Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly versus non-elderly patients with type 2 diabetes mellitus: insights from a systematic review by Yao Wang, Jiangling Wang, Qian Gong, Haoming Wu, Shuhao Yang, Jufeng He, Xulin Hu, Tianfang Huang

“…The incidence of adverse events (AEs) leading to discontinuation was higher in elderly patients (OR = 0.67, 95% CI 0.47 to 0.96, p = 0.028). …”
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Effect of antioxidant capsule supplementation on oxidative stress markers in hypertensive patients by Novaes-Gaeta Ludmila N., Moraes Mariele C., Katayama Keyla Y., Sangaletti Carine T., Irigoyen Maria Claudia, Freitas Sarah, Viana Ariane, de Angelis Katia, Caldini Elia G., Lopes Heno F.

“…Evidence suggests that there is a proportional relationship between diets high in antioxidants and a reduced risk of cardiovascular events. A high antioxidant diet could scavenge the free radicals and other toxic radicals offering better protection to the cardiovascular system. …”
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Efficacy and Safety of HAPC in Barrett's Esophagus – A Multicenter Italian Prospective Study by Davide Massimi, Roberta Maselli, Silvia Pecere, Cristiano Spada, Gianluca Andrisani, Francesco Maria Di Matteo, Antonella La Terra, Franco Coppola, Antonio Capogreco, Roberto De Sire, Ludovico Alfarone, Maddalena Menini, Marco Spadaccini, Cesare Hassan, Alessandro Repici

“…The secondary endpoints were safety in terms of major and minor adverse events (AEs) and tolerability, assessed using pain (0-10) and dysphagia (0-5) scores within 7 days post-ablation. …”
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YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database by Mengge Wang, Shuhan Duan, Qiuxia Sun, Kaijun Liu, Yan Liu, Zhiyong Wang, Xiangping Li, Lanhai Wei, Yunhui Liu, Shengjie Nie, Kun Zhou, 10K_CPGDP consortium, Yongxin Ma, Huijun Yuan, Bing Liu, Lan Hu, Chao Liu, Guanglin He

“…New evidence was provided for extensive gene flow events between minority ethnic groups and Han Chinese people, based on the integrative Chinese Paternal Genomic Diversity Database. …”
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Examining future spatiotemporal changes in blue and green water using an enhanced SWAT model: A Jialing River basin case study by Mingyan Wu, Fuquan Ni, Yu Deng, Nan Jiang, Mengyu Zhu, Huazhun Ren, Ziying Yue, Yuxuan Wang

“…This research focuses on the Jialing River Basin, utilizing an enhanced Soil & Water Assessment Tool (SWAT) model alongside CMIP6 data, and selects representative years of dry-hot composite events through the Dry-Hot Magnitude Index (DHMI) to study the alterations in blue and green water across various future scenarios. …”
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Safety, feasibility and initial efficacy of an app-facilitated telerehabilitation (AFTER) programme for COVID-19 survivors: a pilot randomised study by Kristine M Erlandson, Jacob John Capin, Amy Nordon-Craft, Sarah E Jolley, Jennifer E Stevens-Lapsley, Mary Morrow, Meghan Connors, Kristine Hare, Samantha MaWhinney, Michelle Rauzi, Sheryl Flynn

“…The 30 s chair stand test was the main secondary (efficacy) outcome.Results No adverse events (AEs) occurred during testing or in telerehabilitation sessions; 38% (11/29) of the intervention group compared with 60% (9/15) of the control group experienced an AE (p=0.21), most of which were minor, over the course of the 12-week study. 27 of 29 participants (93%; 95% CI 77% to 99%) receiving the intervention attended ≥75% of sessions. …”
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N-Butyl-2-Cyanoacrylate Adhesive Versus Absorbable Tacks in Laparoscopic Groin Hernia Repair: A Multicenter Randomized Clinical Trial by Clayton C. Petro, MD, Benjamin K. Poulose, MD, Michael J. Rosen, MD, Alfredo M. Carbonell, II, DO, Adel G. El-Ghazzawy, MD, Jeremy A. Warren, MD, Emanuele Lo Menzo, MD, Ajita S. Prabhu, MD, David M. Krpata, MD, Samuel Szomstein, MD, Vimal Narula, MD, Crystal F. Totten, MD, Kelly R. Haisley, MD, Andrew C. Bernard, MD, Henrik O. Berdel, MD, Jessica K. Reynolds, MD, Zachary D. Warriner, MD, John S. Roth, MD

