Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk... by Narayanaswamy Venketasubramanian, Deidre Anne De Silva, Christopher P L H Chen, Cyrus G Escabillas, John Harold Hiyadan, Johnny K Lokin, Romulo U Esagunde, Joel M Advincula, Christian Oliver C Co, Maria Epifania V Collantes, Annabelle Y Lao, Yeow-Hoay Koh, Carol Huilian Tham

“…Additionally, telephone assessment at week 4 includes the simplified mRS and PROMIS-10.Safety will be evaluated by standard assessments and occurrence of adverse events over the duration of the study.Discussion Interventions that enhance recovery beyond the acute period of stroke are needed. …”
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