Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

“…Our platform provides a unique method for producing biologics-based degraders that may be used to treat diseases through event-driven pharmacology, thereby addressing unmet medical needs.…”
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Molecular Phylogenetic Analysis of 16S rRNA Sequences Identified Two Lineages of Helicobacter pylori Strains Detected from Different Regions in Sudan Suggestive of Differential Evo... by Abeer Babiker Idris, Hadeel Gassim Hassan, Maryam Atif Salaheldin Ali, Sulafa Mohamed Eltaher, Leena Babiker Idris, Hisham N. Altayb, Amin Mohamed Abass, Mustafa Mohammed Ahmed Ibrahim, El-Amin Mohamed Ibrahim, Mohamed A. Hassan

“…Phylogeny and Phylogeography of H. pylori strains are known to mirror human migration patterns and reflect significant demographic events in human prehistory. In this study, we analyzed the molecular evolution of H. pylori strains detected from different tribes and regions of Sudan using 16S rRNA gene and the phylogenetic approach. …”
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Diagnosis and Numerical Simulation of Low-level Wind Shear over the Hengduan Mountains in Winter by Ren Juzhang, Yang Xue, Tao Yun, Fu Zhijia, Chen Yan, Zhong Yahan, Wang Man, Jin Yan

“…Using NCEP/NCAR reanalysis data, airport weather station data, encrypted automatic weather station data and wind profile radar data, a low-level wind shear turn-around event at Cangyuan Wushan Airport on 29 December 2021, is diagnosed and analyzed by statistical and numerical simulation methods. …”
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Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe by Barakat MR, Kwong Jr HM, Marcon G, O'Leary OE, Paris LP, Schneider P, Tang Y, Graff JM

“…One patient experienced one mild adverse event of eye irritation that resolved the same day and was deemed unrelated to the study drug.Conclusion: Participants were able to safely and correctly prepare and administer a faricimab 6 mg dose using the PFS in accordance with the instructions for use, under realistic conditions representing the real world. …”
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USSR in World War II by M. Yu. Myagkov

“…Under these conditions, for the USSR, its own security and the conclusion of a non-aggression pact with Germany began to come to the fore, defining the "spheres of interests" of the parties in order to limit the advance of German troops towards the Soviet borders in the event of German aggression against Poland. The non-aggression pact gave the USSR just under two years to rebuild the army and consolidate its defensive potential and pushed the Soviet borders hundreds of kilometers westward. …”
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New strategies in management of severe alcoholic hepatitis by P. Ye. Tkachenko, I. I. Komkova, M. V. Mayevskaya, V. T. Ivashkin

“…In this group the trend to increase survival was marked in comparison to the group receiving prednisolone monotherapy (100 and 90%). The rate of adverse events did not differ (р=0,50) significantly between two groups. …”
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First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours by Michael Smith, Aung Naing, Todd Bauer, Kyriakos P Papadopoulos, Osama Rahma, Elena Garralda, Glenn J Hanna, Michael J Pishvaian, Xuejun Chen, Sven Gogov, Omar Saavedra, Howard Kallender, LuLu Cheng, Emil Kuriakose

“…INCB001158 exposure was similar between groups (median, 56 days (monotherapy); 84 days (combination)). 49 patients (45.8%) on monotherapy and 76 (51.7%) on combination therapy experienced grade ≥3 treatment-emergent adverse events (AEs). The most common INCB001158-related AEs were fatigue (n=10/107 (9.3%)) and nausea (n=10/107 (9.3%)) with monotherapy and diarrhoea (n=24/147 (16.3%)) and fatigue (n=22/147 (15.0%)) with combination therapy. …”
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Metrics for Evaluating Telemedicine in Randomized Controlled Trials: Scoping Review by Yuka Sugawara, Yosuke Hirakawa, Masao Iwagami, Ryota Inokuchi, Rie Wakimizu, Masaomi Nangaku

“…The commonly used metrics that can be used across medical specialties were divided into the following 3 categories: (1) patient-centeredness (67/79, 85%), including patient satisfaction, workload, and quality of life; (2) patient outcomes (57/79, 72%), including general clinical parameters such as death, admission, and adverse events; and (3) cost-effectiveness (40/79, 51%), including cost assessment and quality-adjusted life year. …”
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A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction by Nathan P. Crilly, Marcelle Dina Zita, Alexander K. Beaver, Polina Sysa-Shah, Aashik Bhalodia, Kathy Gabrielson, Luigi Adamo, Monica R. Mugnier

“…On flow cytometry, myocarditis was associated with an increase of most myocardial immune cell populations, including multiple T cell and macrophage subsets, corroborating the notion that T. brucei-associated cardiac damage is an immune-mediated event. This novel mouse model represents a powerful and practical tool to investigate the pathogenesis of T. brucei-mediated heart damage and supports the development of therapeutic options for T. brucei-associated cardiac disease. …”
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Risk Index Model of Property and Cargo Insurance Claims Based on Precipitation in Hunan by Peng Weiying, Li Yueyong, Tan Shiqi, Li Hao, Guan Jianwen, Liao Chunhua, Zhou Wei, Xie Ruiheng

“…Such proactive measures are customized for different types of property and cargo insurance, thereby boosting the region's ability to reduce potential property and casualty insurance risks linked to precipitation events. In conclusion, the study emphasizes the significance of integrating meteorological insights with insurance analytics to enhance risk management strategies. …”
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The proof is in the pudding: patient engagement in studying cannabidiol in mild cognitive impairment by Antonia Keck, Julia-Sophia Scheuermann, Petra Scheerbaum, Elmar Graessel, Kirsten R. Müller-Vahl

