A suite of wildlife crossing structures facilitates mammal movement across tropical forest fragments in a city by Li Si Tay, Ruisheng Choo, Max D. Y. Khoo, Eunice Kong, Yi Xiang Chan, Wivian H. Y. Neo, Sebastian Ow, Yuet Hsin Toh, Han Ling, Malcolm C. K. Soh, Benjamin P. Y.‐H. Lee, Adrian H. B. Loo, Kenneth B. H. Er

“…Using camera traps and closed‐circuit televisions, we documented 1133 independent crossing events across a 9‐month study period from March to November 2021. …”
Get full text

Is it feasible to treat polycystic ovarian syndrome with or without insulin resistance using glucokinase activators as novel hypoglycaemic medications? A protocol for a systematic... by Xiaojing Liu, Lei Zeng, Shuo Yuan, Genping Zeng, Xijing Lu, Peiyin Li, Tan Zeng, Zitong Lin, Yuxi Miao

“…The primary outcomes of interest encompass changes in anthropometric parameters, menstrual frequency, sex hormone levels, and glucose metabolism, while secondary objectives include lipid metabolism and adverse events. The methodological quality of each study will be assessed using Version 2 of the Cochrane Collaboration tool for assessing Risk of Bias (RoB 2.0), and the Grade of Recommendations, Assessment, Development and Evaluation (GRADE) technique will be used to assess the quality of evidence and degree of recommendation. …”
Get full text

How Marine Megabenthos Fauna Responds to River Discharge and Artificial Flood in Large River Estuary by Debin Sun, Qinglu Fu, Jiao Wang, Linlin Chen, Jing Chen, Yilin Wang, Baoquan Li

“…Knowledge of how marine megabenthos responds to river regulation and artificial flooding events remains limited. The study aims to provide a comprehensive understanding of the impacts of river regulation on marine megabenthic fauna. …”
Get full text

Tau oligomers impair memory and synaptic plasticity through the cellular prion protein by Claudia Balducci, Franca Orsini, Milica Cerovic, Marten Beeg, Beatrice Rocutto, Letizia Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, Laura Colombo, Chiara Zucchelli, Giovanna Musco, Nicholas M. Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, Gianluigi Forloni

“…Abstract Deposition of abnormally phosphorylated tau aggregates is a central event leading to neuronal dysfunction and death in Alzheimer’s disease (AD) and other tauopathies. …”
Get full text

Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Abstract Background Clonal myeloproliferation and fibrotic transformation of the bone marrow (BM) are the pathogenetic events most commonly occurring in myelofibrosis (MF). …”
Get full text

Acute kidney injury is associated with liver-related outcomes in patients with hepatitis B virus infection: a retrospective cohort study by Jiao Liu, Ruixuan Chen, Shiyu Zhou, Zhixin Guo, Licong Su, Lisha Cao, Yanqin Li, Xiaodong Zhang, Fan Luo, Ruqi Xu, Qi Gao, Yuxin Lin, Xin Xu, Sheng Nie, the CRDS study Investigators

“…During a mean follow-up of 4.6 ± 2.4 years, 334 (0.4%) patients died of liver-related events. After adjustment, AKI during hospitalization was significantly associated with a higher risk of liver-related mortality after discharge (adjusted hazard ratio (HR), 1.78; 95% confidence intervals (CI), 1.26–2.51, P = 0.001), especially in those with severe AKI. …”
Get full text

Temporal Trends of Stillbirth in Brazil Disaggregated by Maternal and Gestational Age by Maria Isabel do Nascimento, Lara Miranda Marchesi, Wender Emiliano Soares, Jenaine Rosa Godinho Emiliano, Maria Auxiliadora Nogueira Saad, Glaucimara Gonzaga Nunes Hacar, Gabriel Eijiro Chiracava

“…Results: There were 228,386 stillbirths in Brazil, corresponding to 1 event per 133 live births at ≥ 22 gestational weeks in singleton pregnancies. …”
Get full text

WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study by Song Zhang, Sihuai Xiong, Sha Zhang, Keyu Chen, Hua Wang, Ke Li, Xudong Xu, Xianxian Zhao, Ni Zhu, Xinmiao Huang, Yongwen Qin, Zhifu Guo, Yuan Bai

“…The primary efficacy endpoint included ischemic stroke, cardiovascular/unexplained death and device-related thrombus, while the primary safety endpoint included major peri-procedural complications and major bleeding events during clinical follow-ups. 1:1 propensity score matching (PSM) was performed. …”
Get full text

Systematic Review and Network Meta-Analysis on Treating Hormone Receptor-Positive Metastatic Breast Cancer After CDK4/6 Inhibitors by Neha Pathak, Abhenil Mittal, Sudhir Kumar, Chitrakshi Nagpal, Eitan Amir, Partha Haldar, Bharath B. Gangadharaiah, Akash Kumar, Ashutosh Mishra, Atul Batra

“…We calculated the hazard ratio (HR) for progression-free survival (PFS) and overall survival (OS) using generic inverse variance and odds ratios (ORs) using the Mantel–Haenszel method for adverse events (AEs) with Review-Manager version-5.4. NMA was executed using WINBUGS (Microsoft Excel). …”
Get full text

Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan by Yosuke Inoue, Seitaro Suzuki, Norie Sawada, Naho Morisaki, Zui Narita, Taiki Yamaji, Yoshihiro Kokubo, Takehiko Doi, Yukiko Nishita, Motoki Iwasaki, Manami Inoue, Tetsuya Mizoue

“…Cause-specific analysis was performed using the JPHC dataset, which provided a sufficient number of events for mortality due to physical disorders, mental disorders/suicide, and unintentional injuries. …”
Get full text

