A Blueprint for the Problem Formulation Phase of EPA-Type Ecological Risk Assessments for 316(b) Determinations by Webster Van Winkle, William P. Dey, Steve M. Jinks, Mark S. Bevlhimer, Charles C. Coutant

“…The facility-specific problem formulation phase is designed around the hierarchy of biolo gical levels of organization in the generic conceptual model and the sequence of cause-effect events and risk hypotheses represented by this model. …”
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Adverse Maternal Outcomes and Associated Factors Among Mothers of Advanced Age delivering at a Tertiary Hospital, Southwestern Uganda: A Cross-Sectional Study. by Masembe, Sezalio, Migisha, Richard, Turyasingura, Godwin, Aheisibwe, Hillary, Nzabandora, Emmanuel, Lule, John C.

“…We define adverse maternal outcome as any complication sustained by the mother that was related to pregnancy, delivery, and immediate post-partum events (obstructed labor, antepartum hemorrhage, mode of delivery [cesarean or vacuum extraction], postpartum hemorrhage, hypertensive disorders of pregnancy, preterm or postdate pregnancy, anemia, premature rupture of membranes, multiple pregnancy, and maternal death). …”
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Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes by Fang Wang, Yukang Mao, Jinyu Sun, Jiaming Yang, Li Xiao, Qingxia Huang, Chenchen Wei, Zhongshan Gou, Kerui Zhang

“…The study aims to establish models predicting long-term mortality and explore dietary nutrients associated with reduced long-term events to guide daily dietary decisions in people with DM. …”
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Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis by Ziying Wu, Xiang Ding, Guanghua Lei, Chao Zeng, Jie Wei, Jiatian Li, Hui Li, Tuo Yang, Yang Cui, Yilin Xiong, Yilun Wang, Dongxing Xie

“…Three trials reported adverse events, and the combined results showed that there was no significant difference between PEMF and the sham group.Conclusions PEMF could alleviate pain and improve physical function for patients with knee and hand OA, but not for patients with cervical OA. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

“…Grade ≥ 3 treatment-related adverse events were reported in 24 patients (55.8%) overall. …”
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Impact of social determinants and medical mistrust on parent-child HPV vaccination in economically disadvantaged communities: implications for cancer prevention by Marcelo M. Sleiman, Mary Rose Yockel, Mingqian Liu, Joanne Wendolowski, Lucile L. Adams-Campbell, Chiranjeev Dash, Lisa Carter-Bawa, Abraham Aragones, Sahana Arumani, Kenneth P. Tercyak

“…IntroductionHuman papillomavirus (HPV) vaccination and intentions, their correlates, and barriers among age-eligible parents and their children living in very economically disadvantaged communities were assessed.MethodsParents (N=198; 45% Black, 42% Latine, 57% educated <=high school [HS], 74% income <$60k annually) with children ages 10-17 from Washington, DC and Hackensack, NJ were intercepted at community events and surveyed.ResultsAmong age-eligible parents, 20% were vaccinated against HPV. …”
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Arthralgia and Extraintestinal Manifestations in Crohn’s Disease Elevate the Risk of IBD-Related Arthritis over Sacroiliitis by Ivan Giovannini, Nicola Cabas, Marco Marino, Annarita Tullio, Ilaria Tinazzi, Angela Variola, Carmelo Cicciò, Fabro Cinzia, Berretti Debora, Chiara Zuiani, Rossano Girometti, Luca Quartuccio, Alen Zabotti, Lorenzo Cereser

“…The identification of new-onset IBD-related arthritis events during the follow-up was based on rheumatological clinical diagnosis and fulfillment of the ASAS classification criteria. …”
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Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade by Ayana Yamagami, Shintaro Iwama, Tomoko Kobayashi, Xin Zhou, Yoshinori Yasuda, Takayuki Okuji, Masaaki Ito, Tetsushi Izuchi, Masahiko Ando, Takeshi Onoue, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima

“…Anti-thyroglobulin antibodies (TgAb) and/or anti-thyroid peroxidase antibodies (TPOAb) positivity at baseline is a risk marker for thyroid immune-related adverse events (thyroid-irAEs) in anti-programmed cell death-1 antibody (PD-1-Ab) treatment; however, it is unknown if TgAb and TPOAb titers are associated with clinical characteristics of thyroid-irAEs. …”
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Sofosbuvir-Based Therapies for Patients with Hepatitis C Virus Infection: Real-World Experience in China by Chengguang Hu, Guosheng Yuan, Junwei Liu, Huaping Huang, Yanyu Ren, Yinping Li, Xuefu Chen, Wei Li, Tao Wu, Hong Deng, Yanzhong Peng, Yong-Yuan Zhang, Yuanping Zhou

