Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…The quality of non-randomised studies will be appraised.Ethics and dissemination The study will summarise the available evidence on the effect of the clinical utility of 5-ALA in achieving resection and improving survival and its diagnostic accuracy for tumours of the CNS other than HGG. …”
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Research progress of humanistic care in nursing teaching and teacher training (人文关怀在护理教学与师资培养中的应用研究进展) by LI Yuxin (李玉欣), LI Xiuli (李秀丽), DENG Jianhua (邓建华), LIU Sichun (刘司春), TANG Ling (唐玲)

“…The aim of nursing teaching is not only to ensure that nursing students can acquire professional knowledge and practical skills, but also to establish a correct outlook on life, values, and good medical ethics, moreover, simultaneously addressing issues such as the disconnect between theory and practice and improving the effectiveness of clinical teaching. …”
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Efficacy of solution-focused brief therapy versus case management for psychological distress in adolescents and young adults in a community-based youth mental health service in Sin... by Janhavi Ajit Vaingankar, Edimansyah Abdin, Charmaine Tang, Cheryl Yunn Shee Foo, Tianyi Hui, Nur Khairunisa Binte Ngaiman, Darshan s/o Dahjalarrajah, Yi Chian Chua, Yi Ping Lee

“…Adverse events and clinical deterioration will be recorded and reported.Ethics and dissemination The Institute of Mental Health (IMH) Institutional Research Review Committee (reference 822–2022) and the Singapore National Health Group Domain Specific Review Board (DSRB) (reference 2023/00052) have approved the study protocol. …”
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Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial by Hugh Taylor, Hao Huang, Lubna Pal, Heping Zhang, Howard J Li, Sandra Carson, Valerie Flores, Jared Robbins, Nanette F Santoro, James H Segars, David Seifer, Steven Young

“…Secondary outcomes include oocyte number, fertilisation rate, embryo morphology and implantation rates, as well as rates of known endometriosis-related obstetrical outcomes (pregnancy-induced hypertension, antepartum haemorrhage, caesarean delivery and preterm birth).Ethics and dissemination The PREGnant trial was approved by the Institutional Review Board at Johns Hopkins University. …”
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Efficacy of brief intervention for drug misuse in primary care facilities: systematic review and meta-analysis protocol by Toshi A Furukawa, Yan Luo, Norio Watanabe, Ethan Sahker, Masatsugu Sakata, Rie Toyomoto, Chiyoung Hwang, Kazufumi Yoshida

“…If heterogeneity is present, subgroup analyses will consider patient variables of age, sex/gender, race/ethnicity, per cent insured, baseline severity and primary drug misused.Ethics and dissemination This study will use published aggregate data and will not require ethical approval. …”
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Sumber Imajinasi Kreatif Ahmad Tohari dalam Menulis Karya Sastra (Source of Ahmad Tohari's Creative Imagination in Writing Literary Works) by Abdul Wachid Bambang Suharto, Endah Kusumaningrum

“…Islam is used as a source of life guidelines for ethics and aesthetics in the texts written by Ahmad Tohari.…”
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Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol by Jia Liu, Esosa Osagie, Paul Akhigbe, Nosakhare Idemudia, Ozoemene Obuekwe, Ruxton Adebiyi, Nicolas Schlecht, Yana Bromberg, Fidelis E Eki-Udoko, Nosayaba Osazuwa-Peters, Modupe Oluseun Coker

“…Multiple comparisons will be adjusted using the False Discovery Rate (FDR) correction to control for Type I error.Ethics and dissemination The study was approved by Rutgers State University (Pro2022000949) and the UBTH (ADM/E22/A/VOL. …”
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mHealth-based intervention by community workers to support family caregivers of persons with dementia living at home: study protocol for a cluster randomised controlled trial by Pankaj Bhardwaj, Hanne Konradsen, Manoj Kumar Gupta, Abhik Sinha, Nitin Kumar Joshi, Suresh K Sharma, Naresh Nebhinani, Marie Tyrrell, Åsa G Craftman, Zarina Nahar Kabir

“…Additionally, usability and cost analyses will be conducted to evaluate the practicality and economic feasibility of the intervention.The expected outcomes of this study include the creation of a scalable mHealth platform that facilitates remote support, bridges geographical gaps and enhances the well-being of caregivers in India’s evolving healthcare landscape.Ethics and dissemination Ethical approval has been obtained from the Institutional Ethical Committee of AIIMS Jodhpur (AIIMS/IEC/2022/4245).Trial registration number Clinical Trials Registry: CTRI/2022/12/048320.…”
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Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (... by Fabian Yap, See Ling Loy, Yin Bun Cheung, Jerry Kok Yen Chan, Keith Godfrey, Chee Wai Ku, Jun Wei Pek, Melissa D/O Tharmalingam Durgahshree, Melinda Chan, Yie Hou Lee

“…Multivariable linear regression will be used to explore relationships between male modifiable exposures and semen parameters.Ethics and dissemination The study protocol has received approval from the Centralised Institutional Review Board of SingHealth (2024/2120), Singapore. …”
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Use of Complementary and Alternative Medicine Practices in Patients Admitted to The Pediatric Neurology Outpatient Clinic by Deniz Yüksel, Ergin Atasoy, Ülkühan Öztoprak, Erhan Aksoy, Fatih Mehmet Akif Özdemir, Halil Celik, Nesrin Ceylan

