Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis by Ninet Sinaii, Guru Sonpavde, Amin H Nassar, Min Yuen Teo, Andrea B Apolo, Jonathan E Rosenberg, Giovanni Maria Iannantuono, Elias B A Chandran, Saad O Atiq, Dilara Akbulut, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Gisela Butera, Jonathan A Coleman

“…Background Mismatch repair deficiency (dMMR) and microsatellite instability-high (MSI-H) occur in a subset of cancers and have been shown to confer sensitivity to immune checkpoint inhibition (ICI); however, there is a lack of prospective data in urothelial carcinoma (UC).Methods and analysis We performed a systematic review to estimate the prevalence of dMMR and MSI-H in UC, including survival and clinical outcomes. …”
Get full text

A novel nomogram to predict all‐cause readmission or death risk in Chinese elderly patients with heart failure by Mengxi Yang, Liyuan Tao, Hui An, Gang Liu, Qiang Tu, Hu Zhang, Li Qin, Zhu Xiao, Yu Wang, Jiaxai Fan, Dongping Feng, Yan Liang, Jingyi Ren

“…The independent risk factors associated with both 30 day and 1 year readmission or death were older age, stroke, diastolic blood pressure < 60 mmHg, body mass index ≤ 18.5 kg/m2, lower estimated glomerular filtration rate, and BNP > 400 pg/mL (all P < 0.05). …”
Get full text

Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma by Jian‐Hua Wang, Shu‐Ting Huang, Lan Zhang, Zi‐Gang Liu, Rong‐Xin Liang, Sen‐Wei Jiang, Yi‐Nan Jiang, Xing‐Juan Yu, Yu‐Chuan Jiang, Xi‐Zhao Li, Pei‐Fen Zhang, Zhe‐Sheng Wen, Min Zheng

“…Kaplan‐Meier analysis and Cox proportional hazards models were built for estimating the prognostic values of CD47 and CD133 expression and their combined stemness index. …”
Get full text

Laparoscopic excision of deep rectovaginal endometriosis in BSGE endometriosis centres: a multicentre prospective cohort study by Paul Smith, Lucky Saraswat, Sanjay Vyas, Thomas Ind, Ertan Saridogan, Elizabeth Ball, Edward Morris, James Clark, Tony Chalhoub, David Rowlands, Moiad Alazzam, Dominic Byrne, Tamara Curnow, Alfred Cutner, T Justin Clark, Iris Menninger, Yousri Afifi, Kevin Phillips, Saikat Banerjee, Robert Richardson, Jeremy Hawe, Barry Whitlow, Emmanuel Ofuasia, Ashwini Trehan, Tyrone Carpenter, Christian Becker, Stuart Jack, Kumar Kunde, Chris Barnick, Alan Farthing, Graham Phillips, John Bidmead, Mohamed Abdel-aty, George Botros, Marlin Mubarak, Christian Kremer, Stanley Okolo, Edmond Edi-osagi, Kamel Shehata-iskander, Gaity Ahmad, Jonathan Frappell, Brice Rodriguez, Yemi Coker, Gourab Misra, Adam Moors, Chris Guyer, Caroline Overton, Suku George, Oliver Chappatte, Richard Penketh, Funlayo Odejinmi, Keith Louden, Jon Hughes

“…Objective To estimate the effectiveness and safety of laparoscopic surgical excision of rectovaginal endometriosis.Design A multicentre, prospective cohort study.Setting 51 hospitals accredited as specialist endometriosis centres.Participants 5162 women of reproductive age with rectovaginal endometriosis of which 4721 women had planned laparoscopic excision.Interventions Laparoscopic surgical excision of rectovaginal endometriosis requiring dissection of the pararectal space.Main outcome measures Standardised symptom questionnaires enquiring about chronic pelvic pain, bladder and bowel symptoms, analgesia use and quality of life (EuroQol) completed prior to surgery and at 6, 12 and 24 months postoperatively. …”
Get full text

Adjuvant Therapy after Esophagectomy for Esophageal Cancer: Who Needs It?: Multi-institution Worldwide Observational Study by Siva Raja, MD, PhD, Thomas W. Rice, MD, Min Lu, PhD, Marie E. Semple, MPH, Andrew J. Toth, MS, Eugene H. Blackstone, MD, Sudish C. Murthy, MD, PhD, Usman Ahmad, MD, Michael McNamara, MD, Hemant Ishwaran, PhD, for the Worldwide Esophageal Cancer Collaboration Investigators

