Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic agents on digestive system function, intestinal immunity and prognosis in patients with metast... by Xiaolei Wang, Yuxia Huang, Zhen Yang, Yang Yang, Fenfen Wei, Min Yan, Fanfan Li, Chenghao Wang

“…This combination therapeutic strategy can balance the imbalanced intestinal flora, improve intestinal function, and lessen the incidence of adverse events, so it is worthy of clinical application and can lessen the incidence of adverse reactions.…”
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Protection of housing rights of Ukrainian citizens in conditions of armed aggression of the Russian Federation against Ukraine by Samoylenko G., Kosyrev D.

“…Purpose: the purpose of the article is to determine and justify the choice of the optimal model of civil-legal protection of housing rights in the event of their violation, which is caused or is a direct consequence of the armed aggression of the Russian Federation against Ukraine. …”
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Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 He... by S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart

“…In total, 38 adverse events (AEs) occurred. Fourteen AEs were potentially related to the investigational items. …”
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Mitigating effects of Jiawei Chaihu Shugan decoction on necroptosis and inflammation of hippocampal neurons in epileptic mice by Qin Wang, Baijun Qin, Han Yu, Jiawei Zeng, Jingjing Fan, Qiong Wu, Rong Zeng, Haichun Yu, Xian Zhang, Mingfen Li, Yanying Zhou, Limei Diao

“…JWCHSGD reduces epileptic events by regulating the circRNA-Csnk1g3/Csnk1g3-85aa/CK1γ3/TNF-α signaling pathway, impacting necroptosis and inflammation in hippocampal neurons and HT22 cells.…”
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Efficacy and safety of immune checkpoint inhibitors in elderly patients with advanced non-small cell lung cancer: a systematic review and meta-analysisResearch in context by Jiacheng Yao, Sihan Li, Lu Bai, Jun Chen, Chengbo Ren, Tingting Liu, Jingping Qiu, Jun Dang

“…In real-world studies, the pooled median OS of ICIs were 11.8 months (95% CI: 11.2–12.4); Eastern Cooperative Oncology Group (EOCG) score, histological type, PD-L1 status, with immune-related adverse events (irAEs), and treatment mode were predictive for OS; rates of irAEs and discontinuation were numerically higher for combination therapy vs. monotherapy. …”
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The extent of intestinal involvement is closely related to the severity of IgAV: a risk stratification study based on CT by Yuanqiu Li, Ziman Xiong, Yufan Wang, Yuchen Jiang, Yaqi Shen, Xuemei Hu, Daoyu Hu, Zhen Li

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Safety and efficacy of anti-CD30 CAR-T cell therapy in relapsed/refractory classic Hodgkin lymphoma: a systematic review and meta-analysis by Fanqiao Meng, Maoyuan Xiang, Yu Liu, Dongfeng Zeng

“…Outcomes including overall response rate (ORR), complete response (CR), partial response (PR), progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were extracted for meta-analysis. We used the Methodological Index for Non-Randomized Studies (MINORS) to evaluate the quality of the included literature. …”
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Treatment of neovascular age-related macular degeneration: one year real-life results with intravitreal Brolucizumab by Settimio Rossi, Carlo Gesualdo, Ernesto Marano, Raffaele Perrotta, Maria Consiglia Trotta, Antonio Del Giudice, Francesca Simonelli

“…These results were obtained with a low number of injections (3.7 ± 1.9) with only one case of intraocular drug-related adverse event. Finally, the presence of subretinal hyperreflective material correlates with lower visual recovery.DiscussionOur findings highlight the efficacy of Brolucizumab in managing wet-AMD and suggest its role for long-term efficacy in stabilizing retinal exudation and fluid accumulation, resulting in improved visual prognosis.…”
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Effects of early supplemental parenteral nutrition on new-onset infection in adults with acute severe stroke: a single-center retrospective case–control study by Chen Ma, Zhirong Fan, Xuan Wang, Bian Li, Jingjing Zhao, Xiaogang Kang, Wen Jiang, Fang Yang

“…The rates of digestive intolerance events were similar between the two groups (40% in the SPN group vs. 52.5% in the EN group, P = 0.361). …”
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Total neoadjuvant chemotherapy according to the FOLFIRINOX regimen for locally advanced adenocarcinoma of the stomach and cardioesophageal junction: interim results by M. V. Sedova, M. A. Batov, A. A. Kolomeytseva, V. M. Khomyakov, N. N. Volchenko, A. A. Fedenko

“…Median PFS and overall survival (OS) were not reached. The incidence of events (progression or death) was lower in the FOLFIRINOX group (odds ratio [OR] 0,40 [95 % CI 0,16–0,97, p = 0,047]). …”
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Compensatory effects conceal large uncertainties in the modelled processes behind the relationship between the El Niño–Southern Oscillation (ENSO) and CO₂ by I. Dunkl, I. Dunkl, A. Bastos, T. Ilyina, T. Ilyina, T. Ilyina

“…The analysed ESMs agree on the direction of the sensitivity of global NBP to ENSO but exhibit very high uncertainty with regard to its magnitude, with a global NBP anomaly of <span class="inline-formula">−0.15</span> to <span class="inline-formula">−2.13</span> Pg C yr<span class="inline-formula">⁻¹</span> per standardised El Niño event. The largest source of uncertainty lies in the differences in the sensitivity of NBP to climate. …”
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Comprehensive approach to predictive analysis and anomaly detection for road crash fatalities by Chopparapu Gowthami, S. Kavitha