“…Recurrence, successful use of the device, quality of life, and rates of adverse events (AEs) were secondary outcomes. Results:. From 2019 to 2021, 284 patients were randomized to either NB2C adhesive or absorbable tacks (n = 142/142). …”
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Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest by Magnus Gylling, Johanna Krøll, Peder Emil Warming, Carolina Malta Hansen, Fredrik Folke, Steen M. Hansen, Lars Køber, Christian Torp-Pedersen, Rodrigue Garcia, Jacob Tfelt-Hansen, Peter E. Weeke

“…Patients with OHCA were matched 1:4 (age, sex, and number of identifiable parents) with individuals from the background population (controls) to compare family histories (events in first-degree relatives before OHCA) of CVD, all-cause death, cardiovascular death, and premature death (death <60 years). …”
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Influence of environmental variables and anthropogenic activities on soda-saline lakes chemistry in northern Tanzania: A remote sensing and GIS approach by Azaria Stephano Lameck, Brian Rotich, Abdalrahman Ahmed, Harison K. Kipkulei, Peto Akos, Emil Boros

“…The Standardized Precipitation Evapotranspiration Index revealed increased drought events in the lake basins since 1987, with prolonged drought occurrence between 2000 and 2017. …”
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Effect of electroacupuncture on discomfort in patients undergoing colonoscopy: protocol for a multicentre, randomised, controlled clinical trial by Chao Lin, Wenting Chen, Yue Yong, Jiangang Song, Xiangyu Sun, Yongqiang Wang, Liyue Lu, Chunchun Wang, Kuangdi Xu

“…Secondary outcomes will include participants’ tolerance levels, including standard NRS scores for abdominal pain, bloating and anal discomfort reported by the participants, as well as heart rate(HR), blood pressure(BP), surgical pleth index, participant satisfaction, nurses’ and endoscopists’ evaluations, incidence of adverse events and salivary cortisol levels collected before EA and after colonoscopy.Ethics and dissemination Ethics approval was obtained from the Ethics Committee of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (number 2023-1327-94-01), Ethics Committee of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (number 2023LCSY059) and Ethics Committee of Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine (number 2023-062-01). …”
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Impact of ambient temperatures on Alzheimer's disease and other dementia mortality among elderly patients aged 60 years and older in China by Rui Zhang, Lu Sun, Ai-Nan Jia, Si-Yuan Wu, Yu Wang, Song-Wang Wang, Qing Guo, Yu-Jie Meng, Juan Liang, Wan Huang, Yong-Hong Li, Jing Wu

“…As global climate change results in more frequent extreme weather events, and there is a current lack of understanding regarding the impact of non-optimal temperatures, especially cold, on AD and other dementia mortality, the study aimed to identify patterns of temperature sensitivity in order to inform targeted public health strategies. …”
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Multidisciplinary, multicenter consensus for the care of patients affected with Sturge–Weber syndrome by May El Hachem, Andrea Diociaiuti, Angela Galeotti, Francesca Grussu, Elena Gusson, Alessandro Ferretti, Carlo Efisio Marras, Davide Vecchio, Simona Cappelletti, Mariasavina Severino, Carlo Gandolfo, Simone Reali, Rosa Longo, Carmen D’Amore, Lodovica Gariazzo, Federica Marraffa, Marta Luisa Ciofi Degli Atti, Maria Margherita Mancardi, and the Sturge-Weber Syndrome Multidisciplinary Group

