Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain by Darine Villela, Claudia K. Suemoto, Renata Leite, Carlos Augusto Pasqualucci, Lea T. Grinberg, Peter Pearson, Carla Rosenberg

“…Nearly all evidence of genome structural variation in human brains comes from studies detecting changes in single cells which were interpreted as derived from independent, isolated mutational events. The observations based on array-CGH analysis indicate the existence of an extensive clonal mosaicism of CNVs within and between the human brains revealing a different type of variation that had not been previously characterized.…”
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A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia () by Akashlal M. MD (Ay), Pratibha P Nair MD (Ay), Devi R Nair MD (Ay), Azeem Ahmad MD (Ay), B Chandrasekhararao MD (Ay), D Sudhakar MD (Ay), Srikanth Narayanam PhD (Ay), Rabinarayan Acharya PhD (Ay)

“…The trials frequently did not document safety parameters, adverse events (AE), and adverse drug reactions (ADR). Current review could not definitively establish the efficacy and safety of Ayurvedic interventions in hemiplegia/Pakshaghata. …”
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CLINICAL CARE PATHWAY AND MANAGEMENT OF MAJOR BLEEDING ASSOCIATED WITH NON-VITAMIN K ANTAGONIST ORAL ANTICOAGULANTS: A MODIFIED DELPHI CONSENSUS FROM SAUDI ARABIA AND UAE by Abdulrahman Al Raizah, Fakhr Alayoubi, Galal Hassan Abdelnaby, Hazzaa Alzahrani, Majid Farraj Bakheet, Mohammed A Alskaini, Rasha Buhumaid, Sameer Al Awadhi, Sara Nooruddin Kazim, Thiagarajan Jaiganesh, Zohair Al Asiri

“…These statements addressed key aspects of managing major bleeding events associated with NOACs, including the increased use of NOAC in clinical practice, clinical care pathways, and treatment options. …”
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Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes by Ali Tawbeh, Catherine Gondcaille, Fatima-Ezzahra Saih, Quentin Raas, Damien Loichot, Yannick Hamon, Céline Keime, Alexandre Benani, Francesca Di Cara, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary

“…This dysfunction might contribute to the early neurodegenerative events in X-ALD by triggering and sustaining neuroinflammatory cascades. …”
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An ecosystem approach to the evaluation and impact analysis of heterogeneous preventive and/or early interventions projects for veterans and first responders in seven countries by S. Lukersmith, L. Salvador-Carulla, C. Woods, T. Niyonsenga, M.R. Gutierrez-Colosia, I. Mohanty, C.R. Garcia-Alonso, D. Diaz-Milanes, J.A. Salinas-Perez, R. Davey, A. Aryani

“…Background: Cumulative exposure to critical incidents and life-threatening events leads to significant risk for Veterans and First Responders (VFRs) developing mental ill health and disorders. …”
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Adults with reading difficulties demonstrate selective impairments in the fine neural tuning for print by Tongjie Zhuang, Yaowen Li, Yufei Tan, Jiuju Wang, Xiuyue Yue, Licheng Xue, Jing Zhao, Jing Zhao

“…IntroductionNeural tuning for print, reflected in differential responses of the N170 component of event-related potentials to orthographic forms and other visual stimuli, serves as the neural basis for efficient visual word reading. …”
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Extensive Admixture Among Karst‐Obligate Salamanders Reveals Evidence of Recent Divergence and Gene Exchange Through Aquifers by Chris C. Nice, Katherine L. Bell, Zachariah Gompert, Lauren K. Lucas, James R. Ott, Ruben U. Tovar, Paul Crump, Peter H. Diaz

“…Inference of migration events revealed a complex pattern of gene exchange, suggesting that Eurycea salamanders have a dynamic history of dispersal through the aquifer system. …”
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Mapping Nanoscale‐To‐Single‐Cell Phosphoproteomic Landscape by Chip‐DIA by Gul Muneer, Sofani Tafesse Gebreyesus, Ciao‐Syuan Chen, Tzu‐Tsung Lee, Fengchao Yu, Chih‐An Lin, Min‐Shu Hsieh, Alexey I. Nesvizhskii, Chao‐Chi Ho, Sung‐Liang Yu, Hsiung‐Lin Tu, Yu‐Ju Chen