“…Through the possibility of highlighting regions with increased risk or problems with data quality, this part of the research improves our comprehension of unexpected events in accident data. For comparison analysis, other models such as Auto Regressive Integrated Moving Average and Support Vector Regression are used in addition to the Random Forest Regression model. …”
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Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials by Sathish Muthu, Sathish Muthu, Sathish Muthu, Vibhu Krishnan Viswanathan, Vibhu Krishnan Viswanathan, Prakash Gangadaran, Prakash Gangadaran, Prakash Gangadaran

“…Epidural PRP injection was found to offer comparable pain relief (VAS; WMD = −0.09, 95% CI [−0.66, 0.47], p = 0.641; I2 = 96.72%, p &lt; 0.001), functional improvement (ODI; WMD = 0.72, 95% CI [-6.81, 8.25], p = 0.524; I2 = 98.73%, p &lt; 0.001), and overall health improvement (SF-36; WMD = 1.01, 95% CI [−1.14, 3.17], p = 0.224; I2 = 0.0%, p = 0.36) as epidural steroid injection (ESI) at all the observed time points in the included studies without any increase in adverse events or complications. Epidural administration of PRP offers comparable benefit as epidural steroid injection (ESI) in the management of radiculopathy due to LDD. …”
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Efficacy of Curcumin on Treating Cancer Anorexia-Cachexia Syndrome in Locally or Advanced Head and Neck Cancer: A Double-Blind, Placebo-Controlled Randomised Phase IIa Trial (CurCh... by Tawasapon Thambamroong, Kasan Seetalarom, Siriwimon Saichaemchan, Yanisa Pumsutas, Naiyarat Prasongsook

“…Similarly, most adverse events were grade 1 in both groups. Conclusion. The curcumin add-on resulted in a significant increase in muscle mass than standard nutritional support. …”
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Clinical characteristics of patients with coronary artery disease by smoking status by Olga V. Nakhratova, Daria P. Tsygankova, Joseph M. Tsenter, Evgeny D. Bazdyrev

“…Percutaneous coronary interventions, history of acute cardiovascular events, arterial hypertension, multifocal atherosclerosis, and multivessel disease as defined by SYNTAX were more common in this group of patients. …”
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Evaluation of the Performance of an Ocular Surface Modulator Containing ST-Lysyal Versus Hyaluronic Acid Eyedrops in Patients with Dry Eye Disease: A Pilot Study by Stefano Barabino, Andrea Rosa, Sara Marini, Carlo Domenico Bianchi, Maurizio Rolando

“…T-Lys treatment resulted in significant improvements from baseline (V0) to 2 months (V2) in symptoms assessed by visual analogue scale (T-Lys: 4.58 ± 2.57 mm at V0, 2.92 ± 1.38 mm at V2, p < 0.05; control: 5.13 ± 2.29 mm at V0, 5.3 ± 2.4 mm at V2), T-BUT (T-Lys: 2.58 ± 1.31 s at V0, 3.58 ± 1.37 s at V2, p < 0.05; control: 3.07 ± 1.43 s at V0, 3 ± 1.13 s at V2), and corneal staining (T-Lys: 2.16 ± 4.17 at V0, 1.41 ± 3.70 at V2, p < 0.05; control: 1.4 ± 2.19 at V0, 1.4 ± 2.16 at V2). No adverse events were reported. Literature findings supported T-Lys’s efficacy in managing both ophthalmology and non-ophthalmology conditions. …”
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Teaching communication skills to OTL-HNS residents: multisource feedback and simulated scenarios by Pier-Luc Beaudoin, Mathilde Labbé, Amanda Fanous, Meredith Young, Jamie Rappaport, Yoon Soo Park, John Manoukian, Lily H. P. Nguyen

“…Abstract Background Effective communication has been linked to a reduction in adverse events and improved patient compliance. Currently in Otolaryngology – Head and Neck Surgery (OTL-HNS) residency programs, there is limited explicit teaching of communication skills. …”
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Prognostic factors for successful extubation in newborns with congenital diaphragmatic hernia by A. Rannebro, C. Mesas-Burgos, C. Mesas-Burgos, U. Fläring, U. Fläring, S. Eksborg, S. Eksborg, J. Berner, J. Berner

“…CDH-patients (n = 38), aged 0–28 days, with extubation events were identified from 2017 to 2019. Eight patients (21.1%) needed reintubation within 24 h after the first extubation attempt. …”
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Understanding and measuring workplace violence in healthcare: a Canadian systematic framework to address a global healthcare phenomenon by Christian Schulz-Quach, Brendan Lyver, Charlene Reynolds, Trevor Hanagan, Jennifer Haines, John Shannon, Laura Danielle Pozzobon, Yasemin Sarraf, Sam Sabbah, Sahand Ensafi, Natasha Bloomberg, Jaswanth Gorla, Brendan Singh, Lucas B. Chartier, Marnie Escaf, Diana Elder, Marc Toppings, Brian Hodges, Rickinder Sethi

“…At the University Health Network (UHN) in Toronto, Canada, WPV incidents in EDs jumped 169% from 0.43 to 1.15 events per 1000 visits (p < 0.0001). In response, UHN launched a comprehensive, systems-based quality improvement (QI) project to ameliorate WPV. …”
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Examining the association between child development and parental mental health after preterm birth-related stress: a systematic review of the literature and meta-analysis protocol by Lotte Haverman, Cornelieke S H Aarnoudse-Moens, Joost G Daams, Gerbrich E van den Bosch, Kirsten S Muller, Celina E Henke

“…Introduction Preterm infants born before 32 weeks of gestation are generally admitted to a neonatal intensive care unit (NICU) to receive life-saving treatment, resulting in early exposure to stressful events. Yet, NICU admission is not only stressful for the infant but can also have a long-lasting negative impact on parental mental health, who may worry about their child. …”
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