Communication between DNA polymerases and Replication Protein A within the archaeal replisome by Markel Martínez-Carranza, Léa Vialle, Clément Madru, Florence Cordier, Ayten Dizkirici Tekpinar, Ahmed Haouz, Pierre Legrand, Rémy A. Le Meur, Patrick England, Rémi Dulermo, J. Iñaki Guijarro, Ghislaine Henneke, Ludovic Sauguet

“…This study provides a molecular understanding of the WH-mediated regulatory activity in central replication factors such as RPA, which regulate genome maintenance in Archaea and Eukaryotes.…”
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RNA structure in alternative splicing regulation: from mechanism to therapy by Bao Nengcheng, Wang Zhechao, Fu Jiayan, Dong Haiyang, Jin Yongfeng

“…Alternative splicing is a highly intricate process that plays a crucial role in post-transcriptional regulation and significantly expands the functional proteome of a limited number of coding genes in eukaryotes. Its regulation is multifactorial, with RNA structure exerting a significant impact. …”
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Small RNA Expression Profiling by High-Throughput Sequencing: Implications of Enzymatic Manipulation by Fanglei Zhuang, Ryan T. Fuchs, G. Brett Robb

“…Eukaryotic regulatory small RNAs (sRNAs) play significant roles in many fundamental cellular processes. …”
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The ABC transporter Opp imports reduced glutathione, while Gsi imports glutathione disulfide in Escherichia coli by Lisa R. Knoke, Maik Muskietorz, Lena Kühn, Lars I. Leichert

“…Glutathione is the major thiol-based antioxidant in a wide variety of biological systems, ranging from bacteria to eukaryotes. As a redox couple, consisting of reduced glutathione (GSH) and its oxidized form, glutathione disulfide (GSSG), it is crucial for the maintenance of the cellular redox balance. …”
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Control of virulence by small RNAs in Streptococcus pneumoniae. by Beth Mann, Tim van Opijnen, Jianmin Wang, Caroline Obert, Yong-Dong Wang, Robert Carter, Daniel J McGoldrick, Granger Ridout, Andrew Camilli, Elaine I Tuomanen, Jason W Rosch

“…Small noncoding RNAs (sRNAs) play important roles in gene regulation in both prokaryotes and eukaryotes. Thus far, no sRNA has been assigned a definitive role in virulence in the major human pathogen Streptococcus pneumoniae. …”
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Possible Mechanisms of Relations between the Thermal Neutrons Field and Biosphere by Anton V. Syroeshkin, Irina V. Tarabrina, Mariya A. Morozova, Alla V. Marukhlenko, Igor A. Zlatskiy, Mariya P. Makarova

“…This paper proposes some results concerning the interaction of living matter of different organization levels (prokaryotes and eukaryotes) with the flux of thermal neutrons. The phenomenon of the virtual neutron trap was tested during the passage of thermalized neutrons from the Pu-Be couple through a flat layer of E. coli suspension. …”
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Metagenomics approaches for studying the human microbiome by Biniam Moges, Degisew Yinur Mengistu

“…The human body harbors an extremely complex and dynamic microbial community (10-100 trillion) of bacteria, archaea, viruses, and eukaryotes. The human microbiota plays a crucial role in the environment and human health under normal circumstances; nonetheless, dysfunction of the human microbiome has been associated with illnesses ranging from inflammatory bowel disease to multidrug-resistant infections. …”
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Cloning a Chloroplast Genome in Saccharomyces cerevisiae and Escherichia coli by Emma Walker, Bogumil Karas

“…Chloroplast genomes present an alternative strategy for large-scale engineering of photosynthetic eukaryotes. Prior to our work, the chloroplast genomes of Chlamydomonas reinhardtii (204 kb) and Zea mays (140 kb) had been cloned using bacterial and yeast artificial chromosome (BAC/YAC) libraries, respectively. …”
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DNA spontaneously wrapping around a histone core prefers negative supercoiling: A Brownian dynamics study. by Chunhong Long, Hongqiong Liang, Biao Wan

“…In eukaryotes, DNA achieves a highly compact structure primarily due to its winding around the histone cores. …”
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When HSFs bring the heat—mapping the transcriptional circuitries of HSF-type regulators in Candida albicans by Sadri Znaidi

