Donafenib combined with sintilimab for advanced hepatocellular carcinoma: a single arm phase II trial by Xiaoyang Hong, Yongjian Guo, Wenbo Shi, Kangshun Zhu, Licong Liang, Liteng Lin, Ye Chen, Jingwen Zhou, Jingjun Huang, Jiabai Huang, Yaozhu Wu, Wensou Huang, Mingyue Cai

“…Treatment-related adverse events (TRAEs) occurred in 28 patients (93.3%) and grade 3 TRAEs were observed in 9 patients (30.0%). …”
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Early Endoscopic Outcomes After Risankizumab Are Associated With Fewer Hospitalizations and Surgeries in Crohn’s Disease by Brian G. Feagan, Jean-Frederic Colombel, Remo Panaccione, Stefan Schreiber, Marc Ferrante, Koji Kamikozuru, Christopher Ma, Wan-Ju Lee, Jenny Griffith, Namita Joshi, Kristina Kligys, Jasmina Kalabic, Si Xuan, Marla Dubinsky

“…Methods: Patients with moderately to severely active CD and clinical response to 12-week risankizumab induction were rerandomized to continued therapy or drug withdrawal in the phase 3 FORTIFY maintenance trial. Incidence rates (events/100 person-years) of CD-related hospitalization and surgery, and the composite of both, through 52 weeks of maintenance were compared between patients achieving vs not achieving predefined endoscopic outcomes following induction. …”
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Food insecurity and the risk of HIV acquisition: findings from population-based surveys in six sub-Saharan African countries (2016–2017) by Danielle Barradas, Nicholus Mutenda, Hetal Patel, Avi J Hakim, Lloyd Mulenga, Sally Findley, Andrea Low, George Rutherford, Sarah Ayton, Elizabeth Gummerson, Amee Schwitters, Rogerio Bonifacio, Mekleet Teferi, James Juma, Claudia Ahpoe, Choice Ginindza, Samuel Biraro, Karam Sachathep, Ahmed Saadani Hassani, Willford Kirungi, Keisha Jackson, Leah Goeke, Neena Philips, Jennifer Ward, Steven Hong

“…Heightened food insecurity during climactic extremes could imperil HIV epidemic control, and food support to women with SFI during these events could reduce HIV transmission.…”
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Reattempt Percutaneous Coronary Intervention of Chronic Total Occlusions after Prior Failures: A Single-Center Analysis of Strategies and Outcomes by Mingqiang Fu, Shufu Chang, Lei Ge, Dong Huang, Kang Yao, Feng Zhang, Qing Qin, Jianying Ma, Juying Qian, Junbo Ge

“…Data on clinical factors (age, sex, comorbidities, left ventricular ejection fraction, history of cigarette usage, and revascularization), angiographic characteristics of CTOs (target lesion, Japanese Chronic Total Occlusion (J-CTO) score, the morphology of CTO lesions, and collateral channel scale), strategies (procedural approach and use of devices), and major adverse events were obtained and analyzed. Results. The mean age of enrolled patients was 60.96 ± 12.36 years, with a male predominance of 90.3%. …”
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Clinical efficacy of Tuina therapy combined with traditional Chinese exercises in the treatment of symptomatic lumbar disc herniation: a multicentre randomised controlled trial pro... by Zhihong Fan, Shenghong Jia, Xin Zhou, Chao Li, Jiahao Shao, Xiaofeng Liu, Yitao Liao, Yenan Xu, Dandan He, Shixiang Wu, Xian Zhang

“…Gait analysis was only used for comparison between the two groups before and after treatment, and did not involve follow-up. Adverse events occurring during the trial were faithfully recorded.ConclusionThe results of this study are expected to provide a more effective research protocol for symptomatic LDH and an evidence-based rationale for the efficacy and safety of Tuina combined with TCEs in the treatment of symptomatic LDH.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?…”
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Global decadal measurements of methanol, ethene, ethyne, and HCN from the Cross-track Infrared Sounder by K. C. Wells, D. B. Millet, J. F. Brewer, V. H. Payne, K. E. Cady-Pereira, R. Pernak, S. Kulawik, S. Kulawik, C. Vigouroux, N. Jones, E. Mahieu, M. Makarova, T. Nagahama, I. Ortega, M. Palm, K. Strong, M. Schneider, D. Smale, R. Sussmann, M. Zhou

