Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages by Laura Hyväri, Miina Ojansivu, Miia Juntunen, Kimmo Kartasalo, Susanna Miettinen, Sari Vanhatupa

“…The adipose-derived stromal/stem cells (ASCs) have a multilineage differentiation capacity that is regulated through extracellular signals. The cellular events related to cell adhesion and cytoskeleton have been suggested as central regulators of differentiation fate decision. …”
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Hydrogen Leakage Location Prediction in a Fuel Cell System of Skid-Mounted Hydrogen Refueling Stations by Leiqi Zhang, Qiliang Wu, Min Liu, Hao Chen, Dianji Wang, Xuefang Li, Qingxin Ba

“…Hydrogen refueling stations play a pivotal role in the hydrogen energy chain. In the event of an accidental hydrogen leak at a hydrogen refueling station, the ability to quickly predict the leakage location is crucial for taking immediate and effective measures to prevent disastrous consequences. …”
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A Novel Mobility Concept for Terrestrial Wheel-Legged Lunar Rover by Mubarak Yakubu, Yahya Zweiri, Laith Abuassi, Rana Azzam, Ahmad Abubakar, Amna Busoud, Lakmal Seneviratne

“…This mobility concept offers the advantage of a self-locking function, which secures the leg positions even in the event of component failure - an improvement over systems with individual motors for each leg. …”
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Assessing the establishment risk for parthenogenetic populations of Lissorhoptrus oryzophilus in global rice-growing areas and potential economic impact in China by Luoyuan Li, Luoyuan Li, Zhenan Jin, Ming Li, Yantao Xue, Jianyang Guo, Dong Jia, Ruiyan Ma, Zhichuang Lü, Xiaoqing Xian, Wanxue Liu

“…The rice water weevil, Lissorhoptrus oryzophilus Kuschel (Coleoptera: Curculionidae), threatens global rice production, with invasion events driven by its parthenogenetic populations. …”
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Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage: A Randomized,... by Janette Furuzawa-Carballeda, Guadalupe Lima, Luis Llorente, Carlos Nuñez-Álvarez, Blanca H. Ruiz-Ordaz, Santiago Echevarría-Zuno, Virgilio Hernández-Cuevas

“…No differences were found on incidence of adverse events between groups. Conclusion. Polymerized collagen is safe and effective on downregulation of inflammation in patients with knee OA.…”
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Strong volcanic-induced climatic shocks on historical Moselle wine production by F. C. Ljungqvist, F. C. Ljungqvist, F. C. Ljungqvist, B. Christiansen, L. Schneider, L. Schneider, P. Thejll

“…Robust and highly significant wine production declines occurred in the years immediately following major volcanic events. Warmer and, to a lesser extent, drier climate conditions had a moderately strong, but persistent, positive effect on wine production. …”
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Efficacy of Wii-Fit on Static and Dynamic Balance in Community Dwelling Older Veterans: A Randomized Controlled Pilot Trial by Kalpana P. Padala, Prasad R. Padala, Shelly Y. Lensing, Richard A. Dennis, Melinda M. Bopp, Christopher M. Parkes, Mark K. Garrison, Patricia M. Dubbert, Paula K. Roberson, Dennis H. Sullivan

“…There were no study-related adverse events. Intent-to-treat analysis showed a significantly greater improvement in BBS in the exercise group (6.0; 95% CI, 5.1–6.9) compared to the control group (0.5; 95% CI, −0.3–1.3) at 8 weeks (average intergroup difference (95% CI), 5.5 (4.3–6.7), p < 0.001) after adjusting for baseline. …”
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The study protocol of a double-blind randomized controlled trial of EMDR and multifocal transcranial current stimulation (MtCS) as augmentation strategy in patients with fibromyalg... by I. Gardoki-Souto, O. Martín de la Torre, B. Hogg, D Redolar-Ripoll, L. Martínez Sadurní, M. Fontana-McNally, J. M. Blanch, W. Lupo, V. Pérez, J. Radua, B. L. Amann, A. Valiente-Gómez, A. Moreno-Alcázar

“…Methods Ninety-six patients with FM and a history of traumatic events will be randomly allocated to the treatment as usual (TAU) condition, EMDR + active-MtCS condition, or EMDR + sham-MtCS condition. …”
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Formation of Stripped Stars from Stellar Collisions in Galactic Nuclei by Charles F. A. Gibson, Fulya Kiroğlu, James C. Lombardi Jr., Sanaea C. Rose, Hans D. Vanderzyden, Brenna Mockler, Monica Gallegos-Garcia, Kyle Kremer, Enrico Ramirez-Ruiz, Frederic A. Rasio

“…Tidal disruption events (TDEs) are an important way to probe the properties of stellar populations surrounding supermassive black holes. …”
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Limited transmission of avian influenza viruses, avulaviruses, coronaviruses and Chlamydia sp. at the interface between wild birds and a free-range duck farm by Chloé Le Gall-Ladevèze, Benjamin Vollot, Julien Hirschinger, Laëtitia Lèbre, Rachid Aaziz, Karine Laroucau, Jean-Luc Guérin, Mathilde Paul, Julien Cappelle, Guillaume Le Loc’h

“…This study aimed to assess the prevalence of avian influenza viruses (AIV), avulaviruses, coronaviruses and Chlamydia sp. in commensal wild birds on a free-range duck farm in southwestern France and to evaluate possible transmission events at the wild‒domestic interface. From 2019 through 2021, a longitudinal study was conducted on wild birds, domestic ducks and their shared environment on farms. …”
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Assessment of Flood Mitigation Strategies: A Case Study of the Aït Athmane Center in the Errachidia Region by Kadiri Abdelhakim, Essafraoui Badre, Messaoudi Badre, Aït Lahssaine Ismail, Ait Said Brahim, El Ouali Mohamed, Kabiri Lahcen

