Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential by Yijie Huang, Ying Tang, Ruiqi Zhang, Xiao Wu, Li Yan, Xiling Chen, Qianqi Wu, Yiyan Chen, Yingtao Lv, Yuan Su

“…Abstract Periodontal ligament fibroblasts (PDLFs) play a crucial role in the etiology of periodontitis and periodontal tissue regeneration. …”
Get full text

Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging by Wei Liu, Le Zhang, Wenhui Liao, Huiguo Liu, Wukaiyang Liang, Jinhua Yan, Yi Huang, Tao Jiang, Qian Wang, Cuntai Zhang, Peifang Wei

“…Vascular aging (VA) is a common etiology of various chronic diseases and represents a major public health concern. …”
Get full text

Leptin Deficiency and Its Effects on Tibial and Vertebral Bone Mechanical Properties in Mature Genetically Lean and Obese JCR:LA-Corpulent Rats by Raylene A. Reimer, Jeremy M. LaMothe, Ronald F. Zernicke

“…Those combined results suggest that the etiology and duration of obesity may be important determinants of bone mechanical properties, and axial and appendicular bones may be affected differently.…”
Get full text

Lack of Association of Childhood Partial Epilepsy with Brain Derived Neurotrophic Factor Gene by Aycan Unalp, Elcin Bora, Tufan Cankaya, Ozlem Giray Bozkaya, Derya Ercal, Aysel Ozturk, Ayfer Ulgenalp

“…In this study, we tested that BDNF might be involved in the etiology of childhood PE. To assess whether BDNF gene C270T polimorphism could be implicated in vulnerability to PE, we conducted a case-control association analysis (112 partial epileptic and 100 controls) in Turkish children. …”
Get full text

Emergence of Enteric Viruses in Production Chickens Is a Concern for Avian Health by Elena Mettifogo, Luis F. N. Nuñez, Jorge L. Chacón, Silvana H. Santander Parra, Claudete S. Astolfi-Ferreira, José A. Jerez, Richard C. Jones, Antonio J. Piantino Ferreira

“…This study demonstrates the diversity of viruses in Brazilian chicken flocks presenting enteric problems characterized by diarrhea, growth retard, loss weight, and mortality, which reflects the multicausal etiology of this disease.…”
Get full text

Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) by Shumyila Nasir, Muhammad Sufyan Vohra, Danish Gul, Umm E Swaiba, Maira Aleem, Khalid Mehmood, Saadia Andleeb

“…The emergence of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), the chief etiological agent for a range of refractory infections, has rendered all β-lactams ineffective against it. …”
Get full text

Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis by Nanako Kikuchi, Sae Hatanaka, Terufumi Kubo, Ryuta Kamekura, Masatoshi Kanda, Takuya Kakuki, Takashi Sasaya, Kengo Mita, Hiroki Kobayashi, Hajime Ikai, Kenta Sasaki, Naoki Shijubou, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Tadashi Hasegawa, Akihiro Miyazaki, Hiroki Takahashi, Ken-ichi Takano, Toshihiko Torigoe

“…Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration of IgG4-positive plasma cells. …”
Get full text

The Strong Protective Effect of Circumcision against Cancer of the Penis by Brian J. Morris, Ronald H. Gray, Xavier Castellsague, F. Xavier Bosch, Daniel T. Halperin, Jake H. Waskett, Catherine A. Hankins

“…Male circumcision protects against cancer of the penis, the invasive form of which is a devastating disease confined almost exclusively to uncircumcised men. Major etiological factors are phimosis, balanitis, and high-risk types of human papillomavirus (HPV), which are more prevalent in the glans penis and coronal sulcus covered by the foreskin, as well as on the penile shaft, of uncircumcised men. …”
Get full text

Identifying Key Biomarkers and Immune Infiltration in Female Patients with Ischemic Stroke Based on Weighted Gene Co-Expression Network Analysis by Haipeng Xu, Kelin He, Rong Hu, YanZhi Ge, Xinyun Li, Fengjia Ni, Bei Que, Yi Chen, Ruijie Ma

“…Evidence shows that ischemic stroke (IS) accounts for nearly 80 percent of all strokes and that the etiology, risk factors, and prognosis of this disease differ by gender. …”
Get full text

A Case Report of Acute Esotropia in a Young Woman following Heroin Withdrawal by Bethel Shiferaw, Ebisa Bekele, Sara Syed, Lu Fan, Nirav Patel, Samia Qazi, Nicolas Biro

“…Acute onset of esotropia is an uncommon form; in the vast majority of cases, no underlying neurological etiology is found. Case Presentation. A 22-year-old female with a long history of opiate abuse presented with acute onset of diplopia. …”
Get full text

