Synthetic genomics in crop breeding: Evidence, opportunities and challenges by Yuhan Zhou, Ziqi Zhou, Qingyao Shu

“…These advancements open promising avenues for the application of synthetic genomics in multicellular eukaryotic organisms, particularly in the realm of crop improvement. …”
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Mitochondrial DNA Structure in <i>Trypanosoma cruzi</i> by Alfonso Herreros-Cabello, Francisco Callejas-Hernández, Manuel Fresno, Núria Gironès

“…In <i>Trypanosoma cruzi</i>, maxicircles contain typical mitochondrial genes found in other eukaryotes. They consist of coding and divergent/variable regions, complicating their assembly due to repetitive elements. …”
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Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase by Bright Obeng, Lucas J. Bennett, Bailey E. West, Dylan J. Wagner, Patrick J. Fleming, Morgan N. Tasker, Madeleine K. Lorenger, Dorothy R. Smith, Tetiana Systuk, Sydni M. Plummer, Jeongwon Eom, Marissa D. Paine, Collin T. Frangos, Michael P. Wilczek, Juyoung K. Shim, Melissa S. Maginnis, Julie A. Gosse

“…Yet, there is minimal published data on CPC effects on eukaryotes, immune signaling, and human health. Previously, it was shown that low-micromolar CPC inhibits rat mast cell function by inhibiting antigen (Ag)-stimulated Ca2+ mobilization, microtubule polymerization, and degranulation. …”
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Role of calpain system in meat tenderness: A review by Z.F. Bhat, James D. Morton, Susan L. Mason, Alaa El-Din A. Bekhit

“…Calpains are intracellular calcium-dependent cysteine proteases found in most eukaryotes. At least three calpains (μ- and m-calpains and calpain 3) and calpastatin, their specific endogenous inhibitor, are found in muscle. …”
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Systematic expression analysis of cysteine‐rich secretory proteins, antigen 5, and pathogenesis‐related 1 protein (CAP) superfamily in Arabidopsis by Megumi Matsuzawa, Takumi Nakayama, Masa H. Sato, Tomoko Hirano

“…Abstract The Cysteine‐rich secretory proteins (CRISPS), Antigen 5 (Ag5), and Pathogenesis‐related 1 (PR‐1) protein (CAP) superfamily members are found in multiple eukaryotic organisms, including yeasts, animals, and plants. …”
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RAREFAN: A webservice to identify REPINs and RAYTs in bacterial genomes by Fortmann-Grote, Carsten, Irmer, Julia von, Bertels, Frederic

“…Compared to eukaryotes, repetitive sequences are rare in bacterial genomes and usually do not persist for long. …”
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High-Throughput Screening and Molecular Dynamics Simulation of Natural Products for the Identification of Anticancer Agents against MCM7 Protein by Xin Zhang, Hui Chen, Hui Lin, Ronglan Wen, Fan Yang

“…Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome maintenance family that is necessary for the initiation of eukaryotic DNA replication. Overexpression of the MCM7 protein is linked to cellular proliferation and is accountable for critical malignancy in many cancers. …”
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Identification and characterization of the COPII vesicle‐forming GTPase Sar1 in Chlamydomonas by Kin Pan Chung, Daniel Frieboese, Florent Waltz, Benjamin D. Engel, Ralph Bock

“…Abstract Eukaryotic cells are highly compartmentalized, requiring elaborate transport mechanisms to facilitate the movement of proteins between membrane‐bound compartments. …”
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getphylo: rapid and automatic generation of multi-locus phylogenetic trees by T. J. Booth, S. Shaw, P. Cruz-Morales, T. Weber

“…We also demonstrate the flexibility of getphylo across four case studies including bacterial and eukaryotic genomes, and biosynthetic gene clusters. …”
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The study of the regulatory region of the Drosophila melanogaster Notch gene by new methods of directed genome editing by O. V. Andreyenkov, E. I. Volkova, N. G. Andreyenkova, S. A. Demakov

“…The Notch gene plays a key role in the development of organs and tissues of neuroectodermic origin, including the nervous system. In eukaryotic organisms, the Notch pathway is involved in cell fate determination. …”
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Identification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana. by Anthony Ricou, Matthieu Simon, Rémi Duflos, Marianne Azzopardi, Fabrice Roux, Françoise Budar, Christine Camilleri