“…The results reveal robust global distributions of the target VOCs from known biogenic, biomass burning, and industrial source regions, and they demonstrate the impact of anomalous events such as the 2015–2016 El Niño. They also highlight the importance of accurate vertical profile constraints when evaluating and interpreting thermal infrared data records. …”
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Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results... by Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stéphanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwé, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frédéric Amant, Katrien Vandecasteele, Hannelore G. Denys

“…Grade ≥ 3 treatment-related adverse events were reported in 10 (55.6%) cervical cancer patients and 9 (36.0%) endometrial cancer patients. …”
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Infection‐Related Hospitalization and Incident Heart Failure: The Atherosclerosis Risk in Communities Study by Rebecca L. Molinsky, Amil Shah, Melana Yuzefpolskaya, Bing Yu, Jeffrey R. Misialek, Bruno Bohn, David Vock, Richard MacLehose, Barry A. Borlaug, Paolo C. Colombo, Chiadi E. Ndumele, Junichi Ishigami, Kunihiro Matsushita, Pamela L. Lutsey, Ryan T. Demmer

“…Hazard ratio (HR) for incident HF events among participants who had an IRH compared with those who did not was 2.35 (95% CI, 2.19–2.52). …”
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Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure by Yan Chen, Xiao-fang Tang, Run-lin Gao, Yue-jin Yang, Bo Xu, Jin-qing Yuan

“…During a 2-year follow-up, no significant association was observed of β-blocker use with all-cause mortality (with β-blockers 47/5,043 (0.9%) vs. without β-blocker use 8/588 (1.4%); hazard ratio (HR) 0.762, 95% confidence interval 0.36 to 1.64; P=0.485), cardiac death, myocardial infarction (MI), or major adverse cardiovascular and cerebrovascular events. Subgroup analysis demonstrated that the β-blocker use at discharge reduced the 2-year mortality in patients with unstable angina (UA) (HR 0.42, 95% CI 0.19 to 0.94, P=0.034). …”
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Barriers and facilitators to implementation of a home-based cardiac rehabilitation programme for patients with heart failure in the NHS: a mixed-methods study by Rod S Taylor, Paulina Daw, Samantha B van Beurden, Jet J C S Veldhuijzen van Zanten, Alexander Harrison, Sinead T J McDonagh, Patrick J Doherty, Colin J Greaves, Hasnain M Dalal, Grace E R Wood

“…In 2020, 5 online REACH-HF training events were attended by 85 healthcare professionals from 45 National Health Service (NHS) teams across the UK and Ireland.Design Our mixed-methods study used in-depth semi-structured interviews and an online survey. …”
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CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…To this aim, we took advantage of immunodeficient mice reconstituted with a human immune system (HuSGM3) and engrafted with the B-cell acute lymphoblastic leukemia cell line NALM-6, a model that allows to thoroughly study efficacy and toxicity profiles of CD19 CAR-T cell products.Results CD4 CAR-T cells showed superior proliferation and activation potential, which translated into stronger stimulation of myeloid cells, the main triggers of adverse events. Accordingly, toxicity assessment in HuSGM3 mice identified CD4 CAR-T cells as key contributors to CRS development, revealing a safer profile when they harbor CARs embedded with 4-1BB, rather than CD28. …”
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Indocyanine Green Fluorescence Plus Blue Dye for Sentinel Lymph Node Biopsy in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter, Prospective Cohort Stu... by Miao Liu, Yang Yang, Bin Hua, Rui Feng, Tianyu Xu, Mengyuan Wang, Xiaowei Qi, Yingming Cao, Bo Zhou, Fuzhong Tong, Peng Liu, Hongjun Liu, Lin Cheng, Houpu Yang, Fei Xie, Siyuan Wang, Chaobin Wang, Yuan Peng, Danhua Shen, Lei Chen, Jun Jiang, Shu Wang

“…The primary outcome was the detection rate (DR); secondary outcomes included the false‐negative rate (FNR) and adverse events associated with the use of tracers. Results A total of 156 patients were enrolled; all underwent SLNB after NAC. …”
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Booster Vaccination against Yellow Fever in Gambian children-(BoVY) -a Phase 3 clinical trial to establish safety and immunogenicity of repeated YF vaccination in healthy Gambian c... by David Jeffries, Caitlin Pley, Beate Kampmann, Mam Nabou Leigh, Julia Strandmark, Ed Clarke, Peter Ndow, Ebrima Kanteh, Amadou Faal, Elishia Roberts

