Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFα and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment... by Polina Weitzenfeld, Nurit Meron, Tal Leibovich-Rivkin, Tsipi Meshel, Adit Ben-Baruch

“…Here, we show that together with representatives of other important arms of the tumor microenvironment, estrogen (hormonal) and EGF (growth-supporting), TNFα potently induced metastasis-related properties and functions in luminal breast tumor cells, representing the most common type of breast cancer. …”
Get full text

Labial Adhesion with Acute Urinary Retention Secondary to Vaginitis by Şenol Şentürk, Pelin Üstüner, Gülşah Balık, Mehmet Kağıtcı, Ülkü Mete Ural, Figen Kır Şahin

“…Labial adhesion occurs most often in infants and girls and is usually associated with low estrogen levels. Labial adhesion in the reproductive age group is extremely rare due to abundance of estrogen. …”
Get full text

Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy by Alexander L. Pan, David Fergusson, Robert Hong, Ramy A. Badawi

“…Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. …”
Get full text

Analysis of In Vitro Effects of Sex Steroids on Lymphocyte Responsiveness in Murrah Buffaloes (Bubalus bubalis) by Zahoor Ahmad Pampori, Sujata Pandita

“…Estrogen at 100 pg/mL concentration stimulating the proliferation significantly (𝑃<0.05). in all groups and had higher stimulatory effect in lymphocytes from day 10 than day 0 of estrous cycle. …”
Get full text

Epigenetics and Breast Cancers by An T. Vo, Richard M. Millis

“…Hypermethylation at the CpG islands found in estrogen response element (ERE) promoters occurs in conjunction with ligand-bonded alpha subunit estrogen receptor (Erα) dimers wherein the ligand ERα dimer complex acts as a transcription factor and binds to the ERE promoter. …”
Get full text

Hormonal Changes in Menopause and Orexin-A Action by Giovanni Messina, Andrea Viggiano, Vincenzo De Luca, Antonietta Messina, Sergio Chieffi, Marcellino Monda

“…Many researches were conducted to assess the contribution of factors such as estrogen depletion, REE decline, and aging to weight gain. …”
Get full text

The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population by Wei-Chiao Chang, Peng Yeong Woon, Yu-Wen Hsu, Shengyu Yang, Yi-Ching Chiu, Ming Feng Hou

“…Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. …”
Get full text

Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats by Roxana N. Peroni, Tamara Abramoff, Isabel Neuman, Ernesto J. Podestá, Edda Adler-Graschinsky

“…The enhancement of anandamide effects caused by phytoestrogens was prevented by the concomitant administration of the estrogen receptor antagonist fulvestrant (2.5 mg/kg, s.c., 3 daily doses). …”
Get full text

Etoricoxib–NLC Mitigates Radiation-Induced Ovarian Damage in Rats: Insights into Pro-Inflammatory Cytokines, Antioxidant Activity, and Hormonal Responses by Sahar Khateeb

“…Histopathological evaluations and oxidative stress biomarker assessments were conducted, including ELISAs for reactive oxygen species (ROS), pro-inflammatory cytokines (IL-1β, TNF-α), and signaling molecules (PI3K, AKT, P38MAPK, AMH). Serum levels of estrogen, FSH, and LH were measured, and gene expression analysis for <i>TGF-β</i> and <i>Nrf2</i> was performed using qRT-PCR. …”
Get full text

Characterizing safety, toxicity, and breast cancer risk reduction using a long-term fulvestrant eluting implant by Scott Thomas, Elysia Roche, Pujan Desai, Nela Pawlowska, Diana Bauer, David Gingrich, Emily Hsu, Amelia N. Deitchman, Fran Aweeka, Pamela N. Munster

“…Abstract For individuals at high risk of developing breast cancer, interventions to mitigate this risk include surgical removal of their breasts and ovaries or five years treatment with the anti-estrogen tamoxifen or aromatase inhibitors. We hypothesized that a silicone based anti-estrogen-eluting implant placed within the breast would provide the risk reduction benefit of hormonal therapy, but without the adverse effects that limit compliance. …”
Get full text

