Assessment of the southern polar and subpolar warming in the PMIP4 last interglacial simulations using paleoclimate data syntheses by Q. Gao, Q. Gao, Q. Gao, E. Capron, L. C. Sime, R. H. Rhodes, R. Sivankutty, X. Zhang, B. L. Otto-Bliesner, M. Werner

“…We run a 3000-year 128 ka simulation using HadCM3 with a 0.25 Sv North Atlantic freshwater hosing, which approximates the PMIP4 127 ka Tier 2 H11 (Heinrich event 11) simulation. The hosed 128 ka HadCM3 simulation captures much of the warming and sea ice loss shown in the four data syntheses at 127 ka relative to preindustrial: south of 40° S, modeled annual sea surface temperature (SST) rises by 1.3 <span class="inline-formula">±</span> 0.6 °C, while reconstructed average anomalies range from 2.2 to 2.7 °C; modeled summer SST increases by 1.1 <span class="inline-formula">±</span> 0.7 °C, close to the 1.2–2.2 °C reconstructed average anomalies; September sea ice area (SIA) is reduced by 40 <span class="inline-formula"><i>%</i></span>, similar to the reconstructed 40 <span class="inline-formula">%</span> reduction of sea ice concentration (SIC); over the Antarctic Ice Sheet, modeled annual surface air temperature (SAT) increases by 2.6 <span class="inline-formula">±</span> 0.4 °C, even larger than reconstructed average anomalies of 2.2 °C. …”
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Characteristics and real-world medication persistence of people living with HIV treated with DTG/3TC or BIC/FTC/TAF: a hospital claims database study in Japan by Rie Kanamori, Nozomi Aoki, Akio Kanazawa, Mayumi Yuda, Nao Makino, Emi Ohata, Nobuyuki Fukui, Hirotake Mori, Hirohide Yokokawa, Toshio Naito

“…Due to the limitations of the database, further research to assess viral loads, emergence of resistance and adverse events will be encouraged.…”
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A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response i... by Ian J Neeland, Luiz H de Gregório, Roberto Zagury, Bo Ahrén, Joel Neutel, Christian Darimont, John Corthesy, Yohan Grzywinski, Emilie Perrin, Maximilian von Eynatten, Odd Erik Johansen

“…Postprandial plasma BCAA patterns were characterized by a rapid increase and larger iAUC_0–2h (all <i>p</i> < 0.001) after WPM. No adverse events were ascribed to consuming WPM. <b>Conclusions</b>: A 125 mL pre-meal drink containing just 10 g WPM before a mixed meal reduced PPG and increased insulin, GLP-1, and BCAAs. …”
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Comparison of search and rescue operations involving emergency physicians in devastating earthquakes in Turkey: a 24-year experience study by Mustafa Ferudun Celikmen, Gülbin Aydoğdu Umaç, Melih Imamoglu, Mümin Murat Yazici, Elif Çiğdem Keleş, Sarper Yilmaz

“…Disseminating this knowledge is crucial not only for managing earthquakes but also for preparing for other catastrophic events that could cause widespread destruction. Harnessing this accumulated experience can significantly enhance knowledge-sharing and the development of more effective preparedness strategies.…”
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Establishment and Maintenance of a Digital Therapeutic Alliance in People Living With Negative Symptoms of Schizophrenia: Two Exploratory Single-Arm Studies by Cassandra Snipes, Cornelia Dorner‑Ciossek, Brendan D Hare, Olya Besedina, Tim Campellone, Mariya Petrova, Shaheen E Lakhan, Abhishek Pratap

“…There were no adverse events (AEs) in study 1, and 3 nonserious and nontreatment-related AEs in study 2. …”
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Automated Video Assistant Referee in Lead Climbing by Eliane Künzler, David Roder, Urs Stöcker, Peter Wolf

“…The results will then be discussed at the next educational event for judges at national and international level. …”
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Compassionate Use of Omadacycline in a Down Syndrome Pre-Schooler With Critically Ill Atypical Pneumonia Caused by Macrolide-Resistant Mycoplasma Pneumoniae by Wu D, Xie FJ, Wang YJ, Jiang XH, Zhang GL, Zhang H, Zhu YC, Zhang Y, Tang YJ, Lin YL, Xu JX, Zhang JN, Liu BW, Kang K, Gao Y

“…The treatment achieved a favourable therapeutic effect without any related adverse events (AEs) during hospitalization and follow-up.Conclusion: In clinical practice, rapid and accurate identification of causative organisms should be a priority for prompt initiation of pathogen-targeted antibiotics, in which tNGS possesses enormous potential, particularly for difficult-to-culture MP. …”
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Efficacy and safety of PD-1/PD-L1 inhibitors in advanced or recurrent endometrial cancer: a meta-analysis with trial sequential analysis of randomized controlled trials by Ji Ren, Jinghe Wang, Yanan Wang, Dongying Yang, Jianming Sheng, Shili Zhu, Yunli Liu, Xiaoqi Li, Wei Liu, Binbin Zhang

