Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases by Ivana Miše, Majda Vučić

“…In the metastatic epithelium, Sdc1 was negatively correlated with a patient’s age, estrogen receptors (ERs), and PRs in the primary tumors, while the stroma of metastases demonstrated a positive correlation with the focus number in primary tumors and a negative correlation with PRs in primary tumors. …”
Get full text

Advanced-stage Endometrial Stromal Sarcoma Presenting as Primary Infertility in a Young Nulligravida: A Case Report by Ankita PATTANAIK, Jasmina BEGUM, Sweta SINGH, Deepthy BALAKRISHNAN, Suvradeep MITRA

“…Her final diagnosis was estrogen-receptor positive LGESS stage IIIB, and she was suggested anastrozole adjuvant therapy and long-term surveillance. …”
Get full text

Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study by Kiyoshi Shingu, Tokiko Ito, Gengo Kaneko, Nobuo Itoh

“…The immunohistochemical profile of the tumor was also similar to that of salivary gland acinic cell carcinoma: the tumor cells were positive for amylase, lysozyme, α-1-antichymotrypsin, S-100 protein, and epithelial membrane antigen and negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. …”
Get full text

Application of Synthetic Polymeric Scaffolds in Breast Cancer 3D Tissue Cultures and Animal Tumor Models by Girdhari Rijal, Chandra Bathula, Weimin Li

“…Mammary epithelial cells cultured on PLGA- or PCL-coated slides expressed extracellular matrix (ECM) proteins and their receptors. Estrogen receptor- (ER-) positive T47D breast cancer cells are less sensitive to 4-hydroxytamoxifen (4-HT) treatment when cultured on the 3D porous scaffolds than in 2D cultures. …”
Get full text

Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis by Samantha L. Schaffner, Kira N. Tosefsky, Amy M. Inskter, Silke Appel-Cresswell, Julia M. Schulze-Hentrich

“…While the neuroprotective properties of estrogen are strongly implicated in reduced prevalence of PD in women, interactions with genotype and gender-biased lifestyle factors are incompletely understood. …”
Get full text

Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury by Fu-Chao Liu, Yung-Fong Tsai, Hsin-I Tsai, Huang-Ping Yu

“…Such protective phenomenon is reported to be implicated in a variety of intracellular signaling pathways including the activation of estrogen receptor, the regulation of the sirtuin 1/nuclear factor-kappa B and mitogen-activated protein kinases/hemeoxygenase-1 pathway, and the mediation of proinflammatory cytokines and reactive oxygen species formation and reaction. …”
Get full text

Aggressive Angiomyxoma in Pregnancy: A Rare Condition, a Common Misdiagnosis by J. Sampaio, I. Sarmento-Gonçalves, D. Ramada, T. Amaro, P. Tiago-Silva

“…Although aggressive angiomyxoma is rare, it should be considered in differential diagnosis of pelviperineal masses in young women. Its positivity to estrogen and progesterone receptors can justify enlargement and recurrence during pregnancy, although few cases are reported. …”
Get full text

Unveiling FOXO3's metabolic contribution to menopause and Alzheimer's disease by Christopher O'Mahony, Oscar Hidalgo-Lanussa, George E. Barreto

“…The fluctuating endocrine environment, marked by declining estradiol levels and reduced estrogen receptor beta (ERβ) activity, further exacerbates this process. …”
Get full text

Laryngeal Cancer in Women: Unveiling Gender-Specific Risk Factors, Treatment Challenges, and Survival Disparities by Barbara Verro, Simona Fiumara, Giuseppe Saraniti, Carmelo Saraniti

“…In addition, hormonal factors such as estrogen may influence women’s susceptibility to laryngeal cancer, accelerating tumor growth and complicating treatment. …”
Get full text

Efek Pemakaian Hormone Replacement Therapy (HRT): Systematic Review by Biomechy Oktomalio Putri, Noverial Noverial