Neuroinflammation and Oxidative Stress in Diabetic Neuropathy: Futuristic Strategies Based on These Targets by Reddemma Sandireddy, Veera Ganesh Yerra, Aparna Areti, Prashanth Komirishetty, Ashutosh Kumar

“…Several theories of etiologies surfaced down the lane, amongst which the oxidative stress mediated damage in neurons and surrounding glial cell has gained attention as one of the vital mechanisms in the pathogenesis of neuropathy. …”
Get full text

Oxidative impact on lipoprotein structure: Insights from dynamic light scattering by Nickolette Kong, Natalia Penaloza, Gustavo Agreda, Angela B. Nguyen, Joseph Gutheinz, Alison Tran, Nhi Nguyen, Tuong Vi Ho, Ana Marin, Birgit Mellis, Richa Chandra

“…Clinicians often rely on indirect calculations of low-density lipoprotein (LDL) as a primary diagnostic indicator, which can oversimplify and overlook the complex changes in lipoprotein structure and function and therefore the complex etiology of CVD. Here it is demonstrated that dynamic light scattering (DLS) is sensitive and effective at measuring variation in lipoprotein size distributions following oxidative damage caused by peroxidation and nitration—two common physiological processes that play dual roles in both normal and pathogenic states. …”
Get full text

Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression by Acharya Balkrishna, Ritu Paliwal, Surjeet Singh, Rani Singh, Vivek Gohel, Rishabh Dev, Kunal Bhattacharya, Sandeep Sinha, Anurag Varshney

“…Taken together, this study supported Livogrit's potential as hepatoprotective medicine against cholestasis-like-etiologies.…”
Get full text

The Role of Open Lung Biopsy in Critically Ill Patients with Hypoxic Respiratory Failure: A Retrospective Cohort Study by Abdullah Almotairi, Sharmistha Biswas, Jason Shahin

“…The aim of this study was to assess the utility of open lung biopsy in patients with hypoxic respiratory failure of unknown etiology admitted to an ICU and to examine the use of steroid therapy in this patient population. …”
Get full text

Dysfunctional Attitudes in Alcohol Dependents: A Comparative Study by Görkem Karakas Ugurlu, Mustafa Uğurlu, Levent Turhan, M. Hakan Türkçapar

“…Objective: Cognitive behavioral theory provides a theoretical framework for understanding the etiology and persistence of pathological drinking, and a conceptual basis for developing clinical techniques to treat the disorder. …”
Get full text

Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke by Xiao-li Liu, Jian-zong Du, Yu-miao Zhou, Qin-fen Shu, Ya-guo Li

“…These findings indicate that the IL-16 polymorphism may be related to the etiology of ischemic stroke in the Chinese population.…”
Get full text

Utilizing Colpocleisis to Repair a Vesicovaginal Fistula in a Cervical Cancer Patient with History of Pelvic Radiation: A Case Report and Literature Review by Ahmad Dahman, Daniel McClelland, Stanley Zaslau, Valerie Galvan Turner, Omar Duenas, Robert Shapiro

“…It is especially prevalent in developing countries with the predominant etiology secondary to obstructed labor. Radiation therapy in female patients with cervical cancer is a risk factor for vesicovaginal fistula formation in the United States. …”
Get full text

Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis? by Thomas Bertran, Patrick Brachet, Marjolaine Vareille-Delarbre, Julie Falenta, Annie Dosgilbert, Marie-Paule Vasson, Christiane Forestier, Arlette Tridon, Bertrand Evrard

“…Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections. Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosystem. …”
Get full text

Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets by Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao

“…Obstructive hydrocephalus is often associated with excessive ependymal cells produced by differentiation of radial glial cells. The etiology of communicating hydrocephalus is mainly related to the dyskinesia of cerebrospinal fluid. …”
Get full text

Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy by Thaíza Passaglia Bernardes, Thalita Alvarenga Ferradosa Paula, Gabriel Teixeira Montezuma Sales, Patrícia Varela Calais, Renato Demarchi Foresto, Luiz Antonio Moura, Marcelino de Souza Durão Junior, João Bosco Pesquero, Gianna Mastroianni Kirsztajn

“…Abstract Collapsing glomerulopathy (CG) has a severe course typically associated with viral infections, especially HIV and parvovirus B19, systemic lupus erythematosus (SLE), among other etiologies. A 35-year-old woman with recent use of a JAK inhibitor due to rheumatoid arthritis presented with a 2-week history of fever, cervical adenopathy, and facial erythema. …”
Get full text