“…They are widely distributed in eukaryotes and are important for understanding genome evolution and speciation. …”
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METTL3 regulates autophagy of hypoxia-induced cardiomyocytes by targeting ATG7 by Linnan Li, Hao Cheng, Yufei Zhou, Di Zhao, Xiaoxue Zhang, Yajun Wang, Jianying Ma, Junbo Ge

“…Abstract N6-methyladenosine (m6A) mRNA modification is the most common mRNA internal modification in eukaryotes, which participates in a variety of biological processes. …”
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Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex by Harald Bernhard, Hana Petržílková, Barbora Popelářová, Kamil Ziemkiewicz, Karolina Bartosik, Marcin Warmiński, Laura Tengo, Henri Gröger, Luciano G. Dolce, Cameron D. Mackereth, Ronald Micura, Jacek Jemielity, Eva Kowalinski

“…Abstract Kinetoplastids are a clade of eukaryotic protozoans that include human parasitic pathogens like trypanosomes and Leishmania species. …”
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N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential by Qihui Wu, Xiaodan Fu, Guoqian Liu, Xiaoyun He, Yimin Li, Chunlin Ou

“…Abstract N7-methylguanosine (m7G) is an important RNA modification involved in epigenetic regulation that is commonly observed in both prokaryotic and eukaryotic organisms. Their influence on the synthesis and processing of messenger RNA, ribosomal RNA, and transfer RNA allows m7G modifications to affect diverse cellular, physiological, and pathological processes. m7G modifications are pivotal in human diseases, particularly cancer progression. …”
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Lack of Outer Membrane Protein A Enhances the Release of Outer Membrane Vesicles and Survival of Vibrio cholerae and Suppresses Viability of Acanthamoeba castellanii by Soni Priya Valeru, Salah Shanan, Haifa Alossimi, Amir Saeed, Gunnar Sandström, Hadi Abd

“…In conclusion, the results might highlight a regulating rule for OmpA in survival of V. cholerae and OMVs as a potent virulence factor for this bacterium towards eukaryotes in the environment.…”
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Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci) by Alberto Guevara-Flores, Irene P. del Arenal, Guillermo Mendoza-Hernández, Juan Pablo Pardo, Oscar Flores-Herrera, Juan L. Rendón

“…Apparent Km values were 0.87  ±  0.04  μM, 41  ±  6  μM and 19  ±  10  μM for thioredoxin, GSSG and NADPH, respectively. Thioredoxin from eukaryotic sources was accepted as substrate. The enzyme reduced H2O2 in a NADPH-dependent manner, although with low catalytic efficiency. …”
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Taxonomic and functional diversity of protists in saline and hypersaline lakes in southern Western Siberia, a region strongly affected by climate change by Elena A. Gerasimova, Alexander S. Balkin, Vladimir Y. Kataev, Ekaterina S. Filonchikova, Yulia V. Mindolina, Denis V. Tikhonenkov

“…Lakes in southern West Siberia, including saline and hypersaline waterbodies within endorheic basins, remain unexplored in terms of the biodiversity of the microbial eukaryotes inhabiting them. In this study, we investigated the taxonomic and functional diversity of planktonic protist communities in saline and hypersaline lakes (22–220‰) in southern Western Siberia through Illumina 18S rDNA amplicon sequencing. …”
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Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)]4 by Bruno Pagano, Iolanda Fotticchia, Stefano De Tito, Carlo A. Mattia, Luciano Mayol, Ettore Novellino, Antonio Randazzo, Concetta Giancola

“…Quadruplex-prone sequences are found in many regions of human genome and in the telomeres of all eukaryotic organisms. Since small molecules that target G-quadruplexes have been found to be effective telomerase inhibitors, the identification of new specific ligands for G-quadruplexes is emerging as a promising approach to develop new anticancer drugs. …”
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PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response by Ling Cheng, Ian Meliala, Yidi Kong, Jingyuan Chen, Christopher G Proud, Mikael Björklund

“…Depletion of PEBP1 impaired mitochondrial ISR activation by reducing eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and subsequent ISR gene expression, which was independent of PEBP1’s role in inhibiting the RAF/MEK/ERK pathway. …”
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Development of new SSR markers for homoeologous WFZP loci based on the study of structure and location of microsatellites in gene-rich regions of chromosomes 2AS , 2BS, 2DS by O. B. Dobrovolskaya, C. Pont, Yu. L. Orlov, J. Salse

“…Microsatellites, or simple sequence repeats (SSRs), are ubiquitous in genomes of eukaryotes, including plant genomes. The structure and location of SSR loci determine their potential as molecular genetic markers and may have impact on the potential function of microsatellites in important biological processes. …”
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