“…Mapping nanoscale‐to‐single‐cell samples can unravel the heterogeneity of cellular signaling events. However, it remains a formidable analytical challenge due to the low detectability, abundance, and stoichiometry of phosphorylation sites. …”
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Bexarotene-induced hypothyroidism and dyslipidemia; a nation-wide study by Katsunori Manaka, Junichiro Sato, Yusuke Hikima, Hirofumi Horikoshi, Maho Taguchi, Akimichi Morita, Hiraku Suga, Hikari Boki, Taku Fujimura, Yoji Hirai, Takatoshi Shimauchi, Chiharu Tateishi, Eiji Kiyohara, Ikko Muto, Hideki Nakajima, Riichiro Abe, Kazuyasu Fujii, Chikako Nishigori, Eiji Nakano, Kentaro Yonekura, Takeru Funakoshi, Masahiro Amano, Tomomitsu Miyagaki, Reiko Yamashita, Makoto Sugaya, Toshihisa Hamada, Masaomi Nangaku, Taroh Iiri, Noriko Makita

“…Central hypothyroidism and dyslipidemia are well-known adverse events (AEs) of bexarotene therapy. Although hypothyroidism is known to cause dyslipidemia, no study has examined the association between hypothyroidism and dyslipidemia in patients undergoing bexarotene therapy. …”
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Impact of thoracic radiotherapy on first‐line treatment outcomes in ES‐SCLC patients by Xiaoli Mu, Yixin Zhou, Qing Liu, Jiantao Wang, Feng Xu, Feng Luo, Ke Wang, Lu Li, Panwen Tian, Yalun Li, Jiewei Liu, Yan Zhang, Jiyan Liu, Yan Li

“…The incidence of grade 3‐4 adverse events showed nostatistically significant difference between the two cohorts. …”
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Evolution of Self-reported Neuropsychiatric Symptoms After Switching from Dolutegravir/Abacavir/Lamivudine to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Results from the Rand... by Barbara Rossetti, Micol Ferrara, Lucia Taramasso, Francesca Bai, Francesca Lombardi, Nicoletta Ciccarelli, Miriam Durante, Francesca Alladio, Federica Bonazza, Ilaria Rancan, Francesca Montagnani, Antonio Di Biagio, Antonella d’Arminio Monforte, Maurizio Zazzi, Massimiliano Fabbiani, for DOBINeuro study group

“…Abstract Introduction Central nervous system adverse events (AE) have been a cause of discontinuation of dolutegravir-containing therapy, especially in combination with abacavir. …”
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Efficacy and safety of combined low‐dose rituximab regimen for chronic inflammatory demyelinating polyradiculoneuropathy by Ying Du, Qi Yan, Chuan Li, Wenping Zhu, Chao Zhao, Yunfeng Hao, Lin Li, Dan Yao, Xuan Zhou, Ying Li, Yuting Dang, Rong Zhang, Lin Han, Yuanyuan Wang, Tao Hou, Juan Li, Hailin Li, Panpan Jiang, Pei Wang, Fenying Chen, Tingge Zhu, Juntong Liu, Shuyu Liu, Lan Gao, Yingjun Zhao, Wei Zhang

“…No rituximab correlated serious adverse events were reported in our patients. Interpretation Our simplified regimen of combined low‐dose rituximab has been firstly demonstrated for the better efficacy and safety than conventional therapy in CIDP treatment.…”
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The effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, and health-related quality of life in adults with malig... by Charlotte Groenset, Magnus N. Bech, Mary Jarden, Nina Høgdal, Martin Hutchings, Charlotte Suetta, Jan Christensen

“…Exercise interventions during treatment were found to be feasible with few adverse events reported. The included studies indicate positive effects of exercise during chemotherapy on muscle mass, muscle strength, functional performance, aerobic capacity, and HRQoL compared to usual care. …”
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Digital technologies for water use and management in agriculture: Recent applications and future outlook by Carlos Parra-López, Saker Ben Abdallah, Guillermo Garcia-Garcia, Abdo Hassoun, Hana Trollman, Sandeep Jagtap, Sumit Gupta, Abderrahmane Aït-Kaddour, Sureerat Makmuang, Carmen Carmona-Torres

