Why is it so difficult to understand why we don’t understand human systemic lupus erythematosus? Contemplating facts, conflicts, and impact of “the causality cascade paradigm”... by Ole Petter Rekvig, Ole Petter Rekvig

“…A precise and critically important question is if SLE itself is a response to a dominant unified cause that initiates a cascade of downstream effects (criteria) or if SLE represents combined responses to a random interplay of multiple cause-effect events. These principally different explanations are formally not excluded or accepted today. …”
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A Randomized, Double-Masked, Active-Controlled, Crossover Phase III Equivalence Study of Generic Dorzolamide 2% versus Innovator Trusopt® Eye Drop Solution in Subjects with Open-An... by Katharina Bell, Christina Korb, Christina Butsch, Bert Constantin Giers, Anna Beck, Alicja Strzalkowska, Christian Ruckes, Ulrike Klingberg, Norbert Pfeiffer, Katrin Lorenz

“…Goldmann applanation tonometry was performed at 8 am, 12 pm, and 4 pm at each visit, and safety was assessed by documentation of adverse events (AEs). Therapy adherence was documented by self-reporting and eye drop bottle weighing. …”
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Response of Pedunculate Oak (<i>Quercus robur</i> L.) to Adverse Environmental Conditions in Genetic and Dendrochronological Studies by Konstantin V. Krutovsky, Anna A. Popova, Igor A. Yakovlev, Yulai A. Yanbaev, Sergey M. Matveev

“…By examining tree-ring width, density, and dynamics, researchers can identify periods of growth suppression or enhancement and predict forest responses to future climatic events. Genetic studies further complement this by uncovering adaptive genetic diversity and inheritance patterns. …”
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WETLAND AND BIOCULTURAL HERITAGE REGENERATION THROUGH THEMATIC ECOLOGICAL TOURISM PRACTICE: THE CASE OF PATAN SUB-DISTRICT, KHUN TAN DISTRICT, CHIANG RAI, THAILAND by Siripen YIAMJANYA, Kannapat KANKAEW, Bussaba SITIKARN, Parinya NAKPATHOM, Ali Mohsin Salim Ba AWAIN, Teerarat JABJAINAI

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Responses of Loess Ground with Different Slopes and Vegetation Covers to Rainfall Infiltration by ZHANG Lina, LI Ping, HU Xiangyang, ZHONG Jianping, YANG Kai, ZHAO Zhiyan, LI Tonglu

“…However, after a number of short-term rainfall events, the moisture content and saturation in the wetting zone were slightly higher in flat ground than those in slopes. …”
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Randomised controlled trial to investigate the effectiveness of local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery (LOTUS): a pilot study to... by Jane Daniels, Lee Middleton, Tina Sara Verghese, Versha Cheed, Lisa Leighton, Pallavi Manish Latthe

“…Of these, 89% (79/89) returned complete questionnaires at 6 months and 78% (32/41) reported good compliance with oestrogen. No serious adverse events were attributable to oestrogen use.Conclusions A large multicentre RCT of oestrogen versus no treatment is feasible, as it is possible to randomise and follow up participants with high fidelity. …”
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Moral and exhausting distress working in the frontline of COVID-19: a Swedish survey during the first wave in four healthcare settings by Mia Svantesson, Lars Sandman, Linda Durnell, Erik Hammarström, Gustav Jarl

“…Preventive measures for major events should focus on connectedness between all parties concerned, preventing inhumane care and burn-out.…”
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Harnessing AI for Enhanced Weather Prediction: A Focus on Rainfall by Hira Farman, Noman Islam, Noman Hasany

“…The goal is to maximize the level of predicted events to include rainfall cases. The primary objective of study is to design and evaluate single and combine machine learning models, a stacking approach to forecast rainfall in Pakistan. …”
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Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion by Zhao-Hui Yao, Xiao-li Yao, Shao-feng Zhang, Ji-chang Hu, Yong Zhang

“…Low cerebral blood flow (CBF) during CCH leads to disturbances in the homeostasis of hemodynamics and energy metabolism, which in turn results in oxidative stress, astroglia overactivation, and synaptic protein downregulation. These events contribute to synaptic plasticity and cognitive dysfunction after CCH. …”
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Co-designing a film showcasing the dental experiences of community returners (ex-offenders) by Joelle Booth, Joelle Booth, Heather McMullen, Andrea Rodriguez, Vanessa Muirhead

“…The film was screened at an open event for stakeholders and included a question-and-answer session and recorded videos where viewers shared their feedback to inform future research projects.ConclusionCo-design can be an empowering platform to hear the voices of community returners. …”
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An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…The most frequent adverse events (AEs) were fatigue and nausea (53 % each) and vomiting (38 %). …”
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COVID-19 pandemic: mental health (distress as depression) in orthodontists by Eloisa Peixoto Soares Ueno, Liana Fattori, Edgard Michel-Crosato, Wilze Laura Bruscato, José Rino Neto, João Batista de Paiva

