Creation of new anastomosis for management of obstructive symptoms related to gastrojejunal anastomosis in patients who undergo gastric bypass: a case series by Rohit Agrawal, MD, Ethan M. Cohen, MD, Ayowumi A. Adekolu, MD, Soban Maan, MD, Mouaz Haffar, MD, Monica Chowdhry, MD, Shyam Thakkar, MD, Shailendra Singh, MD

“…EUS-guided anastomosis between the gastric pouch and Roux limb was created successfully in all patients, with no major adverse events. One patient experienced LAMS migration after 54 days. …”
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Acute and chronic effects of physical exercise on atherosclerosis, kynurenine pathway, endothelial function and inflammation in patients with coronary artery disease: a clinical tr... by Eliete Bouskela, Gabriela Andrade Paz, Marcus VDS Rangel, Caio Luan Farias, André Luiz Conveniente Soares, Erica Langner, Tatiana Teixeira, Patrícia M L Dutra, Paulo Farinatti, Maria das Graças C Souza, Juliana P Borges

“…Patients with CAD exhibit increased levels of kynurenine (KYN) pathway (KP) metabolites, which are key products of tryptophan (TRP) catabolism and have been identified as predictive markers for cardiovascular events and atherosclerosis progression. However, the effects of exercise on KP metabolites and their influence on atherosclerosis and inflammation in these patients remain poorly understood. …”
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Weekend-Based Parent-Group Intervention to Reduce Stress in Parents of Children and Adolescents with Type 1 Diabetes: A Pilot Study by Lucia Ferrito, Barbara Predieri, Dorina Pjetraj, Maria Cristina Alessandrelli, Manuela Pagnini, Antonio Iannilli, Monica Marino, Stefano Tombolini, Basilio Pintaudi, Giuseppe Lucisano, Fabiana Zani, Lorenzo Iughetti, Antonio Nicolucci, Valentino Cherubini

“…Intervention was based on the reexamination of the traumatic event of diagnosis of T1D through spatial and time-line anchorage, retracing of the future, emotional awareness, and interactive discussion. …”
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Effects of coenzyme Q10 on endothelial and cardiac function in patients undergoing haemodialysis: study protocol for a pilot randomised controlled trial by Yongxing Xu, Enhong Han, Jianjun Gao, Xinlou Li, Xiaowen Zuo, Huaping Jia, Fugui Liang, Lei Xie

“…Secondary outcomes are death or hospitalisation due to cardiovascular events, all-cause mortality, change of CoQ10 concentration, the ratio of ubiquinol to ubiquinone, the change of oxidative stress markers (including malondialdehyde and 8-hydroxy-deoxyguanosine) and Left Ventricular Mass Index.Ethics and dissemination Risks associated with CoQ10 are minor, even at doses as high as 1800 mg according to previous studies. …”
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HIV-Envelope–Dependent Cell-Cell Fusion: Quantitative Studies by Leonor Huerta, Nayali López-Balderas, Evelyn Rivera-Toledo, Guadalupe Sandoval, Guillermo Gómez-Icazbalceta, Carlos Villarreal, Edmundo Lamoyi, Carlos Larralde

“…We used lymphocytic cells transfected for the expression of the HIV-envelope (Env) glycoproteins to develop a method for the direct quantification of fusion events by flow cytometry (Huerta et al., 2006, J. …”
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Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting by Wenjie Yang, Zhuoshan Huang, Ke Yang, Dinghui Liu, Junpeng Xiao, Zhen Wu, Ling Jiang, Shan Cao, Xujing Xie, Shujie Yu

“…OSA was diagnosed when the apnea-hypopnea index (AHI) was ≥5 events/hour. ISR was defined as >50% restenosis of the vessel diameter in which the DES was implanted. …”
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Liver transplantation for homozygous familial hypercholesterolemia: a retrospective analysis from Chinese experience by Hao-Su Zhan, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, Yu-Le Tan, Jun Wang, Liang Zhang, En-Hui He, Guang-Peng Zhou, Hai-Ming Zhang, Zhi-Jun Zhu, Li-Ying Sun

“…Abstract Background Homozygous familial hypercholesterolaemia (HoFH) increases risk of premature cardiovascular events and cardiac death. In severe cases of HoFH, clinical signs and symptoms cannot be controlled well by non-surgical treatments, liver transplantation (LT) currently represents the viable option. …”
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Heightened demand for mental health information resources during the SARS-CoV-2 pandemic in Germany: A retrospective longitudinal analysis of helpline calls by Jil Zippelius, Simon Schreynemackers, Ulrich Hegerl, Hanna Reich

“…Conclusion: The study demonstrated that information-seeking behaviour changed during the pandemic, especially during the lockdown phases. In the event of health crises, more resources must be allocated to meet the increased demand for mental health services. …”
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Development and validation of a prediction model for all-cause mortality in maintenance dialysis patients: a multicenter retrospective cohort study by Jingcan Wu, Xuehong Li, Hong Zhang, Lin Lin, Man Li, Gangyi Chen, Cheng Wang