“…UAV-mounted multispectral cameras) can accurately monitor soil moisture to optimise irrigation scheduling, while AI-driven models (e.g. random forest or neural networks) can predict groundwater recharge or forecast rainfall events. However, several barriers to widespread adoption are identified, including high implementation costs, lack of technical expertise, data management challenges, and infrastructure and connectivity constraints. …”
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Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis by Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang, Yifan Miao, Xiajia Wu, Hang Lei, Zhijun Xie, Yong Tian, Xianlin Zhao, Juan Li, Lv Zhu, Meihua Wan, Wenfu Tang

“…The necrosis of pancreatic acinar cells is a key molecular event in the progression of acute pancreatitis (AP), with disturbances in mitochondrial energy metabolism considered to be a direct causative factor of acinar cell necrosis. …”
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Functional connectivity in burnout syndrome: a resting-state EEG study by Natalia Afek, Dmytro Harmatiuk, Magda Gawłowska, João Miguel Alves Ferreira, Krystyna Golonka, Sergii Tukaiev, Sergii Tukaiev, Anton Popov, Anton Popov, Tadeusz Marek

“…Studies on neural mechanisms indicate significant changes in brain activity and changed patterns of event-related potentials in burnout subjects. This study presents an analysis of brain functional connectivity in a resting state, thus providing a deeper understanding of the mechanisms accompanying burnout syndrome. …”
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Predicting CMEs Using ELEvoHI With STEREO‐HI Beacon Data by Maike Bauer, Tanja Amerstorfer, Jürgen Hinterreiter, Andreas J. Weiss, Jackie A. Davies, Christian Möstl, Ute V. Amerstorfer, Martin A. Reiss, Richard A. Harrison

“…In this study, we use the ELlipse Evolution model based on Heliospheric Imager (ELEvoHI) to predict the arrival time and speed of 10 CME events that were observed by HI on the STEREO‐A spacecraft between 2010 and 2020. …”
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احتمال فلج ناقص عصب سوم پس از واکسیناسیون کووید-19: گزارش یک مورد by افسانه نادری, حامد رادمهر, محمد علی دیانی, علی صالحی, زهرا نادری بنی, محمد ملک احمدی

“…عوارض شدیدتر مورد توجه (Adverse events of special interest) AESI نیز گزارش شده‌اند، مانند فلج عصب صورت، میلیت، ایسکمی و فلج اعصاب جمجمه. . …”
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The Stress and Adversity Inventory for Adults (Adult STRAIN) in Korean: Initial Validation and Associations with Psychiatric Disorders by Eun Soo Kim, Yun Tae Kim, Kang-Seob Oh, Young Chul Shin, Sang-Won Jeon, Dong-Won Shin, Sung Joon Cho, George M. Slavich, Junhyung Kim

“…Results: The Korean STRAIN exhibited sufficient usability and acceptability; good concurrent validity with other measures of early adversity, life events, and perceived stress (<i>r</i>s = 0.48–0.61); and strong predictive validity in relation to anxiety and depressive symptoms (β = 0.08–0.47; ΔR2 = 0.11–0.21). …”
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Late-time Radio Brightening and Emergence of a Radio Jet in the Changing-look AGN 1ES 1927+654 by Eileen T. Meyer, Sibasish Laha, Onic I. Shuvo, Agniva Roychowdhury, David A. Green, Lauren Rhodes, Amelia M. Hankla, Alexander Philippov, Rostom Mbarek, Ari laor, Mitchell C. Begelman, Dev R. Sadaula, Ritesh Ghosh, Gabriele Bruni, Francesca Panessa, Matteo Guainazzi, Ehud Behar, Megan Masterson, Haocheng Zhang, Xiaolong Yang, Mark A. Gurwell, Garrett K. Keating, David Williams-Baldwin, Justin D. Bray, Emmanuel K. Bempong-Manful, Nicholas Wrigley, Stefano Bianchi, Federica Ricci, Fabio La Franca, Erin Kara, Markos Georganopoulos, Samantha Oates, Matt Nicholl, Main Pal, S. Bradley Cenko

“…This source joins a growing number of CL-AGNs and tidal disruption events that show late-time radio activity, years after the initial outburst.…”
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