Cost-Utility Analysis of Add-on Cannabidiol vs Usual Care Alone for the Treatment of Seizures in Patients With Treatment-Resistant Lennox-Gastaut Syndrome or Dravet Syndrome in the... by Jamshaed Siddiqui, Sally Bowditch

“…Drug acquisition, disease management, adverse events, and societal costs from published literature were included. …”
Get full text

Intra-Articular Injection of Human Bone Marrow–Derived Mesenchymal Stem Cells in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial by Bong-Woo Lee, Jennifer Jooha Lee, Joon-Yong Jung, Ji Hyeon Ju

“…The MSC group exhibited a less sharp increase in the mean T2 value of the medial compartment than the control group at 12 months, with no serious adverse events observed during follow-up. A single IA injection of allogeneic BM-MSCs provided satisfactory pain relief for patients with knee OA compared with the control group at 9 months. …”
Get full text

Diversification outbreaks and dynamics of Asian leaf-litter frogs, genus Leptobrachella (Anura, Megophryidae), with the description of a new species from Guizhou Province, China by Tao Luo, Zi-Fa Zhao, Zhong-Lian Wang, Chang-Ting Lan, Ming-Yuan Xiao, Huai-Qing Deng, Ning Xiao, Jiang Zhou

“…The uplift of the Qinghai-Tibet Plateau and the Indochina extrusion are two of the most prominent consequences of the India–Asia collision. These two geologic events greatly altered topography and drainage patterns that, in turn, affected the regional climate, the landscape and the evolution of biodiversity. …”
Get full text

Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study by Henrik Toft Sørensen, Kasper Adelborg, Péter Szentkúti, Jens Sundbøll, Szimonetta Komjáthiné Szépligeti, Hans Gregersen

“…Constipation was also associated with arterial events, including myocardial infarction (1.24, 95% CI 1.14 to 1.35), ischaemic stroke (1.50, 95% CI 1.41 to 1.60), haemorrhagic stroke (1.46, 95% CI 1.26 to 1.69), peripheral artery disease (1.34, 95% CI 1.20 to 1.50), atrial fibrillation or atrial flutter (1.27, 95% CI 1.20 to 1.34) and heart failure (1.52, 95% CI 1.42 to 1.62). …”
Get full text

A measure of the difference between test sets for generating controlled random tests by V. N. Yarmolik, V. V. Petrovskaya, I. Mrozek

“…Based on the characteristic of the interval used in the theory of the chain of successive events, a new measure of the difference between two symbolic test sets is determined. …”
Get full text

Issues of diagnostics and treatment of abdominal pain at irritable bowel syndrome at outpatient stage of the healthcare by Yu. A. Kucheryavy, T. L. Lapina, M. A. Livzan, M. F. Osipenko

“…Course treatment effectively reduces intensity and frequency of abdominal pain at IBS. The rate of adverse events and tolerability of hyoscine butylbromide are comparable to that of placebo.Conclusion. …”
Get full text

Biopolitical Strategies in Media Discourses: Responses to the COVID-19 Pandemic in Russia, Germany, and France by N. K. Radina, Yu. V. Balakina, K. V. Bannikov

“…The objective of this study is to conduct a comparative analysis of how media outlets in Russia, France, and Germany reported on events during the COVID-19 pandemic. The analysis was carried out in three stages: comparing the actors of biopolitics, examining the ideologemes of biopolitics, and analyzing the spheres in which biopolitics were implemented. …”
Get full text

Effect of flood on the cutaneous leishmaniasis incidence in northeast of Iran: an interrupted time series study by Mostafa Majidnia, Atefeh Khoshkchali, Ahmad Khosravi

“…Methods Interrupted Time Series Analysis (ITSA) is a study design used to study the effects of an intervention, disaster, or natural event on occurrence of a disease over time. In March 2019, a major flood occurred in Golestan Province, and it had a particularly strong effect on the Gonbad Kavous county (region 1). …”
Get full text

Subseasonal forecasts of heat waves in West African cities by C. G. Ngoungue Langue, C. G. Ngoungue Langue, C. Lavaysse, C. Lavaysse, C. Flamant

“…Accurate forecasts of these events are useful for policy makers and climate services to anticipate the consequences of extreme heat. …”
Get full text

Implementing the Copenhagen Adductor Exercise and Nordic Hamstring Exercise in West African Academy Soccer Players: An Intervention Study by Matthew D DeLang, Lasse Ishøi, Maren Nielsen Hole, Prince Wilson, Michael Segbefia, Kristian Thorborg

“… # RESULTS Ninety-six and 95% of CAE and NHE sessions were completed in each intervention, with no adverse events related to the execution of the exercises. …”
Get full text

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production by Parnian Arafi, Sujan Devkota, Emily Williams, Masato Maesako, Michael S Wolfe