“…The development of impoverished and marginalized communities is being increasingly jeopardized by the risks associated with climate change. Extreme weather events, like floods, can impact infrastructure, ecosystems, agriculture, water, and other vital sectors. …”
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Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer by Parik Kakani, Shruti Ganesh Dhamdhere, Deepak Pant, Rushikesh Joshi, Sachin Mishra, Anchala Pandey, Dimple Notani, Sanjeev Shukla

“…Additionally, hypoxia drives exon64A inclusion in a mutually exclusive alternative splicing event of COL5A1exon64 (exon64A/64B). Notably, CTCF mediates COL5A1 promoter-alternatively spliced exon upstream looping that regulates DNA demethylation at distal exon64A. …”
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Effect of Multiple Gene Copy Number of Bacterial Lipase to Increase Lipase Production in Pichia pastoris by Esti Puspitasari, Yepy Hardi Rustam, Andreas Adhi Satya, Antonius Suwanto, Aris Tri Wahyudi, Rika Indri Astuti

“…Three copies of the lipase gene in pPIC9K_T1.2RQ(3x) recombinant plasmid were integrated into the genome of Pichia pastoris GS115, and quantitative analysis using qPCR technique confirmed that the GS115 transformant strain contained six copies of T1.2RQ gene, indicating two integration events. Lipase activity measurement showed that the GS115/T1.2RQ(6x) strain exhibited a 111% increase compared to that containing a copy of the T1.2RQ gene. …”
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Digging for Literature on Tailoring Cultural Offers With and for Older People From Ethnic Minority Groups: A Scoping Review by Stephanie Tierney, Jordan Gorenberg, Marta Santillo, Debra Westlake, Geoffrey Wong, Kerryn Husk, Sofia Vougioukalou, Ruthanne Baxter, Shoba Dawson, Nia Roberts, Caroline Potter, Harriet Warburton, Beth McDougall, Johannah Latchem, Kamal R Mahtani

“…It involves connecting people to external support or services, including ‘cultural offers’–events, groups and activities run within or by cultural organisations. …”
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‘Will my fingerprint be enough?’: secondary school students struggle to purchase a healthy, tasty and sustainable meal on the UK free school meal allowance by Sundus Mahdi, Annie Connolly, Bob Doherty, Maria Bryant

“…Young people verified these findings, which they presented to policymakers at a parliamentary event. …”
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Solar Flare Forecasting Using Hybrid Neural Networks by Dan Xu, Pengchao Sun, Song Feng, Bo Liang, Wei Dai

“…We built two solar flare prediction models based on a combination of convolutional neural networks (CNN) and a temporal convolutional network (TCN), called CNN-TCN, and predicted whether a ≥C- or ≥M-class flare event would erupt in ARs in the next 24 hr, respectively. …”
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Successful Management of Refractory Heart Failure and Multi-Organ Dysfunction in a Patient with CRT-D and Acute Pulmonary Edema: A Case Report by Marsela Goga, Saimir Kuci, Alfred Ibrahimi, Ermal Likaj, Alvi Cela, Romina Teliti, Ormir Shurdha, Erilda Selimi, Jacob Zeitani

“…However, challenges persist when faced with acute events such as pulmonary edema, pneumonia, and multi-organ dysfunction syndrome. …”
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Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis by Motoi Uchino, Koji Tamura, Shinsuke Nomura, Seiichi Shinji, Keita Kouzu, Hiroji Shinkawa, Tomohiro Ishinuki, Toru Mizuguchi, Hiroki Ohge, Seiji Haji, Junzo Shimizu, Yasuhiko Mohri, Chizuru Yamashita, Yuichi Kitagawa, Katsunori Suzuki, Motomu Kobayash, Masahiro Kobayashi, Yuki Hanai, Hiroshi Nobuhara, Hiroki Imaoka, Masahiro Yoshida, Toshihiko Mayumi, Hiroki Ikeuchi, on behalf of SSI Prevention Guideline Committee in Japan Society for Surgical Infection

“…The following inclusion criteria were set for the systematic review. 1) Studies comparing with or without antiseptic/antibiotic irrigation/lavage during gastrointestinal surgery. 2) Studies that described surgical site infections and adverse events. 3) Studies conducted after 2000. Results A total of 8 randomized controlled studies (RCTs) and 3 observational studies were included in this meta-analysis. …”
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An open-label study evaluating the safety and efficacy of AMO-01 for the treatment of seizures in Phelan-McDermid syndrome by Tess Levy, J. Lloyd Holder, Jr., Joseph P. Horrigan, Michael F. Snape, Alison McMorn, Christina Layton, Hailey Silver, Kate Friedman, Hannah Grosman, Slayton Underwood, Danielle Halpern, Jessica Zweifach, Paige M. Siper, Alexander Kolevzon

“…AMO-01 was well tolerated, with no serious adverse events (AEs) reported. All AEs were mild or moderate in severity. …”
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Multi-Temporal Analysis and Techno-Economic Evaluation of Offshore Wind Energy Integration to the Western Interconnection by Li He, Shahnawaz Siddiqui, Sameer Nekkalapu, Sohom Datta, Travis Douville, Konstantinos Oikonomou, Manisha Maharjan

“…The intermittent nature of renewable energy generation introduces distinctive capacity challenges that hinge on various weather events occurring at different time intervals, ranging from rapid sub-hourly ramping to prolonged decadal droughts. …”
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