“…This study analysed sociodemographic factors, post-traumatic stress disorder symptoms (PTSD), and depression levels caused by the coronavirus disease 2019 (COVID-19) pandemic in orthodontists.Materials and Methods A sociodemographic questionnaire, the Impact of Event Scale (IES), and the Patient Health Questionnaire (PHQ-9) were used. …”
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Quality of Life as Medicine: A Pilot Studyof Patients with Chronic Illness and Pain by Soren Ventegodt, Joav Merrick, JØrgen Anderson

“…The pilot study demonstrated that in the course of only 1 week, patients had time to revise essential life-denying views and to integrate important, unfinished life events involving negative feelings. Consequently, the patients became more present in the body’s blocked-off areas and subjectively healthier. …”
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Milk production and nitrogen excretion of grazed dairy cows in response to plantain (Plantago lanceolata) content and lactation season by Thi Truong Nguyen, Soledad Navarrete, David Horne, Daniel Donaghy, Peter Kemp

“…Methods Four pasture treatments: perennial ryegrass (Lolium perenne) – white clover (Trifolium repens) (RGWC), RGWC + low plantain rate, RGWC + medium plantain rate, and RGWC + high plantain rate, were established in four adaptation areas (1 ha each) and 20 experimental plots (800 m2 each), and rotationally grazed by dairy cows over 14 grazing events during two lactation years. In each grazing (8 to 9 days), 60 or 80 Jersey-Friesian lactation cows were assigned to their pasture treatments, adapted to their pastures over the first six days, then each group of 15 or 20 cows were randomly allocated for grazing in five treatment plots over a two or three-day measurement period. …”
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Meta Analysis of Clinical Literature on Mental Retardation Treated by External Therapy of Traditional Chinese Medicine by Lili LIN, Qianwen WU, Qiang WU

“…The count data was greater than the event rate 20%, using the smaller value of the risk ratio (<italic>RR</italic>) as an indicator. …”
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Cost-Effectiveness of the CNIC-Polypill Strategy Compared With Separate Monocomponents in Secondary Prevention of Cardiovascular and Cerebrovascular Disease in Portugal: The MERCUR... by Carlos Aguiar, Francisco Araujo, Gabriel Rubio-Mercade, David Carcedo, Silvia Paz, Jose María Castellano, Valentín Fuster

“…Patients with previous CV events are at high risk of recurrence. Secondary prevention therapies improve CV risk factor control and reduce disease costs. …”
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Short- and Intermediate-Term Morbidity Following Total Pelvic Exenteration in Colorectal Cancer by Christopher Guske BS, Nusheen Immen BS, Devon Conant BS, Jose Laborde PhD, Joshua Linscott MD, PhD, Mitchell Hayes MD, Seyed Behzad Jazayeri MD, Adnan Fazili MD, Erin Siegel PhD, MPH, Sophie Dessureault MD, Julian Sanchez MD, Amalia Stefanou MD, Brandon Manley MD, Seth Felder MD

“…Ten (37.0%) patients experienced a CD ≥ 3 event, of which 40% took place beyond 30 days. The most common complication overall was anemia requiring transfusion, while the most common major complication was pelvic abscess. …”
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KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS OPEN EDUCATIONAL RESOURCES IN HIGHER EDUCATION INSTITUTIONS IN THE PHILIPPINES by Liezel G. Mohillo, Angie R. Jalandoon, Dave E. Marcial

“…With the update in education and the shift in learning modality a great need for educational resources - free and open to the public increases, especially in the outrage of the pandemic. These events and phenomena also create a schism between librarians' perspectives and practices on OER. …”
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Non-HDL-c/TC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes by Anan Huang, Xin Qi, Liping Wei, Mingyin Zhang, Shiqi Zhou

“…In unadjusted Cox model, high non-HDL-c/TC (RR: 1.976, 95% CI: 1.155–3.382; P=0.013) predicted the occurrence of adverse events. After multivariate adjustment, high non-HDL-c/TC (RR: 1.921, 95% CI: 1.105–3.339; P=0.021) was an independent predictor of poor outcomes. …”
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Efficacy and Safety of Drug-Eluting Bead TACE in the Treatment of Primary or Secondary Liver Cancer by Jiabing Wang, Haoqian Xu, Ying Wang, Long Feng, Fengming Yi

“…Adverse reactions were assessed according to Common Terminology Criteria for Adverse Events 4.0 (CTCAE4.0). Results. In the subgroup of primary liver cancer, 3 patients (7.32%) got complete response, 13 patients (31.71%) got partial response, 21 patients (51.22%) experienced stable disease, and 4 patients (9.76%) suffered progressive disease; ORR was 39.02% and DCR was 90.24%. …”
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