A Rare Case of Spontaneous Heterotopic Pregnancy at 12 weeks of Gestation Following Natural Conception With Literature Review by Wang F, Xu Y, Dong X, Jiang P, Yu QQ

“…Transvaginal ultrasound (TVUS) revealed a single live fetus in the uterus, estimated at 12 weeks and six days, alongside a thick-walled cystic structure in the right ovary and an irregular hypoechoic mass inferior to the right ovary. …”
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Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning by Jianhui Chen, Qun Li, Xiaofang Liu, Fang Lin, Yaling Jing, Jiayan Yang, Lianfang Zhao

“…Moreover, immune cell infiltration was estimated using CIBERSORTx, and the Cancer Genome Atlas (TCGA) database was employed to elucidate the role of key genes in endometrial carcinoma (EC).Results26 common differentially expressed genes (DEGs) were screened in both diseases, three of which were identified as common core genes (MAN2A1, PAPSS1, RIBC2) through the combination of WGCNA, PPI network, and machine learning-based feature selection. …”
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Clinical Holistic Medicine (Mindful,Short-Term Psychodynamic Psychotherapy Complemented with Bodywork) in the Treatment of Experienced Mental Illness by Søren Ventegodt, Suzette Thegler, Tove Andreasen, Flemming Struve, Lars Enevoldsen, Laila Bassaine, Margrethe Torp, Joav Merrick

“…Calculated from this we find 1.41 < NNT < 2.31; we estimate NNH > 500. Of the 54 patients, 40% had already had traditional treatment that did not help them. …”
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End-of-life health literacy, knowledge and behaviours towards advance care planning among older adults: cross-sectional evidence from Switzerland by Ralf J Jox, Maud Wieczorek, Clément Meier, Sarah Vilpert, Jürgen Maurer, Carmen Borrat-Besson

“…Behaviours toward ACP were measured by whether respondents have discussed their end-of-life wishes, completed advance directives (AD) and appointed a potential surrogate for medical decisions in case of incapacity. Associations were estimated using separate ordinary least square and probit regressions, controlling for social, health and regional characteristics.Results Respondents with higher end-of-life health literacy tended to have better end-of-life knowledge and were more likely to have discussed their end-of-life wishes, to have completed AD and to have appointed a surrogate for medical decisions in case of incapacity. …”
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Global terrestrial moisture recycling in Shared Socioeconomic Pathways by A. Staal, P. Meijer, P. Meijer, M. K. Nyasulu, M. K. Nyasulu, M. K. Nyasulu, O. A. Tuinenburg, S. C. Dekker

“…We find that the global terrestrial precipitation recycling ratio decreases with the severity of the SSPs and estimate a decrease in this ratio of 1.5 % with every degree of global warming. …”
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Human phospholipases A2: a functional and evolutionary analysis by I. I. Turnaev, M. E. Bocharnikova, D. A. Afonnikov

“…Localization of the PLA2 genes in human genome showed they are placed on 12 human chromosomes, some of them forming clusters. Their RVI scores estimating gene tolerance to the mutations that accumulate in the human population demonstrated that the G4-type PLA2 genes belonging to one of the two largest clusters (4 genes) were most tolerant. …”
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The Characteristic of Biofilm Formation in ESBL-Producing K. pneumoniae Isolates by Xiaofang Gao, Haili Wang, Zhijuan Wu, Pan Sun, Wei Yu, Donghua Chen, Yuhua Mao, Lili Fang, Jia Qian, Li Li, Qian Peng, Yanping Han

“…Thirty ESBL-producing K. pneumoniae isolates from 25 inpatients at Ruijin Hospital, Shanghai, were subjected to pulsed-field gel electrophoresis (PFGE) to estimate genomic relatedness. Based on the chromosomal DNA patterns we obtained, we identified 21 PFGE profiles from the 30 isolates, eight of which had high homology indicating that they may have genetic relationships and/or potential clonal advantages within the hospital. …”
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Comprehensive Analysis of the Mechanism of Anoikis in Hepatocellular Carcinoma by Dongqian Li, Qian Bao, Shiqi Ren, Haoxiang Ding, Chengfeng Guo, Kai Gao, Jian Wan, Yao Wang, MingYan Zhu, Yicheng Xiong

“…The Cell-Type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) algorithm was used to determine the proportions of immune cell types. …”
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Autonomic Nervous System Activity before Atrial Fibrillation Onset as Assessed by Heart Rate Variability by Jean-Marie Grégoire, Cédric Gilon, François Marelli, Pascal Godart, Hugues Bersini, Stéphane Carlier

“…We computed parameters estimating parasympathetic activity (root mean square of successive RR interval differences (RMSSD) and percentage of successive RR intervals that differ by more than 50 ms (pNN50)), as well as HRV frequential parameters a few minutes before AF onset. …”
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The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia by Kai Shen, Chenlu Yang, Jie Huang, Xiao Shuai, Ting Niu, Hongbing Ma