“…This study was approved with the decision number E-20-12-62 at the meeting dated 21.12.2020 of the Clinical Research Ethics Committee of SBU Ankara Dr Sami Ulus Gynecology and Childhood Health and Diseases Training and Research Hospital. …”
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Application of the flipped classroom model based on Bloom’s Taxonomy of Educational Objectives in endodontics education for undergraduate dental students by Yaru Wei, Zhengjun Peng

“…Students’ understanding of ideological and humanistic objectives as well as medical ethics were both significantly improved by 11.4% (t = 2.267, p = 0.009) and 13.9% (t = 2.600, p = 0.014), respectively. …”
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Improving quality and safety in nursing homes and home care: the study protocol of a mixed-methods research design to implement a leadership intervention by Eline Ree, Terese Johannessen, Siri Wiig, Torunn Strømme, Ingunn Aase, Roland Bal, Karina Aase, Marianne Storm, Berit Ullebust, Elisabeth Holen-Rabbersvik, Line Hurup Thomsen, Anne Torhild Sandvik Pedersen, Hester van de Bovenkamp

“…A comparative study of Norway and the Netherlands will establish knowledge of the context dependency of the intervention.Ethics and dissemination The study is approved by the Norwegian Centre for Research Data (2017/52324 and 54855). …”
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ASSOCIATION BETWEEN POLYMORPHISMS IN GENES ENCODING 2′-5′-OLIGOADENYLATE SYNTHETASES AND THE HUMORAL IMMUNE RESPONSE UPON VACCINATION AGAINST TICK-BORNE ENCEPHALITIS by N. S. Yudin, A. V. Igoshin, S. L. Lutova, Ya. Gon, M. I. Voevoda, V. A. Belyavskaya

“…However, excessive vaccination is unjustified in terms of economics and medical ethics. One of the individualized approaches to vaccines is the selection of vaccine doses depending on the expected levels of immune response. …”
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Embedding the patient voice into research on spontaneous preterm birth-themes from a Preterm Birth Advisory Council. by Gillian Corbett, Mandy Daly, Dylan Keegan, Patricia Horgan, Catriona Keyes, Larissa Luethe, Siobhan Corcoran, Fionnuala M McAuliffe

“…Responses were analysed for themes most important to those with lived experience. Ethical approval was granted by NMH Research Ethics Committee.…”
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Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis by Timothy P Hanna, Elizabeth T Jacobs, Kristin E Morrill, Rogelio Robles-Morales, Melissa Lopez-Pentecost, Raigam J Martínez Portilla, Ahlam A Saleh, Meghan B Skiba, Taylor S Riall, Jessica D Austin, Rachel Hirschey, Lena Spotleson

“…Risk of bias will be assessed independently by two authors using validated tools according to the article’s study design.Ethics and dissemination Formal ethical approval is not required because the work is being carried out on publicly accessible studies. …”
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Patients’ Perspectives on the Preference for the Gender of Medical Professionals in Perioperative Care and Attitudes Toward Anaesthesiologists: A Cross-sectional Study by Usha Devi, Minnu Panditrao, Shilpa Bansal

“…After obtaining approval from the Institutional Ethics Committee (IEC) and patient consent, the study was conducted on 400 patients aged 18 to 85 years who were admitted for elective surgeries in different specialties. …”
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Non-pharmacological interventions for the reduction and maintenance of blood pressure in people with prehypertension: a systematic review protocol by Paul Rutter, Andrew Clegg, Valerio Benedetto, Caroline Watkins, Nefyn Williams, Joseph Spencer, Lucy Hives, Emma P Bray, Cath Harris, Rachel F Georgiou, Nafisa Iqbal

“…Where relevant, the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) will be used to assess the certainty of the evidence found.Ethics and dissemination Ethical approval is not needed. …”
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Strategies to mitigate the impact of the COVID-19 pandemic on child and youth well-being: a scoping review protocol by Jeanna Parsons Leigh, Henry T Stelfox, Perri R Tutelman, Diane L Lorenzetti, Melanie C Anglin, Kirsten M Fiest, Stephana Julia Moss, Emily A FitzGerald, Stacie Smith, Micaela Harley, Kathryn Birnie, Sara J Mizen

“…Data synthesis will be performed according to the convergent integrated approach described by the Joanna Briggs Institute.Ethics and dissemination Ethical approval is not applicable as this review will be conducted on published data. …”
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Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis... by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

“…Publication bias will be identified with the funnel plot.Ethics and dissemination Ethical approval is not required since it is not carried out in humans. …”
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Oral health improvement for nursing home residents through delegated remotivation and reinstruction (MundZaRR Study): study protocol of a cluster-randomised controlled trial by Falk Schwendicke, Peter Schlattmann, Gabriele Meyer, Katrin Hertrampf, Georg Gassmann, Jens Abraham, Volker Hammen

“…A process evaluation using mixed methods will be conducted alongside the trial.Ethics and dissemination Ethical approval by the University of Kiel was granted (D480/18).Trial registration number NCT04140929.…”
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