“…We sought to obtain a granular estimate of patient-level risk-adjusted survival for each therapeutic option by cancer histopathology and stage. …”
Get full text

Exploring the epidemiological impact of attractive targeted sugar bait against malaria in combination with standard malaria control by Nima R. Moghaddas, Mohamed M. Traore, Gunter C. Müller, Joseph Wagman, Javan Chanda, Julian Entwistle, Christen M. Fornadel, Thomas S. Churcher

“…The dyed fraction in Mali varies substantially in space and time (mean 0.34, standard deviation 0.15), causing estimates of the bait-feeding rate to be highly uncertain, especially in areas with existing vector control tools. …”
Get full text

Transient Elastography for Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis B: A Meta-Analysis by Xiaolong Qi, Min An, Tongwei Wu, Deke Jiang, Mengyun Peng, Weidong Wang, Jing Wang, Chunqing Zhang, on behalf of the CHESS Study Group

“…Hierarchical summary receiver-operating curves model and the bivariate mixed-effects binary regression model were applied to generate summary receiver-operating characteristic curves and pooled estimates of sensitivity and specificity. Results. …”
Get full text

Global burden and cross-country inequalities of nutritional deficiencies in adults aged 65 years and older, 1990–2021: population-based study using the GBD 2021 by Shuang Liang, Shao-Zhi Xi, Jia-Yi Liu, Gui-Chun Tang, Wei-Guang Zhang, Xin-Ru Guo, Chen Yang, Chun Zhang, Guang-Yan Cai

“…Methods Age-standardised prevalence, disability-adjusted life years (DALYs), and average annual percentage changes (AAPCs) of these deficiencies in people aged ≥ 65 years at global, regional, and national levels were estimated from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. …”
Get full text

Deep-learning-based canopy height model generation from sub-meter resolution panchromatic satellite imagery by Charles J Abolt, Javier E Santos, Adam L Atchley, Lucas Wells, Daithi Martin, Russell A Parsons, Rodman R Linn

“…With modest additions to the training dataset, the same model generates minimally biased estimates of canopy height in both conifer and deciduous forests during multiple seasons. …”
Get full text

Long-term exposure to PM2.5 and its constituents and visual impairment in schoolchildren: A population-based survey in Guangdong province, China by Jia-Hui Li, Hui-Xian Zeng, Jing Wei, Qi-Zhen Wu, Shuang-Jian Qin, Qing-Guo Zeng, Bin Zhao, Guang-Hui Dong, Ji-Chuan Shen, Xiao-Wen Zeng

“…Methods: We conducted a large cross-sectional population-based study to recruit 59,054 schoolchildren from four cities in Guangdong province, China, and used the ChinaHighAirPollutants (CHAP) dataset to estimate 3-year average concentrations of PM2.5 and its constituents (black carbon (BC), organic matter (OM), nitrate (NO3–), sulfate (SO42−) and ammonium (NH4+)) based on individuals’ home addresses. …”
Get full text

Analysis of mutations in CDC27, CTBP2, HYDIN and KMT5A genes in carotid paragangliomas by E. N. Lukyanova, A. V. Snezhkina, D. V. Kalinin, A. V. Pokrovsky, A. L. Golovyuk, O. A. Stepanov, E. A. Pudova, G. S. Razmakhaev, M. V. Orlova, A. P. Polyakov, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva

“…Previously, we performed the exome sequencing of 52 CPGLs and estimated mutational load (ML). Paired histologically normal tissues or blood were unavailable, so potentially germline mutations were excluded from the analysis with strong filtering conditions using 1000 Genomes Project and ExAC databases. …”
Get full text

Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

“…We adopt a Gaussian kernel density estimate with two different spatial scales (10″ and 60″) to draw a density map of massive ( $\mathrm{log}({M}_{* }/{M}_{\odot })\gt 10.5$ ) and quiescent ( $\mathrm{log}(\mathrm{sSFR}\,[{\mathrm{yr}}^{-1}])\lt -10$ ) galaxies at z  ∼ 2. …”
Get full text

Oxidative damage to DNA, expression of Mt-1, and activation of repair mechanisms induced by vanadium trioxide in cultures of human lymphocytes by V.A. Alcántara-Mejía, A.A. Beltrán-Flores, R.A. Mateos-Nava, L. Álvarez-Barrera, I.U. Bahena-Ocampo, E. Santiago-Osorio, E. Bonilla-González, J.J. Rodríguez-Mercado

