Cis‐Regulation of an m6A Eraser by an Insertion Variant Associated with Survival of Patients With Non‐Small Cell Lung Carcinoma by Lei Cheng, Qiangsheng Hu, Yanan Wang, Wei Nie, Haijiao Lu, Bo Zhang, Genming Zhao, Shiyun Ding, Feng Pan, Yinchen Shen, Runbo Zhong, Ruoxin Zhang

“…Triggered by an insertion variant, this remote cis‐regulation of m6A eraser and the downstream molecular events modulate the survival of NSCLC patients.…”
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Dynamic of seismic noise sources in the Mediterranean Sea: implication for monitoring using noise correlations by Stehly, Laurent, Delouche, Estelle, Tomasetto, Lisa, Ranjan, Pratul

“…Thus, the noise field is more stable in northern Europe where the influence of the Atlantic Ocean predominates, while along the Adriatic coast and around the Aegean Sea, micro-seismic events lasting several hours are regularly detected, especially in summer. …”
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Case report: Clonal evolution analysis of a rare case of meningioma lung metastases identifies actionable alterations in matched longitudinal tumour samples by Nicola Cosgrove, Orla M. Fitzpatrick, Orla M. Fitzpatrick, Liam Grogan, Liam Grogan, Bryan T. Hennessy, Bryan T. Hennessy, Simon J. Furney, Sinead Toomey

“…In the same cancer clone as NF2, we identified a BRCA2 (p.E51K) mutation was present in all tumors, which may represent a potential driver event, though evidence supporting this is currently limited. …”
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CDK9 Expression Shows Role as a Potential Prognostic Biomarker in Breast Cancer Patients Who Fail to Achieve Pathologic Complete Response after Neoadjuvant Chemotherapy by Ashley J. Schlafstein, Allison E. Withers, Soumon Rudra, Diana Danelia, Jeffrey M. Switchenko, Donna Mister, Saul Harari, Hui Zhang, Waaqo Daddacha, Shahrzad Ehdaivand, Xiaoxian Li, Mylin A. Torres, David S. Yu

“…Data recorded included disease presentation, treatment, pathologic response, overall survival (OS), locoregional recurrence free survival (LRRFS), distant-failure free survival (DFFS), recurrence-free survival (RFS), and event-free survival (EFS). Immunohistochemistry was performed on patient samples to determine CDK9 expression levels after NACT. …”
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Adaptive cognitive control in 4 to 7-year-old children and potential effects of school-based yoga-mindfulness interventions: an exploratory study in Italy by Lisa Toffoli, Giulia Stefanelli, Giulia Manca, Fiorella Del Popolo Cristaldi, Gian Marco Duma, Michele Guidi, Francesca Incagli, Luca Sbernini, Luca Sbernini, Vincenza Tarantino, Giovanni Mento, Giovanni Mento

“…IntroductionRecent findings showed that adaptive cognitive control (CC) can be instantiated by bottom-up mechanisms, including statistical contingency of event occurrence. However, the developmental evidence in this domain remains limited.MethodsTo address this gap, our study delves into the exploration of different mechanisms underlying adaptive CC in a substantial cohort of young children (211 participants aged between 4 and 7 years). …”
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Tunable structuring of nanocellulose-based sustainable lubricants by an external electric field by Samuel D. Fernández-Silva, Miguel A. Delgado, María García-Pérez, Claudia Roman, Moisés García-Morales

“…The highest pre-shear yielded a structural break which, under the action of an electric voltage, enabled the formation of a different structural conformation when pre-shear halted, in comparison with the lowest pre-shear. Such event led to a notorious reduction in both storage and loss moduli, mainly at the lowest electric field intensities.…”
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Sterol‐Targeted Laboratory Evolution Allows the Isolation of Thermotolerant and Respiratory‐Competent Clones of the Industrial Yeast Saccharomyces cerevisiae by Isabel‐Elena Sánchez‐Adriá, Jose A. Prieto, Gemma Sanmartín, Miguel Morard, Estéfani García‐Ríos, Francisco Estruch, Francisca Randez‐Gil

“…The clones were categorised into two groups based on their respiratory competence or deficiency, the latter associated with mtDNA loss, an event seemingly linked to FCNZ and heat tolerance. …”
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Efficacy of Neoadjuvant Chemotherapy DOX and XELOX Regimens for Patients with Resectable Gastric or Gastroesophageal Junction Adenocarcinoma by Yuan Tian, Qun Zhao, Yong Li, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Bibo Tan, Dong Wang, Peigang Yang

“…The most common grade 3-4 adverse events in these three groups were neutropenia (32.3%, 30.4%, and 21.1%), leucopenia (21.5%, 22.8%, and 15.8%), nausea (15.1%, 16.3%, and 12.6%), and fatigue (10.8%, 7.6%, and 8.4%). …”
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The Resuscitation, Equilibrium and De-escalation (RED) strategy: a phased, personalized hemodynamic support in children with sepsis by Jaime Fernández-Sarmiento, Sushitra Ranjit, L. Nelson Sanchez-Pinto, Vinay M. Nadkarni, Roberto Jabornisky, Niranjan Kissoon

“…However, their use has been linked to adverse events due to factors such as their composition, high volumes and rapid infusion rates, and the variable response of individual patients. …”
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Expression pattern of Calbindin-D28k, NeuN proteins, ATOH1 and EN2 genes in the human fetal cerebellum by Phanindra Prasad Poudel, Arnab Ghosh, Chacchu Bhattarai, Saman Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, R. Vani Lakshmi, Sneha Guruprasad Kalthur

