Efficacy and safety of immune checkpoint inhibitors in elderly patients with advanced non-small cell lung cancer: a systematic review and meta-analysisResearch in context by Jiacheng Yao, Sihan Li, Lu Bai, Jun Chen, Chengbo Ren, Tingting Liu, Jingping Qiu, Jun Dang

“…In real-world studies, the pooled median OS of ICIs were 11.8 months (95% CI: 11.2–12.4); Eastern Cooperative Oncology Group (EOCG) score, histological type, PD-L1 status, with immune-related adverse events (irAEs), and treatment mode were predictive for OS; rates of irAEs and discontinuation were numerically higher for combination therapy vs. monotherapy. …”
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The extent of intestinal involvement is closely related to the severity of IgAV: a risk stratification study based on CT by Yuanqiu Li, Ziman Xiong, Yufan Wang, Yuchen Jiang, Yaqi Shen, Xuemei Hu, Daoyu Hu, Zhen Li

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Safety and efficacy of anti-CD30 CAR-T cell therapy in relapsed/refractory classic Hodgkin lymphoma: a systematic review and meta-analysis by Fanqiao Meng, Maoyuan Xiang, Yu Liu, Dongfeng Zeng

“…Outcomes including overall response rate (ORR), complete response (CR), partial response (PR), progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were extracted for meta-analysis. We used the Methodological Index for Non-Randomized Studies (MINORS) to evaluate the quality of the included literature. …”
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Effects of early supplemental parenteral nutrition on new-onset infection in adults with acute severe stroke: a single-center retrospective case–control study by Chen Ma, Zhirong Fan, Xuan Wang, Bian Li, Jingjing Zhao, Xiaogang Kang, Wen Jiang, Fang Yang

“…The rates of digestive intolerance events were similar between the two groups (40% in the SPN group vs. 52.5% in the EN group, P = 0.361). …”
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Compensatory effects conceal large uncertainties in the modelled processes behind the relationship between the El Niño–Southern Oscillation (ENSO) and CO₂ by I. Dunkl, I. Dunkl, A. Bastos, T. Ilyina, T. Ilyina, T. Ilyina

“…The analysed ESMs agree on the direction of the sensitivity of global NBP to ENSO but exhibit very high uncertainty with regard to its magnitude, with a global NBP anomaly of <span class="inline-formula">−0.15</span> to <span class="inline-formula">−2.13</span> Pg C yr<span class="inline-formula">⁻¹</span> per standardised El Niño event. The largest source of uncertainty lies in the differences in the sensitivity of NBP to climate. …”
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Comprehensive approach to predictive analysis and anomaly detection for road crash fatalities by Chopparapu Gowthami, S. Kavitha

“…Through the possibility of highlighting regions with increased risk or problems with data quality, this part of the research improves our comprehension of unexpected events in accident data. For comparison analysis, other models such as Auto Regressive Integrated Moving Average and Support Vector Regression are used in addition to the Random Forest Regression model. …”
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Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials by Sathish Muthu, Sathish Muthu, Sathish Muthu, Vibhu Krishnan Viswanathan, Vibhu Krishnan Viswanathan, Prakash Gangadaran, Prakash Gangadaran, Prakash Gangadaran

“…Epidural PRP injection was found to offer comparable pain relief (VAS; WMD = −0.09, 95% CI [−0.66, 0.47], p = 0.641; I2 = 96.72%, p &lt; 0.001), functional improvement (ODI; WMD = 0.72, 95% CI [-6.81, 8.25], p = 0.524; I2 = 98.73%, p &lt; 0.001), and overall health improvement (SF-36; WMD = 1.01, 95% CI [−1.14, 3.17], p = 0.224; I2 = 0.0%, p = 0.36) as epidural steroid injection (ESI) at all the observed time points in the included studies without any increase in adverse events or complications. Epidural administration of PRP offers comparable benefit as epidural steroid injection (ESI) in the management of radiculopathy due to LDD. …”
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Efficacy of Curcumin on Treating Cancer Anorexia-Cachexia Syndrome in Locally or Advanced Head and Neck Cancer: A Double-Blind, Placebo-Controlled Randomised Phase IIa Trial (CurCh... by Tawasapon Thambamroong, Kasan Seetalarom, Siriwimon Saichaemchan, Yanisa Pumsutas, Naiyarat Prasongsook

“…Similarly, most adverse events were grade 1 in both groups. Conclusion. The curcumin add-on resulted in a significant increase in muscle mass than standard nutritional support. …”
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Clinical characteristics of patients with coronary artery disease by smoking status by Olga V. Nakhratova, Daria P. Tsygankova, Joseph M. Tsenter, Evgeny D. Bazdyrev

“…Percutaneous coronary interventions, history of acute cardiovascular events, arterial hypertension, multifocal atherosclerosis, and multivessel disease as defined by SYNTAX were more common in this group of patients. …”
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Prognostic factors for successful extubation in newborns with congenital diaphragmatic hernia by A. Rannebro, C. Mesas-Burgos, C. Mesas-Burgos, U. Fläring, U. Fläring, S. Eksborg, S. Eksborg, J. Berner, J. Berner

