BINGO! Elevating Medical Physiology Tutorials Through Gamification by Kelsey Temprine Grellinger, Hong Phan, Maria Sheakley, Gerrit J. Bouma, Alexandra Bayer, Biren A. Shah

“…Methods Each BINGO tutorial utilized a template featuring 50–60 questions aligned with prior learning events, was delivered to 90 second-year medical students, and lasted 50–80 minutes. …”
Get full text

Safety and immunogenicity of a bivalent norovirus vaccine candidate in infants from 6 weeks to 5 months of age: A phase 2, randomized, double-blind trial by Xavier Sáez-Llorens, Rodrigo deAntonio, Eduardo López-Medina, Pío López, Taisei Masuda, Paul M Mendelman, Jim Sherwood, Frank Baehner, Astrid Borkowski

“…Solicited injection-site and systemic adverse events (AE) were collected within 7 days after each dose, unsolicited AEs were collected within 28 days after each, and serious AEs throughout the study. …”
Get full text

Preliminary Experiment on the Effect of 18% Substitute Salt on Home Blood Pressure Variability in Hypertensives by Jing Li, Lisha Mu, Huakun Rao, Yangfeng Wu, Hao Wang, Hongbing Tao, Lihong Mu

“…Daily home blood pressure and weekly adverse events were collected. The systolic blood pressure (SBP) in the morning (−10.0 mmHg, 95% CI: −16.5 to −3.5, P = 0.003), SBP at night (−10.2 mmHg, 95% CI: −16.1 to −4.3, P = 0.001), and diastolic blood pressure (DBP) at night (−4.0 mmHg, 95% CI: −7.1 to −0.8, P = 0.014) decreased significantly. …”
Get full text

Comparison of Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Biopsy Device for Lymphadenopathy by Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Tomoya Ogawa, Ryuichiro Araki, Masahiro Suzuki, Hiromune Katsuda, Youichi Saito, Kazuya Miyaguchi, Tomoaki Tashima, Yumi Mashimo, Masami Yasuda, Shomei Ryozawa

“…No procedural adverse events occurred in either group. Conclusions. Although the diagnostic accuracy between the groups was not statistically significant, EUS-FNB with a Franseen needle provided high diagnostic accuracy and required fewer passes to establish a diagnosis. …”
Get full text

Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering by Jai K Das, Zulfiqar Ahmed Bhutta, Abigail Smith, Aamer Imdad, Emily Tanner-Smith, Melissa François, Fanny F Chen, Olivia J Tsistinas

“…We will consider the following outcomes: mortality, clinical deterioration, antimicrobial resistance, recovery from comorbidity, adverse events, markers of intestinal inflammation, markers of systemic inflammation, hospital-acquired infections, non-response. …”
Get full text

Asymptomatic testing people for SARS-CoV-2 in healthcare facilities: A systematic review by Olabisi A. Oduwole, Glory Bassey, Grace Esebanmen, Samuel Shoyinka, Johnsolomon Ohenhen, Elise Cogo, Nicholas Henschke, Eleanor Ochodo, Martin M. Meremikwu

“…Conclusion: There is limited quality evidence to support asymptomatic testing of individuals for SARS-CoV-2 in the prevention of virus transmission in health care settings. Contribution: In the event of a future pandemic, this review offers current evidence on the potential effects of asymptomatic testing.…”
Get full text

Bubble connectivity in experimentally-sheared crystal-bearing silicic melts by Daffos, Camille, Martel, Caroline, Arbaret, Laurent, Champallier, Rémi

“…Indeed, magmas able to evacuate gases mostly erupt effusively whereas magmas that retain pressurised gases are likely to trigger explosive events. In order to evaluate the explosive potential of magmas residing at shallow level, we investigated the influence of crystal content and shear on the development of bubble connectivity in bubble- and crystal-bearing silicic melts. …”
Get full text

TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled and Parallel‐Group Trial by Xuefei Zhao, Xuedong An, Yashan Cui, Liu Dong, Zhaohui Fang, Zhonghua Zheng, Xinhe Zuo, Huailin Gao, Tianshu Gao, Qing Ni, Fengmei Lian, Xiaolin Tong