“…Here, we conducted full quantitative analysis of all proteolytic events on APP substrate by γ-secretase with six additional PSEN1 FAD mutations and found that all six are deficient in multiple processing steps. …”
Get full text

Anomalous Circulation Patterns in Association with Summertime Regional Daily Precipitation Extremes over Northeast China by Chuanlei Chen, Zhaoyong Guan, Min Jiao, Pengyu Hu

“…Results indicate that 26 extreme precipitation events occurred during the 36-year period of 1979–2014. …”
Get full text

Developing incisional hernia after open liver resection and liver transplantation: A single-center risk factor analysis by Saeed Aldarwish, Paula Guda, Mark Philipp, Clemens Schafmayer, Sebastian Hinz

“…From our experience and according to this analysis, we recommend the careful selection of the surgical approach for each patient and promotion of the use of the minimally invasive approaches, avoiding the angulated incisions as much as possible, applying the running suture technique with (polydioxanone) PDS-loops for the fascial reconstruction, minimizing the intraoperative blood loss and need for blood transfusion, shortening the operative time as much as possible, early detection of postoperative formation of ascites, and managing it properly. In the event of need for a revision operation due to a postoperative complication, a reinforced reconstruction of the fascia can be considered.…”
Get full text

Early initiation of ceftaroline-based combination therapy for methicillin-resistant Staphylococcus aureus bacteremia by Addison S. Hicks, Mackenzie A. Dolan, Megan D. Shah, Sarah E. Elwood, James A. Platts-Mills, Gregory R. Madden, Zachary S. Elliott, Joshua C. Eby

“…Time to microbiological cure was longer with combination therapy (mean difference 1.50 days, 95% CI 0.60, 2.41). Adverse event rates were similar in both groups. Conclusions Early initiation of ceftaroline-based combination therapy did not improve outcomes for patients with MRSA-B in comparison to monotherapy therapy.…”
Get full text

Efficacy and safety of acupuncture for postoperative gastroparesis syndrome: a systematic review and meta-analysis by Yichuan Xv, Yiyi Feng, Jiang Lin

“…Four studies reported no adverse events in either group, but the majority of studies did not provide safety data.ConclusionAcupuncture may alleviate clinical symptoms and shorten hospitalization, potentially by enhancing gastrointestinal motility. …”
Get full text

Association of whole grain food consumption with lung cancer risk: a prospective cohort study by Kanran Wang, Junhan Zhao, Dingyi Yang, Mao Sun, Yongzhong Wu, Wei Zhou

“…Results During a median follow-up of 12.2 years, a total of 1,706 incident lung cancer events occurred, including 1,473 (86.3%) cases of non-small cell lung cancer (NSCLC) and 233 (13.7%) of small cell lung cancer (SCLC). …”
Get full text

Hooliganism as a problem of public order in the Ukrainian SSR in the early 1950s by V. A. Grechenko

“…The factors of hooliganism had their roots in the years of war and post-war devastation, which were the childhood and adolescence of the majority of those who committed crimes under the relevant article “Hooliganism” of the Criminal Code of the Ukrainian SSR. The complex events of this time certainly affected the psyche and psychology of these people: they saw violence in all its forms, often being brought up in the absence of their father, who was at the front. …”
Get full text

ENSURING HUMAN RIGHTS IN THE CONTEXT OF IMPLEMENTATION OF ELECTRONIC VOTING IN UKRAINE: PERSPECTIVES AND RISKS by Liudmyla Gudz

“…For example, in Switzerland, e-voting was used experimentally in some cantons but faced significant security issues, while in India, EVMs have become standard in most polling stations, increasing public confidence in the electoral process. However, recent events in Brazil and the United States show that unscrupulous politicians can challenge the operation of any electronic voting system, which can lead to mass protests and unrest. …”
Get full text

Microvascular disease and heart failure with reduced and preserved ejection fraction in type 2 diabetes by Ify R. Mordi, Aaron Tee, Colin N. Palmer, Rory J. McCrimmon, Alexander S.F. Doney, Chim C. Lang

“…In total, there were 900 HF events. The presence of any MiVD was independently associated with both HF with reduced ejection fraction (hazard ratio 1.40; 95% confidence interval 1.11–1.76, P = 0.004) and HF with preserved ejection fraction (hazard ratio 1.38; 95% confidence interval 1.10–1.72, P = 0.005), with a stepwise association between the number of MiVD states and risk of incident HF (P for trend <0.001). …”
Get full text

First-line treatment for advanced or metastatic EGFR mutation-positive non-squamous non-small cell lung cancer: a network meta-analysis by Mengyao Zhang, Lan Sun

“…The primary endpoints were progression-free survival (PFS) and overall survival (OS), while secondary outcomes included objective response rate (ORR) and grade 3 or higher adverse events (≥3AEs). Stata 15.0 and R 4.3.2 software were utilized for the network meta-analysis.ResultsA total of 30 RCTs, comprising 8654 participants, were included. …”
Get full text