Association of age at menopause with type 2 diabetes mellitus in postmenopausal women: a systematic review and meta-analysis by Faezeh Zakerinasab, Taif Haiham Al Saraireh, Amirhesam Amirbeik, Rasoul Hossein Zadeh, Fariba Arbab Mojeni, Qumars Behfar

“…The onset of menopause usually occurs between the ages of 48 and 52, leading to diverse symptoms in various body systems due to a decrease in estrogen level. Visceral obesity and diminished estrogen level during the menopausal phase are associated with unfavorable metabolic changes, resulting in insulin resistance and increased risk of type 2 diabetes mellitus (T2DM). …”
Get full text

Prediction of the Sex-Associated Genomic Region in Tunas (Thunnus Fishes) by Yoji Nakamura, Kentaro Higuchi, Kazunori Kumon, Motoshige Yasuike, Toshinori Takashi, Koichiro Gen, Atushi Fujiwara

“…As a result, we found a unique region carrying the male-specific haplotype, where a homolog of estrogen sulfotransferase gene was predicted to be encoded. …”
Get full text

S-Equol, a Major Isoflavone from Soybean, Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated Rat Astrocytes Partially via the GPR30-Mediated Pathway by Mitsuaki Moriyama, Ayano Hashimoto, Hideyo Satoh, Kenji Kawabe, Mizue Ogawa, Katsura Takano, Yoichi Nakamura

“…Cumulative evidence indicates that estrogen receptor (ER) agonists attenuate neuroinflammation. …”
Get full text

Role of BDNF-mTORC1 Signaling Pathway in Female Depression by Xianquan An, Xiaoxiao Yao, Bingjin Li, Wei Yang, Ranji Cui, Guoqing Zhao, Yang Jin

“…Hence, we focused on the modulation of estrogen-BDNF-mTORC1 signaling in depression and its possible mechanisms in recent years.…”
Get full text

Sparse Gene Coexpression Network Analysis Reveals EIF3J-AS1 as a Prognostic Marker for Breast Cancer by Xin Chen, Zuyuan Yang, Chao Yang, Kan Xie, Weijun Sun, Shengli Xie

“…EIF3J-AS1 may function in an estrogen-independent manner and could be inhibited by the compound FDI-6. …”
Get full text

Pregnancy and the Biliary System by Helga Witt, J Joseph Connon

“…These changes are related to the effects of estrogen and progesterone. Biliary cholesterol saturation and the cholic acid/chenodeoxycholic acid ratio increase. …”
Get full text

Dyspareunia in Postmenopausal Women: A Critical Review by Alina Kao, Yitzchak M Binik, Anita Kapuscinski, Samir Khalifé

“…Past literature has almost unanimously attributed dyspareunic pain occurring during or after the menopausal transition to declining estrogen levels and vaginal atrophy.…”
Get full text

Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisph... by Yingying Zhang, Yinan Jiang, Ziying Wang, Jiayu Wang, Mingzhen Zhu, Hui Yang

“…The present study will provide important reference for solving the problem of fatty liver caused by environmental estrogen in aquaculture.…”
Get full text

Transcriptome analysis reveals effects of ethynylestradiol and bisphenol A on multiple endocrine and metabolic pathways in the pituitary and liver of female Atlantic cod (Gadus mor... by Fekadu Yadetie, Xiaokang Zhang, Anna Reboa, Gwenaëlle Samantha Chloe Noally, Mariann Eilertsen, Mitchell Stewart Fleming, Jon Vidar Helvik, Inge Jonassen, Anders Goksøyr, Odd André Karlsen

“…IntroductionThe pituitary and liver are among the main sites of action of estrogens in fish. Years of research has shown that xenoestrogens can interfere with functions of estrogens. …”
Get full text

Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density by Ufuk Atlihan, Onur Yavuz, Huseyin Aytug Avsar, Can Ata, Tevfik Berk Bildaci, Selcuk Erkilinc

“… OBJECTIVE: Early menopause causes several health concerns that are related directly to the deficiency of ovarian hormones, especially estrogen insufficiency. The purpose of the research was to investigate the impact of low-dose hormone therapy on metabolic parameters and bone densitometry in patients with early menopause. …”
Get full text