“…Among the five non-ED patients, three did not recover from renal function and were still dialysis-dependent during the follow-up. The estimated 2-year overall survival rate for all patients was 42%, and the ED rate was 30.8%. …”
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Τhiazolidine-4-One Derivatives with Variable Modes of Inhibitory Action Against DPP4, a Drug Target with Multiple Activities and Established Role in Diabetes Mellitus Type II by Dionysia Amanatidou, Phaedra Eleftheriou, Anthi Petrou, Athina Geronikaki, Theodoros Lialiaris

“…Docking analysis was used to estimate probable sites and ways of binding. However, crystallographic or NMR studies are needed to elucidate the exact way of binding especially for uncompetitive and non-competitive inhibitors.…”
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Assessing Sugarcane Molasses’ Bioactive Compound Content upon Ultrasound-Assisted Hydroethanolic Extraction at Various pH Values by Boukaga Farmani, Miljana Djordjević, Somayeh Mohammadkhani, Marijana Djordjević

“…In the obtained sugarcane molasses extracts, the content of total phenolics, monomeric anthocyanins, total flavonoids, total tannins, and antioxidant capacity (DPPH) was estimated alongside the determination of molasses’ major components through GC-MS analysis Based on the GC-MS analysis of molasses, sugars and nitrogenous compounds emerged as the most abundant compounds classes. …”
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Enhanced Multi‐Objective Optimization Model for Bridge Performance Assessment and Prediction, Based on Improved PCA, K‐Means Clustering, and Kaplan–Meier Survival Algorithm by Chengzhong Gui, Zhi Duan, Zuwei Huang, Zhiguo Sun, Wei Qiao, Yu Cheng

“…Finally, a multi‐parameter regression model is used to evaluate and update the performance of the bridge structure, taking into account survival probability (using the Kaplan–Meier method), maintenance history, and material deterioration to estimate the most critical time for the bridge system. …”
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Optimising primary molecular profiling in non-small cell lung cancer. by R D Schouten, I Schouten, M M F Schuurbiers, V van der Noort, R A M Damhuis, E H F M van der Heijden, J A Burgers, N P Barlo, A S R van Lindert, K W Maas, J J G van den Brand, A A J Smit, J M W van Haarst, B van der Maat, E Schuuring, H Blaauwgeers, S M Willems, K Monkhorst, D van den Broek, M M van den Heuvel

“…Profiling of EGFR and ALK was performed in 69.9% of 136 patients included in the run-in phase, significantly more than real-world data estimates of 55% (p<0.001). Protocolised molecular profiling increased the rate to 77.0% (p = 0.049). …”
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The prognostic importance of the pan-immune-inflammation value in patients with septic shock by Yasemin Bozkurt Turan

“…The multivariate CPH model showed the age-adjusted risk estimates for these six laboratory parameters. High lactate (HR = 7.97 (2.19 – 29.08)) and high SOFA scores (HR = 4.85 (1.22 – 19.32)) were significantly associated with shorter survival in ICU patients (p < 0.05). …”
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Treatment Patterns and Health Care Costs in Commercially Insured Patients with Follicular Lymphoma by Nathan H. Fowler, Guifang Chen, Stephen Lim, Stephanie Manson, Qiufei Ma, Frank Li

“…**Background:** Few studies have estimated the real-world economic burden such as all-cause and follicular lymphoma-related costs and health care resource utilization (HCRU) in patients with follicular lymphoma (FL). …”
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Neuromuscular monitoring and incidence of postoperative residual neuromuscular blockade: a prospective observational study by Alessandra Piersanti, Rossella Garra, Fabio Sbaraglia, Miryam Del Vicario, Rosa Lamacchia, Marco Rossi

“…The secondary objectives were the number of postoperative adverse respiratory events and, for exploratory purposes, the estimation of potential risk factors through logistic regression analysis. …”
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Evaluation of Four Multiple Imputation Methods for Handling Missing Binary Outcome Data in the Presence of an Interaction between a Dummy and a Continuous Variable by Sara Javadi, Abbas Bahrampour, Mohammad Mehdi Saber, Behshid Garrusi, Mohammad Reza Baneshi

“…It is investigated, using simulated and real datasets, whether recursive partitioning creates appropriate variability between imputations and unbiased parameter estimates with appropriate confidence intervals. We compared four multiple imputation (MI) methods on a real and a simulated dataset. …”
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Safety and accuracy of digitally supported primary and secondary urgent care telephone triage in England: an observational study using routine data by Vanashree Sexton, Catherine Grimley, Jeremy Dale, Helen Atherton, Gary Abel

“…Mixed effects regression models were used to explore potential under-estimation of clinical risk (under-triage). Results Sensitivity was greater in primary triage, whilst specificity was greater in secondary triage. …”
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Water Risk and Mining Firms’ Stock Return by Maryam Davallou, Shirin Mehrali

“…The purpose of the current research is to test the pricing of water risk in mining companies of the Tehran Stock Exchange (TSE) and to estimate the drop in the value of their shares in the event of a water crisis. …”
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