“…Menopausal women have a risk of suffering from several diseases due to decreased levels of the hormone estrogen in the body. One effort to reduce this risk is to use Hormone Replacement Therapy (HRT). …”
Get full text

The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer by J. L. Schwartz, A. N. Shajahan, R. Clarke

“…Resistance to endocrine therapy is common among breast cancer patients with estrogen receptor alpha-positive (ER+) tumors and limits the success of this therapeutic strategy. …”
Get full text

Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

“…In 40% of cases, a key mechanism of endocrine resistance to the standard first line is a mutation of the ligand-binding domain (LBD) of Estrogen Receptor 1 (ESR1) encoding estrogen receptor α (ER). …”
Get full text

The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis by Raja Alyusuf, Javed Fayyaz Wazir, Urmil Prabha Brahmi, Abdul Rahman Fakhro, Moiz Bakhiet

“…The role of estrogen and progesterone receptors in breast cancer biology is well established. …”
Get full text

Pregnancy Followed by Delivery May Affect Circulating Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels in Women of Reproductive Age by Mehmet Balin, Ahmet Çelik, M. Ali Kobat, Adil Baydas

“…It is known that menopause or lack of endogenous estrogen is a risk factor for endothelial dysfunction and CAD. …”
Get full text

Impact of Vitamin D on Skin Aging, and Age-Related Dermatological Conditions by Sankalya S. Ambagaspitiya, Gayan A. Appuhamillage, Sunil J. Wimalawansa

“…Intrinsic factors associated with advanced age gradually degrade the dermal collagen matrix, resulting in fine wrinkles and reduced elasticity; this is accelerated in post-menopausal women due to estrogen deficiency. In contrast, extrinsic factors associated with advanced age, primarily caused by exposure to ultraviolet (UV) radiation, lead to coarse wrinkles, solar elastosis, hyperkeratosis, irregular pigmentation, and skin cancers. …”
Get full text

Risk Factors for Hypertension in Women of Childbearing Age by Natasya Vidia, Betty Yosephin Simanjuntak, Diah Eka Nugraheni

“…Hormonal contraceptives contain the hormones estrogen and progesterone, resulting in a hormonal imbalance that leads to hypertension. …”
Get full text

In Silico, In Vitro, and In Vivo Wound Healing Activity of Astragalus microcephalus Willd. by Fatemeh Akbari, Mohammad Azadbakht, Ali Bagheri, Lale Vahedi

“…In silico examination was performed based on the LC/MS results, and the binding affinity of these compounds to estrogen receptors (ERs) α and β was evaluated. Wound healing evaluation in both in vitro (NHDF cell line, by 500 μg/ml concentration of the extract, 24 h) and in vivo (Wistar rat, topical daily treated with 1.5% of the extract ointment, 21 days) conditions in comparison to control groups was conducted. …”
Get full text

Endometriosis in Postmenopausal Woman Without Previous Hormonal Therapy: A Case Report by Mine İslimye Taşkın, Meltem Çağrı Menteşe, Engin Uzgören, Ümit İnceboz

“… Endometriosis is a benign, estrogen-dependent, chronic gynecological disorder commonly associated with pelvic pain and infertility. …”
Get full text

Breast Cancer Treatment Practices in Elderly Women in a Community Hospital by Hua Wang, Awinder P. Singh, Serena A. St. Luce, Alan R. Go

“…Eighty-six percent of patients who were estrogen receptor-positive received adjuvant hormonal therapy. …”
Get full text

Axillary Metastasis from an Occult Tubal Serous Carcinoma in a Patient with Ipsilateral Breast Carcinoma: A Potential Diagnostic Pitfall by Chantal Atallah, Gulbeyaz Altinel, Lili Fu, Jocelyne Arseneau, Atilla Omeroglu

“…In this context, the poorly differentiated appearance of the metastatic tumor and positive staining for estrogen receptor, might lead to a misdiagnosis of metastatic breast carcinoma. …”
Get full text