“…Efficacy was measured by progression-free survival (PFS) and overall survival (OS), while safety was assessed by the incidence of any grade or grade ≥ 3 adverse events (AEs). We calculated hazard ratios (HRs) for PFS and OS, as well as risk ratios (RRs) for AEs, each accompanied by 95% confidence intervals (CIs). …”
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Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…Meta-analyses were performed to evaluate the frequencies of progression-free survival (PFS), overall survival (OS), complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD), objective response rate (ORR), disease control rate (DCR), and grade ≥ 3 treatment-related adverse events (trAEs).ResultsTotally six studies were included for meta-analysis. …”
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Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients by Xiaowen Guo, Yang Qiao, Sijie Yin, Fengqin Luo, Lingmei Yi, Jiajia Chen, Man Lu

“…Perioperative vital signs, injection pain, adverse events (AEs), BIS values, eyelid reflex disappearance times, and recovery times were recorded. …”
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Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro... by Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye

“…Abstract Purpose To identify key cellular changes and molecular events in atrophic mucosa, we aimed to elucidate the molecular mechanisms driving the occurrence of chronic atrophic gastritis (CAG). …”
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Advanced Fractional Mathematics, Fractional Calculus, Algorithms and Artificial Intelligence with Applications in Complex Chaotic Systems by Dumitru Baleanu, Yeliz Karaca

“…Given that slight perturbation leads to a significantly divergent future concatenation of events, pinning down the state of different systems precisely can enable one to unveil uncertainty to some extent. …”
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Facing migration under adverse conditions: challenges and resilience in the Colombo-Venezuelan border area by Gloria Omaira Bautista, Axel Kroeger, Nelly Rosero Castillo, Eduardo Gabriel Osorio Sanchez, Dianne Sofía Gonzales Escobar, Rafael Olarte, Sonia Diaz Monsalve

“…They all had stressful life events recently, with economic hardship being the most significant one, especially among migrants. …”
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Dva příběhy z kriminálního podsvětí – padělatelé peněz na hradě Žampachu a přepadání Židů v roce 1542 by František Šebek

“…This reconstruction greatly enhances our know- ledge of the unsettled events surrounding the exodus of the Jews from Bohemia in 1542. …”
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Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…The main limitations of this study include the failure to take into account some potential confounding factors and the inability to analyze some groups of the studied population (8.5% of the sample) because of the very small number of events in these groups.<h4>Conclusions</h4>The significant overall reduction in the prevalence of episiotomy in France has not been followed by an overall increase in OASI. …”
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Twelve-Month Outcomes and Optical Coherence Tomography (OCT) Biomarkers After Intravitreal Dexamethasone Implantation in Pseudophakic Eyes with Post-Vitrectomy Cystoid Macular Edem... by Francesco Pignatelli, Alfredo Niro, Giuseppe Addabbo, Pasquale Viggiano, Giacomo Boscia, Maria Oliva Grassi, Francesco Boscia, Cristiana Iaculli, Giulia Maria Emilia Clima, Antonio Barone, Ermete Giancipoli

“…The impact of OCT biomarkers on the exposure to DEX implants was assessed. Adverse events, potentially related to the treatment, were investigated as well. …”
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How to estimate the probability of a live birth after one or more complete IVF cycles? the development of a novel model in a single-center by Xiangyi Kong, Zhiqiang Liu, Chunyu Huang, Xiuyu Hu, Meilan Mo, Hongzhan Zhang, Yong Zeng

“…A Nomogram model was built based on potential predictive factors that might influence the event of a live birth. Conclusions The Cox regression and Nomogram prediction models effectively predicted the probability of infertile couples having a live birth. …”
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La poésie lyrique, un outil d’unification linguistique et politique by Anne-Marie Le Baillif

“…The second act was Defence et Illustration de la langue française published by Joachim du Bellay in 1549 ruling on the use of vernacular language in lyrical poetry. Both events gave impetus to the unification of the language, not only in official documents but also in everyday life. …”
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Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial by Thanawala S, Shah R, Alluri KV, Bhupathiraju K, Prasad N, Agarwal Y

“…Inflammatory biomarkers (hsCRP, TNF-α, IL-6, and IL-1β) were significantly reduced from baseline to day 90 in the WDTE60N group compared to the placebo group (p < 0.0001). Four mild adverse events were reported during the study period.Conclusion: Supplementation with the low-dose water-dispersible turmeric extract containing 60% natural curcuminoids for three months was safe and effective in alleviating pain, improving functional status and quality of life and reducing inflammation in participants with mild-to-moderate knee osteoarthritis.CTRI Registration Number: CTRI/2023/07/055411Keywords: curcuminoids, inflammatory biomarkers, KOOS, pain, QoL, visual analog scale…”
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Degassing at the Volcanic/Geothermal System of Kos (Greece): Geochemical Characterization of the Released Gases and CO2 Output Estimation by Kyriaki Daskalopoulou, Antonina Lisa Gagliano, Sergio Calabrese, Lorenza Li Vigni, Manfredi Longo, Konstantinos Kyriakopoulos, Giovannella Pecoraino, Walter D’Alessandro

“…Changes in the degassing areas along with significant variations in the geochemical parameters of the released gases were observed both before and after the seismic event; however, no coherent model explaining those changes was obtained. …”
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