Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review by Brian Hutton, Beverley Shea, Kimberly Corace, David Moher, Danielle B Rice, Becky Skidmore, Kednapa Thavorn, Sheena Taha, Dianna Wolfe, Fatemeh Yazdi, Beth A Sproule, Melanie Willows, Patricia Poulin, Gary Garber, Amy Porath, Leila Esmaeilisaraji

“…Secondary outcomes will include self-reported opioid use, abstinence from illicit drugs, adherence to psychosocial therapy and opioid agonist therapy, risk for sexually transmitted disease, risk for blood borne pathogens, changes in mental health symptoms (eg, depression), measures of craving and changes in patients’ quality of life and relevant adverse events. If sufficient data and adequate homogeneity exists, network meta-analyses (NMA) will be performed.Ethics and dissemination This will be the first systematic review to incorporate NMA to compare psychosocial treatments used as an adjunct to opioid agonist therapy for OUD. …”
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RAPID: real-time automated plankton identification dashboard using Edge AI at sea by Sophie G. Pitois, Robert E. Blackwell, Hayden Close, Noushin Eftekhari, Sarah L. C. Giering, Mojtaba Masoudi, Eric Payne, Joseph Ribeiro, James Scott

“…This concept offers a rapid and cost-effective method for the monitoring of trends and events at fine temporal and spatial scales, thus making the most of the continuous data collection in real time and allowing for adaptive sampling to be deployed. …”
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Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential by Aseel O. Rataan, Yan Xu, Sean M. Geary, Yousef Zakharia, Eman S. Kamel, Youcef M. Rustum, Aliasger K. Salem

“…Major clinical challenges to current ccRCC treatments include high drug-resistance rates as well as dose-limiting adverse events; underlining the need to identify additional ‘druggable’ targets. …”
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Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report... by Yohei Ishiki, Atsuko Tamaki, Ken-ichiro Honma, Ken Yonaha, Takamitsu Yabiku, Taiki Teruya, Moriyuki Uehara, Yoshiro Nakayama, Rei Chinen, Tsugumi Uema, Sawako Nakachi, Shiki Okamoto, Hiroaki Masuzaki

“…PSIS has been thought to be a prenatal developmental event resulting from a couple of genetic aberrations. …”
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A cross-sectional study to determine prevalence of neonatal dermatoses in a tertiary health care centre of Andhra Pradesh, South India by Deepti Vemu, Shalini Eslavat, Shankar Kunti, Prasad Naik NM, Ritu Gujarati Vishwanath, Sruthi Kamatham

“…Dermatologists and paediatricians must be able to recognize typical events and distinguish them from the more serious cutaneous illnesses that affect newborns. …”
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GnRH pulse generator activity in mouse models of polycystic ovary syndrome by Ziyue Zhou, Su Young Han, Maria Pardo-Navarro, Ellen G Wall, Reena Desai, Szilvia Vas, David J Handelsman, Allan E Herbison

“…We began with the peripubertal androgen (PPA) mouse model of PCOS but found that it had a reduction in the frequency of ARNKISS neuron synchronization events (SEs) that drive LH pulses. Examining the prenatal androgen (PNA) model of PCOS, we observed highly variable patterns of pulse generator activity with no significant differences detected in ARNKISS neuron SEs, pulsatile LH secretion, or serum testosterone, estradiol, and progesterone concentrations. …”
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Weighing temporal fluctuations of drought features in Rwanda through the implementation of the standardized precipitation evapotranspiration index and standardized precipitation in... by Kazora Jonah, Zhu Weijun, Kyaw Oo Than, Temesgen Gebremariam Asfaw, Emmanuel Adu Gyamfi Kedjanyi, Abraham Okrah, Akimana Diane, Mathieu Mbati Mugunga

“…Climate change poses significant challenges globally, affecting weather patterns and leading to more frequent and severe extreme events such as droughts. In Rwanda, a country highly reliant on rainfed agriculture, understanding the changing nature of droughts is crucial for effective climate adaptation and resilience-building efforts. …”
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Ferroptosis genes and ST-segment elevation myocardial infarction outcomes: A predictive signature by Xing-jie Wang, Lei Huang, Min Hou, Jie Guo, Xi-ming Li

“…The external validation cohort confirmed the significant difference in major adverse cardiovascular events (MACEs) between the low- and high-risk groups. …”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…The primary endpoint was all-cause death or new neurological event over the first 12 months after randomisation. …”
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Effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults: protocol for a cluster randomised control... by Max K Bulsara, Christopher Etherton-Beer, Rosemary Saunders, Kate Crookes, Mustafa Atee, Caroline Bulsara, Beverley Ewens, Olivia Gallagher, Renee M Graham, Karen Gullick, Sue Haydon, Kim-Huong Nguyen, Bev O'Connell, Karla Seaman, Jeff Hughes, Seng Giap Marcus Ang, Debra Scaini

“…The primary outcome of this study will be the change in frailty between both admission and discharge, and admission and 30 days, and secondary outcomes include length of stay, adverse events, discharge destination, quality of life, depression, cognitive function, functional independence, pain scores, pain management intervention (type and frequency) and unplanned 30-day readmissions. …”
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Protective Efficacy of Decreasing Antigen Doses of a <i>Chlamydia abortus</i> Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model by Morag Livingstone, Kevin Aitchison, Javier Palarea-Albaladejo, Francesco Ciampi, Clare Underwood, Antonia Paladino, Francesca Chianini, Gary Entrican, Sean Ranjan Wattegedera, David Longbottom