“…CDH-patients (n = 38), aged 0–28 days, with extubation events were identified from 2017 to 2019. Eight patients (21.1%) needed reintubation within 24 h after the first extubation attempt. …”
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Understanding and measuring workplace violence in healthcare: a Canadian systematic framework to address a global healthcare phenomenon by Christian Schulz-Quach, Brendan Lyver, Charlene Reynolds, Trevor Hanagan, Jennifer Haines, John Shannon, Laura Danielle Pozzobon, Yasemin Sarraf, Sam Sabbah, Sahand Ensafi, Natasha Bloomberg, Jaswanth Gorla, Brendan Singh, Lucas B. Chartier, Marnie Escaf, Diana Elder, Marc Toppings, Brian Hodges, Rickinder Sethi

“…At the University Health Network (UHN) in Toronto, Canada, WPV incidents in EDs jumped 169% from 0.43 to 1.15 events per 1000 visits (p < 0.0001). In response, UHN launched a comprehensive, systems-based quality improvement (QI) project to ameliorate WPV. …”
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Examining the association between child development and parental mental health after preterm birth-related stress: a systematic review of the literature and meta-analysis protocol by Lotte Haverman, Cornelieke S H Aarnoudse-Moens, Joost G Daams, Gerbrich E van den Bosch, Kirsten S Muller, Celina E Henke

“…Introduction Preterm infants born before 32 weeks of gestation are generally admitted to a neonatal intensive care unit (NICU) to receive life-saving treatment, resulting in early exposure to stressful events. Yet, NICU admission is not only stressful for the infant but can also have a long-lasting negative impact on parental mental health, who may worry about their child. …”
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Using a Clinical Decision Support System to Improve Anticoagulation in Patients with Nonvalve Atrial Fibrillation in China’s Primary Care Settings: A Feasibility Study by Xueying Ru, Tianhao Wang, Lan Zhu, Yunhui Ma, Liqun Qian, Huan Sun, Zhigang Pan

“…It seemed that the incidence of adverse clinical events in the software group was lower than that in the control group. …”
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Clinical Outcomes of Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib and Tislelizumab for Treating Hepatocellular Carcinoma and Type IV Portal Vein Tumor Thrombus by Li X, Cao K, Fu Z, Chen X, Zhong J, Liu L, Ding N, Zhang X, Qu Z, Zhu L, Zhai J

“…Data on patient characteristics, adverse events (AEs), treatment, and survival were collected. …”
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Bibliotherapy Services in Public Libraries: the Case of Lithuania by Jurgita Girčienė, Miglė Damijonaitytė

“…Although librarians both independently and institutionally, usually through projects or occasional trainings deepen their knowledge in this field, yet its lack is still mentioned, and in particular, the lack of practical skills necessary for organizing more formal active bibliotherapy activities, which leads to a lack of confidence in their own abilities and induces them to limit themselves to the role of an event organizer with a guest lecturer. As one of the ways to solve this problem, long-term institutionalized training in bibliotherapy is mentioned. …”
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Intravitreal Injections for Macular Edema Secondary to Retinal Vein Occlusion: Long-Term Functional and Anatomic Outcomes by Emilia Maggio, Maurizio Mete, Giorgia Maraone, Marcella Attanasio, Massimo Guerriero, Grazia Pertile

“…The mean number of injections administered each year and the incidence of adverse events were recorded. Results. The mean BCVA and CMT at baseline were 0.79 logMar (SD 0.71) and 615.7 μm (SD 257.5), respectively. …”
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Socially inclusive valorization of gold mill tailings from the small-scale gold mining sector by R.M. Balanay, R.P. Varela, A. Balbin, M.A. Lavapiez

“…There is a high risk of contaminating the neighboring ecosystem during flooding events and waste overflow. The tailings also contain fine particles of about 75 percent fine sand and 25 percent clay. …”
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The fate of recessive deleterious or overdominant mutations near mating-type loci under partial selfing by Tezenas, Emilie, Giraud, Tatiana, Véber, Amandine, Billiard, Sylvain

“…We also showed that rare events of deleterious mutation maintenance during strikingly long evolutionary times could occur, suggesting that deleterious mutations can indeed accumulate near the mating-type locus over evolutionary time scales. …”
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The effect of SARS-CoV-2 Omicron BA. 5.2 infection on perioperative physiological indicators in orthopedic patients by Hao Wu, JunZhe Yang, YuQin Yan, Xiao Hu, BiXi Li, PengFei Cheng, XiaoYang Song

“…Early surgery is feasible, but thrombotic events need to be considered.…”
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Healthcare workers’ perspectives on trauma and mental health access for Rohingya refugees in Cox’s Bazar by Lindsey Green, Linda Kaljee, Shahanoor Akter Chowdhury, Thomas McHale, Ranit Mishori, Ranit Mishori, Dahlia Fateen, Nima Sheth

“…These findings show the mental health impact of protracted human rights violations on the Rohingya, revealing how trauma is not a singular event but a continuous experience. Detailing the limited mental health infrastructure and structural barriers facing Rohingya refugees in Bangladesh, the findings underscore the urgent need for trauma-informed interventions that address the complex psychological consequences of systemic violence and displacement. …”
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