“…Background: Human cerebellum plays a crucial role in motor coordination and cognitive functions. Series of events such as cell proliferation, migration, and differentiation occur during the development, which are tightly regulated by specific genes. …”
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Impact of socio-demographic structure of the deaf people communities in prevalence of hereditary hearing loss by O. L. Posukh, M. S. Bady-Khoo, M. V. Zytsar, V. Yu. Mikhalskaia, S. A. Lashin, N. A. Barashkov, G. P. Romanov

“…It is assumed that high prevalence of hearing loss due to mutations in the GJB2 (Cx26) gene was also influenced by some social factors: a long-standing tradition of assortative marriages between deaf people, combined with growth of their social adaptation and genetic fitness. The start for these events was the breakdown of the deep social isolation of deaf people, which occurred about 300 years ago in Europe, and later in the US, when special schools for the deaf with learning sign language as a common tool for communication were established (linguistic homogamy). …”
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Assessment of the efficacy of on-demand tegoprazan therapy in gastroesophageal reflux disease through a randomized controlled trial by Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Sun Moon Kim, Ki Bae Kim, Seung Woo Lee, Young Sin Cho, Ki Bae Bang, Kyung Ho Song

“…No serious treatment-emergent adverse events were reported. Tegoprazan is effective as on-demand therapy for GERD and offers the expectation of faster symptom improvement than with PPIs. …”
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Dynamic analysis of growth characteristics, secondary metabolites accumulation, and an in-depth understanding of anthraquinones biosynthesis in Rubia cordifolia Linn. by Conglong Lian, Conglong Lian, Conglong Lian, Xiuyu Liu, Xiuyu Liu, Kaihua Guo, Kaihua Guo, Hao Yang, Hao Yang, Jingfan Yang, Jingfan Yang, Jinxu Lan, Jinxu Lan, Suiqing Chen, Suiqing Chen, Suiqing Chen, Suiqing Chen

“…Furthermore, we sequenced R. cordifolia using SMRT technology for the first time and obtained 45,925 full-length transcripts, 564 alternative splicing events, 3182 transcription factors, 6454 SSRs, and 6361 lncRNAs. …”
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Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial by Pavlos Msaouel, Kai Yu, Ying Yuan, Jianfeng Chen, Xinmiao Yan, Menuka Karki, Fei Duan, Rahul A. Sheth, Priya Rao, Kanishka Sircar, Amishi Y. Shah, Amado J. Zurita, Giannicola Genovese, Min Li, Chih-Chen Yeh, Minghao Dang, Guangchun Han, Yanshuo Chu, Max Hallin, Peter Olson, Rui Yang, Daniela Slavin, Hirak Der-Torossian, Curtis D. Chin, Nizar M. Tannir, Linghua Wang, Jianjun Gao

“…Sitravatinib dose of 35 mg daily plus nivolumab 3 mg/kg and ipilimumab 1 mg/kg resulted in high frequency of immune-related adverse events. Subsequent dose reduction of ipilimumab to 0.7 mg/kg allowed safe escalation of sitravatinib up to 100 mg daily. …”
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A multicenter, single‐group, open feasibility study of a new individual cognitive behavioral therapy program for adult Japanese patients with attention‐deficit/hyperactivity disord... by Naoki Takamatsu, Misuzu Nakashima, Kei Matsuura, Ikue Umemoto, Masaya Ito, Junichiro Kanazawa, Hirofumi Tomiyama, Masaki Kondo, Hisateru Tachimori, Tomohiro Nakao, Masaru Horikoshi, Hironori Kuga

“…Results The primary objective is to determine feasibility using dropout rates, adverse events, and CAARS score changes between Weeks 1 and 16. …”
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The Dutch-translated cultural competence assessment scale for nurses: Cross-cultural adaptation and validation by P.B. Sutharson, J.M. Maaskant, A.M. Eskes

“…Background: Researchers have revealed significant disparities in safety events and patient outcomes between minority and non-minority populations, highlighting the need for a deeper understanding of cultural competence. …”
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Mucosal snare resection-endoscopic submucosal excavation for gastric submucosal tumors: a retrospective study (with video) by Wei Wei, Xiaolong Zheng, Yongli Ye, Hongxia Li, Yiping Hong, Jianting Cai

“…Factors such as operation time, intraoperative perforation, postoperative adverse events, postoperative fasting time, antibiotic use, hospitalization duration, costs, and pathological diagnosis were compared between the two procedures.ResultsA total of 180 patients with submucosal tumors were included in this study. …”
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Classification and Physical Characteristic Analysis of Fermi-GBM Gamma-Ray Bursts Based on Deep Learning by Jia-Ming Chen, Ke-Rui Zhu, Zhao-Yang Peng, Li Zhang

“…By using count maps that incorporate both temporal and spectral features as inputs, we successfully classify 593 overlapping events into two distinct categories, thereby refuting the existence of an intermediate GRB class. …”
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Ribosome pausing in amylase producing Bacillus subtilis during long fermentation by Yaozu Han, Biwen Wang, Alberto Agnolin, Gaurav Dugar, Frans van der Kloet, Christopher Sauer, Paul Igor Costea, Max Fabian Felle, Mathis Appelbaum, Leendert W. Hamoen

“…Conclusions Expression of the α-amylase gene amyM in B. subtilis is accompanied by several ribosome pausing events. Since these sites can neither be predicted based on codon specificity nor on secondary protein structures, we speculate that secondary mRNA structures are responsible for these translation pausing sites. …”
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Impacts of meteorology and emission reductions on haze pollution during the lockdown in the North China Plain by L. Liu, L. Liu, X. Long, Y. Li, Y. Li, Z. Zang, Z. Zang, F. Wang, Y. Han, Z. Bao, Y. Chen, T. Feng, J. Yang

“…<p>Haze events in the North China Plain (NCP) during the COVID-19 lockdown underscore the intricate challenges of air quality management amid reduced human activities. …”
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