“…Results: No obvious dose–response relationship was observed across the groups, with a single abortion event occurring in four of the groups and three in the lowest dose group (2.5 µg). …”
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Factors influencing emotional driving: examining the impact of arousal on the interplay between age, personality, and driving behaviors by Zhegong Shangguan, Xiao Han, Younesse El Mrhasli, Nengchao Lyu, Adriana Tapus

“…Appraisal theory posits that emotional reactions are influenced by individuals' attitudes toward current circumstances and events, thereby shaping their driving attitudes and styles. …”
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Angiographic Complete versus Clinical Selective Incomplete Percutaneous Revascularization in Heart Failure Patients with Multivessel Coronary Disease by Chieh-Yu Chang, Chun-Chi Chen, I-Chang Hsieh, Ming-Jer Hsieh, Cheng-Hung Lee, Dong-Yi Chen, Ming-Lung Tsai, Ming-Yun Ho, Jih-Kai Yeh, Yu-Chang Huang, Yu-Ying Lu, Chao-Yung Wang, Shang-Hung Chang, Ming-Shien Wen

“…Major adverse cardiac events (MACEs) were defined as a composite of recurrent myocardial infarction, any revascularization, and all-cause mortality at 5 years. …”
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Technologically-Treated Polyclonal Affinity-Purified Antibodies to the Tumor Necrosis Factor-α, Brain Specific S-100 Protein and Histamine in Treatment of Functional Dyspepsia: Res... by Yu. O. Shulpekova, I. V. Maev, V. B. Grinevich, I. B. Khlynov, Yu. G. Shvarts, V. T. Ivashkin

“…There were 29 adverse events (AEs) recorded in 25 patients including 16 cases in 13 (8.6 %) patients in Kolofort® group and 13 AEs in 12 (7.6 %) patients in placebo group.Conclusion: the clinical trial demonstrates the positive effect of Kolofort® in FD with a favorable safety profile.…”
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High peripheral T cell diversity is associated with lower risk of toxicity and superior response to dual immune checkpoint inhibitor therapy in patients with metastatic NSCLC by Alexandre Reuben, Mehmet Altan, Latasha Little, Jianjun Zhang, Ajay Sheshadri, Hai T Tran, Mara B Antonoff, Stephen G Swisher, John V Heymach, Saumil Gandhi, Natalie Vokes, Ziyi Li, Ruoxing Li, Runzhe Chen, Joshua Baguley, Jefferson Sinson, Greg Lizee

“…Introduction Despite significant successes, immune checkpoint blockade fails to achieve clinical responses in a significant proportion of patients, predictive markers for responses are imperfect and immune-related adverse events (irAEs) are unpredictable. We used T-cell receptor (TCR) sequencing to systematically analyze prospectively collected patient blood samples from a randomized clinical trial of dual immune checkpoint inhibitor therapy to evaluate changes in the T-cell repertoire and their association with response and irAEs.Methods Patients with immunotherapy-naïve metastatic non-small cell lung cancer (NSCLC) were treated with ipilimumab and nivolumab according to trial protocol (LONESTAR, NCT03391869). …”
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Bacterial communities as bioindicators of climate change in freshwater ecosystems: Tank bromeliads as model systems by Daniel Di Pace Soares Penna, Gustavo Quevedo Romero, Mark P. Nessel, Angélica L. González, Valéria Maia Oliveira

“…Climate change, characterized by rising temperatures and extreme weather events, threatens tropical freshwater ecosystems. …”
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Wild Boar Attacks on Hunting Dogs in Czechia: The Length of the Hunting Season Matters by Jana Adámková, Karolína Lazárková, Jan Cukor, Hana Brinkeová, Jitka Bartošová, Luděk Bartoš, Kateřina Benediktová

“…This study investigated the impact of increased hunting pressure—both across the hunting season and within individual hunting events—on the risk of wild boar attacks on hunting dogs, i.e., the length of the hunting season (2.68 ± 0.76 months, mean ± standard deviation), the number of driven hunts per season (3.99 ± 0.43), the intervals between hunts (17.85 ± 4.83 days), the number of wild boars harvested per season (14.46 ± 13.10), and the number of participants (23.8 ± 10.69) and dogs (4.56 ± 2.66) involved per hunt. …”
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Assessing Short-term Flood Impact on Land Use Dynamics in Iran’s Central Zagros: A Case Study of Sefid Kuh Protected Area by Soheyl Moradi, Hossein Moradi, Jafar Dolatshah, Azita Rezvani

“… Floods are extreme events that can alter the land cover and land use patterns in mountainous regions, with significant consequences for biodiversity, ecosystem services, and human well-being. …”
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Late Ediacaran juvenile magmatism in the Variscan Monts-du-Lyonnais metamorphic complex (Massif Central, France) by Couzinié Simon, Laurent Oscar, Bouilhol Pierre, Chelle-Michou Cyril, Ganzhorn Anne-Céline, Gardien Véronique, Moyen Jean-François

“…Instead, it can be correlated to a juvenile Ediacaran magmatic event identified throughout the Variscan realm, interpreted as reflecting Cadomian arc/back-arc magmatism.…”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

“…All tested vaccines and regimens were safe and well tolerated with no serious adverse events reported related to study products. Solicited local and systemic reactogenicity was mostly mild to moderate in severity. …”
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