“…The follow-up endpoint event was all-cause death. Variables were selected by LASSO-Cox regression, and the model was constructed by Cox regression, which was presented in the form of nomogram and web-based tool. …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…These data provide the rationale for the 2 ongoing studies evaluating CPX-351 vs 7+3 in non–MRC-AML and non–t-AML using MRD as the primary end point for ALFA-2101 phase 2 clinical trial and event-free survival for AMLSG 30-18 phase 3 clinical trial.…”
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FLOT Neoadjuvant Chemotherapy Followed by Laparoscopic D2 Gastrectomy in the Treatment of Locally Resectable Advanced Gastric Cancer by Shun Zhang, Dongyi Yan, Qi Sun, Tao Du, Dongliang Cao, Yao Yang, Biao Yuan, Haiqiang Li, Xiaohua Jiang, Chun Song

“…The common grade 3/4 adverse events from chemotherapy were leucopenia (17.4%), neutropenia (30.4%), anemia (13%), anorexia (13%), and nausea (17.4%). …”
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Exploration of the feasibility of clinical application of phage treatment for multidrug-resistant Serratia marcescens-induced pulmonary infection by Xiangke Duan, Wenfeng Liu, Yanyu Xiao, Man Rao, Liyin Ji, Xiaofu Wan, Shuhong Han, Zixun Lin, Haichen Liu, Peifen Chen, Kun Qiao, Mingbin Zheng, Jiayin Shen, Yang Zhou, Tetsuya Asakawa, Minfeng Xiao, Hongzhou Lu

“…Importantly, no adverse events were reported during the treatment or follow-up periods. …”
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Neoadjuvant chemoimmunotherapy for locally advanced squamous cell carcinoma of the head and neck: Systematic review and meta-analysis by Xiayi Zhu, Jie Qiu, Ya Zhang, Chunni Lin, Xiaohui Wang, Xiwei Shi, Siya Yang, Qiaoyan Wu, Li Cong

“…Regarding safety outcomes, in the single-arm trials, grade 3–4 treatment-related adverse events (TRAEs) occurred in 14 % of the chemoimmunotherapy group and 13 % of the chemotherapy group, with grade 5 TRAEs at 0 % and 4 %, respectively, showing no significant difference (P = 0.80; P = 0.08). …”
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Arterial Thromboembolism in Patients With Advanced Lung Cancer: Secondary Analyses of the Rising‐VTE/NEJ037 Study by Naoki Furuya, Yukari Tsubata, Takamasa Hotta, Toshihide Yokoyama, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazunori Fujitaka, Tetsuya Kubota, Kunihiko Kobayashi, Takeshi Isobe

“…Excluding patients with a contraindication to DOACs, those with VTE were treated with EDO. ATE events were identified in 41 patients (4.1%). The most common location for ATE was cerebral infarction (N = 31, 75.6%), followed by myocardial infarction (N = 4, 9.8%). …”
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Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…The primary endpoint is safety indicators, including general and specific adverse events which will be monitored continuously. Secondary endpoints are progression-free survival, objective response rate, objective duration of remission, 1-year survival rate and overall survival.Ethics and dissemination This study has received approval from the Ethics Committee of Chongqing University Cancer Hospital on 21 November 2019 (207/2019). …”
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Fracture behavior of sandstone with partial filling flaw under mixed-mode loading: Three-point bending tests and discrete element method by Dongdong Ma, Yu Wu, Xiao Ma, Xunjian Hu, Wenbao Dong, Decheng Li, Lingyu Li

“…In terms of crack propagation pattern, the increasing filling strength of the partial filling flaw induced the transformation of the fracture mechanism toward deflection, with a tortuosity path, while the filling ratio and inclination of partial filling flaw led to fracture mechanism change from deflection to penetration and attraction, accompanied with a larger AE event source in filler. Accordingly, the b-value based on the Gutenberg-Richter equation fluctuated between 5 and 4 at low filling ratio and inclination and remained around 5 at high filling ratio and inclination of partial filling flaw. …”
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Exploring the efficacy of fluorouracil and platinum based chemotherapy in advanced hepatocellular carcinoma to bridge the treatment gap in resource limited settings by Se Jun Park, Kabsoo Shin, In-Ho Kim, MyungAh Lee, Tae Ho Hong, Hyunho Kim

“…Hematologic toxicities related to the treatment were substantial, with 62.5% of patients experiencing grade 3 or 4 events, primarily neutropenia, which affected 60.4% of them. …”
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Serious Bacterial Infections and Hepatitis C Virus Among People Who Inject Drugs: A Syndemic or Intertwined Epidemics? by Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean DeJace, Judith Feinberg, April M. Young, Wei-Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann

“…Injection behaviors were correlated with other SBI risk factors, including multiple injections in the same injection event (MIPIE), injection equipment sharing, and fentanyl use. …”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…The Steered MD simulations demonstrated the high affinity of the compounds for PKM2, as evidenced by the requirement of high rupture forces to induce an unbinding event. These results highlight the potential of the compounds as oligomeric modulators of PKM2. …”
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Phylogenetic analysis and detection of positive selection in the SIRT gene family across vertebrates by Qiuxi Zhou, Xiongtao Yang, Da Li, Jing Li, Ling Peng, Wenwu He

“…Phylogenetic analysis revealed that the seven SIRT gene family members in vertebrates originated from gene duplication events. Asymmetric evolutionary rates and natural selection were identified as the primary drivers of SIRT gene divergence. …”
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