“…The expression levels of sensor proteins (ATM and ATR) involved in DNA damage were determined via Western blotting, and the mRNA expression levels of metallothionein 1 (Mt-1) and genes involved in DNA repair (OGG1, APE1, XPB, XPD, MRE11, RAD50, Ku70, and Ku80) were estimated via RT-PCR and qPCR. The results showed that V2O3 is an oxidant that is responsible for DNA damage through oxidized bases, as demonstrated by increased DNA migration in the presence of the FPG enzyme. …”
Get full text

Children with autoimmune hepatitis receiving standard-of-care therapy demonstrate long-term obesity and linear growth delay by Or Steg Saban, Shannon M. Vandriel, Syeda Aiman Fatima, Celine Bourdon, Amrita Mundh, Vicky L. Ng, Simon C. Ling, Robert H.J. Bandsma, Binita M. Kamath

“…Kaplan-Meier survival methods were used to estimate the cumulative incidence of new-onset growth impairments. …”
Get full text

Effectiveness of HPV vaccination in reducing infection among young Brazilian women by Ana Carolina da Silva Santos, Nayara Nascimento Toledo Silva, Ismael Dale Cotrim Guerreiro da Silva, Mariângela Carneiro, Wendel Coura-Vital, Angélica Alves Lima

“…Poisson and Cox multivariate regression models were used to estimate vaccine effectiveness. Results There was no significant difference in the overall prevalence of HPV infection between vaccinated and unvaccinated groups (23.6% vs. 18.7%; p = 0.364). …”
Get full text

Gender-based Morphometric Analysis of the Human Orbital Aperture Profile using 3D Reconstruction Computed Tomography: A Cross-sectional Retrospective Study by Muhammad Omer Afzal Bhatti, Mujeeb Ur Rehman Parrey, Muhammad Ikram Ali, Allah Rakhyo Shoro, Abdulkrem Ahmed Alenazi, Rayan Alhumaidi Alruwaili

“…Introduction: Sex estimation is a crucial aspect of forensic medicine and requires primary consideration when examining skeletal remains. …”
Get full text

The Patient-Reported Outcomes Thermometer–5-Item Scale (5T-PROs): Validation of a New Tool for the Quick Assessment of Overall Health Status in Painful Rheumatic Diseases by Fausto Salaffi, Marco Di Carlo, Marina Carotti, Sonia Farah

“…We used the intraclass correlation coefficient (ICC) as an estimate of test-retest reliability. Additionally, discriminant validity was tested using analysis of variance (ANOVA) with Bonferroni post hoc multiple comparisons, in different disease conditions. …”
Get full text

Association of per- and polyfluoroalkyl substances with gout risk: a cross-sectional analysis of NHANES 2007–2018 data emphasizing mixture effects by Haixin Feng, Siran Li, Shiqing Huang, Linxi He, Ruihao Huang, Renhuizi Wei, Xin Peng, Haiyi Yan, Chongxiang Xiong, Bingsong Zhang

“…Mediation analysis was conducted to estimate effect of uric acid.ResultsIn fully adjusted model, the associations were nonsignificant, with PFOA showing a marginally positive association. …”
Get full text

Incidence and risk factors for clinical omphalitis among neonates in Eastern Uganda using chlorhexidine gel for cord care: a community-cohort study by John Wogabaga, Kathy Burgoine, Abel Kakuru, Brendah Nambozo, Martin Chebet, Josephine Tumuhamye, Benon Wanume, Faith Oguttu, Milton W. Musaba, Agnes Napyo, Solomon Wani, Peter Olupot-Olupot, Andrew D. Weeks, Thorkild Tylleskär, David Mukunya

“…Bivariable and multivariable analyses were conducted using Cox proportional hazard regression models to estimate hazard ratios (HR) of selected exposures and time to omphalitis. …”
Get full text

Biogeochemical evidence raises questions on the longevity of warming‐induced growth enhancements in wet boreal forests by Susan E. Ziegler, Sharon A. Billings, Frances A. Podrebarac, Kate A. Edwards, Andrea Skinner, Kate M. Buckeridge, Trevor C. VandenBoer

“…Third, in contrast with soil N, estimates of soil P residence times are not coupled with those of C, and soil C:P does not correlate with tree growth across sites signifying that N, not P, may limit tree growth in these forests. …”
Get full text