“…ABSTRACT Heat shock factor (HSF)-type regulators are stress-responsive transcription factors widely distributed among eukaryotes, including fungi. They carry a four-stranded winged helix-turn-helix DNA-binding domain considered as the signature domain for HSFs. …”
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The expanded genome of Hexamita inflata, a free-living diplomonad by Zeynep Akdeniz, Michal Havelka, Michal Stoklasa, Alejandro Jiménez-González, Vojtěch Žárský, Feifei Xu, Courtney W. Stairs, Jon Jerlström-Hultqvist, Martin Kolísko, Jan Provazník, Staffan Svärd, Jan O. Andersson, Jan Tachezy

“…Abstract Diplomonads are anaerobic, flagellated protists, being part of the Metamonada group of Eukaryotes. Diplomonads either live as endobionts (parasites and commensals) of animals or free-living in low-oxygen environments. …”
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Re-evaluating evidence for giant genomes in amoebae by Daniel Barzilay, João P. B. Alcino, Giulia M. Ribeiro, Alfredo L. P. Sousa, Daniel J. G. Lahr

“…Fully sequenced amoebozoa genomes range from 14.4 to 52.37 mega basepairs, well within the typical single-celled eukaryote expectation. While the whole genome of the historically relevant Amoeba proteus has not yet been fully sequenced, we provide here a statistical analysis using protein-coding genes from transcriptomic data, suggesting that the genome size is consistent with this range, far smaller than previously claimed. …”
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Introns: The Functional Benefits of Introns in Genomes by Bong-Seok Jo, Sun Shim Choi

“…First, all of the completely sequenced eukaryotes harbor introns in the genomic structure, whereas no prokaryotes identified so far carry introns. …”
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Single-molecule two- and three-colour FRET studies reveal a transition state in SNARE disassembly by NSF by Sudheer K. Cheppali, Chang Li, Wenjing Xing, Ruirui Sun, Mengyi Yang, Yi Xue, Si-Yao Lu, Jun Yao, Shan Sun, Chunlai Chen, Sen-Fang Sui

“…Abstract SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins are the minimal machinery required for vesicle fusion in eukaryotes. Formation of a highly stable four-helix bundle consisting of SNARE motif of these proteins, drives vesicle/membrane fusion involved in several physiological processes such as neurotransmission. …”
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Photosynthetic directed endosymbiosis to investigate the role of bioenergetics in chloroplast function and evolution by Bidhan Chandra De, Jay Cournoyer, Yang-le Gao, Catherine L. Wallace, Stanley Bram, Angad P. Mehta

“…Here, we investigate the preferences of plastidic ADP/ATP carrier translocases from key lineages of photosynthetic eukaryotes including red algae, glaucophytes, and land plants. …”
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RNA-seq reproducibility of Pseudomonas aeruginosa in laboratory models of cystic fibrosis by Rebecca P. Duncan, Gina R. Lewin, Daniel M. Cornforth, Frances L. Diggle, Ananya Kapur, Dina A. Moustafa, Yasmin Hilliam, Jennifer M. Bomberger, Marvin Whiteley, Joanna B. Goldberg

“…While most studies on RNA-seq reproducibility focus on eukaryotes, we evaluate bias in bacteria using Pseudomonas aeruginosa gene expression data from five laboratory models of cystic fibrosis. …”
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Metabolic Analysis of the Mode of Action and Mode of Resistance for Novobiocin in Staphylococcus aureus by Weile Xie, Dan Luo, Zhe Wang

“…Targeting of bacterial gyrase, specifically the gyrB subunit, is a promising approach because of this enzyme’s essential role in bacterial DNA replication and its absence in higher eukaryotes. However, understanding of the mode of action of gyrB inhibitors remains largely incomplete. …”
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A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9 by Akram Hosen, Md Nakibul Hasan Nishat, MD. Mohaimin Hossain Soaib, Omar Sharif Sharkar, Md. Sahabuddin, Imdadul Haque Sharif, Sujay Kumar Bhajan

“…We have analyzed recent kinds of literature in this work to integrate a deep learning way that contributes over the next time with some important discussion about viral resistance in eukaryotes along with some cancer treatment strategies, and crop improvement by the CRISPR Cas system.…”
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Cov-trans: an efficient algorithm for discontinuous transcript assembly in coronaviruses by Xiaoyu Guo, Zhenming Wu, Shu Zhang, Jin Zhao

“…However, traditional transcript assembly methods primarily designed for variable alternative splicing events in eukaryotes are not suitable for the viral transcript assembly problem. …”
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Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation by Ayla Valinezhad Orang, Reza Safaralizadeh, Mina Kazemzadeh-Bavili

“…Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered and there are certainly more to come. …”
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