“…Methods We asked 209 individuals with MCI to complete an online survey assessing (i) willingness to participate in a trial using CBD; (ii) importance of improvements in various domains; (iii) acceptance of adverse events (AEs); (iv) reasons for AE-related dropout; (v) willingness to undergo blood sampling and lumbar puncture to assess AD pathology; and (vi) willingness to participate in a trial with a 50% chance of receiving a placebo. …”
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Evolocumab safety and efficacy in hypercholesteremia patients with or without diabetes: a retrospective real-world analysis by Sultan Ibrahim Alraddadi, Hind Almodaimegh, Abdullah Kharbosh, Hadeel Alharbi, Ahmed Ibrahim Fathelrahman, Mona Yaser Alsheikh, Lama Alfehaid

“…Abstract Background Proprotein convertase subtilisin/kexin type 9 inhibitors effectively reduce LDL cholesterol and adverse cardiovascular events with a safety profile comparable to a placebo. …”
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An exploratory analysis of differences in serum protein expression by sex in patients with systemic sclerosis associated interstitial lung disease by Giuliana Cerro-Chiang, Matthew Ayres, Alejandro Rivas, Sarah J. Parker, Mitra Mastali, Peter Chen, Jennifer E. Van Eyk, Paul J. Wolters, Francesco Boin, Tanzira Zaman

“…The association between protein biomarkers and sex was assessed through logistic regression. Time to event analysis was performed to determine any differences in the time to FVC decline of > 5% and the proportion of subjects who experienced FVC decline of > 5% by sex over the total period of observation. …”
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Sistem Pendeteksi Banjir dan Badai Angin serta Monitoring Cuaca Berbasis Internet of Things by Ida Bagus Made Lingga Pradirta, I Nyoman Piarsa, I Putu Arya Dharmaadi

“…This research creates a prototype tool using the concept of the Internet of Things that can provide early warning and monitoring of water levels in the event of flooding, wind speed, temperature, humidity, light intensity, and rain in a specific and real time place displayed on an Android mobile application for users and web applications for admins. …”
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Economic and relationship-strengthening intervention to reduce alcohol use in couples living with HIV in Malawi: a study protocol for a randomised controlled trial of Mlambe by Torsten B Neilands, Lynae A Darbes, James Mkandawire, Derek S Brown, Fred M Ssewamala, Judith A Hahn, Amy A Conroy, Nancy Mulauzi, Scott Tebbetts

“…Programmatic costs will be ascertained throughout the study and incremental cost-effectiveness ratios will be computed for each arm.Ethics and dissemination The RCT has been approved by the University of California, San Francisco (UCSF) (Human Research Protection Program; Protocol Number 23-40642), and the study has been approved by the National Health Sciences Research Committee (NHSRC; Protocol Number 24/05/4431) in Malawi. Adverse events and remedial actions will be reported to authorities both in Malawi and at UCSF. …”
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Real-world data of dacomitinib as first-line treatment for patients with EGFR-mutant non-small-cell lung cancer by Ji Eun Shin, Hyun Ae Jung, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Byoung Yong Shim

“…Grade 3 or higher adverse events were observed in 7.2% of patients. Initially administered at a dose of 45 mg, dose reduction was necessary for 85.6% of patients, with a final dosage of 30 mg in 49.0% and 15 mg in 36.6% of cases. …”
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Reinforcement Learning-Based Generative Security Framework for Host Intrusion Detection by Yongsik Kim, Su-Youn Hong, Sungjin Park, Huy Kang Kim

“…HIDS can quickly identify potential security threats by closely monitoring and analyzing system logs, configurations, file integrity, and events specific to a host machine. It helps maintain the security and integrity of individual systems by detecting unauthorized activities or policy violations. …”
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Approaches for difficult-to-induce-seizures electroconvulsive therapy cases (DEC): a Japanese expert consensus by Yoshiteru Takekita, Taro Suwa, Kazuyuki Yasuda, Hirotsugu Kawashima, Wataru Omori, Naoki Kurimoto, Takashi Tsuboi, Takamasa Noda, Nobuatsu Aoki, Ken Wada, Ken Inada, Minoru Takebayash, Expert Consensus Development Working Group, Electroconvulsive Therapy Committee, Japanese Society of General Hospital Psychiatry

“…The results of rating approaches for patients with mood disorders and schizophrenia were similar, with differences observed among the approaches for patients with catatonia, high risk of cognitive impairment, and cardiovascular events. Conclusions ECT expert recommendations are useful and can assist in clinical decision-making. …”
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The Closer, The Harder? Investigating the use of peripheral vision in 3vs3 counter-attack VR situations in football by Božo Vukojević, Svitlana Pinchuk, Christian Vater

“…It seems that they anchor their gaze on the player's possession of the ball to monitor peripheral events (e.g., movements of other players). In this experimental study, we challenged the use of peripheral vision by varying the distance between the direct opponent and the participant in a virtual-reality counterattack situation. …”
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Comparison of integrated versus parallel continuous renal replacement therapy combined with veno-venous extracorporeal membrane oxygenation in patients with COVID-19 ARDS by Kristina Schönfelder, Felix Helmenstein, Frank Herbstreit, Johanna Reinold, Andreas Kribben, Michael Jahn, Justa Friebus-Kardash

“…The integrated group exhibited higher rates of bleeding events (37% vs. 23%; p = 0.08). Thromboembolism occurred in four cases in the integrated group, while one pneumothorax was observed in the parallel group. …”
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