“…Serum samples will be taken before and 28 days after the booster, with additional sampling for exploratory endpoints in subgroups. Adverse events are solicited for the first three days following vaccination and recorded throughout the study period. …”
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Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

“…The fundamental rationale for promoting health resilience in T2DM stems from its high prevalence of 10.5% of the world’s adult population and its contribution to many adverse health events.Methods AI-READI is a cross-sectional study whose target enrollment is 4000 people aged 40 and older, triple-balanced by self-reported race/ethnicity (Asian, black, Hispanic, white), T2DM (no diabetes, pre-diabetes and lifestyle-controlled diabetes, diabetes treated with oral medications or non-insulin injections and insulin-controlled diabetes) and biological sex (male, female) (Clinicaltrials.org approval number STUDY00016228). …”
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INTERNATIONAL FORUM OF AMERICAN SOCIETY FOR ENGINEERING EDUCATION by Vasily Ivanov, Yulia Ziyatdinova

“…The Conference was a very large scale event, and included 2 plenary sessions, 6 distinguished lectures, 132 business meetings, around 300 technical sessions, 27 workshops, 20 poster sessions, and around 50 panel sessions. …”
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Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes by Fang Wang, Yukang Mao, Jinyu Sun, Jiaming Yang, Li Xiao, Qingxia Huang, Chenchen Wei, Zhongshan Gou, Kerui Zhang

“…The study aims to establish models predicting long-term mortality and explore dietary nutrients associated with reduced long-term events to guide daily dietary decisions in people with DM. …”
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Association of coronary revascularisation after physician-referred non-invasive diagnostic imaging tests with outcomes in patients with suspected coronary artery disease: a post ho... by Takao Kato, Moriaki Inoko, Naoya Matsumoto, Yukari Uemura, Masanao Naya, Mitsuru Momose, Satoshi Hida, Takao Yamauchi, Takatomo Nakajima, Eriko Suzuki, Tohru Shiga, Nagara Tamaki

“…We assessed the effect of revascularisation (within 90 days) in each diagnostic imaging stratum and the interaction between the two strata.Primary and secondary outcome measures Major adverse cardiac events (MACEs), including death, myocardial infarction, hospitalisation for heart failure and late revascularisation, were followed up for 1 year. …”
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Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor by Guohui Lu, Linfeng Luo, Maolin Liu, Zijian Zheng, Bohan Zhang, Xiaosi Chen, Xing Hua, Houyou Fan, Guoheng Mo, Jian Duan, MeiHua Li, Tao Hong, Dongwei Zhou

“…The most common adverse event was dysarthria (10.5%), which is a stimulation-related AE (23.6%), while the rates of the surgical-related and device-related AEs were 6.4% and 11.5%, respectively. …”
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Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis by Ziying Wu, Xiang Ding, Guanghua Lei, Chao Zeng, Jie Wei, Jiatian Li, Hui Li, Tuo Yang, Yang Cui, Yilin Xiong, Yilun Wang, Dongxing Xie

“…Three trials reported adverse events, and the combined results showed that there was no significant difference between PEMF and the sham group.Conclusions PEMF could alleviate pain and improve physical function for patients with knee and hand OA, but not for patients with cervical OA. …”
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Preoperative Analgesia Efficacy of Liposomal Bupivacaine Following Pericapsular Nerve Group (PENG) Block in Patients with Hip Fracture: A Randomized Controlled Observer-Blinded Stu... by Haobin Peng, Jiajun Wen, Manli Chen, Zhengyuan Xia, Ying Jiang, Kaiqi Xie, Weitao Huang, Bangsheng Cui, Peixing Li, Yiwen Zhang, Xianping Wu

“…Pain scores at 12, 24, 36, 60, and 72 h post-block, rescue analgesia rate, time to first opioid, additional morphine consumption, and adverse events were assessed as the secondary outcomes. Results LB versus ropivacaine group at 48 h post-block, with a median interquartile range (IQR) of 2 (1.0–2.0) versus 3 (2.0–3.0) at static pain score and 2 (1.75–3.0) versus 4 (4.0–5.0) at dynamic pain score. …”
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