“…The primary observation point was the percentage of patients with a sustained virologic response (SVR) at posttreatment week 12 (SVR12), and all adverse events were monitored during treatment and follow-up period. …”
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Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: a randomized controlled trial [version 2; peer review: 1 approved,... by Hary Sakti Muliawan, Erlina Burhan, Mia Elhidsi, Heri Wibowo, Triya Damayanti, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Ismail Hadisoebroto Dilogo, Mira Yulianti, Adityo Susilo, Irandi Putra Pratomo, Raden Rara Diah Handayani, Rahyussalim -, Murdani Abdullah, Cosphiadi Irawan, Robert Sinto, Dita Aditianingsih

“…However, we found no significant differences in inflammatory marker levels on the seventh day and 14th day after intervention between both groups. There was no adverse event reported. There were no significant differences in the laboratory outcome, radiology outcome, RT-PCR result conversion, and safety profiles between both groups. …”
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Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial by Ling Zhao, Qifu Li, Yanan Wang, Jialei Feng, Xinghe Zhang, Siwen Zhao, Chonghui Xing, Yongli Song, Xuanxiang Zeng, Meng Kong, Yunqiu Zheng, Taipin Guo

“…The data will be collected at the baseline time (week 0), end of treatment (week 4–8) and the follow-up time (week 12–16). Adverse events will be collected and recorded during each treatment.Ethics and dissemination Ethics approval was obtained from the Ethics Committee of the Sports Trauma Specialist Hospital of Yunnan Province (2021-01). …”
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The Use of Social Network in Daily Pediatric Practice and Education: Turkish Pediatric Atelier by Erdem Gönüllü, Ahmet Soysal, İlkay Can, Ercan Tutak, Turan Tunç, İsmail Yıldız, Osman Yeşilbaş, Naci Öner, Ali Anarat, Feryal Gün Soysal, Cengiz Bayram, Mehmet Cihan Balcı, Emine Betül Tavil, Teoman Akçay, Metin Karaböcüoğlu

“…Of the 520 consulted cases, 44 (8%) were related to life-threatening events, and 25 of them were hospitalized in the intensive care units, and 6 of them were required surgical operations. …”
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TAME 2.0: expanding and improving online data science training for environmental health research by Alexis Payton, Alexis Payton, Alexis Payton, Elise Hickman, Elise Hickman, Elise Hickman, Jessie Chappel, Jessie Chappel, Jessie Chappel, Kyle Roell, Kyle Roell, Lauren E. Koval, Lauren E. Koval, Lauren A. Eaves, Lauren A. Eaves, Chloe K. Chou, Chloe K. Chou, Chloe K. Chou, Allison Spring, Allison Spring, Sarah L. Miller, Sarah L. Miller, Sarah L. Miller, Oyemwenosa N. Avenbuan, Oyemwenosa N. Avenbuan, Oyemwenosa N. Avenbuan, Rebecca Boyles, Rebecca Boyles, Paul Kruse, Cynthia V. Rider, Grace Patlewicz, Caroline Ring, Cavin Ward-Caviness, David M. Reif, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Rebecca C. Fry, Rebecca C. Fry, Rebecca C. Fry, Julia E. Rager, Julia E. Rager, Julia E. Rager, Julia E. Rager

“…TAME 2.0 effectiveness was evaluated via participant surveys during graduate-level workshops and coursework, as well as undergraduate-level summer research training events, and suggested edits were incorporated while overall metrics of effectiveness were quantified.DiscussionCollectively, TAME 2.0 now serves as a valuable resource to address the growing demand of increased data science training in environmental health research. …”
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Aetiology of chronic liver disease is a valuable factor for stratifying adverse outcomes of acute decompensation: prospective observational study by Jung Hee Kim, Sung-Eun Kim, Do Seon Song, Hee Yeon Kim, Eileen L. Yoon, Ji Won Park, Tae Hyung Kim, Young-Kul Jung, Ki Tae Suk, Hyung Joon Yim, Jung Hyun Kwon, Sung Won Lee, Seong Hee Kang, Moon Young Kim, Soung Won Jeong, Jae-Young Jang, Jeong Ju Yoo, Sang Gyune Kim, Young-Joo Jin, Gab Jin Cheon, Byung Seok Kim, Yeon Seok Seo, Hyoungsu Kim, Dong Hyun Sinn, Woo Jin Chung, Hwi Young Kim, Han Ah Lee, Seung Woo Nam, In Hee Kim, Ji Hoon Kim, Hee Bok Chae, Joo Hyun Sohn, Ju Yeon Cho, Yoon Jun Kim, Jin Mo Yang, Jung Gil Park, Won Kim, Hyun Chin Cho, Dong Joon Kim