“…The spectrum of clinical manifestations includes headache, seizures, stroke-like events, intellectual disability, glaucoma, facial asymmetry, gingival hyperplasia, etc. …”
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Clinical features and long-term outcomes in patients under 35 years with coronary artery disease: Nested case–control study by Pablo Juan-Salvadores, Dahyr Olivas-Medina, Luis Mariano de la Torre Fonseca, Cesar Veiga, Silvia Campanioni, Francisco Caamaño Isorna, Andrés Iñiguez Romo, Víctor Alfonso Jiménez Díaz

“…The probability of major adverse cardiovascular events was associated with being ≤35 years old, diabetes, dyslipidemia, and depression. …”
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Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies by Ramin Assempoor, Mohammad Shahabaddin Daneshvar, Aryan Taghvaei, Alireza Sattari Abroy, Amir Azimi, John R. Nelson, Kaveh Hosseini

“…In populations without established CAD, higher AIP levels were associated with an increased risk of Major adverse cardiovascular events (MACE) (hazard ratio (HR): 1.28, 95% CI 1.22–1.35, P < 0.00001). …”
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Lumbosacral Plexopathy After Carbon-ion Radiation Therapy for Postoperative Pelvic Recurrence of Rectal Cancer: Subanalysis of a Prospective Observational Study (GUNMA 0801) by Takuya Kumazawa, MD, PhD, Shintaro Shiba, MD, PhD, Yuhei Miyasaka, MD, PhD, Masahiko Okamoto, MD, PhD, Daijiro Kobayashi, MD, PhD, Tatsuya Ohno, MD, PhD

“…RILSP was graded according to the Common Terminology Criteria for Adverse Events version 4.0. Results: Median follow-up was 24 months. …”
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Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III by Bernadette Corica, Giulio Francesco Romiti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip, on behalf of the GLORIA-AF Investigators

“…We analysed associations with oral anticoagulant (OAC) use and risk of a composite primary outcome (all-cause death and major adverse cardiovascular events (MACE)) and secondary outcomes. Results Among 21,245 patients (mean age 70.2 ± 10.3 years, 44.9% females), we identified 6 patterns: i) Low Medicated pattern (18.3%); ii) Hypertension pattern (21.1%); iii) Heart Failure pattern (20.0%); iv) CV Prevention pattern (21.0%); v) Mixed Morbidity pattern (4.5%); and vi) High Medicated pattern (15.0%). …”
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Comparative Analysis of Adverse Drug Reactions Associated with Fluoroquinolones and Other Antibiotics: A Retrospective Pharmacovigilance Study by Alshareef H, Alenzi KA, Albalawi BR, Alanazi RM, Albalawi NS, Alasoufi WS, Alqifari S, Ahmed R, Ali MAS

“…Patients who received FQs were fourfold more likely to experience neurological adverse events (OR 4.15, 95% CI 2.48– 6.93, p < 0.001).Conclusion: The FQs drug class exhibited a higher incidence of ADRs than other ABs. …”
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Accelerated expansion of NATO into the Balkans as a consequence of Euro-Atlantic Discord by S. Gajić, E. G. Ponomareva

“…Subsequently, post-Cold War ideological consensus in the West has also been challenged even further by the growth of non-systemic political movements – many of them directed not only against the EU expansion, but also against the EU itself.The significance of all these events for the Balkans is somewhat surprising and paradoxical, as the mainstream forces that have been weakened in the West forcefully push for a stronger Atlantic integration of the remaining Balkan countries. …”
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The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States by Yi Zhang, Tingzhen Li, Qixin Chen, Maobiao Shen, Xinyang Fu, Changjin Liu

“…Data regarding ED were extracted from the 2001–2004 National Health and Nutrition Examination Survey(NHANES), and mortality events were ascertained through the National Death Index up to December 2019. …”
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Polyploidization-driven transcriptomic dynamics in Medicago sativa neotetraploids: mRNA, smRNA and allele-specific gene expression by D. F. Santoro, G. Marconi, S. Capomaccio, M. Bocchini, A. W. Anderson, A. Finotti, M. Confalonieri, E. Albertini, D. Rosellini

“…This material can help to elucidate events at the base of the domestication of cultivated 4x alfalfa, the world’s most important leguminous forage. …”
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