Mental health disorder symptom changes among public safety personnel after emotional resilience skills training by R.N. Carleton, S. Sauer-Zavala, T.A. Teckchandani, K.Q. Maguire, L. Jamshidi, R.E. Shields, T.O. Afifi, J. Nisbet, K.L. Andrews, S.H. Stewart, A.J. Fletcher, R. Martin, R.S. MacPhee, J.C. MacDermid, T.M. Keane, A. Brunet, M. McCarron, L.M. Lix, N.A. Jones, G.P. Krätzig, J.P. Neary, G. Anderson, R. Ricciardelli, H. Cramm, J. Sareen, G.J.G. Asmundson

“…Objectives: Public safety personnel (PSP) are frequently exposed to psychologically traumatic events. The exposures potentiate posttraumatic stress injuries (PTSIs), including posttraumatic stress disorder (PTSD). …”
Get full text

Discrimination of Selected Cold-Pressed and Refined Oils by Untargeted Profiling of Phase Transition Curves of Differential Scanning Calorimetry by Mahbuba Islam, Montowska Magdalena, Fornal Emilia, Tomaszewska-Gras Jolanta

“…Flaxseed and hempseed oils exhibited four endothermic peaks, while three peaks with one exothermic event were detected for camelina seed oil. In the case of refined oils, two endothermic peaks were detected for rapeseed oil, three for sunflower oil and four for soybean oil. …”
Get full text

Heat Tolerance Differences Between Hu Sheep and Hu Crossbred Sheep in Microbial Community Structure and Metabolism by Jing-Da Yuan, Li-Wei Wang, Shao-Yin Fu, Ri-Ge-Li-Tu E, Xiao-Qi Ren, Hua Sun, Fang Liu, Biao Wang, Jiang-Hong An, Meng-Ran Zhao, Jiang-Feng He, Xiao-Long He

“…Background: The frequent occurrence of extreme temperature events causes significant economic losses to the livestock industry. …”
Get full text

The impact of drought on forest spring phenology in northern China by Haowen Hu, Pengcheng Xue, Shaodong Huang, Zong Wang, Nina Xiong, Liang Shi, Boyi Liang, Jia Wang

“…These changes are driven not only by rising temperatures but also by the increasing intensity and frequency of extreme events, particularly drought. While the response of the start of the growing season (SOS) to the rising temperature has been widely studied, the mechanisms by which pre-seasonal meteorological drought influence spring phenology in forest ecosystems across different hydroclimatic regions remain poorly understood. …”
Get full text

Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…The choice of a specific CDK4/6i may be influenced by adverse events (AEs). Recently, the Italian Medicines Agency (AIFA) approved the possibility of switching between CDK4/6i for unacceptable toxicity. …”
Get full text

Patient-reported outcome measures following surgeries in implant dentistry and associated factors: a cross-sectional study by Xinyu Wu, Qi Yan, Bin Shi, Mengjie Ye, Jiahui Sun, Haibin Xia

“…The most frequent postoperative adverse events were pain and swelling. Patient-related factors (age, sex, smoking, alcohol consumption, history of periodontitis, and pain and anxiety during surgery) and surgery-related factors (type and extent of surgical procedure) were analysed. …”
Get full text

Cardioattentionnet: advancing ECG beat characterization with a high-accuracy and portable deep learning model by Youfu He, Youfu He, Youfu He, Yu Zhou, Yu Zhou, Yu Qian, Jingjie Liu, Jinyan Zhang, Debin Liu, Qiang Wu, Qiang Wu

“…Specifically, CANet achieved high accuracy in classifying various arrhythmic events, with the following accuracies reported for different categories: Normal (97.37 ± 0.30%), Supraventricular (98.09 ± 0.25%), Ventricular (92.92 ± 0.09%), Atrial Fibrillation (99.07 ± 0.13%), and Unclassified arrhythmias (99.68 ± 0.06%). …”
Get full text

Urban vegetation benefits in mediterranean cities for climate change adaptation and water usage efficiency – a case study in Algarve, Portugal by Pedro Matias, Pedro Matias, Pedro Matias, Manuela Moreira da Silva, Manuela Moreira da Silva, Manuela Moreira da Silva, João Teigão, Amílcar Duarte, Amílcar Duarte

“…In the current climate change scenario, Mediterranean cities face heatwaves and reduced availability of freshwater alternated with intense precipitation events in short periods. The demand for water, especially for urban and tourism purposes, is rising, particularly in coastal cities. …”
Get full text

Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis by Yijian Deng, Liying Zeng, Yigui Lai, Shuai Ji, Baizhao Peng, Hanqi Lu, Ming Wang, Hiu Yee Kwan, Qi Wang, Xiaoshan Zhao

“…Background: Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. …”
Get full text

Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Re... by Cristina Vocca, Diana Marisol Abrego-Guandique, Erika Cione, Vincenzo Rania, Gianmarco Marcianò, Caterina Palleria, Luca Catarisano, Manuela Colosimo, Gregorio La Cava, Italo Michele Palumbo, Giovambattista De Sarro, Tommaso Ceccato, Simone Botti, Tommaso Cai, Alessandro Palmieri, Luca Gallelli

“…<i>Lactobacillus casei</i> DG^® induced a significantly (<i>p</i> < 0.01) faster recovery of symptoms than placebo (2 days vs. 8 days) and an increased time free from symptoms (86 days vs. 42 days) without the occurrence of adverse events. In the probiotic group, the appearance of <i>Lactobacilli</i> after 30 days (T1) was higher vs. the placebo group, and a significant reduction in <i>Corynebacterium</i>, <i>Peptoniphilus</i>, <i>Pseudomonas</i>, <i>Veillonella</i>, <i>Staphylococcus,</i> and <i>Streptococcus</i> was also observed. …”
Get full text