“…In this study, we assess the clinical attributes and prognostic implications of AD with CLD/LC stratified by the aetiology.Results Among 1,501 patients, the mean age was 54.7 years old and 1,118 patients (74.5%) were men. The common events of AD were GI bleeding (35.3%) and jaundice (35.0%). …”
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Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…Additionally, innate immune activation following IRI links PGD to adaptive alloimmunity, highlighting the impact of early events on LTx outcomes. Immune checkpoints (ICPs) such as PD-1/PD-L1, CD40/CD40LG, and OX40/OX40L, regulate post-LTx T cell responses, and dysregulation of microRNAs (miRNAs) has been implicated in altering ICP expression, influencing the amplification of immune responses.In this preliminary study, we used the taqMan low-density array (TLDA) cards to investigate miRNA dysregulation's prognostic potential as a PGD marker in pre-transplant back-table lung biopsies. …”
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Cerebral vascular shunting and oxygen metabolism in sickle cell disease by Alexander K. Song, Wesley T. Richerson, Megan A. Aumann, Spencer L. Waddle, R. Sky Jones, Samantha Davis, Lauren Milner, Chelsea Custer, L. Taylor Davis, Sumit Pruthi, Dann Martin, Lori C. Jordan, Manus J. Donahue

“…Abstract: Patients with sickle cell disease (SCD) are at elevated risk of silent cerebral infarcts and strokes; however, they frequently lack established stroke risk factors (eg, macrovascular arterial steno-occlusion) and the mechanisms underlying such events are incompletely characterized. This study evaluated cerebral hemometabolism with respect to imaging markers of vascular shunting in 143 participants with SCD, including 73 pediatric (aged 6-17 years) and 70 adult (aged 18-40 years) participants using 3-Tesla brain magnetic resonance imaging (MRI). …”
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Use and Outcomes of Dexamethasone in the Management of Malignant Small Bowel Obstruction by Frank F. Yang, MD, Elina Serrano, MD, Kyle S. Bilodeau, MD, Michael Weykamp, MD, Caitlin J. Silvestri, MD, Ashleigh C. M. Bull, MD, Brenda Lin, MD, Sara L. Schaefer, MD, Colette Galet, PhD, Luis J. Garcia, MD, FACS, Baraka Gitonga, BS, David T. Kolodziej, BS, Samantha Esposito, BS, Molly Parker-Brigham, BS, Rohan Luhar, BS, Avinash Mamgain, MS, Kendrick C. Brown, BS, Summer Dewdney, MD, Thea P. Price, MD, FACS, Nicole Siparsky, MD, FACS, Sarah Knerr, PhD, Pauline K. Park, MD, FACS, Sabrina Sanchez, MD, FACS, Dionne A. Skeete, MD, FACS, Katherine N. Fischkoff, MD, FACS, David R. Flum, MD, FACS

“…Among dexamethasone recipients, 13% (95% CI = 9%–20%) subsequently required nonelective surgery during the same admission and 4 dexamethasone-related safety-events were reported. Amongst 421 eligible admissions where dexamethasone was not used, 17% (95% CI = 14%–21%) required nonelective surgery. …”
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The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study by Ruotong Wang, Shaodi Wen, Xiaoyue Du, Jingwei Xia, Bowen Hu, Yihan Zhang, Guoren Zhou, Feng Jiang, Xiaomin Lu, Miaolin Zhu, Xinyu Xu, Bo Shen

“…The ICT group demonstrated a superior pathological response rate (PRR) (47.2% vs. 29.4%, p = 0.034) with comparable adverse events and postoperative complications. The ICT group also showed a median disease‐free survival (DFS) of 39.8 months, unattained by the CT group. …”
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Impact of family socio-economic status on the prognosis of heart transplantation in children by Shun Liu, Han Mo, Yiqi Zhao, Xiao Chen, Weiteng Wang, Yijing Li, Ningning Zhang, Mengni Bao, Zeyu Cui, Qian Zhao, Jun Yan, Xiumeng Hua, Jiangping Song

“…To assess the impact of socio-economic status, we followed up with the discharged children until September 30, 2023, monitoring for all-cause mortality and unplanned readmission events. To evaluate the relationship between socio-economic status and prognosis, we assigned a composite score based on an assessment of household income, parental education level, and occupation. …”
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Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM by Krzysztof Kalwak, Laura M. Moser, Ulrike Pötschger, Peter Bader, Katharina Kleinschmidt, Roland Meisel, Jean-Hugues Dalle, Akif Yesilipek, Adriana Balduzzi, Gergely Krivan, Evgenios Goussetis, Raquel Staciuk, Petr Sedlacek, Herbert Pichler, Peter Svec, Melissa Gabriel, Tayfun Güngör, Ernest Bilic, Jochen Buechner, Marleen Renard, Kim Vettenranta, Marianne Ifversen, Cristina Diaz-de-Heredia, Jerry Stein, Jacek Toporski, Marc Bierings, Christina Peters, Marc Ansari, Franco Locatelli

“…Data were analyzed as of February 2023, with a median follow-up of 4.2 years (range, 0.3-9.1). 3-year overall survival was 0.71 (BU, 95% confidence interval [0.64-0.77]) and 0.72 (TREO, [0.63-0.79]) and 3-year event-free survival was 0.60 (BU, [0.53-0.67]) and 0.55 (TREO, [0.46-0.63]). …”
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