“…A statistically significant difference in the change value of TCSS after treatment compared to baseline was found between the two groups (p = 0.033 at 12 weeks and p = 0.030 at 24 weeks). No severe adverse events due to study participation or study intervention were reported. …”
Get full text

Microbiota, parasitic infections and their relationship with nutritional status and neurocognitive functioning in children from Ecuador—Proyecto Guagua: research protocol for a cro... by Sandra Victoria Abril-Ulloa, Tannia Valeria Carpio-Arias, Renata Alejandra Alvarado-Barba, Cristina Gabriela Ríos-Romero, Pamela Vinueza-Veloz, Sueny Paloma Lima-dos-Santos, Sueny Paloma Lima-dos-Santos, Igor Eduardo Astudillo-Skliarova, Igor Eduardo Astudillo-Skliarova, Ruth Irene Arias-Gutiérrez, Manuel Pérez-Quintana, Henk-Jan Boele, Henk-Jan Boele, Henk-Jan Boele, María Fernanda Vinueza-Veloz

“…The findings of “Proyecto Guagua” will be disseminated through open-access, peer-reviewed publications and presented at local and international scientific events.…”
Get full text

Fermented Ophiocordyceps sinensis mycelium products for preventing contrast-associated acute kidney injury: a systematic review of randomized controlled trials by Fenglan Pu, Tianli Li, Chen Shen, Yingqiao Wang, Chunmei Tang, Xiaowen Zhang, Lijiao Yan, Qihe Xu, Jianping Liu

“…There was no statistical difference in adverse events between these two groups.Conclusions Low certainty evidence suggests that preventive oral use of FOSM products as an adjuvant agent was safe and might decrease the incidence of CA-AKI. …”
Get full text

Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study by Si Nae Oh, Hye Jun Kim, Jae Yong Shim, Kyuwoong Kim, Seogsong Jeong, Sun Jae Park, Sang Hyun Lee, Joong Won Ha, Sang Min Park

“…Over a maximum of 14-year follow-up, the incidence rates (events per 1000 person-years) of all-cause dementia were 6.1 for nonusers, 6.2 for those with cumulative tramadol use of 1–14 days, 7.7 for those with 15–90 days of use, and 8.0 for those with > 90 days of use. …”
Get full text

An Arctic Marine Source of Fluorescent Primary Biological Aerosol Particles During the Transition from Summer to Autumn at the North Pole by Julia Kojoj, Gabriel Pereira Freitas, Morven Muilwijk, Mats A. Granskog, Tuomas Naakka, Annica M. L. Ekman, Benjamin Heutte, Julia Schmale, Anderson Da Silva, Rémy Lapere, Louis Marelle, Jennie L. Thomas, Christian Melsheimer, Benjamin J. Murray, Paul Zieger

“…In contrast, other fluorescent particles were correlated with wind speed and coarse mode particle concentration. A multi-day event of high concentrations of fPBAPs was observed at the North Pole, during which the contribution of fPBAPs to the total concentration of coarse mode aerosol increased dramatically from less than 0.1% up to 55%. …”
Get full text

Protocol of a randomised controlled phase II clinical trial investigating PREoperative endoscopic injection of BOTulinum toxin into the sphincter of Oddi to reduce postoperative pa... by Phillip Knebel, Thilo Hackert, Markus W Büchler, Thomas Bruckner, Peter Sauer, Markus K Diener, Christine Tjaden, Ulla Klaiber, Pascal Probst, Eike Martin, Steffen Luntz

“…For safety analysis, rates of adverse events (AEs) and serious AEs will be calculated with 95% CIs for group comparisons.Ethics, funding and dissemination PREBOTPilot has been approved by the German Federal Institute for Drugs and Medical Devices (reference number 4043654) and the Ethics Committee of Heidelberg University (reference number AFmo-523/2019). …”
Get full text

How Does Heavy Precipitation of Varying Durations Respond to Urbanization in China? by Xue Xie, Kairong Lin, Mingzhong Xiao, Xudong Zhou, Gang Zhao, Dai Yamazaki

“…Anthropogenic‐related factors (population density, nighttime light data, impervious surface percent, land surface temperature) significantly influence shorter‐duration heavy precipitation in more UACs than natural factors (distance from the coast, wind and elevation), while natural factors dominate longer‐duration events in larger UACs across China. Our results highlight the necessity of considering the spatial difference between the UAC center and UAC periphery for accurate projections and effective prevention of heavy precipitation and potential flood risks in the future.…”
Get full text

Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease by Carolinne Thaísa de Oliveira Fernandes Miranda, Victor Hugo Rezende Duarte, Marina Sampaio de Menezes Cruz, Mychelle Kytchia Rodrigues Nunes Duarte, Jéssica Nayara Góes de Araújo, Ayda Maria Quirino Silva dos Santos, Juliana Marinho de Oliveira, Maria Sanali Moura Oliveira Paiva, Adriana Augusto Rezende, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Karla Danielly da Silva Ribeiro, André Ducati Luchessi, Vivian Nogueira Silbiger

“…The low level of alpha-tocopherol together with the presence of dyslipidemia is probably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensive coronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress.…”
Get full text

Strain rebound and inhomogeneity in glass-to-metal seals: Radial vs axial strain evolution by Keqian Gong, Zheng Liu, Zifeng Song, Chao Zhou, Zhangjing Shi, Siyue Nie, Weisong Zhou, He Yan, Zhichun Fan, Yong Zhang

“…Both directions exhibited pronounced strain rebound at lower temperatures, driven by the accumulation of smaller rebound events, effectively explained by FV theory. Moreover, the mismatch in thermal expansion coefficients between the glass and the metal housing significantly amplified radial strain, resulting in marked directional differences in strain behavior. …”
Get full text

Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells by Marina Di Domenico, Antonia Feola, Pasqualina Ambrosio, Federica Pinto, Giovanni Galasso, Armando Zarrelli, Giovanni Di Fabio, Marina Porcelli, Salvatore Scacco, Francesco Inchingolo, Lucio Quagliuolo, Andrea Ballini, Mariarosaria Boccellino

“…In the presence of an intense stressing event, cells activate specific responses to counteract cell death or senescence which is known to act as a key-task in the onset of age-related pathologies and in the loss of tissue homeostasis. …”
Get full text

Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients by Yongjie Xie, Xiaoran Feng, Youqun Gao, Xiaojiang Zhan, Fenfen Peng, Qian Zhou, Xianfeng Wu, Xiaoyang Wang, Na Tian, Qingdong Xu, Ning Su, Xingming Tang, Jianbo Liang, Jiao Li, Yueqiang Wen

“…Competitive risk analysis revealed significant differences for all-cause mortality (p < 0.001), while there was no statistical significance for other competing events.Conclusions Low albumin to non-HDL-C ratio was associated with a high risk of all-cause mortality in PD patients. …”
Get full text

Novel combination therapy for platinum-eligible patients with locally advanced or metastatic urothelial carcinoma: a systematic review and network meta-analysis by Takafumi Yanagisawa, Keiichiro Mori, Akihiro Matsukawa, Tatsushi Kawada, Satoshi Katayama, Ekaterina Laukhtina, Pawel Rajwa, Fahad Quhal, Benjamin Pradere, Wataru Fukuokaya, Kosuke Iwatani, Renate Pichler, Jeremy Yuen-Chun Teoh, Marco Moschini, Wojciech Krajewski, Jun Miki, Shahrokh F. Shariat, Takahiro Kimura, European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)

“…Network meta-analysis (NMA) was conducted to compare outcomes, including overall survival (OS), progression-free survival (PFS), objective response rates (ORRs), complete response rates (CRRs), and treatment-related adverse events (TRAEs). Subgroup analyses were based on PD-L1 status and cisplatin eligibility. …”
Get full text

Real-world experiences with brentuximab vedotion-based regimens in systemic anaplastic large cell lymphoma: a multi-center retrospective study by Zhiqiang Zhao, Qinchuan Yu, Liping Su, Jianxia He, Jie Tao, Yanfeng Xi, Yujiao Guo, Yanhong Luo, Lieyang Wang

“…Primary endpoints were complete response rate (CRR) and overall response rate (ORR); secondary endpoints included progression-free survival (PFS), overall survival (OS), duration of response (DOR), and the incidence of adverse events (AEs).ResultsAmong the 38 patients (28 newly diagnosed and 10 with refractory/relapsed disease), the ORR were 100% (with 89.3% CR) for newly diagnosed patients and 70% (with 50% CR) for refractory/relapsed patients. …”
Get full text